Cholecystokinin but not ghrelin stimulates mucosal bicarbonate secretion in rat duodenum: Independence of feeding status and cholinergic stimuli

Regulatory Peptides

Volumn 183, Issue 1, 2013, Pages 46-53

  Sjöblom, Markus ^a   Lindqvist, Ramin ^a   Bengtsson, Magnus W ^a   Jedstedt, Gunilla ^a   Flemström, Gunnar ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Duodenal enterocytes; Fed and fasting state; Galanin; Gastrin; Luzindole

Indexed keywords

ATROPINE; BICARBONATE; CALCIUM; CHOLECYSTOKININ; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; DEVAZEPIDE; GHRELIN; LUZINDOLE; UNCLASSIFIED DRUG; YMM 022; CHOLECYSTOKININ OCTAPEPTIDE; CHOLECYSTOKININ RECEPTOR; CHOLINERGIC RECEPTOR STIMULATING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CHOLINERGIC STIMULATION; CONTROLLED STUDY; DOSE RESPONSE; DUODENUM MUCOSA; FEEDING; GASTROINTESTINAL SECRETION; IN VIVO STUDY; INTESTINE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; DUODENUM; INBRED RAT STRAIN; INTESTINE MUCOSA; METABOLISM; SECRETION (PROCESS);

ANIMALIA; RATTUS;

ANIMALS; BICARBONATES; CALCIUM; CHOLINERGIC AGENTS; DEVAZEPIDE; DUODENUM; ENTEROCYTES; GHRELIN; INTESTINAL MUCOSA; MALE; RATS; RATS, INBRED STRAINS; RECEPTORS, CHOLECYSTOKININ; SINCALIDE;

EID: 84875762030     PISSN: 01670115     EISSN: 18731686     Source Type: Journal    
DOI: 10.1016/j.regpep.2013.03.008     Document Type: Article

References (50)

