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Volumn 55, Issue , 2013, Pages 659-675

Critical appraisal of the assessment of benefits and risks for foods, 'BRAFO Consensus Working Group'

Author keywords

Benefit risk assessment; BRAFO; Consensus; Risk management; Tiered approach

Indexed keywords

ACRYLAMIDE; ALPHA TOCOPHEROL; BENZO[A]PYRENE; BIOLOGICAL MARKER; CARBOHYDRATE; CHLORINE; DISACCHARIDASE; DRINKING WATER; FISH OIL; FOLIC ACID; LIPID; MONOUNSATURATED FATTY ACID; NITRATE; POLYCHLORINATED BIPHENYL; SATURATED FATTY ACID; SODIUM; SOYBEAN PROTEIN; SWEETENING AGENT;

EID: 84875549901     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.10.028     Document Type: Article
Times cited : (35)

References (97)
  • 4
    • 77649302384 scopus 로고    scopus 로고
    • Categorical versus continuous risk factors and the calculation of potential impact fractions
    • Barendregt J.J., Veerman J.L. Categorical versus continuous risk factors and the calculation of potential impact fractions. J. Epidemiol. Commun. Health 2010, 64(3):209-212.
    • (2010) J. Epidemiol. Commun. Health , vol.64 , Issue.3 , pp. 209-212
    • Barendregt, J.J.1    Veerman, J.L.2
  • 8
    • 20544472593 scopus 로고    scopus 로고
    • A comparison of ratio distributions based on the NOAEL and the benchmark approach for subchronic-to-chronic extrapolation
    • Bokkers B.G., Slob W. A comparison of ratio distributions based on the NOAEL and the benchmark approach for subchronic-to-chronic extrapolation. Toxicol. Sci. 2005, 85:1033-1040.
    • (2005) Toxicol. Sci. , vol.85 , pp. 1033-1040
    • Bokkers, B.G.1    Slob, W.2
  • 9
    • 35448980740 scopus 로고    scopus 로고
    • Risk assessment of dietary supplements
    • Boobis A.R. Risk assessment of dietary supplements. Novartis Found Symp. 2007, 282:3-25.
    • (2007) Novartis Found Symp. , vol.282 , pp. 3-25
    • Boobis, A.R.1
  • 12
    • 69849093485 scopus 로고    scopus 로고
    • Application of key events analysis to chemical carcinogens and noncarcinogens
    • Boobis A.R., Daston G.P., Preston R.J., Olin S.S. Application of key events analysis to chemical carcinogens and noncarcinogens. Crit. Rev. Food Sci. Nutr. 2009, 49:690-707.
    • (2009) Crit. Rev. Food Sci. Nutr. , vol.49 , pp. 690-707
    • Boobis, A.R.1    Daston, G.P.2    Preston, R.J.3    Olin, S.S.4
  • 13
    • 58249129142 scopus 로고    scopus 로고
    • A framework for integrated environmental health impact assessment of systemic risks
    • Briggs D.J. A framework for integrated environmental health impact assessment of systemic risks. Environ. Health 2008, 7:61.
    • (2008) Environ. Health , vol.7 , pp. 61
    • Briggs, D.J.1
  • 14
    • 68249152290 scopus 로고    scopus 로고
    • Prediction of hepatic clearance in human from in vitro data for successful drug development
    • Chiba M., Ishii Y., Sugiyama Y. Prediction of hepatic clearance in human from in vitro data for successful drug development. AAPS J. 2009, 11:262-276.
    • (2009) AAPS J. , vol.11 , pp. 262-276
    • Chiba, M.1    Ishii, Y.2    Sugiyama, Y.3
  • 15
    • 37549042390 scopus 로고    scopus 로고
    • Development and specification of physiologically based pharmacokinetic models for use in risk assessment
    • Clewell R.A., Clewell H.J. Development and specification of physiologically based pharmacokinetic models for use in risk assessment. Regul. Toxicol. Pharmacol. 2008, 50:129-143.
    • (2008) Regul. Toxicol. Pharmacol. , vol.50 , pp. 129-143
    • Clewell, R.A.1    Clewell, H.J.2
  • 16
    • 84875533528 scopus 로고    scopus 로고
    • Commission of the European Communities, 2000. White paper on food safety. Brussels, 12 January. Available from: .
    • Commission of the European Communities, 2000. White paper on food safety. Brussels, 12 January 2000. Available from: http://ec.europa.eu/dgs/health_consumer/library/pub/pub06_en.pdf.
