Comparison of cancer slope factors using different statistical approaches

Risk Analysis

Volumn 26, Issue 3, 2006, Pages 825-830

  Subramaniam, Ravi P ^a   White, Paul ^a   Cogliano, V James ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

Cancer guidelines; Cancer slope factor; Confidence limit; IRIS; Multistage model

Indexed keywords

COMPUTATIONAL METHODS; CONSTRAINT THEORY; DATA ACQUISITION; DRUG DOSAGE; EXTRAPOLATION; GRAPH THEORY; MAXIMUM LIKELIHOOD ESTIMATION; RISK ASSESSMENT; STATISTICAL METHODS; TUMORS;

CANCER GUIDELINES; CANCER SLOPE FACTORS; CONFIDENCE LIMIT; IRIS; MULTISTAGE MODEL;

DISEASE CONTROL;

CANCER; CARCINOGEN; CONFIDENCE INTERVAL; RISK ASSESSMENT;

ARTICLE; CANCER; CANCER RISK; CANCER SLOPE FACTOR; CANCER STATISTICS; COMPARATIVE STUDY; DOSE RESPONSE; LINEAR SYSTEM; MAXIMUM LIKELIHOOD METHOD; METHODOLOGY; RISK ASSESSMENT; STATISTICAL ANALYSIS;

BIOLOGICAL ASSAY; CARCINOGENICITY TESTS; CARCINOGENS; CARCINOGENS, ENVIRONMENTAL; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; HUMANS; MODELS, STATISTICAL; NEOPLASMS; RISK ASSESSMENT; RISK FACTORS;

EID: 33745381903     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2006.00769.x     Document Type: Article

References (9)

1. Crump, K. S., & Howe, R. B. (1985). A review of methods for calculating statistical confidence limits in low-dose extrapolation. In D. B. Clayson, D. Krewski, & I. Munro (Eds Toxicological Risk Assessment. Vol. 1. Biological and Statistical Criteria (pp. 187 203). Boca Raton : CRC Press.
2. Gaylor, D. W., Kodell, R. L., Chen, J. J., Springer, J. A., Lorentzen, R. J., & Scheuplein, R. J. (1994). Point estimates of cancer risk at low doses. Risk Analysis, 14, 843 850.
3. Guess, H., Crump, K., & Peto, R. (1977). Uncertainty estimates for low dose-rate extrapolations of animal carcinogenicity data. Cancer Research, 37, 3475 3483.
4. Howe, R. B., Crump, K. S., & van Landingham, C. (1986). GLOBAL86. A computer program to extrapolate quantal animal toxicity data to low doses. Prepared for U.S. EPA. Subcontract 2-251U-2745.
5. Lovell, D. P., & Thomas, G. (1996). Quantitative risk assessment and the limitations of the linearized multistage model. Human & Experimental Toxicology, 15, 87 104.
6. Rosner, B. (2000). Fundamentals of Biostatistics, 5th ed. Pacific Grove : Duxbury.
7. U.S. Environmental Protection Agency (USEPA) 1986). Guidelines for carcinogen risk assessment. Federal Register, 51 (185 33992 34003.
8. U.S. Environmental Protection Agency (USEPA) 2001). The Benchmark Dose Software 3.1. Available at http://www.epa.gov/ncea.
9. U.S. Environmental Protection Agency (USEPA) 2005). Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001F. Washington, DC. Available on the Internet at http://www.epa.gov/cancerguidelines.