Int6/eIF3e silenced HIF2α stabilization enhances migration and tube formation of HUVECs via IL-6 and IL-8 signaling

Cytokine

Volumn 62, Issue 1, 2013, Pages 115-122

  Endler, Alexander ^a,b   Chen, Li ^b   Li, Qin ^d   Uchida, Kazuyo ^b   Hashimoto, Takuya ^c   Lu, Lixia ^a   Xu, Guo Tong ^a   Shibasaki, Futoshi ^b  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d FUDAN UNIVERSITY   (China)

Author keywords

Angiogenesis; HIF2 ; IL 6; INT6; Migration

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INITIATION FACTOR 3; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; SCATTER FACTOR; SMALL INTERFERING RNA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL MIGRATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENDOTHELIUM CELL; EPIDERMAL GROWTH FACTOR GENE; GENE; GENE EXPRESSION REGULATION; GENE SILENCING; HELA CELL; HEPATOCYTE GROWTH FACTOR GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERLEUKIN 6 GENE; INTERLEUKIN 8 GENE; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR GENE;

BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL MOVEMENT; DNA; EUKARYOTIC INITIATION FACTOR-3; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; MOLECULAR SEQUENCE DATA; NEOVASCULARIZATION, PHYSIOLOGIC; OXYGEN; PROTEIN BINDING; PROTEIN STABILITY; RESPONSE ELEMENTS; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84875810004     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2013.01.021     Document Type: Article

References (43)