    • (2000)
  • 17
    • 0025832982 scopus 로고
    • Biologically based pharmacodynamic models: tools for toxicological research and risk assessment
    • Conolly R.B., Andersen M.E. Biologically based pharmacodynamic models: tools for toxicological research and risk assessment. Annu. Rev. Pharmacol. Toxicol. 1991, 31:503-523.
    • (1991) Annu. Rev. Pharmacol. Toxicol. , vol.31 , pp. 503-523
    • Conolly, R.B.1    Andersen, M.E.2
  • 18
    • 8444227400 scopus 로고    scopus 로고
    • Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modelling of a combined rodent and human dataset
    • Conolly R.B., Kimbell J.S., Janszen D., Schlosser P.M., Kalisak D., Preston J., Miller F.J. Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modelling of a combined rodent and human dataset. Toxicol. Sci. 2004, 82:279-296.
    • (2004) Toxicol. Sci. , vol.82 , pp. 279-296
    • Conolly, R.B.1    Kimbell, J.S.2    Janszen, D.3    Schlosser, P.M.4    Kalisak, D.5    Preston, J.6    Miller, F.J.7
  • 20
    • 77953530648 scopus 로고    scopus 로고
    • Predicting developmental toxicity through toxicogenomics
    • Daston G.P., Naciff J.M. Predicting developmental toxicity through toxicogenomics. Birth Defects Res. C Embryo Today 2010, 90:110-117.
    • (2010) Birth Defects Res. C Embryo Today , vol.90 , pp. 110-117
    • Daston, G.P.1    Naciff, J.M.2
  • 23
    • 26944449329 scopus 로고    scopus 로고
    • The refinement of uncertainty/safety factors in risk assessment by the incorporation of data on toxicokinetic variability in humans
    • Dorne J.L., Renwick A.G. The refinement of uncertainty/safety factors in risk assessment by the incorporation of data on toxicokinetic variability in humans. Toxicol. Sci. 2005, 86:20-26.
    • (2005) Toxicol. Sci. , vol.86 , pp. 20-26
    • Dorne, J.L.1    Renwick, A.G.2
  • 26
    • 85047137669 scopus 로고    scopus 로고
    • Statement on possible public health risks for infants and young children from the presence of nitrates in leafy vegetables
    • EFSA Contam
    • EFSA Contam Statement on possible public health risks for infants and young children from the presence of nitrates in leafy vegetables. EFSA J. 2010, 8(12):1935. www.efsa.europa.eu/en/efsajournal/pub/689.htm. 10.2903/j.efsa.2010.1935.
    • (2010) EFSA J. , vol.8 , Issue.12 , pp. 1935
  • 27
    • 84875543031 scopus 로고    scopus 로고
    • EFSA NDA,a. Nutrition and health claims. Avaliable from: Accessed 16/08/11.
    • EFSA NDA, 2011a. Nutrition and health claims. Avaliable from: Accessed 16/08/11. http://www.efsa.europa.eu/en/nda/ndaclaims.htm.
    • (2011)
  • 28
    • 84906803115 scopus 로고    scopus 로고
    • General guidance for stakeholders on the evaluation of Article 13.1, 13.5 and 14 health claims
    • EFSA NDA
    • EFSA NDA General guidance for stakeholders on the evaluation of Article 13.1, 13.5 and 14 health claims. EFSA J. 2011, 9:2135-2159. http://www.efsa.europa.eu/en/efsajournal/doc/2135.pdf.
    • (2011) EFSA J. , vol.9 , pp. 2135-2159
  • 29
    • 78649526102 scopus 로고    scopus 로고
    • Guidance on human health risk-benefit assessment of food
    • EFSA Scientific Committee
    • EFSA Scientific Committee Guidance on human health risk-benefit assessment of food. EFSA J. 2010, 8:1673-1713.
    • (2010) EFSA J. , vol.8 , pp. 1673-1713
  • 30
    • 36649036960 scopus 로고    scopus 로고
    • Nutrigenomic approaches for benefit-risk analysis of foods and food components: defining markers of health
    • Elliott R., Pico C., Dommels Y., Wybranska I., Hesketh J., Keijer J. Nutrigenomic approaches for benefit-risk analysis of foods and food components: defining markers of health. Br. J. Nutr 2007, 98:1095-1100.
