DNA polymorphisms of apolipoprotein B and angiotensin I-converting enzyme genes and relationships with lipid levels in Italian patients with vascular dementia or Alzheimer's disease

Dementia and Geriatric Cognitive Disorders

Volumn 9, Issue 4, 1998, Pages 186-190

  Scacchi, Renato ^a,c   DeBernardini, L ^d   Mantuano, E ^a   Vilardo, T ^e   Donini, L M ^d   Ruggeri, M ^f   Gemma, A T ^f   Pascone, R ^b   Corbo, R M ^a,c  

^a Department of Genetics

^b Faculty of Medicine

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d Geriatric Hosp Villa Delle Querce

^e Dept Surg Prev Vasc Metab Dis ^*

^f MOLINETTE HOSPITAL   (Italy)

Author keywords

Alzheimer's disease; Angiotensin I converting enzyme; Apoliprotein B; Lipids; Vascular dementia

Indexed keywords

APOLIPOPROTEIN B; CHOLESTEROL; DIPEPTIDYL CARBOXYPEPTIDASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ALZHEIMER DISEASE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE LOCUS; GENETIC VARIABILITY; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; MULTIINFARCT DEMENTIA; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEINS B; CASE-CONTROL STUDIES; CHOLESTEROL; CHOLESTEROL, HDL; DEMENTIA, VASCULAR; DNA; FEMALE; GENE DOSAGE; GENOTYPE; HUMANS; ITALY; LIPIDS; MALE; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC;

EID: 0031865155     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017045     Document Type: Article

References (34)

1. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-923.
2. Frisoni GB, Bianchetti A, Govoni S, Trabucchi M, Calabresi L, Franceschini G: Association of apolipoprotein E E4 with vascular dementia. JAMA 1994;271:1317.
3. Sakoda S, Kuriyama M, Osame M, Takahashi K, Yamano T, Sasaki J, Matsunaga A: Apolipo- protein E ε4. Neurology 1994;44:2420.
4. Scacchi R, De Bernardini L, Mantuano E, Donini LM, Vilardo T, Corbo RM: Apolipo- protein E (APOE) allele frequencies in late- onset sporadic Alzheimer's disease (AD), mixed dementia and vascular dementia: Lack of association of ε4 allele with AD in Italian octogenarian patients. Neurosci Lett 1995;201:231-234.
5. Hachinski VC, Lassen NA, Marshall J: Multi-infarct dementia. A cause of mental deterioration in the elderly. Lancet 1974;ii:207-210.
6. Hofman A, Ott A, Breteler MMB, Bots ML, Slooter AJC, van Harskamp F, van Duijn CN, Van Broeckhoven C, Grobbee DE: Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet 1997;349:151-154.
7. Kalaria RN: Arteriosclerosis, apolipoprotein E, and Alzheimer's disease. Lancet 1997;349: 1174.
8. Brown MS, Goldstein JL: How LDL receptors influence cholesterol and atherosclerosis. Sci Am 1984;251:52-60.
9. Hansen PS, Klausen IC, Lemming L, Gerdes LU, Gregersen N, Faergeman O: Apolipoprotein B gene polymorphisms in ischemic heart disease and hypercholesterolemia: Effects of age and sex. Clin Genet 1994;45:78-83.
10. Humphries SE: DNA polymorphisms of the apolipoprotein genes - Their use in the investigation of the genetic component of hyperlipidaemia and atherosclerosis. Atherosclerosis 1988;72:89-108.
11. Renges H-H, Peacock R, Dunning AM, Talmud P, Humphries SE: Genetic relationship between the 3′-VNTR and diallelic apolipoprotein B gene polymorphisms: Haplotype analysis in individuals of European and South Asian origin. Ann Hum Genet 1992;56:11-33.
12. Cambien F, Poirier O, Lecerf L, Evans A, Cambou J-P, Arveiler D, Luc G, Bard J-M, Bara L, Ricard S, Tiret L, Amouyel P, Alhenc-Gelas F, Soubrier F: Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor of myocardial infarction. Nature 1992;359:641-644.
13. Cambien F: The angiotensin-converting enzyme (ACE) genetic polymorphism: Its relationship with plasma ACE level and myocardial infarction. Clin Genet 1994;46:94-101.
14. Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G, Corvol P: Two putative active centers in human angiotensin I- converting enzyme revealed by molecular cloning. Proc Natl Acad Sci USA 1988;85:9386-9390.
15. Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F, Soubrier F: Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 1992;51:197-205.
16. Tiret L, Kee F, Poirier O, Nicaud V, Lecerf L, Evans A, Cambou J-P, Arveiler D, Luc G, Amouyel P, Cambien F: Deletion polymorphism in angiotensin-converting enzyme gene associated with parental history of myocardial infarction. Lancet 1993;341:991-992.
17. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 3. Washington, APA, 1987, pp 101-107.
18. Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, et al: Vascular dementia: Diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993;43:250-260.
19. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939-944.
20. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
21. Zak B: Cholesterol methodologies: A review. Clin Chem 1977;23:1201-1214.
22. McGowan MW, Artiss JD, Strandbergh DR, Zak B: A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin Chem 1983;29:538-542.
23. DeLong DM, DeLong ER, Wood PD, Lippel K, Rifkind BM: A comparison of methods for the estimation of plasma low- and very low- density lipoprotein cholesterol. The Lipid Research Clinics Prevalence Study. JAMA 1986;256:2372-2377.
24. Stepanov VA, Puzyrev VP: Apolipoprotein B gene polymorphism in a Russian population. Hum Biol 1994;66:527-531.
25. Boerwinkle E, Shyun Lee S, Butler R, Schumaker VN, Chan L: Rapid typing of apolipo- protein B DNA polymorphisms by DNA amplification. Association between Ag epitopes of human apolipoprotein B-100, a signal peptide insertion/deletion polymorphism, and a 3′ flanking DNA variable number of tandem repeats polymorphism of the apolipoprotein B gene. Atherosclerosis 1990;81:225-232.
26. Schächter F, Faure-Delanef L, Guénot F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D: Genetic associations with human longevity at the APOE and ACE loci. Nat Genet 1994;6: 29-32.
27. Miettinen HE, Korpela K, Hämäläinen L, Kontula K: Polymorphisms of the apolipoprotein and angiotensin converting enzyme genes in young North Karelian patients with coronary heart disease. Hum Genet 1994;94:189-192.
28. Berge KE, Bøhn M, Berg K: DNA polymorphism at the locus for angiotensinogen I-converting enzyme in Norwegian patients with myocardial infarction and controls. Clin Genet 1994;46:102-104.
29. Castellano M, Muiesan ML, Rizzoni D, Beschi M, Pasini G, Cinelli A, Salvetti M, Porteri E, Bettoni G, Kreutz R, Lindpaintner K, Agabiti Rosei E: Angiotensin-converting enzyme I/D polymorphism and arterial wall thickness in a general population. The Vobarno study. Circulation 1995;91:2721-2724.
30. Hogan DB, Ebly EM, Rockwood K: Weight, blood pressure, osmolarity, and glucose levels across various stages of Alzheimer's disease and vascular dementia. Dement Geriatr Cogn Disord 1997;8:147-151.
31. Sandman P, Adolfsson R, Nygren C, Hallmans G, Winblad B: Nutritional status and dietary intake in institutionalized patients with Alzheimer's disease and multiinfarct dementia. J Am Geriatr Soc 1987;35:31-38.
32. O'Neill D, McKiernan M, Gibney M, Walsh JB, Coakley D: Dietary and anthropometric measures in mild to moderate senile dementia of the Alzheimer type (SDAT). J Hum Nutr Diet 1990;3:177-181.
33. Smith Claggett M: Nutritional factors relevant to Alzheimer's disease. J Am Diet Assoc 1989;89:392-396.
34. Muckle TJ, Roy JR: High-density lipoprotein cholesterol in differential diagnosis of senile dementia. Lancet 1985;i:1191-1193.