-
2
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
-
Hirsch, E., V.L. Katanaev, C. Garlanda, et al. 2000. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287: 1049-1053.
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
Katanaev, V.L.2
Garlanda, C.3
-
3
-
-
68149164783
-
PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells
-
Bohnacker, T., R. Marone, E. Collmann, et al. 2009. PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3, 4, 5)P3 pools in mast cells. Sci. Signal. 2: ra27.
-
(2009)
Sci. Signal
, vol.2
-
-
Bohnacker, T.1
Marone, R.2
Collmann, E.3
-
4
-
-
0030887632
-
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
-
Stephens, L.R., A. Eguinoa, H. Erdjument-Bromage, et al. 1997. The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 89: 105-114.
-
(1997)
Cell
, vol.89
, pp. 105-114
-
-
Stephens, L.R.1
Eguinoa, A.2
Erdjument-Bromage, H.3
-
5
-
-
73949143149
-
Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma
-
Kurig, B., A. Shymanets, T. Bohnacker, et al. 2009. Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma. Proc. Natl. Acad. Sci. USA 106: 20312-20317.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 20312-20317
-
-
Kurig, B.1
Shymanets, A.2
Bohnacker, T.3
-
6
-
-
4644232654
-
Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice
-
Del Prete, A., W. Vermi, E. Dander, et al. 2004. Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice. EMBO J. 23: 3505-3515.
-
(2004)
EMBO J
, vol.23
, pp. 3505-3515
-
-
Del Prete, A.1
Vermi, W.2
Dander, E.3
-
7
-
-
24744435115
-
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
-
Camps, M., T. Ruckle, H. Ji, et al. 2005. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat. Med. 11: 936-943.
-
(2005)
Nat. Med
, vol.11
, pp. 936-943
-
-
Camps, M.1
Ruckle, T.2
Ji, H.3
-
8
-
-
29644443728
-
Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion
-
Barber, D.F., A. Bartolome, C. Hernandez, et al. 2006. Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion. J. Immunol. 176: 589-593.
-
(2006)
J. Immunol
, vol.176
, pp. 589-593
-
-
Barber, D.F.1
Bartolome, A.2
Hernandez, C.3
-
9
-
-
0036200415
-
Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function
-
Laffargue, M., R. Calvez, P. Finan, et al. 2002. Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function. Immunity 16: 441-451.
-
(2002)
Immunity
, vol.16
, pp. 441-451
-
-
Laffargue, M.1
Calvez, R.2
Finan, P.3
-
10
-
-
0035464192
-
Resistance to thromboembolism in PI3Kgamma-deficient mice
-
Hirsch, E., O. Bosco, P. Tropel, et al. 2001. Resistance to thromboembolism in PI3Kgamma-deficient mice. FASEB J. 15: 2019-2021.
-
(2001)
FASEB J
, vol.15
, pp. 2019-2021
-
-
Hirsch, E.1
Bosco, O.2
Tropel, P.3
-
11
-
-
4344714889
-
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects
-
Patrucco, E., A. Notte, L. Barberis, et al. 2004. PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118: 375-387.
-
(2004)
Cell
, vol.118
, pp. 375-387
-
-
Patrucco, E.1
Notte, A.2
Barberis, L.3
-
12
-
-
34249951624
-
Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis
-
Chang, J.D., G.K. Sukhova, P. Libby, et al. 2007. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc. Natl. Acad. Sci. USA 104: 8077-8082.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 8077-8082
-
-
Chang, J.D.1
Sukhova, G.K.2
Libby, P.3
-
13
-
-
40549131271
-
Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes
-
Fougerat, A., S. Gayral, P. Gourdy, et al. 2008. Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes. Circulation 117: 1310-1317.
-
(2008)
Circulation
, vol.117
, pp. 1310-1317
-
-
Fougerat, A.1
Gayral, S.2
Gourdy, P.3
-
14
-
-
84862741643
-
Key role of PI3Kγ in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration
-
Fougerat, A., N.F. Smirnova, S. Gayral, et al. 2012. Key role of PI3Kγ in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration. Br. J. Pharmacol. 166: 1643-1653.
-
(2012)
Br. J. Pharmacol
, vol.166
, pp. 1643-1653
-
-
Fougerat, A.1
Smirnova, N.F.2
Gayral, S.3
-
15
-
-
20944433770
-
Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma
-
Vecchione, C., E. Patrucco, G. Marino, et al. 2005. Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma. J. Exp. Med. 201: 1217-1228.
-
(2005)
J. Exp. Med
, vol.201
, pp. 1217-1228
-
-
Vecchione, C.1
Patrucco, E.2
Marino, G.3
-
16
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil, G.S. 2006. Inflammation and metabolic disorders. Nature 444: 860-867.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
17
-
-
77955806634
-
JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction
-
Solinas, G. & M. Karin. 2010. JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J. 24: 2596-2611.
-
(2010)
FASEB J
, vol.24
, pp. 2596-2611
-
-
Solinas, G.1
Karin, M.2
-
18
-
-
84868147961
-
Molecular pathways linking metabolic inflammation and thermogenesis
-
Solinas, G. 2012. Molecular pathways linking metabolic inflammation and thermogenesis. Obes. Rev. 13, (Suppl 2): 69-82.
-
(2012)
Obes. Rev
, vol.13
, Issue.SUPPL. 2
, pp. 69-82
-
-
Solinas, G.1
-
19
-
-
79955012753
-
Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance
-
Kobayashi, N., K. Ueki, Y. Okazaki, et al. 2011. Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc. Natl. Acad. Sci. USA 108: 5753-5758.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 5753-5758
-
-
Kobayashi, N.1
Ueki, K.2
Okazaki, Y.3
-
20
-
-
80054811005
-
PI3K{gamma} within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance
-
Becattini, B., R. Marone, F. Zani, et al. 2011. PI3K{gamma} within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance. Proc. Natl. Acad. Sci. USA 108: E854-E863.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
-
-
Becattini, B.1
Marone, R.2
Zani, F.3
|