Regulation of intracellular pH and blood flow in rat duodenal epithelium in vivo

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 276, Issue 1 39-1, 1999, Pages

  Akiba, Yasutada ^a   Kaunitz, Jonathan D ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Amiloride analogs; Epithelial cells; Fluorescent dyes; In vivo microscopy; Laser Doppler flowmerry

Indexed keywords

5 (N,N DIMETHYL)AMILORIDE;

ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE TRANSPORT; CELL PH; CONTROLLED STUDY; DUODENUM MUCOSA; INTESTINE BLOOD FLOW; INTESTINE EPITHELIUM CELL; LASER DOPPLER FLOWMETRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT;

EID: 0345059362     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1999.276.1.g293     Document Type: Article

References (53)

1. Ahn, H., J. Lindhagen, G. E. Nilsson, E. G. Salerud, M. Jodal, and O. Lundgren. Evaluation of laser Doppler flowmetry in the assessment of intestinal blood flow in cat. Gastroenterology 88: 951-957, 1985.
2. Ainsworth, M. A., M. Amelsberg, D. L. Hogan, and J. I. Isenberg. Acid-base transport in isolated rabbit duodenal villus and crypt cells. Scand. J. Gastroenterol. 31: 1069-1077, 1996.
3. 3 secretion on acid-induced injury to porcine duodenal mucosa. Scand. J. Gastroenterol. 28: 1091-1097, 1993.
4. Allen, A., G. Flemström, A. Garner, and E. Kivilaakso. Gastroduodenal mucosal protection. Physiol. Rev. 73: 823-857, 1993.
5. Apkon, M., R. A. Weed, and W. F. Boron. Motor responses of cultured rat cerebral vascular smooth muscle cells to intra- and extracellular pH changes. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H434-H445, 1997.
6. Austin, C., K. Dilly, D. Eisner, and S. Wray. Simultaneous measurement of intracellular pH, calcium, and tension in rat mesenteric vessels: effects of extracellular pH. Biochem. Biophys. Res. Commun. 222: 537-540, 1996.
7. Benoit, J. N., W. A. Womack, R. J. Korthuis, W. H. Wilborn, and D. N. Granger. Chronic portal hypertension: effects on gastrointestinal blood flow distribution. Am. J. Physiol. 250 (Gastrointest. Liver Physiol. 13): G535-G539, 1986.
8. Bevan, S., and P. Geppetti. Protons: small stimulants of capsaicin-sensitive sensory nerves. Trends Neurosci. 17: 509-512, 1994.
9. Boron, W. F. Intracellular pH transients in giant barnacle muscle fibers. Am. J. Physiol. 233 (Cell Physiol. 2): C61-C73, 1977.
10. Boron, W. F., S. J. Waisbren, I. M. Modlin, and J. P. Geibel. Unique permeability barrier of the apical surface of parietal and chief cells in isolated perfused gastric glands. J. Exp. Biol. 196: 347-360, 1994.
11. 3. Am. J. Physiol. 255 (Cell Physiol. 24): C844-C856, 1988.
12. Boyarsky, G., C. Hanssen, and L. A. Clyne. Superiority of in vitro over in vivo calibrations of BCECF in vascular smooth muscle cells. FASEB J. 10: 1205-1212, 1996.
13. Boyer, M. J., and D. W. Hedley. Measurement of intracellular pH. Methods Cell Biol. 41: 135-148, 1994.
14. Bruggeman, T. M., J. G. Wood, and H. W. Davenport. Local control of blood flow in the dog's stomach: vasodilatation caused by acid backdiffusion following topical application of salicylic acid. Gastroenterology 77: 736-744, 1979.
15. 3 secretion across murine duodenum. Am. J. Physiol. 274 (Gastrointest. Liver Physiol. 37): G718-G726, 1998.
