-
1
-
-
0024160877
-
Banting lecture 1988. Role of insulin resistance in human disease
-
Reaven G.M. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988, 37:1595-1607.
-
(1988)
Diabetes
, vol.37
, pp. 1595-1607
-
-
Reaven, G.M.1
-
3
-
-
0033957339
-
Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit
-
Maddux B.A., Goldfine I.D. Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. Diabetes 2000, 49:13-19.
-
(2000)
Diabetes
, vol.49
, pp. 13-19
-
-
Maddux, B.A.1
Goldfine, I.D.2
-
4
-
-
0028795761
-
Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus
-
Maddux B.A., Sbraccia P., Kumakura S., Sasson S., Youngren J., Fisher A., Spencer S., Grupe A., Henzel W., Stewart T.A., et al. Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus. Nature 1995, 373:448-451.
-
(1995)
Nature
, vol.373
, pp. 448-451
-
-
Maddux, B.A.1
Sbraccia, P.2
Kumakura, S.3
Sasson, S.4
Youngren, J.5
Fisher, A.6
Spencer, S.7
Grupe, A.8
Henzel, W.9
Stewart, T.A.10
-
5
-
-
0030444778
-
Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity
-
Belfiore A., Costantino A., Frasca F., Pandini G., Mineo R., Vigneri P., Maddux B., Goldfine I.D., Vigneri R. Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity. Mol. Endocrinol. 1996, 10:1318-1326.
-
(1996)
Mol. Endocrinol.
, vol.10
, pp. 1318-1326
-
-
Belfiore, A.1
Costantino, A.2
Frasca, F.3
Pandini, G.4
Mineo, R.5
Vigneri, P.6
Maddux, B.7
Goldfine, I.D.8
Vigneri, R.9
-
6
-
-
60949083043
-
Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity
-
Chin C.N., Dallas-Yang Q., Liu F., Ho T., Ellsworth K., Fischer P., Natasha T., Ireland C., Lu P., Li C., Wang I.M., Strohl W., Berger J.P., An Z., Zhang B.B., Jiang G. Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity. Eur. J. Pharmacol. 2009, 606:17-24.
-
(2009)
Eur. J. Pharmacol.
, vol.606
, pp. 17-24
-
-
Chin, C.N.1
Dallas-Yang, Q.2
Liu, F.3
Ho, T.4
Ellsworth, K.5
Fischer, P.6
Natasha, T.7
Ireland, C.8
Lu, P.9
Li, C.10
Wang, I.M.11
Strohl, W.12
Berger, J.P.13
An, Z.14
Zhang, B.B.15
Jiang, G.16
-
7
-
-
0035080028
-
The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)
-
Costanzo B.V., Trischitta V., Di Paola R., Spampinato D., Pizzuti A., Vigneri R., Frittitta L. The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121). Diabetes 2001, 50:831-836.
-
(2001)
Diabetes
, vol.50
, pp. 831-836
-
-
Costanzo, B.V.1
Trischitta, V.2
Di Paola, R.3
Spampinato, D.4
Pizzuti, A.5
Vigneri, R.6
Frittitta, L.7
-
8
-
-
41149171157
-
Role of ENPP1 on adipocyte maturation
-
Liang J., Fu M., Ciociola E., Chandalia M., Abate N. Role of ENPP1 on adipocyte maturation. PLoS One 2007, 2:e882.
-
(2007)
PLoS One
, vol.2
-
-
Liang, J.1
Fu, M.2
Ciociola, E.3
Chandalia, M.4
Abate, N.5
-
9
-
-
67651085620
-
Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo
-
Zhou H.H., Chin C.N., Wu M., Ni W., Quan S., Liu F., Dallas-Yang Q., Ellsworth K., Ho T., Zhang A., Natasha T., Li J., Chapman K., Strohl W., Li C., Wang I.M., Berger J., An Z., Zhang B.B., Jiang G. Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo. Eur. J. Pharmacol. 2009, 616.
-
(2009)
Eur. J. Pharmacol.
, vol.616
-
-
Zhou, H.H.1
Chin, C.N.2
Wu, M.3
Ni, W.4
Quan, S.5
Liu, F.6
Dallas-Yang, Q.7
Ellsworth, K.8
Ho, T.9
Zhang, A.10
Natasha, T.11
Li, J.12
Chapman, K.13
Strohl, W.14
Li, C.15
Wang, I.M.16
Berger, J.17
An, Z.18
Zhang, B.B.19
Jiang, G.20
more..
