Modeling xenobiotic susceptibility to hepatotoxicity using an in vitro oxidative stress inflammation model

Canadian Journal of Physiology and Pharmacology

Volumn 91, Issue 3, 2013, Pages 236-240

  MacAllister, Stephanie L ^a   Maruf, Abdullah A ^a   Wan, Luke ^a   Chung, Erin ^a   O'Brien, Peter ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Inflammation; Iron; Mitochondrial membrane potential; Oxidative stress; Peroxidase; Reactive oxygen species

Indexed keywords

ACETALDEHYDE; ALCOHOL; AROMATIC AMINE; AROMATIC NITRO COMPOUND; CLOZAPINE; FERROUS ION; FLUTAMIDE; GLUCOSE; GLUCOSE OXIDASE; HYDROGEN PEROXIDE; NILUTAMIDE; NIMESULIDE; PEROXIDASE; REACTIVE OXYGEN METABOLITE; THIORIDAZINE; XENOBIOTIC AGENT;

ALCOHOL ABUSE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; IN VITRO STUDY; INFLAMMATION; LIVER CELL; LIVER INJURY; LIVER TOXICITY; MALE; MODEL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RISK FACTOR; SCREENING;

ANIMALS; CELL SURVIVAL; HEPATOCYTES; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; MODELS, CHEMICAL; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; XENOBIOTICS;

EID: 84875490299     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2012-0255     Document Type: Article

References (32)

