Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells

Journal of Proteomics

Volumn 82, Issue , 2013, Pages 14-26

  Dal Piaz, Fabrizio ^a   Cotugno, Roberta ^a   Lepore, Laura ^a   Vassallo, Antonio ^b   Malafronte, Nicola ^a   Lauro, Gianluigi ^a   Bifulco, Giuseppe ^a   Belisario, Maria Antonietta ^a   De Tommasi, Nunziatina ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF BASILICATA   (Italy)

Author keywords

Chemical proteomics; HSP70 1A; Jurkat cells; Oridonin; Target discovery

Indexed keywords

ANTINEOPLASTIC AGENT; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70 1A; ORIDONIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BINDING SITE; CANCER INHIBITION; CANCER SURVIVAL; CELL CYCLE ARREST; CELL FREE SYSTEM; CELL PROLIFERATION; CHEMOPROPHYLAXIS; DRUG BINDING; DRUG TARGETING; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MOLECULARLY TARGETED THERAPY; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEOMICS; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; SURVIVAL RATE;

ANTINEOPLASTIC AGENTS; DITERPENES, KAURANE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; JURKAT CELLS; LEUKEMIA; MOLECULAR DYNAMICS SIMULATION; NEOPLASM PROTEINS; PROTEOMICS;

RABDOSIA RUBESCENS;

EID: 84875598212     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2013.01.030     Document Type: Article

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