-
10
-
-
79955872917
-
ENPP1 affects insulin action and secretion: evidences from in vitro studies
-
Di Paola R., Caporarello N., Marucci A., Dimatteo C., Iadicicco C., Del Guerra S., Prudente S., Sudano D., Miele C., Parrino C., Piro S., Beguinot F., Marchetti P., Trischitta V., Frittitta L. ENPP1 affects insulin action and secretion: evidences from in vitro studies. PLoS One 2011, 6:e19462.
-
(2011)
PLoS One
, vol.6
-
-
Di Paola, R.1
Caporarello, N.2
Marucci, A.3
Dimatteo, C.4
Iadicicco, C.5
Del Guerra, S.6
Prudente, S.7
Sudano, D.8
Miele, C.9
Parrino, C.10
Piro, S.11
Beguinot, F.12
Marchetti, P.13
Trischitta, V.14
Frittitta, L.15
-
11
-
-
12744274524
-
Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance
-
Dong H., Maddux B.A., Altomonte J., Meseck M., Accili D., Terkeltaub R., Johnson K., Youngren J.F., Goldfine I.D. Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance. Diabetes 2005, 54:367-372.
-
(2005)
Diabetes
, vol.54
, pp. 367-372
-
-
Dong, H.1
Maddux, B.A.2
Altomonte, J.3
Meseck, M.4
Accili, D.5
Terkeltaub, R.6
Johnson, K.7
Youngren, J.F.8
Goldfine, I.D.9
-
12
-
-
33646078811
-
Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia
-
Maddux B.A., Chang Y.N., Accili D., McGuinness O.P., Youngren J.F., Goldfine I.D. Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia. Am. J. Physiol. Endocrinol. Metab. 2006, 290:E746-E749.
-
(2006)
Am. J. Physiol. Endocrinol. Metab.
, vol.290
-
-
Maddux, B.A.1
Chang, Y.N.2
Accili, D.3
McGuinness, O.P.4
Youngren, J.F.5
Goldfine, I.D.6
-
13
-
-
0031026510
-
Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity
-
Frittitta L., Youngren J.F., Sbraccia P., D'Adamo M., Buongiorno A., Vigneri R., Goldfine I.D., Trischitta V. Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity. Diabetologia 1997, 40:282-289.
-
(1997)
Diabetologia
, vol.40
, pp. 282-289
-
-
Frittitta, L.1
Youngren, J.F.2
Sbraccia, P.3
D'Adamo, M.4
Buongiorno, A.5
Vigneri, R.6
Goldfine, I.D.7
Trischitta, V.8
-
14
-
-
0031747108
-
Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling
-
Frittitta L., Spampinato D., Solini A., Nosadini R., Goldfine I.D., Vigneri R., Trischitta V. Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling. Diabetes 1998, 47:1095-1100.
-
(1998)
Diabetes
, vol.47
, pp. 1095-1100
-
-
Frittitta, L.1
Spampinato, D.2
Solini, A.3
Nosadini, R.4
Goldfine, I.D.5
Vigneri, R.6
Trischitta, V.7
-
15
-
-
0032799097
-
Increased activity of membrane glycoprotein PC-1 in the fibroblasts from non-insulin-dependent diabetes mellitus patients with insulin resistance
-
Teno S., Kanno H., Oga S., Kumakura S., Kanamuro R., Iwamoto Y. Increased activity of membrane glycoprotein PC-1 in the fibroblasts from non-insulin-dependent diabetes mellitus patients with insulin resistance. Diabetes Res. Clin. Pract. 1999, 45:25-30.
-
(1999)
Diabetes Res. Clin. Pract.
, vol.45
, pp. 25-30
-
-
Teno, S.1
Kanno, H.2
Oga, S.3
Kumakura, S.4
Kanamuro, R.5
Iwamoto, Y.6
-
16
-
-
38949109352
-
Transcriptome and proteome expressions involved in insulin resistance in muscle and activated T-lymphocytes of patients with type 2 diabetes
-
Stentz F.B., Kitabchi A.E. Transcriptome and proteome expressions involved in insulin resistance in muscle and activated T-lymphocytes of patients with type 2 diabetes. Genomics Proteomics Bioinformatics 2007, 5:216-235.
-
(2007)
Genomics Proteomics Bioinformatics
, vol.5
, pp. 216-235
-
-
Stentz, F.B.1
Kitabchi, A.E.2
-
17
-
-
84870735641
-
Adipose tissue dysfunction in humans: a potential role for the transmembrane protein ENPP1
-
Chandalia M., Davila H., Pan W., Szuszkiewicz M., Tuvdendorj D., Livingston E.H., Abate N. Adipose tissue dysfunction in humans: a potential role for the transmembrane protein ENPP1. J. Clin. Endocrinol. Metab. 2012, 97.
