In vivo PET imaging in rat of dopamine terminals reveals functional neural transplants

Annals of Neurology

Volumn 43, Issue 3, 1998, Pages 387-390

  Brownell, Anna Liisa ^a,b   Livni, Eli ^b   Galpern, Wendy ^a   Isacson, Ole ^a,b,c  

^a MCLEAN HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; DOPAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VIABILITY; DOPAMINE BRAIN LEVEL; FEMALE; FOLLOW UP; GRAFT SURVIVAL; NERVE TRANSPLANTATION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; PRESYNAPTIC NERVE; PRIORITY JOURNAL; RAT;

ANIMALS; CORPUS STRIATUM; DOPAMINE; FEMALE; FETAL TISSUE TRANSPLANTATION; MESENCEPHALON; NERVE ENDINGS; PARKINSON DISEASE, SECONDARY; RATS; RATS, SPRAGUE-DAWLEY; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0031890991     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410430318     Document Type: Article

References (18)

1. Lindvall O, Sawle G, Widner H, et al. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann Neurol 1994;35:172-180
2. Spencer DD, Robbins RJ, Naftolin F, et al. Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's disease. N Engl J Med 1992;327:1541-1548
3. Freeman TB, Olanow CW, Hauser RA, et al. Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease. Ann Neurol 1995;38:379-388
4. Kordower JH, Freeman TB, Snow BJ, et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med 1995;332:1118-1124
5. Freed CR, Breezr RE, Rosenberg NL, et al. Survival of implanted fetal dopaminergic cells and neurologic improvement 12 and 46 months after transplantation for Parkinson's disease. N Engl J Med 1992;327:1549-1555
6. Olanow CW, Kordower JH, Freeman TB. Fetal nigral transplantation as a thetapy for Parkinson's disease. TINS 1996;19:102-109
7. Bjorklund A, Dunnett SB. Staging and dissection of rat embryos. In: Dunnett SB, Bjorklund A, eds. Neural transplantation: a practical approach. Oxford: IRL Press, 1992:1-19
8. 11C]-CFT and PET in a primate model of parkinsonism. NeuroReport 1992;3:265-268
9. 11C-CFT. Exp Neurol 1994;126:305-309
10. 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. Ann Neurol 1993;34:423-431
11. Kaufman MJ, Madras BK. Severe depletion of cocaine recognition sites associates with the dopamine transporter in Parkinson's diseased striatum. Synapse 1991;9:43-49
12. Jacobs A, Herholz K, Pietrzyk U, et al. Diaschisis of specific cerebellar lobules: pontine haematoma studied with high-resolution PET and MRI. J Neurol 1996;243:131-136
13. Torres ED, Fricker RA, Hume SP, et al. Assessment of striatal graft viability in the rat in vivo using a small diameter PET scanner. NeuroReport 1995;6:2017-2021
14. Brownell A-L, Hantraye P, Wullner U, et al. PET- and MRI-based assessment of glucose utilization, dopamine receptor binding, and hemodynamic changes after lesions to the caudate-putamen in primates. Exp Neurol 1994;125:41-52
15. Brownell GL, Burnham CA, Chesler DA. High resolution tomograph using analog coding. In: Greitz T, Ingvar DH, Widen L, eds. The metabolism of the human brain studied with positron emission tomography. New York: Raven Press, 1985:13-19
16. Galpern WR, Burns LH, Deacon TW, et al. Xenotransplantation of porcine fetal ventral mesencephalon in a rat model of Parkinson's disease: functional recovery and graft morphology. Exp Neurol 1996;140:1-13
17. Brownell A-L, Elmaleh D, Meltzer P, et al. Cocaine congeners as PET imaging probes for dopamine terminals. J Nucl Med 1996;37:1186-1192
18. 11C-WIN 35,428. Ann Neurol 1994;35:377-378