    • (2007) Br. J. Nutr , vol.98 , pp. 1095-1100
    • Elliott, R.1    Pico, C.2    Dommels, Y.3    Wybranska, I.4    Hesketh, J.5    Keijer, J.6
  • 31
    • 34548362114 scopus 로고    scopus 로고
    • Experimental and mathematical modeling methods for the investigation of toxicological interactions
    • El-Masri H.A. Experimental and mathematical modeling methods for the investigation of toxicological interactions. Toxicol. Appl. Pharmacol. 2007, 223:148-154.
    • (2007) Toxicol. Appl. Pharmacol. , vol.223 , pp. 148-154
    • El-Masri, H.A.1
  • 32
    • 84875486828 scopus 로고    scopus 로고
    • E.U. Regulation, 2006. REGULATION (EC) No 1924/2006 Of The European Parliament and of the Council of 20 December 2006. Official Journal of the European Union. L 404/9.
    • E.U. Regulation, 2006. REGULATION (EC) No 1924/2006 Of The European Parliament and of the Council of 20 December 2006. Official Journal of the European Union. L 404/9.
  • 33
    • 0142010683 scopus 로고    scopus 로고
    • The benchmark dose method - review of available models, and recommendations for application in health risk assessment
    • Filipsson A.F., Sand S., Nilsson J., Victorin K. The benchmark dose method - review of available models, and recommendations for application in health risk assessment. Crit. Rev. Toxicol. 2003, 33:505-542.
    • (2003) Crit. Rev. Toxicol. , vol.33 , pp. 505-542
    • Filipsson, A.F.1    Sand, S.2    Nilsson, J.3    Victorin, K.4
  • 34
    • 0034648274 scopus 로고    scopus 로고
    • The use of Haber's law in standard setting and risk assessment
    • Gaylor D.W. The use of Haber's law in standard setting and risk assessment. Toxicology 2000, 149:17-19.
    • (2000) Toxicology , vol.149 , pp. 17-19
    • Gaylor, D.W.1
  • 36
    • 14344258860 scopus 로고    scopus 로고
    • Molecular approaches to the identification of biomarkers of exposure and effect - report of an expert meeting organized by COST Action B15. November 28, 2003
    • Gundert-Remy U., Dahl S.G., Boobis A., Kremers P., Kopp-Schneider A., Oberemm A., Renwick A., Pelkonen O. Molecular approaches to the identification of biomarkers of exposure and effect - report of an expert meeting organized by COST Action B15. November 28, 2003. Toxicol. Lett. 2005, 156:227-240.
    • (2005) Toxicol. Lett. , vol.156 , pp. 227-240
    • Gundert-Remy, U.1    Dahl, S.G.2    Boobis, A.3    Kremers, P.4    Kopp-Schneider, A.5    Oberemm, A.6    Renwick, A.7    Pelkonen, O.8
  • 39
    • 0036386331 scopus 로고    scopus 로고
    • A straw man proposal for a quantitative definition of the RfD
    • Hattis D., Baird S., Goble R. A straw man proposal for a quantitative definition of the RfD. Drug Chem. Toxicol. 2002, 25:403-436.
    • (2002) Drug Chem. Toxicol. , vol.25 , pp. 403-436
    • Hattis, D.1    Baird, S.2    Goble, R.3
  • 40
    • 65649128629 scopus 로고    scopus 로고
    • Using biomonitoring equivalents to interpret human biomonitoring data in a public health risk context
    • Hays S.M., Aylward L.L. Using biomonitoring equivalents to interpret human biomonitoring data in a public health risk context. J. Appl. Toxicol. 2009, 29:275-288.
    • (2009) J. Appl. Toxicol. , vol.29 , pp. 275-288
    • Hays, S.M.1    Aylward, L.L.2
  • 41
    • 31844443695 scopus 로고
    • The environment of disease: association or causation?
    • Hill B. The environment of disease: association or causation?. Proc. R. Soc. Med. 1965, 58:295-300.
    • (1965) Proc. R. Soc. Med. , vol.58 , pp. 295-300
    • Hill, B.1
  • 45
    • 3242663485 scopus 로고    scopus 로고
    • PASSCLAIM - report of the Second Plenary Meeting: review of a wider set of interim criteria for the scientific substantiation of health claims
    • Howlett J., Shortt C. PASSCLAIM - report of the Second Plenary Meeting: review of a wider set of interim criteria for the scientific substantiation of health claims. Eur. J. Nutr. 2004, 43(Suppl. 2):174-183.