-
(2012)
J. Clin. Endocrinol. Metab.
, vol.97
-
-
Chandalia, M.1
Davila, H.2
Pan, W.3
Szuszkiewicz, M.4
Tuvdendorj, D.5
Livingston, E.H.6
Abate, N.7
-
18
-
-
0032857338
-
A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance
-
Pizzuti A., Frittitta L., Argiolas A., Baratta R., Goldfine I.D., Bozzali M., Ercolino T., Scarlato G., Iacoviello L., Vigneri R., Tassi V., Trischitta V. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Diabetes 1999, 48:1881-1884.
-
(1999)
Diabetes
, vol.48
, pp. 1881-1884
-
-
Pizzuti, A.1
Frittitta, L.2
Argiolas, A.3
Baratta, R.4
Goldfine, I.D.5
Bozzali, M.6
Ercolino, T.7
Scarlato, G.8
Iacoviello, L.9
Vigneri, R.10
Tassi, V.11
Trischitta, V.12
-
19
-
-
0347993139
-
Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance
-
Abate N., Carulli L., Cabo-Chan A., Chandalia M., Snell P.G., Grundy S.M. Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance. J. Clin. Endocrinol. Metab. 2003, 88:5927-5934.
-
(2003)
J. Clin. Endocrinol. Metab.
, vol.88
, pp. 5927-5934
-
-
Abate, N.1
Carulli, L.2
Cabo-Chan, A.3
Chandalia, M.4
Snell, P.G.5
Grundy, S.M.6
-
20
-
-
33746726490
-
Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects
-
Grarup N., Urhammer S.A., Ek J., Albrechtsen A., Glumer C., Borch-Johnsen K., Jorgensen T., Hansen T., Pedersen O. Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects. Diabetologia 2006, 49:2097-2104.
-
(2006)
Diabetologia
, vol.49
, pp. 2097-2104
-
-
Grarup, N.1
Urhammer, S.A.2
Ek, J.3
Albrechtsen, A.4
Glumer, C.5
Borch-Johnsen, K.6
Jorgensen, T.7
Hansen, T.8
Pedersen, O.9
-
21
-
-
58149354288
-
Role of the ENPP1 K121Q polymorphism in glucose homeostasis
-
Baratta R., Rossetti P., Prudente S., Barbetti F., Sudano D., Nigro A., Farina M.G., Pellegrini F., Trischitta V., Frittitta L. Role of the ENPP1 K121Q polymorphism in glucose homeostasis. Diabetes 2008, 57:3360-3364.
-
(2008)
Diabetes
, vol.57
, pp. 3360-3364
-
-
Baratta, R.1
Rossetti, P.2
Prudente, S.3
Barbetti, F.4
Sudano, D.5
Nigro, A.6
Farina, M.G.7
Pellegrini, F.8
Trischitta, V.9
Frittitta, L.10
-
22
-
-
48249098981
-
Haplotype structure of the ENPP1 gene and nominal association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study
-
Stolerman E.S., Manning A.K., McAteer J.B., Dupuis J., Fox C.S., Cupples L.A., Meigs J.B., Florez J.C. Haplotype structure of the ENPP1 gene and nominal association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study. Diabetes 2008, 57:1971-1977.
-
(2008)
Diabetes
, vol.57
, pp. 1971-1977
-
-
Stolerman, E.S.1
Manning, A.K.2
McAteer, J.B.3
Dupuis, J.4
Fox, C.S.5
Cupples, L.A.6
Meigs, J.B.7
Florez, J.C.8
-
23
-
-
23044493861
-
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
-
Meyre D., Bouatia-Naji N., Tounian A., Samson C., Lecoeur C., Vatin V., Ghoussaini M., Wachter C., Hercberg S., Charpentier G., Patsch W., Pattou F., Charles M.A., Tounian P., Clement K., Jouret B., Weill J., Maddux B.A., Goldfine I.D., Walley A., Boutin P., Dina C., Froguel P. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat. Genet. 2005, 37:863-867.
-
(2005)
Nat. Genet.
, vol.37
, pp. 863-867
-
-
Meyre, D.1
Bouatia-Naji, N.2
Tounian, A.3
Samson, C.4
Lecoeur, C.5
Vatin, V.6
Ghoussaini, M.7
Wachter, C.8
Hercberg, S.9
Charpentier, G.10
Patsch, W.11
Pattou, F.12
Charles, M.A.13
Tounian, P.14
Clement, K.15
Jouret, B.16
Weill, J.17
Maddux, B.A.18
Goldfine, I.D.19
Walley, A.20
Boutin, P.21
Dina, C.22
Froguel, P.23
more..