16. 2. Gastroenterology 102: 1252-1258, 1992.
17. Hirst, B. H. The gastric mucosal barrier. In: Handbook of Physiology. The Gastrointestinal System. Salivary, Gastric, Pancreatic, and Hepatobiliary Secretion. Bethesda, MD: Am. Physiol. Soc., 1989, sect. 6, vol. III, chapt. 15, p. 279-308.
18. Hogan, D. L., M. A. Ainsworth, and J. I. Isenberg. Review article: gastroduodenal bicarbonate secretion. Aliment. Pharmacol. Ther. 8: 475-488, 1994.
19. Holm, M., B. Johansson, C. von Bothmer, C. Jonson, A. Pettersson, and L. Fändriks. Acid-induced increase in duodenal mucosal alkaline secretion in the rat involves the L-arginine/NO pathway. Acta Physiol. Scand. 161: 527-532, 1997.
20. Holzer, P. Chemosensitive afferent nerves in the regulation of gastric blood flow and protection. Adv. Exp. Med. Biol. 371B: 891-895, 1995.
21. Holzer, P., E. H. Livingston, and P. H. Guth. Sensory neurons signal for an increase in rat gastric mucosal blood flow in the face of pending acid injury. Gastroenterology 101: 416-423, 1991.
22. 3 transport. Am. J. Physiol. 265 (Gastrointest. Liver Physiol. 28): G677-G685, 1993.
23. 2, and inhibition of endogenous prostaglandin synthesis on proximal duodenal bicarbonate secretion in unanesthetized rat. Gastroenterology 88: 303-307, 1985.
24. Iwanaga, T., H. Han, K. Adachi, and T. Fujita. A novel mechanism for disposing of effete epithelial cells in the small intestine of guinea pigs. Gastroenterology 105: 1089-1097, 1993.
25. Kaneko, K., P. H. Guth, and J. D. Kaunitz. In vivo measurement of rat gastric surface cell intracellular pH. Am. J. Physiol. 261 (Gastrointest. Liver Physiol. 24): G548-G552, 1991.
26. Kao, J., F. Iwata, X. Y. Zhang, M. Baker, K. Seno, and F. W. Leung. Inhibition of endogenous nitric oxide reduces basal mesenteric vascular tone but does not alter intraduodenal hydrochloric acid-induced intestinal hyperemia in rats. Dig. Dis. Sci. 40: 1729-1737, 1995.
27. Kaunitz, J. D. Preparation and characterization of viable epithelial cells from rabbit distal colon. Am. J. Physiol. 254 (Gastrointest. Liver Physiol. 17): G502-G512, 1988.
28. Kaunitz, J. D., Y. Nishizaki, K. Kaneko, and P. H. Guth. Effect of orogastric nicotine on rat gastric mucosal gel thickness, surface cell viability, and intracellular pH. J. Pharmacol. Exp. Ther. 265: 948-954, 1993.
29. 2 clearance, and microsphere estimates of mucosal blood flow. Am. J. Physiol. 249 (Gastrointest. Liver Physiol. 12): G221-G227, 1985.
30. Leung, F. W. Primary sensory nerves mediate in part the protective mesenteric hyperemia after intraduodenal acidification in rats. Gastroenterology 105: 1737-1745, 1993.
31. Leung, F. W., M. Itoh, K. Hirabayashi, and P. H. Guth. Role of blood flow in gastric and duodenal mucosal injury in the rat. Gastroenterology 88: 281-289, 1985.
32. Li, D. S., H. E. Raybould, E. Quintero, and P. H. Guth. Role of calcitonin gene-related peptide in gastric hyperemic response to intragastric capsaicin. Am. J. Physiol. 261 (Gastrointest. Liver Physiol. 24): G657-G661, 1991.
33. Lin, S. K., and J. R. Lambert. Helicobacter pylori in ulcerogenesis. Scand. J. Gastroenterol. 30, Suppl. 210: 64-69, 1995.
34. Livingston, E. H., E. P. Passaro, J. Miller, and P. H. Guth. Spectrum of injury produced in the duodenum by perfusion with luminal acid in the rat. Gastroenterology 103: 481-489, 1992.