    • (2004) Eur. J. Nutr. , vol.43 , Issue.SUPPL. 2 , pp. 174-183
    • Howlett, J.1    Shortt, C.2
  • 46
    • 77955924780 scopus 로고    scopus 로고
    • An integrated assessment scheme for assessing the adequacy of (eco)toxicological data under REACH
    • Hulzebos E., Gunnarsdottir S., Rila J.P., Dang Z., Rorije E. An integrated assessment scheme for assessing the adequacy of (eco)toxicological data under REACH. Toxicol. Lett. 2010, 198:255-262.
    • (2010) Toxicol. Lett. , vol.198 , pp. 255-262
    • Hulzebos, E.1    Gunnarsdottir, S.2    Rila, J.P.3    Dang, Z.4    Rorije, E.5
  • 48
    • 67649392513 scopus 로고    scopus 로고
    • A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: a tale of 'bottom-up' vs 'top-down' recognition of covariates
    • Jamei M., Dickinson G.L., Rostami-Hodjegan A. A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: a tale of 'bottom-up' vs 'top-down' recognition of covariates. Drug Metab. Pharmacokinet. 2009, 24:53-75.
    • (2009) Drug Metab. Pharmacokinet. , vol.24 , pp. 53-75
    • Jamei, M.1    Dickinson, G.L.2    Rostami-Hodjegan, A.3
  • 49
    • 67349146751 scopus 로고    scopus 로고
    • Biomarkers in nutritional epidemiology: applications, needs and new horizons
    • Jenab M., Slimani N., Bictash M., Ferrari P., Bingham S.A. Biomarkers in nutritional epidemiology: applications, needs and new horizons. Hum. Genet. 2009, 125:507-525.
    • (2009) Hum. Genet. , vol.125 , pp. 507-525
    • Jenab, M.1    Slimani, N.2    Bictash, M.3    Ferrari, P.4    Bingham, S.A.5
  • 50
    • 69849101419 scopus 로고    scopus 로고
    • ILSI research foundation threshold working group. The key events dose-response framework: a cross-disciplinary mode-of-action based approach to examining dose-response and thresholds
    • Julien E., Boobis A.R., Olin S.S. ILSI research foundation threshold working group. The key events dose-response framework: a cross-disciplinary mode-of-action based approach to examining dose-response and thresholds. Crit. Rev. Food Sci. Nutr. 2009, 49:682-689.
    • (2009) Crit. Rev. Food Sci. Nutr. , vol.49 , pp. 682-689
    • Julien, E.1    Boobis, A.R.2    Olin, S.S.3
  • 52
    • 63249097581 scopus 로고    scopus 로고
    • Physiologically based toxicokinetic models and their application in human exposure and internal dose assessment
    • Kim D., Nylander-French L.A. Physiologically based toxicokinetic models and their application in human exposure and internal dose assessment. EXS 2009, 99:37-55.
    • (2009) EXS , vol.99 , pp. 37-55
    • Kim, D.1    Nylander-French, L.A.2
  • 53
    • 0031080387 scopus 로고    scopus 로고
    • A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data
    • Klimisch H.J., Andreae M., Tillmann U. A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Regul. Toxicol. Pharmacol. 1997, 25:1-5.
    • (1997) Regul. Toxicol. Pharmacol. , vol.25 , pp. 1-5
    • Klimisch, H.J.1    Andreae, M.2    Tillmann, U.3
  • 54
    • 0033451217 scopus 로고    scopus 로고
    • Combining uncertainty factors in deriving human exposure levels of noncarcinogenic toxicants
    • Kodell R.L., Gaylor D.W. Combining uncertainty factors in deriving human exposure levels of noncarcinogenic toxicants. Ann. NY Acad. Sci. 1999, 895:188-195.
    • (1999) Ann. NY Acad. Sci. , vol.895 , pp. 188-195
    • Kodell, R.L.1    Gaylor, D.W.2
  • 56
    • 60749083654 scopus 로고    scopus 로고
    • Metabolic stability: main enzymes involved and best tools to assess it
    • Laine R. Metabolic stability: main enzymes involved and best tools to assess it. Curr. Drug Metab. 2008, 9:921-927.
    • (2008) Curr. Drug Metab. , vol.9 , pp. 921-927
    • Laine, R.1
  • 57
    • 34247505574 scopus 로고    scopus 로고
    • Human hepatocytes: isolation, cryopreservation and applications in drug development
    • Li A.P. Human hepatocytes: isolation, cryopreservation and applications in drug development. Chem. Biol. Interact. 2007, 168:16-29.