-
24
-
-
58549097645
-
The role of HSP70 on ENPP1 expression and insulin-receptor activation
-
Marucci A., Miscio G., Padovano L., Boonyasrisawat W., Florez J.C., Doria A., Trischitta V., Di Paola R. The role of HSP70 on ENPP1 expression and insulin-receptor activation. J. Mol. Med. 2009, 87:139-144.
-
(2009)
J. Mol. Med.
, vol.87
, pp. 139-144
-
-
Marucci, A.1
Miscio, G.2
Padovano, L.3
Boonyasrisawat, W.4
Florez, J.C.5
Doria, A.6
Trischitta, V.7
Di Paola, R.8
-
25
-
-
0035434678
-
A cluster of three single nucleotide polymorphisms in the 3'-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities
-
Frittitta L., Ercolino T., Bozzali M., Argiolas A., Graci S., Santagati M.G., Spampinato D., Di Paola R., Cisternino C., Tassi V., Vigneri R., Pizzuti A., Trischitta V. A cluster of three single nucleotide polymorphisms in the 3'-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities. Diabetes 2001, 50:1952-1955.
-
(2001)
Diabetes
, vol.50
, pp. 1952-1955
-
-
Frittitta, L.1
Ercolino, T.2
Bozzali, M.3
Argiolas, A.4
Graci, S.5
Santagati, M.G.6
Spampinato, D.7
Di Paola, R.8
Cisternino, C.9
Tassi, V.10
Vigneri, R.11
Pizzuti, A.12
Trischitta, V.13
-
26
-
-
56049090306
-
Cis-Acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins
-
Russo A., Cirulli C., Amoresano A., Pucci P., Pietropaolo C., Russo G. cis-Acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins. Biochim. Biophys. Acta, Gene Regul. Mech. 2008, 1779:820-829.
-
(2008)
Biochim. Biophys. Acta, Gene Regul. Mech.
, vol.1779
, pp. 820-829
-
-
Russo, A.1
Cirulli, C.2
Amoresano, A.3
Pucci, P.4
Pietropaolo, C.5
Russo, G.6
-
27
-
-
58849147164
-
The molecular chaperone Hsp90 is a component of the cap-binding complex and interacts with the translational repressor Cup during Drosophila oogenesis
-
Pisa V., Cozzolino M., Gargiulo S., Ottone C., Piccioni F., Monti M., Gigliotti S., Talamo F., Graziani F., Pucci P., Verrotti A.C. The molecular chaperone Hsp90 is a component of the cap-binding complex and interacts with the translational repressor Cup during Drosophila oogenesis. Gene 2009, 432:67-74.
-
(2009)
Gene
, vol.432
, pp. 67-74
-
-
Pisa, V.1
Cozzolino, M.2
Gargiulo, S.3
Ottone, C.4
Piccioni, F.5
Monti, M.6
Gigliotti, S.7
Talamo, F.8
Graziani, F.9
Pucci, P.10
Verrotti, A.C.11
-
28
-
-
34249067403
-
Sulfatase modifying factor 1 trafficking through the cells: from endoplasmic reticulum to the endoplasmic reticulum
-
Zito E., Buono M., Pepe S., Settembre C., Annunziata I., Surace E.M., Dierks T., Monti M., Cozzolino M., Pucci P., Ballabio A., Cosma M.P. Sulfatase modifying factor 1 trafficking through the cells: from endoplasmic reticulum to the endoplasmic reticulum. EMBO J. 2007, 26:2443-2453.
-
(2007)
EMBO J.
, vol.26
, pp. 2443-2453
-
-
Zito, E.1
Buono, M.2
Pepe, S.3
Settembre, C.4
Annunziata, I.5
Surace, E.M.6
Dierks, T.7
Monti, M.8
Cozzolino, M.9
Pucci, P.10
Ballabio, A.11
Cosma, M.P.12
-
29
-
-
0037234565
-
All in the family: the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases
-
Ten Hagen K.G., Fritz T.A., Tabak L.A. All in the family: the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases. Glycobiology 2003, 13:1R-16R.
-
(2003)
Glycobiology
, vol.13
-
-
Ten Hagen, K.G.1
Fritz, T.A.2
Tabak, L.A.3
-
30
-
-
0033863689
-
Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis
-
Gu H.F., Almgren P., Lindholm E., Frittitta L., Pizzuti A., Trischitta V., Groop L.C. Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis. Diabetes 2000, 49:1601-1603.