1. 2-regulated gene expression. Faseb J 2002, 16:1151-1162.
2. Wiesener M.S., Turley H., Allen W.E., Willam C., Eckardt K.U., Talks K.L., et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Blood 1998, 92:2260-2268.
3. Ema M., Hirota K., Mimura J., Abe H., Yodoi J., Sogawa K., et al. Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J 1999, 18:1905-1914.
4. Reyes H., Reisz-Porszasz S., Hankinson O. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 1992, 256:1193-1195.
5. Ben-Shoshan J., Maysel-Auslender S., Luboshits G., Barshack I., Polak-Charcon S., Tzahor E., et al. Hypoxia-inducible factor-1alpha and -2alpha additively promote endothelial vasculogenic properties. J Vasc Res 2009, 46:299-310.
6. Tian H., McKnight S.L., Russell D.W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997, 11:72-82.
7. Pugh C.W., Ratcliffe P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 2003, 9:677-684.
8. Savale L., Tu L., Rideau D., Izziki M., Maitre B., Adnot S., et al. Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice. Respir Res 2009, 10:6.
9. Mole D.R., Blancher C., Copley R.R., Pollard P.J., Gleadle J.M., Ragoussis J., et al. Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem 2009, 284:16767-16775.
10. Sowter H.M., Raval R.R., Moore J.W., Ratcliffe P.J., Harris A.L. Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Res 2003, 63:6130-6134.
11. Imamura T., Kikuchi H., Herraiz M.T., Park D.Y., Mizukami Y., Mino-Kenduson M., et al. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer 2009, 124:763-771.
12. Loboda A., Jozkowicz A., Dulak J. HIF-1 and HIF-2 transcription factors - similar but not identical. Mol Cells 2010, 29:435-442.
13. Brat D.J., Van Meir E.G. Glomeruloid microvascular proliferation orchestrated by VPF/VEGF: a new world of angiogenesis research. Am J Pathol 2001, 158:789-796.
14. Hong D.S., Angelo L.S., Kurzrock R. Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer 2007, 110:1911-1928.
15. Waugh D.J., Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res 2008, 14:6735-6741.
16. Rius J., Guma M., Schachtrup C., Akassoglou K., Zinkernagel A.S., Nizet V., et al. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 2008, 453:807-811.
17. Kang H.B., Kim Y.E., Kwon H.J., Sok D.E., Lee Y. Enhancement of NF-kappaB expression and activity upon differentiation of human embryonic stem cell line SNUhES3. Stem Cells Dev 2007, 16:615-623.
18. He W., Luistro L., Carvajal D., Smith M., Nevins T., Yin X., et al. High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the gamma-secretase inhibitor, RO4929097. Mol Oncol 2011, 5:292-301.
19. Smith D.R., Polverini P.J., Kunkel S.L., Orringer M.B., Whyte R.I., Burdick M.D., et al. Inhibition of interleukin-8 attenuates angiogenesis in bronchogenic carcinoma. J Exp Med 1994, 179:1409-1415.
20. Nilsson M.B., Langley R.R., Fidler I.J. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Cancer Res 2005, 65:10794-10800.
21. Brat D.J., Bellail A.C., Van Meir E.G. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol 2005, 7:122-133.
22. Mizukami Y., Jo W.S., Duerr E.M., Gala M., Li J., Zhang X., et al. Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells. Nat Med 2005, 11:992-997.
23. Samaras V., Piperi C., Levidou G., Zisakis A., Kavantzas N., Themistocleous M.S., et al. Analysis of interleukin (IL)-8 expression in human astrocytomas: associations with IL-6, cyclooxygenase-2, vascular endothelial growth factor, and microvessel morphometry. Hum Immunol 2009, 70:391-397.
24. Negaard H.F., Iversen N., Bowitz-Lothe I.M., Sandset P.M., Steinsvik B., Ostenstad B., et al. Increased bone marrow microvascular density in haematological malignancies is associated with differential regulation of angiogenic factors. Leukemia 2009, 23:162-169.
25. Chen L., Endler A., Uchida K., Horiguchi S., Morizane Y., Iijima O., et al. Int6/eIF3e silencing promotes functional blood vessel outgrowth and enhances wound healing by upregulating hypoxia-induced factor 2alpha expression. Circulation 2010, 122:910-919.
26. Chen L., Uchida K., Endler A., Shibasaki F. Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation. J Biol Chem 2007, 282:12707-12716.
27. Hunt M.A., Currie M.J., Robinson B.A., Dachs G.U. Optimizing transfection of primary human umbilical vein endothelial cells using commercially available chemical transfection reagents. J Biomol Technol 2010, 21:66-72.
28. Kato H., Tamamizu-Kato S., Shibasaki F. Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J Biol Chem 2004, 279:41966-41974.
29. Ali M.H., Schlidt S.A., Chandel N.S., Hynes K.L., Schumacker P.T., Gewertz B.L. Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction. Am J Physiol 1999, 277:L1057-L1065.
30. Huang Y.H., Lei H.Y., Liu H.S., Lin Y.S., Liu C.C., Yeh T.M. Dengue virus infects human endothelial cells and induces IL-6 and IL-8 production. Am J Trop Med Hyg 2000, 63:71-75.
31. Kaplanski G., Teysseire N., Farnarier C., Kaplanski S., Lissitzky J.C., Durand J.M., et al. IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway. J Clin Invest 1995, 96:2839-2844.
32. Shin H.S., Xu F., Bagchi A., Herrup E., Prakash A., Valentine C., et al. Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. J Immunol 2011, 186:1119-1130.
33. Shin H.S., Xu F., Bagchi A., Herrup E., Prakash A., Valentine C., et al. Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. J Immunol 2011, 186:1119-1130.
34. Hooper W.C., Phillips D.J., Renshaw M.A., Evatt B.L., Benson J.M. The up-regulation of IL-6 and IL-8 in human endothelial cells by activated protein C. J Immunol 1998, 161:2567-2573.
35. Wang W., Deng M., Liu X., Ai W., Tang Q., Hu J. TLR4 activation induces nontolerant inflammatory response in endothelial cells. Inflammation 2011, 34:509-518.
36. Imtiyaz H.Z., Williams E.P., Hickey M.M., Patel S.A., Durham A.C., Yuan L.J., et al. Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest 2010, 120:2699-2714.
37. Forooghian F., Das B. Anti-angiogenic effects of ribonucleic acid interference targeting vascular endothelial growth factor and hypoxia-inducible factor-1alpha. Am J Ophthalmol 2007, 144:761-768.
38. Loboda A., Stachurska A., Florczyk U., Rudnicka D., Jazwa A., Wegrzyn J., et al. HIF-1 induction attenuates Nrf2-dependent IL-8 expression in human endothelial cells. Antioxid Redox Signal 2009, 11:1501-1517.
39. Jee S.H., Chu C.Y., Chiu H.C., Huang Y.L., Tsai W.L., Liao Y.H., et al. Interleukin-6 induced basic fibroblast growth factor-dependent angiogenesis in basal cell carcinoma cell line via JAK/STAT3 and PI3-kinase/Akt pathways. J Invest Dermatol 2004, 123:1169-1175.
40. Son Y.H., Jeong Y.T., Lee K.A., Choi K.H., Kim S.M., Rhim B.Y., et al. Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells. J Cardiovasc Pharmacol 2008, 51:71-77.
41. Kunsch C., Rosen C.A. NF-kappa B subunit-specific regulation of the interleukin-8 promoter. Mol Cell Biol 1993, 13:6137-6146.
42. Gorlach A., Bonello S. The cross-talk between NF-kappaB and HIF-1: further evidence for a significant liaison. Biochem J 2008, 412:e17-e19.
43. Bracken C.P., Whitelaw M.L., Peet D.J. Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator. J Biol Chem 2005, 280:14240-14251.