    • (2007) Chem. Biol. Interact. , vol.168 , pp. 16-29
    • Li, A.P.1
  • 58
    • 68049111383 scopus 로고    scopus 로고
    • Weight-of-evidence evaluation in environmental assessment: review of qualitative and quantitative approaches
    • Linkov I., Loney D., Cormier S., Satterstrom F.K., Bridges T. Weight-of-evidence evaluation in environmental assessment: review of qualitative and quantitative approaches. Sci. Total Environ. 2009, 407:5199-5205.
    • (2009) Sci. Total Environ. , vol.407 , pp. 5199-5205
    • Linkov, I.1    Loney, D.2    Cormier, S.3    Satterstrom, F.K.4    Bridges, T.5
  • 59
    • 79953781379 scopus 로고    scopus 로고
    • Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence
    • Luke N.S., Sams R., DeVito M.J., Conolly R.B., El-Masri H.A. Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence. Toxicol. Sci. 2010, 115:253-266.
    • (2010) Toxicol. Sci. , vol.115 , pp. 253-266
    • Luke, N.S.1    Sams, R.2    DeVito, M.J.3    Conolly, R.B.4    El-Masri, H.A.5
  • 63
    • 23044527655 scopus 로고    scopus 로고
    • Categorical default uncertainty factors - interspecies variation and adequacy of database
    • Meek M.E. Categorical default uncertainty factors - interspecies variation and adequacy of database. Hum. Ecol. Risk Assess 2001, 7:157-163.
    • (2001) Hum. Ecol. Risk Assess , vol.7 , pp. 157-163
    • Meek, M.E.1
  • 64
    • 0034648284 scopus 로고    scopus 로고
    • Haber's rule: a special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint
    • Miller F.J., Schlosser P.M., Janszen D.B. Haber's rule: a special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint. Toxicology 2000, 149:21-34.
    • (2000) Toxicology , vol.149 , pp. 21-34
    • Miller, F.J.1    Schlosser, P.M.2    Janszen, D.B.3
  • 66
    • 60049095001 scopus 로고    scopus 로고
    • Integration of risk and benefit analysis - the window of benefit as a new tool?
    • Palou A., Pico C., Keijer J. Integration of risk and benefit analysis - the window of benefit as a new tool?. Crit. Rev. Food Sci. Nutr. 2009, 49:670-680.
    • (2009) Crit. Rev. Food Sci. Nutr. , vol.49 , pp. 670-680
    • Palou, A.1    Pico, C.2    Keijer, J.3
  • 67
    • 35648944767 scopus 로고    scopus 로고
    • In vitro-in vivo extrapolation of hepatic clearance. Biological tools, scaling factors, model assumptions and correct concentrations
    • Pelkonen O., Turpeinen M. In vitro-in vivo extrapolation of hepatic clearance. Biological tools, scaling factors, model assumptions and correct concentrations. Xenobiotica 2007, 37:1066-1089.
    • (2007) Xenobiotica , vol.37 , pp. 1066-1089
    • Pelkonen, O.1    Turpeinen, M.2
  • 69
    • 69449093131 scopus 로고    scopus 로고
    • The influence of thresholds on the risk assessment of carcinogens in food
    • Pratt I., Barlow S., Kleiner J., Larsen J.C. The influence of thresholds on the risk assessment of carcinogens in food. Mutat. Res. 2009, 678:113-117.
    • (2009) Mutat. Res. , vol.678 , pp. 113-117
    • Pratt, I.1    Barlow, S.2    Kleiner, J.3    Larsen, J.C.4
  • 70
    • 28144437142 scopus 로고    scopus 로고
    • DNA-reactive carcinogens: mode of action and human cancer hazard
    • Preston J.R., Williams G.M. DNA-reactive carcinogens: mode of action and human cancer hazard. Crit. Rev. Toxicol. 2005, 35:673-683.
    • (2005) Crit. Rev. Toxicol. , vol.35 , pp. 673-683
    • Preston, J.R.1    Williams, G.M.2
  • 72
    • 44149087583 scopus 로고    scopus 로고
    • The current state of knowledge on the use of the benchmark dose concept in risk assessment
    • Sand S., Victorin K., Filipsson A.F. The current state of knowledge on the use of the benchmark dose concept in risk assessment. J. Appl. Toxicol. 2008, 28:405-421.
    • (2008) J. Appl. Toxicol. , vol.28 , pp. 405-421
    • Sand, S.1    Victorin, K.2    Filipsson, A.F.3
  • 74
    • 84890659505 scopus 로고    scopus 로고
    • Interpreting results and drawing conclusions. In: Higgins, J.P.T., Green, S., (Eds.), Cochrane Handbook for Systematic Reviews of Interventions. Version 5.0.1, Chapter 12. The Cochrane Collaboration, 2008. Available from: .