-
(2000)
Diabetes
, vol.49
, pp. 1601-1603
-
-
Gu, H.F.1
Almgren, P.2
Lindholm, E.3
Frittitta, L.4
Pizzuti, A.5
Trischitta, V.6
Groop, L.C.7
-
31
-
-
0035217903
-
The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance
-
Frittitta L., Baratta R., Spampinato D., Di Paola R., Pizzuti A., Vigneri R., Trischitta V. The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance. J. Clin. Endocrinol. Metab. 2001, 86:5888-5891.
-
(2001)
J. Clin. Endocrinol. Metab.
, vol.86
, pp. 5888-5891
-
-
Frittitta, L.1
Baratta, R.2
Spampinato, D.3
Di Paola, R.4
Pizzuti, A.5
Vigneri, R.6
Trischitta, V.7
-
32
-
-
0344944629
-
Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms
-
Baratta R., Di Paola R., Spampinato D., Fini G., Marucci A., Coco A., Vigneri R., Frittitta L., Trischitta V. Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms. J. Mol. Med. 2003, 81:718-723.
-
(2003)
J. Mol. Med.
, vol.81
, pp. 718-723
-
-
Baratta, R.1
Di Paola, R.2
Spampinato, D.3
Fini, G.4
Marucci, A.5
Coco, A.6
Vigneri, R.7
Frittitta, L.8
Trischitta, V.9
-
33
-
-
0041808862
-
The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia
-
Kubaszek A., Pihlajamaki J., Karhapaa P., Vauhkonen I., Laakso M. The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia. Diabetes Care 2003, 26:464-467.
-
(2003)
Diabetes Care
, vol.26
, pp. 464-467
-
-
Kubaszek, A.1
Pihlajamaki, J.2
Karhapaa, P.3
Vauhkonen, I.4
Laakso, M.5
-
34
-
-
12144289924
-
The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes
-
Hamaguchi K., Terao H., Kusuda Y., Yamashita T., Hazoury Bahles J.A., Cruz L.M., Brugal V.L., Jongchong W.B., Yoshimatsu H., Sakata T. The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes. J. Clin. Endocrinol. Metab. 2004, 89:1359-1364.
-
(2004)
J. Clin. Endocrinol. Metab.
, vol.89
, pp. 1359-1364
-
-
Hamaguchi, K.1
Terao, H.2
Kusuda, Y.3
Yamashita, T.4
Hazoury Bahles, J.A.5
Cruz, L.M.6
Brugal, V.L.7
Jongchong, W.B.8
Yoshimatsu, H.9
Sakata, T.10
-
35
-
-
15944371462
-
ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes
-
Abate N., Chandalia M., Satija P., Adams-Huet B., Grundy S.M., Sandeep S., Radha V., Deepa R., Mohan V. ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes. Diabetes 2005, 54:1207-1213.
-
(2005)
Diabetes
, vol.54
, pp. 1207-1213
-
-
Abate, N.1
Chandalia, M.2
Satija, P.3
Adams-Huet, B.4
Grundy, S.M.5
Sandeep, S.6
Radha, V.7
Deepa, R.8
Mohan, V.9
-
36
-
-
25844490514
-
The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction
-
Bacci S., Ludovico O., Prudente S., Zhang Y.Y., Di Paola R., Mangiacotti D., Rauseo A., Nolan D., Duffy J., Fini G., Salvemini L., Amico C., Vigna C., Pellegrini F., Menzaghi C., Doria A., Trischitta V. The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction. Diabetes 2005, 54:3021-3025.
-
(2005)
Diabetes
, vol.54
, pp. 3021-3025
-
-
Bacci, S.1
Ludovico, O.2
Prudente, S.3
Zhang, Y.Y.4
Di Paola, R.5
Mangiacotti, D.6
Rauseo, A.7
Nolan, D.8
Duffy, J.9
Fini, G.10
Salvemini, L.11
Amico, C.12
Vigna, C.13
Pellegrini, F.14
Menzaghi, C.15
Doria, A.16
Trischitta, V.17
-
37
-
-
33845426384
-
The association of PC-1 (ENPP1) K121Q polymorphism with metabolic syndrome in patients with coronary heart disease
-
Tasic I., Milojkovic M., Sunder-Plassmann R., Lazarevic G., Tasic N.M., Stefanovic V. The association of PC-1 (ENPP1) K121Q polymorphism with metabolic syndrome in patients with coronary heart disease. Clin. Chim. Acta 2007, 377:237-242.