35. McColl, K. E. Helicobacter pylori, gastric acid, and duodenal gastric metaplasia. Gut 39: 615-616, 1996.
36. Nishizaki, Y., P. H. Guth, and J. D. Kaunitz. Isoproterenol enhances rat gastric mucosal barrier function in vivo. Gastroenterology 105: 340-346, 1993.
37. Nylander, O., L. Holm, E. Wilander, and A. Hällgren. Exposure of the duodenum to high concentrations of hydrochloric acid. Effects on mucosal permeability, alkaline secretion, and blood flow. Scand. J. Gastroenterol. 29: 437-444, 1994.
38. Nylander, O., P. Kvietys, and D. N. Granger. Effects of hydrochloric acid on duodenal and jejunal mucosal permeability in the rat. Am. J. Physiol. 257 (Gastrointest. Liver Physiol. 20): G653-G660, 1989.
39. Ovesen, L., F. Bendtsen, U. Tage-Jensen, N. T. Pedersen, B. R. Gram, and S. J. Rune. Intraluminal pH in the stomach, duodenum, and proximal jejunum in normal subjects and patients with exocrine pancreatic insufficiency. Gastroenterology 90: 958-962, 1986.
40. Paimela, H., T. Kiviluoto, H. Mustonen, and E. Kivilaakso. Intracellular pH of isolated Necturus duodenal mucosa exposed to luminal acid. Gastroenterology 102: 862-867, 1992.
41. Peura, D. A. Ulcerogenesis: integrating the roles of Helicobacter pylori and acid secretion in duodenal ulcer. Am. J. Gastroenterol. 92, Suppl.: 8S-13S, 1997.
42. Powell, D. W. Barrier function of epithelia. Am. J. Physiol. 241 (Gastrointest. Liver Physiol. 4): G275-G288, 1981.
43. + exchange inhibitors on agonist-induced contraction of rat aorta. J. Pharmacol. Exp. Ther. 247: 1146-1151, 1988.
44. Schreiber, S., and P. Scheid. Gastric mucus of the guinea pig: proton carrier and diffusion barrier. Am. J. Physiol. 272 (Gastrointest. Liver Physiol. 35): G63-G70, 1997.
45. Scremin, O. U., F. W. Leung, and P. H. Guth. Pathogenesis of duodenal ulcer in the rat: dissociation of acid load and blood flow, Am. J. Physiol. 256 (Gastrointest. Liver Physiol. 19): G1058-G1062, 1989.
46. 3 secretion. J. Physiol. (Lond.) 505: 411-423, 1997.
47. Shimamura, K., L. B. Zou, K. Moriyama, K. Yamamoto, F. Sekiguchi, and S. Sunano. Effects of amiloride on the neurally mediated contraction of rat mesenteric artery. Eur. J. Pharmacol. 320: 37-42, 1997.
48. Silver, R. B. Ratio imaging: practical considerations for measuring intracellular calcium and pH in living tissue. Methods Cell Biol. 56: 237-251, 1998.
49. Starlinger, M., J. Matthews, C. Yoon, E. Wenzl, W. Feil, and R. Schiessel. The effect of acid perfusion on mucosal blood flow and intramural pH of rabbit duodenum. Surgery 101: 433-438, 1987.
50. i) of rat duodenal epithelial cells (Abstract). Gastroenterology 114: A306, 1998.
51. Weinlich, M., U. Heydasch, M. Starlinger, and R. K. Kinne. Intracellular pH measurements in rat duodenal mucosa in vitro using confocal laserscan microscopy. Z. Gastroenterol. 35: 263-270, 1997.
52. Wyatt, J. I., B. J. Rathbone, G. M. Sobala, T. Shallcross, R. V. Heatley, A. T. R. Axon, and M. F. Dixon. Gastric epithelium in the duodenum: its association with Helicobacter pylori and inflammation. J. Clin. Pathol. 43: 981-986, 1990.
53. 2, and cyclic adenosine monophosphate. Gastroenterology 104: 732-740, 1993.