    • Schünemann, H.J., Oxman, A.D., Vist, G.E., Higgins, J.P.T., Deeks, J.J., Glasziou, P., Guyatt, G.H., 2008. Interpreting results and drawing conclusions. In: Higgins, J.P.T., Green, S., (Eds.), Cochrane Handbook for Systematic Reviews of Interventions. Version 5.0.1, Chapter 12. The Cochrane Collaboration, 2008. Available from: http://www.cochrane-handbook.org.
    • (2008)
    • Schünemann, H.J.1    Oxman, A.D.2    Vist, G.E.3    Higgins, J.P.T.4    Deeks, J.J.5    Glasziou, P.6    Guyatt, G.H.7
  • 78
    • 0032411446 scopus 로고    scopus 로고
    • A probabilistic approach for deriving acceptable human intake limits and human health risks from toxicological studies: general framework
    • Slob W., Pieters M.N. A probabilistic approach for deriving acceptable human intake limits and human health risks from toxicological studies: general framework. Risk Anal. 1998, 18:787-798.
    • (1998) Risk Anal. , vol.18 , pp. 787-798
    • Slob, W.1    Pieters, M.N.2
  • 82
    • 33745381903 scopus 로고    scopus 로고
    • Comparison of cancer slope factors using different statistical approaches
    • Subramaniam R.P., White P., Cogliano V.J. Comparison of cancer slope factors using different statistical approaches. Risk Anal. 2006, 26:825-830.
    • (2006) Risk Anal. , vol.26 , pp. 825-830
    • Subramaniam, R.P.1    White, P.2    Cogliano, V.J.3
  • 86
    • 79952073198 scopus 로고    scopus 로고
    • Evaluation of the impact of the exposure route on the human kinetic adjustment factor
    • Valcke M., Krishnan K. Evaluation of the impact of the exposure route on the human kinetic adjustment factor. Regul. Toxicol. Pharmacol. 2011, 59:258-269.
    • (2011) Regul. Toxicol. Pharmacol. , vol.59 , pp. 258-269
    • Valcke, M.1    Krishnan, K.2
  • 94
    • 84875487513 scopus 로고    scopus 로고
    • WHO, Diet, nutrition and the prevention of chronic diseases: report of a joint WHO/FAO expert consultation. WHO Technical Report Series 916. World Health Organization, Geneva, Switzerland. Available from: (accessed 06/04/2011).
    • WHO, 2003. Diet, nutrition and the prevention of chronic diseases: report of a joint WHO/FAO expert consultation. WHO Technical Report Series 916. World Health Organization, Geneva, Switzerland. Available from: (accessed 06/04/2011). http://www.fao.org/DOCREP/005/AC911E/AC911E00.HTM.
    • (2003)
  • 95
    • 84875536531 scopus 로고    scopus 로고
    • WHO, Chemical-specific adjustment factors for interspecies differences and human variability: Guidance document for use of data in dose/concentration-response assessment, WHO, Geneva. Available from: (accessed 30/10/10).
    • WHO, 2005. Chemical-specific adjustment factors for interspecies differences and human variability: Guidance document for use of data in dose/concentration-response assessment, WHO, Geneva. Available from: (accessed 30/10/10). http://www.inchem.org/documents/harmproj/harmproj/harmproj2.pdf.
    • (2005)
  • 96
    • 84875545000 scopus 로고    scopus 로고
    • WHO, Principles and methods for the risk assessment of chemicals in food. EHC 240, ISBN 978 92 4 157240 8, WHO, Geneva. Available online at .
    • WHO, 2009. Principles and methods for the risk assessment of chemicals in food. EHC 240, ISBN 978 92 4 157240 8, WHO, Geneva. Available online at http://www.who.int/ipcs/food/principles/en/index1.html.
    • (2009)
  • 97
    • 77953964154 scopus 로고    scopus 로고
    • Computational systems biology and dose-response modeling in relation to new directions in toxicity testing
    • Zhang Q., Bhattacharya S., Andersen M.E., Conolly R.B. Computational systems biology and dose-response modeling in relation to new directions in toxicity testing. J. Toxicol. Environ. Health B Crit. Rev. 2010, 13:253-276.
    • (2010) J. Toxicol. Environ. Health B Crit. Rev. , vol.13 , pp. 253-276
    • Zhang, Q.1    Bhattacharya, S.2    Andersen, M.E.3    Conolly, R.B.4


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