-
(2007)
Clin. Chim. Acta
, vol.377
, pp. 237-242
-
-
Tasic, I.1
Milojkovic, M.2
Sunder-Plassmann, R.3
Lazarevic, G.4
Tasic, N.M.5
Stefanovic, V.6
-
38
-
-
42449116149
-
The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects
-
McAteer J.B., Prudente S., Bacci S., Lyon H.N., Hirschhorn J.N., Trischitta V., Florez J.C. The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects. Diabetes 2008, 57:1125-1130.
-
(2008)
Diabetes
, vol.57
, pp. 1125-1130
-
-
McAteer, J.B.1
Prudente, S.2
Bacci, S.3
Lyon, H.N.4
Hirschhorn, J.N.5
Trischitta, V.6
Florez, J.C.7
-
39
-
-
0035937586
-
Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAc
-
Wells L., Vosseller K., Hart G.W. Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAc. Science 2001, 291:2376-2378.
-
(2001)
Science
, vol.291
, pp. 2376-2378
-
-
Wells, L.1
Vosseller, K.2
Hart, G.W.3
-
40
-
-
22244471058
-
O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes
-
Park S.Y., Ryu J., Lee W. O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes. Exp. Mol. Med. 2005, 37:220-229.
-
(2005)
Exp. Mol. Med.
, vol.37
, pp. 220-229
-
-
Park, S.Y.1
Ryu, J.2
Lee, W.3
-
41
-
-
56049101623
-
Regulation of Akt signaling by O-GlcNAc in euglycemia
-
Soesanto Y.A., Luo B., Jones D., Taylor R., Gabrielsen J.S., Parker G., McClain D.A. Regulation of Akt signaling by O-GlcNAc in euglycemia. Am. J. Physiol. Endocrinol. Metab. 2008, 295:E974-E980.
-
(2008)
Am. J. Physiol. Endocrinol. Metab.
, vol.295
-
-
Soesanto, Y.A.1
Luo, B.2
Jones, D.3
Taylor, R.4
Gabrielsen, J.S.5
Parker, G.6
McClain, D.A.7
-
42
-
-
39749104251
-
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance
-
Yang X., Ongusaha P.P., Miles P.D., Havstad J.C., Zhang F., So W.V., Kudlow J.E., Michell R.H., Olefsky J.M., Field S.J., Evans R.M. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature 2008, 451:964-969.
-
(2008)
Nature
, vol.451
, pp. 964-969
-
-
Yang, X.1
Ongusaha, P.P.2
Miles, P.D.3
Havstad, J.C.4
Zhang, F.5
So, W.V.6
Kudlow, J.E.7
Michell, R.H.8
Olefsky, J.M.9
Field, S.J.10
Evans, R.M.11
-
43
-
-
67449114009
-
Gene expression analysis of hepatic roles in cause and development of diabetes in Goto-Kakizaki rats
-
Almon R.R., DuBois D.C., Lai W., Xue B., Nie J., Jusko W.J. Gene expression analysis of hepatic roles in cause and development of diabetes in Goto-Kakizaki rats. J. Endocrinol. 2009, 200:331-346.
-
(2009)
J. Endocrinol.
, vol.200
, pp. 331-346
-
-
Almon, R.R.1
DuBois, D.C.2
Lai, W.3
Xue, B.4
Nie, J.5
Jusko, W.J.6
-
44
-
-
24944489239
-
Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes
-
Lee Y.H., Nair S., Rousseau E., Allison D.B., Page G.P., Tataranni P.A., Bogardus C., Permana P.A. Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes. Diabetologia 2005, 48:1776-1783.
