15d-prostaglandin J2 protects brain from ischemia-reperfusion injury

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 26, Issue 3, 2006, Pages 481-487

  Lin, Teng Nan ^a   Cheung, Wai Mui ^a   Wu, Jui Sheng ^a   Chen, Jean Ju ^a   Lin, Heng ^a   Chen, Jin Jer ^a   Liou, Jun Yang ^b   Shyue, Song Kun ^a   Wu, Kenneth K ^b  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

15d PGJ2; Apoptosis; COX 1; PPAR ; Stroke

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2 CHLORO 5 NITROBENZANILIDE; ADENOVIRUS VECTOR; CASPASE 3; CYCLOOXYGENASE 1; HEME OXYGENASE 1; HYDROGEN PEROXIDE; LIPOCALIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; PROSTAGLANDIN D SYNTHASE; PROSTAGLANDIN D2 DERIVATIVE; PROSTAGLANDIN D2 SYNTHASE; PROSTAGLANDIN J2; ROSIGLITAZONE; UNCLASSIFIED DRUG; 15 DEOXYPROSTAGLANDIN J2; 15-DEOXYPROSTAGLANDIN J2; 2,4 THIAZOLIDINEDIONE DERIVATIVE; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, RAT; CASPASE; DRUG DERIVATIVE; NEUROPROTECTIVE AGENT; PROSTAGLANDIN D2; VASODILATOR AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INFUSION; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; GENE AMPLIFICATION; GENE TRANSFER; HUMAN; HUMAN CELL; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ADENOVIRUS; ANIMAL; APOPTOSIS; CELL CULTURE; CEREBRAL ARTERY DISEASE; DRUG EFFECT; GENE THERAPY; GENETICS; LONG EVANS RAT; METABOLISM; NECROSIS; NERVE CELL; PATHOLOGY; PHYSIOLOGY; REPERFUSION INJURY;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELLS, CULTURED; CYCLOOXYGENASE 1; GENE THERAPY; GENE TRANSFER TECHNIQUES; HEME OXYGENASE-1; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NECROSIS; NEURONS; NEUROPROTECTIVE AGENTS; PPAR GAMMA; PROSTAGLANDIN D2; RATS; RATS, LONG-EVANS; REPERFUSION INJURY; THIAZOLIDINEDIONES; VASODILATOR AGENTS;

EID: 33646591929     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000201933.53964.5b     Document Type: Article

References (40)