1. Andersson, B.S., Aw, T.Y., and Jones, D.P. 1987. Mitochondrial transmembrane potential and pH gradient during anoxia. Am. J. Physiol. 252: C349-C355. PMID:3565555.
2. Boelsterli, U.A., Ho, H.K., Zhou, S., and Leow, K.Y. 2006. Bioactivation and hepatotoxicity of nitroaromatic drugs. Curr. Drug Metab. 7(7): 715-727. doi:10. 2174/138920006778520606.PMID:17073576.
3. Buchweitz, J.P., Ganey, P.E., Bursian, S.J., and Roth, R.A. 2002. Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy? J. Pharmacol. Exp. Ther. 300: 460-467. doi:10.1124/jpet. 300.2.460.PMID:11805205.
4. CCAC (Canadian Council on Animal Care). 1993. Guide to the care and use of experimental animals. 2nd ed., vol. 1. Bradda Printing Services, Ottawa, Ont.
5. ghbal, M.A., Tafazoli, S., Pennefather, P.O', and Brien, P.J. 2004. Peroxidase catalysed formation of cytotoxic prooxidant phenothiazine free radicals at physiological pH. Chem. Biol. Interact. 151(1): 43-51. doi:10.1016/j.cbi.2004.10. 005.PMID:15607761.
6. Fau, D., Eugene, D., Berson, A., Letteron, P., Fromenty, B., Fisch, C., et al. 1994. Toxicity of the antiandrogen flutamide in isolated rat hepatocytes. J. Pharmacol. Exp. Ther. 269(3): 954-962. PMID:8014883.
7. Ganey, P.E., and Roth, R.A. 2001. Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents. Toxicology, 169: 195-208. doi:10.1016/S0300-483X(01)00523-6.PMID:11718960.
8. Gardner, I., Zahid, N., MacCrimmon, D., and Uetrecht, J.P. 1998. A comparison of the oxidation of clozapine and olanzapine to reactive metabolites and the toxicity of these metabolites to human leukocytes. Mol. Pharmacol. 53: 991-998. PMID:9614200.
9. Gutiérrez-Correa, J., and Stoppani, A.O. 2002. Myeloperoxidase-generated phenothiazine cation radicals inactivate Trypanosoma cruzi dihydrolipoamide dehydrogenase. Rev. Argent. Microbiol. 34(2): 83-94. PMID:12180262.
10. ills, K.S., and Westaby, D. 1997. Alcohol and the liver. Br. J. Hosp. Med. 57(10): 517-521. PMID:9330004.
11. Kane, F.J., Jr., and Moore, L.P. 1971. Hepatotoxicity occurring with thioridazine therapy. South. Med. J. 64(5): 573. doi:10.1097/00007611-197105000-00012.PMID:5573073.
12. Liu, Z.C., and Uetrecht, J.P. 1995. Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells. J. Pharmacol. Exp. Ther. 275: 1476-1483. PMID:8531118.
13. Luyendyk, J.P., Shores, K.C., Ganey, P.E., and Roth, R.A. 2002. Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose nalysis for markers of liver injury. Toxicol. Sci. 68: 220-225. doi:10.1093/ toxsci/68.220.PMID:12075124.
14. MacAllister, S.L., Choi, J., Dedina, L.O', and Brien, P.J. 2011. Metabolic mechanisms of methanol/formaldehyde in isolated rat hepatocytes: carbonyl-metabolizing enzymes versus oxidative stress. Chem. Biol. Interact. 191(1-3): 308-314. doi:10. 1016/j.cbi.2011.01.017.PMID:21276436.
15. Mandrekar, P., and Szabo, G. 2009. Signalling pathways in alcohol-induced liver inflammation. J. Hepatol. 50(6): 1258-1266. doi:10.1016/j.jhep.2009.03.007.PMID:19398236.
16. Mingatto, F.E., Cardozo dos Santos, A., Rodrigues, T., Pigoso, A.A., Uyemura, S.A., and Curti, C. 2000. Effects of nimesulide and its reduced metabolite on mitochondria. Br. J. Pharmacol. 131: 1154-1160. doi:10.1038/sj.bjp.0703667.PMID:11082123.
17. Moldeus, P., Hogberg, J., and Orrenius, S. 1978. Isolation and use of liver cells. Methods Enzymol. 52: 60-71. doi:10.1016/S0076-6879(78)52006-5.PMID: 672656.
18. Nakao, L.S., Kadiiska, M.B., Mason, R.P., Grijalba, M.T., and Augusto, O. 2000. Metabolism of acetaldehyde to methyl and acetyl radicals: in vitro and in vivo electron paramagnetic resonance spin-trapping studies. Free Radic. Biol. Med. 29(8): 721-729. doi:10.1016/S0891-5849(00)00374-9.PMID:11053773.
19. O'Brien, P.J., and Siraki, A.G. 2005. Accelerated cytotoxicity mechanism screening using drug metabolizing enzyme modulators. Curr. Drug Metab. 6: 101-109. PMID:15853762.
20. Possel, H., Noack, H., Augustin, W., Keilhoff, G., and Wolf, G. 1997. 2,7-Dihy-drodichlorofluorescein diacetate as a fluorescent marker or peroxynitrite formation, FEBS Lett. 416: 175-178. doi:10.1016/S0014-5793(97)01197-6.PMID: 9369208
21. Reinke, L.A., Rau, J.M., and McCay, P.B. 1994. Characteristics of an oxidant formed during iron (II) autoxidation. Free Radic. Biol. Med. 16(4): 485-492. doi:10.1016/0891-5849(94)90126-0.PMID:8005533.
22. Roth, R.A., Harkema, J.R., Pestka, J.P., and Ganey, P.E. 1997. Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xeno-biotic agents? Toxicol. Appl. Pharmacol. 147(2): 300-311. doi:10.1006/taap.1997. 8301.PMID:9439725.
23. Stål, P., and Hultcrantz, R. 1993. Iron increases ethanol toxicity in rat liver. J. Hepatol. 17: 108-115. doi:10.1016/S0168-8278(05)80530-6.PMID:8445209.
24. Tafazoli, S., and O'Brien, P.J. 2008. Accelerated cytotoxic mechanism screening of hydralazine using an in vitro hepatocyte inflammatory cell peroxidase model. Chem. Res. Toxicol. 21: 904-910. doi:10.1021/tx70371x.PMID:18393451.
25. Tafazoli, S., and O'Brien, P.J. 2009. Amodiaquine-induced oxidative stress in a hepatocyte inflammation model. Toxicology, 256: 101-109. doi:10.1016/j.tox. 2008.11.006.PMID:19059302.
26. Tafazoli, S., Wright, J.S., and O'Brien, P.J. 2005. Prooxidant and antioxidant activity of vitamin E analogues and troglitazone. Chem. Res. Toxicol. 18: 1567-1574. doi:10.1021/tx0500575.PMID:16533021.
27. Tafazoli, S., Mashregi, M., and O'Brien, P.J. 2008. Role of hydrazine in isoniazidinduced hepatotoxicity in a hepatocyte inflammation model. Toxicol. Appl. Pharmacol. 229: 94-101. doi:10.1016.j.tapp.2008.01.002.PMID:18295292.
28. Tay, V.K., Wang, A.S., Leow, K.Y., Ong, M.M., Wong, K.P., and Boelsterli, U.A. 2005. Mitochondrial permeability transition as a source of superoxide anion induced by the nitroaromatic drug nimesulide in vitro. Free Radic. Biol. Med. 39: 949-959. doi:10.1016/j.freeradbiomed.2005.05.013.PMID:16140214.
29. Uetrecht, J.P. 1992. Metabolism of clozapine by neutrophils. Possible implica-tions for clozapine-induced agranulocytosis. Drug Saf. 7(Suppl. 1): 51-56. doi:10.2165/00002018-199200071-00011.PMID:1503678.
30. Uetrecht, J. 2007. Idiosyncratic drug reactions: current understanding. Annu. Rev. Pharmacol. Toxicol. 47: 513-539. doi:10.1146/annurev.pharmtox.47.120505.105150.PMID:16879083.
31. Weiden, P.L., and Buckner, C.D. 1973. Thioridazine toxicity. Agranulocytosis and hepatitis with encephalopathy. JAMA, 224: 518-520. doi:10.1001/jama.1973.03220170044011.PMID:4739612.
32. Yang, M., Chordia, M.D., Li, F., Huang, T., Linden, J., and Macdonald, T.L. 2010. Neutrophil and myeloperoxidase-mediated metabolism of reduced nimesulide: evidence for bioactivation. Chem. Res. Toxicol. 23: 1691-1700. doi:10. 1021/tx1001496.PMID:20939553.