-
(2005)
Diabetologia
, vol.48
, pp. 1776-1783
-
-
Lee, Y.H.1
Nair, S.2
Rousseau, E.3
Allison, D.B.4
Page, G.P.5
Tataranni, P.A.6
Bogardus, C.7
Permana, P.A.8
-
45
-
-
77955505564
-
Biological, clinical and population relevance of 95 loci for blood lipids
-
Teslovich T.M., Musunuru K., Smith A.V., Edmondson A.C., Stylianou I.M., Koseki M., Pirruccello J.P., Ripatti S., Chasman D.I., Willer C.J., Johansen C.T., Fouchier S.W., Isaacs A., Peloso G.M., Barbalic M., Ricketts S.L., Bis J.C., Aulchenko Y.S., Thorleifsson G., Feitosa M.F., Chambers J., Orho-Melander M., Melander O., Johnson T., Li X., Guo X., Li M., Shin Cho Y., Jin Go M., Jin Kim Y., Lee J.Y., Park T., Kim K., Sim X., Twee-Hee Ong R., Croteau-Chonka D.C., Lange L.A., Smith J.D., Song K., Hua Zhao J., Yuan X., Luan J., Lamina C., Ziegler A., Zhang W., Zee R.Y., Wright A.F., Witteman J.C., Wilson J.F., Willemsen G., Wichmann H.E., Whitfield J.B., Waterworth D.M., Wareham N.J., Waeber G., Vollenweider P., Voight B.F., Vitart V., Uitterlinden A.G., Uda M., Tuomilehto J., Thompson J.R., Tanaka T., Surakka I., Stringham H.M., Spector T.D., Soranzo N., Smit J.H., Sinisalo J., Silander K., Sijbrands E.J., Scuteri A., Scott J., Schlessinger D., Sanna S., Salomaa V., Saharinen J., Sabatti C., Ruokonen A., Rudan I., Rose L.M., Roberts R., Rieder M., Psaty B.M., Pramstaller P.P., Pichler I., Perola M., Penninx B.W., Pedersen N.L., Pattaro C., Parker A.N., Pare G., Oostra B.A., O'Donnell C.J., Nieminen M.S., Nickerson D.A., Montgomery G.W., Meitinger T., McPherson R., McCarthy M.I., et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010, 466:707-713.
-
(2010)
Nature
, vol.466
, pp. 707-713
-
-
Teslovich, T.M.1
Musunuru, K.2
Smith, A.V.3
Edmondson, A.C.4
Stylianou, I.M.5
Koseki, M.6
Pirruccello, J.P.7
Ripatti, S.8
Chasman, D.I.9
Willer, C.J.10
Johansen, C.T.11
Fouchier, S.W.12
Isaacs, A.13
Peloso, G.M.14
Barbalic, M.15
Ricketts, S.L.16
Bis, J.C.17
Aulchenko, Y.S.18
Thorleifsson, G.19
Feitosa, M.F.20
Chambers, J.21
Orho-Melander, M.22
Melander, O.23
Johnson, T.24
Li, X.25
Guo, X.26
Li, M.27
Shin Cho, Y.28
Jin Go, M.29
Jin Kim, Y.30
Lee, J.Y.31
Park, T.32
Kim, K.33
Sim, X.34
Twee-Hee Ong, R.35
Croteau-Chonka, D.C.36
Lange, L.A.37
Smith, J.D.38
Song, K.39
Hua Zhao, J.40
Yuan, X.41
Luan, J.42
Lamina, C.43
Ziegler, A.44
Zhang, W.45
Zee, R.Y.46
Wright, A.F.47
Witteman, J.C.48
Wilson, J.F.49
Willemsen, G.50
Wichmann, H.E.51
Whitfield, J.B.52
Waterworth, D.M.53
Wareham, N.J.54
Waeber, G.55
Vollenweider, P.56
Voight, B.F.57
Vitart, V.58
Uitterlinden, A.G.59
Uda, M.60
Tuomilehto, J.61
Thompson, J.R.62
Tanaka, T.63
Surakka, I.64
Stringham, H.M.65
Spector, T.D.66
Soranzo, N.67
Smit, J.H.68
Sinisalo, J.69
Silander, K.70
Sijbrands, E.J.71
Scuteri, A.72
Scott, J.73
Schlessinger, D.74
Sanna, S.75
Salomaa, V.76
Saharinen, J.77
Sabatti, C.78
Ruokonen, A.79
Rudan, I.80
Rose, L.M.81
Roberts, R.82
Rieder, M.83
Psaty, B.M.84
Pramstaller, P.P.85
Pichler, I.86
Perola, M.87
Penninx, B.W.88
Pedersen, N.L.89
Pattaro, C.90
Parker, A.N.91
Pare, G.92
Oostra, B.A.93
O'Donnell, C.J.94
Nieminen, M.S.95
Nickerson, D.A.96
Montgomery, G.W.97
Meitinger, T.98
McPherson, R.99
more..
-
46
-
-
38649132270
-
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
-
Kathiresan S., Melander O., Guiducci C., Surti A., Burtt N.P., Rieder M.J., Cooper G.M., Roos C., Voight B.F., Havulinna A.S., Wahlstrand B., Hedner T., Corella D., Tai E.S., Ordovas J.M., Berglund G., Vartiainen E., Jousilahti P., Hedblad B., Taskinen M.R., Newton-Cheh C., Salomaa V., Peltonen L., Groop L., Altshuler D.M., Orho-Melander M. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat. Genet. 2008, 40:189-197.