1. Wu KK. Inducible cyclooxygenase and nitric oxide synthase. Adv Pharmacol. 1995;33:179-207.
2. Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem. 2000;69:145-182.
3. Iadecola C, Sugimoto K, Niwa K, Kazama K, Ross ME. Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice. J Cereb Blood Flow Metab. 2001;21:1436-1441.
4. Lin H, Lin T. -N., Cheung, W.M., Nian, G.M., Tseng, P.H., Chen, S.F., Chen, J.J., Shyue, S.K., Liou, J.Y., Wu, C.W., Wu, K.K. Cyclooxygenase-1 (COX-1) and Bicistronic COX-1/Prostacyclin synthase gene transfer protect against ischemic cerebral infarction. Circulation. 2002;105:1962-1969.
5. Hsu CY, Liu TH, Xu J, Hogan EL, Chao J, Sun G, Tai HH, Beckman JS, Freeman BA. Arachidonic acid and its metabolites in cerebral ischemia. Ann NY Acad Sci. 1989;559:282-295.
6. Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid receptors: structures, properties, and functions. Physiol Rev. 1999;79:1193-1226.
7. Hao CM, Redha R, Morrow J, Breyer MD. Peroxisome proliferator-activated receptor delta activation promotes cell survival following hypertonic stress. J Biol Chem. 2002;277:21341-21345.
8. Igarashi M, Nagata A, Toh H, Urade Y, Hayaishi O. Structural organization of the gene for prostaglandin D synthase in the rat brain. Proc Natl Acad Sci U S A. 1992;89:5376-5380.
9. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell. 1995;83:803-812.
10. 2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995;83:813-819.
11. Gilroy DW, Colville-Nash PR, Willis D, Chivers J, Paul-Clark MJ, Willoughby DA. Inducible cyclooxygenase may have anti-inflammatory properties. Nature Med. 1999;5:698-701.
12. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature. 1998;391:79-82.
13. Jiang C, Ting AT, Seed, B. PPAR. -gamma agonists inhibit production of monocyte inflammatory cytokines. Nature. 1998;391:82-86.
14. 2 and the ligation of PPARgamma. J Clin Invest. 2003;112:945-955.
15. Choi DW, Maulucci-Gedde M, Kriegstein AR. Glutamate neurotoxicity in cortical cell culture. J Neurosci. 1987;7:357-368.
16. Shih CL, Chi SI, Chiu TH, Sun GY, Lin TN. Ethanol effects on nitric oxide production in cerebral pial cultures. Alcohol Clin Exp Res. 2001;25:612-618.
17. Zoldhelyi P, McNatt J, Xu XM, Loose-Mitchell D, Meidell RS, Clubb FJ Jr, Buja LM, Willerson JT, Wu KK. Prevention of arterial thrombosis by adenovirus-mediated transfer of cyclooxygenase gene. Circulation. 1996;93:10-17.
18. An G, Lin T -N, Liu JS, Xue JJ, He YY, Hsu CY. Expression of c-fos and c-jun family genes after focal cerebral ischemia. Ann Neurol. 1993;33:457-464.
19. O'Neill LA, Kaltschmidt CNF. -kappa B: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci. 1997;20:252-258.
20. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab. 2001;21:2-14.
21. 2 in vitro. Brain Res. 1995;671:181-186.
22. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999;22:391-397.
23. Gobbel GT, Chan PH. Neuronal death is an active, caspase-dependent process after moderate but not severe DNA damage. J Neurochem. 2001;76:520-531.
24. Ruan YW, Ling GY, Zhang JL, Xu ZC. Apoptosis in the adult striatum after transient forebrain ischemia and the effects of ischemic severity. Brain Res. 2003;982:228-240.
25. Juan SH, Lee TS, Tseng KW, Liou JY, Shyue SK, Wu KK, Chau LY. Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2001;104:1519-1525.
26. 2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. J Biol Chem. 2004;279:21929-21937.
27. Subbaramaiah K, Lin DT, Hart JC, Dannenberg AJ. Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300. J Biol Chem. 2001;276:12440-12448.
28. 2: the endogenous electrophile that induces neuronal apoptosis. Proc Natl Acad Sci U S A. 2002;99:7367-7372.
29. Bishop-Bailey D, Hla T. Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2. J Biol Chem. 1999;274:17042-17048.
30. Padilla J, Kaur K, Cao HJ, Smith TJ, Phipps RP. Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells. J Immunol. 2000;165:6941-6948.
31. Piva R, Gianferretti P, Ciucci A, Taulli R, Belardo G, Santoro MG. 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins. Blood. 2005;105:1750-1758.
32. Ward C, Dransfield I, Murray J, Farrow SN, Haslett C, Rossi AG. Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. J Immunol. 2002;168:6232-6243.
33. Heneka MT, Feinstein DL, Galea E, Gleichmann M, Wullner U, Klockgether T. Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase. J Neuroimmuno. 1999;100:156-168.
34. 2 on glutathione induction and apoptosis in human endothelial cells. Arterioscler Thromb Vasc Biol. 2001;21:1846-1851.
35. Sundararajan S, Gamboa JL, Victor NA, Wanderi EW, Lust WD, Landreth GE. Peroxisome proliferator-activated receptor-gamma ligands reduce inflammation and infarction size in transient focal ischemia. Neuroscience. 2005;130:685-696.
36. Shimazu T, Inoue I, Araki N, Asano Y, Sawada M, Furuya D, Nagoya H, Greenberg JHA. peroxisome proliferator-activated receptor-gamma agonist reduces infarct size in transient but not in permanent ischemia. Stroke. 2005;36:353-359.
37. Uryu S, Harada J, Hisamoto M, Oda T. Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons. Brain Res. 2002;924:229-236.
38. Yue TL, Chen J, Bao W, Narayanan PK, Bril A, Jiang W, Lysko PG, Gu JL, Boyce R, Zimmerman DM, Hart TK, Buckingham RE, Ohlstein EH. In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Circulation. 2001;104:2588-2594.
39. Matsuda S, Wen TC, Karasawa Y, Araki H, Otsuka H, Ishihara K, Sakanaka M. Protective effect of a prostaglandin 12 analog, TEI-7165, on ischemic neuronal damage in gerbils. Brain Res. 1997;769:321-328.
40. Cui Y, Kataoka Y, Satoh T, Yamagata A, Shirakawa N, Watanabe Y, Suzuki M, Yanase H, Kataoka K, Watanabe Y. Protective effect of prostaglandin 1(2) analogs on ischemic delayed neuronal damage in gerbils. Biochem Biophys Res Commun. 1999;265:301-304.