1. Chaudhri O.B., Salem V., Murphy K.G., Bloom S.R. Gastrointestinal satiety signals. Annu Rev Physiol 2008, 70:239-255.
2. Rehfeld J.F. Accurate measurement of cholecystokinin in plasma. Clin Chem 1998, 44:991-1001.
3. Dockray G.J. Cholecystokinin and gut-brain signalling. Regul Pept 2009, 155:6-10.
4. Rehfeld J.F., Friis-Hansen L., Goetze J.P., Hansen T.V. The biology of cholecystokinin and gastrin peptides. Curr Top Med Chem 2007, 7:1154-1165.
5. Woods S.C. Gastrointestinal satiety signals I. An overview of gastrointestinal signals that influence food intake. Am J Physiol Gastrointest Liver Physiol 2004, 286:G7-G13.
6. Allen A., Flemström G. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol 2005, 288:C1-C19.
7. Flemström G., Kivilaakso E. Demonstration of a pH gradient at the luminal surface of rat duodenum in vivo and its dependence on mucosal alkaline secretion. Gastroenterology 1983, 84:787-794.
8. Seidler U., Sjöblom M. Gastroduodenal bicarbonate secretion. Physiology of the Gastrointestinal Tract 2012, 1311-1340. Academic Press, Oxford. L.R. Johnson (Ed.).
9. Akiba Y., Kaunitz J.D. Luminal chemosensing in the duodenal mucosa. Acta Physiol (Oxf) 2011, 201:77-84.
10. Sjöblom M. Duodenal epithelial sensing of luminal acid: role of carbonic anhydrases. Acta Physiol (Oxf) 2011, 201:85-95.
11. - supply is critically dependent on carbonic anhydrase II expression. Proc Natl Acad Sci U S A 2009, 106:13094-13099.
12. Aoi M., Aihara E., Nakashima M., Takeuchi K. Participation of prostaglandin E receptor EP4 subtype in duodenal bicarbonate secretion in rats. Am J Physiol Gastrointest Liver Physiol 2004, 287:G96-G103.
13. --secretion by uroguanylin. Am J Physiol Gastrointest Liver Physiol 1998, 274:G633-G644.
14. Heinonen M.V., Purhonen A.K., Mäkelä K.A., Herzig K.H. Functions of orexins in peripheral tissues. Acta Physiol (Oxf) 2008, 192:471-485.
15. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richarson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998, 92:573-585.
16. Bengtsson M.W., Mäkelä K., Sjöblom M., Uotila S., Åkerman K.E., Herzig K.H., Flemström G. Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A. Am J Physiol Gastrointest Liver Physiol 2007, 293:G501-G509.
17. Flemström G., Sjöblom M., Jedstedt G., Åkerman K.E. Short fasting dramatically decreases rat duodenal secretory responsiveness to orexin A but not to VIP or melatonin. Am J Physiol Gastrointest Liver Physiol 2003, 285:G1091-G1096.
18. Bengtsson M.W., Mäkelä K., Herzig K.H., Flemström G. Short food deprivation inhibits orexin receptor 1 expression and orexin-A induced intracellular calcium signaling in acutely isolated duodenal enterocytes. Am J Physiol Gastrointest Liver Physiol 2009, 296:G651-G658.
19. Flemström G., Mäkelä K., Purhonen A.K., Sjöblom M., Jedstedt G., Walkowiak J., Herzig K.H. Apelin stimulation of duodenal bicarbonate secretion: feeding-dependent and mediated via apelin-induced release of enteric cholecystokinin. Acta Physiol (Oxf) 2011, 201:141-150.
20. Tatemoto K., Hosoya M., Habata Y., Fujii R., Kakegawa T., Zou M.X., Kawamata Y., Fukusumi S., Hinuma S., Kitada C., Kurokawa T., Onda H., Fujino M. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 1998, 251:471-476.
21. Sato T., Nakamura Y., Shiimura Y., Ohgusu H., Kangawa K., Kojima M. Structure, regulation and function of ghrelin. J Biochem 2012, 151:119-128.
22. Masuda Y., Tanaka T., Inomata N., Ohnuma N., Tanaka S., Itoh Z., Hosoda H., Kojima M., Kangawa K. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 2000, 276:905-908.
23. Lang R., Gundlach A.L., Kofler B. The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacol Ther 2007, 115:177-207.
24. - secretion in the human colon. Potential significance of inflammation-associated NF-kappa B activation on galanin-1 receptor expression and function. Ann N Y Acad Sci 1998, 863:64-77.
25. Sjöblom M., Jedstedt G., Flemström G. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Clin Invest 2001, 108:625-633.
26. Sjöblom M., Säfsten B., Flemström G. Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes. Am J Physiol Gastrointest Liver Physiol 2003, 284:G1034-G1044.
27. Säfsten B., Sjöblom M., Flemström G. Serotonin increases protective duodenal bicarbonate secretion via enteric ganglia and a 5-HT4-dependent pathway. Scand J Gastroenterol 2006, 41:1279-1289.
28. Bengtsson M.W., Jedstedt G., Flemström G. Duodenal bicarbonate secretion in rats: stimulation by intra-arterial and luminal guanylin and uroguanylin. Acta Physiol (Oxf) 2007, 191:309-317.
29. Wren A.M., Bloom S.R. Gut hormones and appetite control. Gastroenterology 2007, 132:2116-2130.
30. Chew C.S., Säfsten B., Flemström G. Calcium signaling in cultured human and rat duodenal enterocytes. Am J Physiol Gastrointest Liver Physiol 1998, 275:G296-G304.
31. Akiba Y., Kaunitz J.D. Regulation of intracellular pH and blood flow in rat duodenal epithelium in vivo. Am J Physiol Gastrointest Liver Physiol 1999, 276:G293-G302.
32. Wank S.A. G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family. Am J Physiol Gastrointest Liver Physiol 1998, 274:G607-G613.
33. Crampton J.R., Gibbons L.G., Rees W.D. Neural regulation of duodenal alkali secretion: effects of electrical field stimulation. Am J Physiol Gastrointest Liver Physiol 1988, 254:G162-G167.
34. Mellander A., Järbur K., Sjövall H. Pressure and frequency dependent linkage between motility and epithelial secretion in human proximal small intestine. Gut 2000, 46:376-384.
35. Raybould H.E. Gut chemosensing: interactions between gut endocrine cells and visceral afferents. Auton Neurosci 2010, 153:41-46.
36. Zhang J., Ritter R.C. Circulating GLP-1 and CCK-8 reduce food intake by capsaicin-insensitive, nonvagal mechanisms. Am J Physiol Regul Integr Comp Physiol 2012, 302:R264-R273.
37. Dockray G.J., Burdyga G. Plasticity in vagal afferent neurones during feeding and fasting: mechanisms and significance. Acta Physiol (Oxf) 2011, 201:313-321.
38. Sun D., Lennernäs H., Welage L.S., Barnett J.L., Landowski C.P., Foster D., Fleisher D., Lee K.D., Amidon G.L. Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs. Pharm Res 2002, 19:1400-1416.
39. - transport in vitro: effects of hormones and local transmitters. Am J Physiol Gastrointest Liver Physiol 1982, 242:G100-G110.
40. Ainsworth M.A., Ladegaard L., Svendsen P., Cantor P., Olsen O. Schaffalitzky de Muckadell OB. Pancreatic, hepatic, and duodenal mucosal bicarbonate secretion during infusion of secretin and cholecystokinin. Evidence of the importance of hepatic bicarbonate in the neutralization of acid in the duodenum of anaesthetized pigs. Scand J Gastroenterol 1991, 26:1035-1041.
41. Konturek S.J., Bilski J., Tasler J., Laskiewicz J. Gut hormones in stimulation of gastroduodenal alkaline secretion in conscious dogs. Am J Physiol Gastrointest Liver Physiol 1985, 248:G687-G691.
42. Eissele R., Koop I., Schaar M., Koop H., Arnold R. Role of cholecystokinin in the control of gastric somatostatin in the rat: in vivo and in vitro studies. Regul Pept 1991, 32:333-340.
43. Hayashi K., Kishimoto S., Kannbe M. Endogenous CCK inhibits colonic contractions in unrestrained conscious rats. Regul Pept 1997, 72:131-137.
44. Liddle R.A. Regulation of cholecystokinin synthesis and secretion in rat intestine. J Nutr 1994, 124:1308S-1314S.
45. Dockray G.J. Cholecystokinin. Curr Opin Endocrinol Diabetes Obes 2012, 19:8-12.
46. Chen Y.F., Chey W.Y., Chang T.M., Lee K.Y. Duodenal acidification releases cholecystokinin. Am J Physiol 1985, 249:G29-G33.
47. 2+-dependent mechanism in the enteroendocrine cell line STC-1. J Physiol 1998, 513:11-18.
48. 2+-sensing receptor. Am J Physiol Gastrointest Liver Physiol 2011, 300:G528-G537.
49. Isenberg J.I., Selling J.A., Hogan D.L., Koss M.A. Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. N Engl J Med 1987, 316:374-379.
50. Seidler U., Song P., Xiao F., Riederer B., Bachmann O., Chen M. Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells. Acta Physiol (Oxf) 2011, 201:3-20.