-
(2008)
Nat. Genet.
, vol.40
, pp. 189-197
-
-
Kathiresan, S.1
Melander, O.2
Guiducci, C.3
Surti, A.4
Burtt, N.P.5
Rieder, M.J.6
Cooper, G.M.7
Roos, C.8
Voight, B.F.9
Havulinna, A.S.10
Wahlstrand, B.11
Hedner, T.12
Corella, D.13
Tai, E.S.14
Ordovas, J.M.15
Berglund, G.16
Vartiainen, E.17
Jousilahti, P.18
Hedblad, B.19
Taskinen, M.R.20
Newton-Cheh, C.21
Salomaa, V.22
Peltonen, L.23
Groop, L.24
Altshuler, D.M.25
Orho-Melander, M.26
more..
-
47
-
-
38649125868
-
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
-
Willer C.J., Sanna S., Jackson A.U., Scuteri A., Bonnycastle L.L., Clarke R., Heath S.C., Timpson N.J., Najjar S.S., Stringham H.M., Strait J., Duren W.L., Maschio A., Busonero F., Mulas A., Albai G., Swift A.J., Morken M.A., Narisu N., Bennett D., Parish S., Shen H., Galan P., Meneton P., Hercberg S., Zelenika D., Chen W.M., Li Y., Scott L.J., Scheet P.A., Sundvall J., Watanabe R.M., Nagaraja R., Ebrahim S., Lawlor D.A., Ben-Shlomo Y., Davey-Smith G., Shuldiner A.R., Collins R., Bergman R.N., Uda M., Tuomilehto J., Cao A., Collins F.S., Lakatta E., Lathrop G.M., Boehnke M., Schlessinger D., Mohlke K.L., Abecasis G.R. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat. Genet. 2008, 40:161-169.
-
(2008)
Nat. Genet.
, vol.40
, pp. 161-169
-
-
Willer, C.J.1
Sanna, S.2
Jackson, A.U.3
Scuteri, A.4
Bonnycastle, L.L.5
Clarke, R.6
Heath, S.C.7
Timpson, N.J.8
Najjar, S.S.9
Stringham, H.M.10
Strait, J.11
Duren, W.L.12
Maschio, A.13
Busonero, F.14
Mulas, A.15
Albai, G.16
Swift, A.J.17
Morken, M.A.18
Narisu, N.19
Bennett, D.20
Parish, S.21
Shen, H.22
Galan, P.23
Meneton, P.24
Hercberg, S.25
Zelenika, D.26
Chen, W.M.27
Li, Y.28
Scott, L.J.29
Scheet, P.A.30
Sundvall, J.31
Watanabe, R.M.32
Nagaraja, R.33
Ebrahim, S.34
Lawlor, D.A.35
Ben-Shlomo, Y.36
Davey-Smith, G.37
Shuldiner, A.R.38
Collins, R.39
Bergman, R.N.40
Uda, M.41
Tuomilehto, J.42
Cao, A.43
Collins, F.S.44
Lakatta, E.45
Lathrop, G.M.46
Boehnke, M.47
Schlessinger, D.48
Mohlke, K.L.49
Abecasis, G.R.50
more..
-
48
-
-
82955239839
-
Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man
-
Holleboom A.G., Karlsson H., Lin R.S., Beres T.M., Sierts J.A., Herman D.S., Stroes E.S., Aerts J.M., Kastelein J.J., Motazacker M.M., Dallinga-Thie G.M., Levels J.H., Zwinderman A.H., Seidman J.G., Seidman C.E., Ljunggren S., Lefeber D.J., Morava E., Wevers R.A., Fritz T.A., Tabak L.A., Lindahl M., Hovingh G.K., Kuivenhoven J.A. Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man. Cell Metab. 2011, 14:811-818.
-
(2011)
Cell Metab.
, vol.14
, pp. 811-818
-
-
Holleboom, A.G.1
Karlsson, H.2
Lin, R.S.3
Beres, T.M.4
Sierts, J.A.5
Herman, D.S.6
Stroes, E.S.7
Aerts, J.M.8
Kastelein, J.J.9
Motazacker, M.M.10
Dallinga-Thie, G.M.11
Levels, J.H.12
Zwinderman, A.H.13
Seidman, J.G.14
Seidman, C.E.15
Ljunggren, S.16
Lefeber, D.J.17
Morava, E.18
Wevers, R.A.19
Fritz, T.A.20
Tabak, L.A.21
Lindahl, M.22
Hovingh, G.K.23
Kuivenhoven, J.A.24
more..
|