Neutrophil- and myeloperoxidase-mediated metabolism of reduced nimesulide: Evidence for bioactivation

Chemical Research in Toxicology

Volumn 23, Issue 11, 2010, Pages 1691-1700

  Yang, Min ^a   Chordia, Mahendra D ^a   Li, Fengping ^a   Huang, Tao ^a   Linden, Joel ^a   MacDonald, Timothy L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; MYELOPEROXIDASE; NIMESULIDE; NUCLEOPHILE; REACTIVE NITROGEN SPECIES;

ARTICLE; CELL ACTIVATION; CONJUGATE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME METABOLISM; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE; LIQUID CHROMATOGRAPHY; METABOLITE; NEUTROPHIL; OXIDATION; TANDEM MASS SPECTROMETRY;

ACETYLCYSTEINE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, LIQUID; HUMANS; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; MICROSOMES, LIVER; NEUTROPHILS; OXIDATION-REDUCTION; PEROXIDASE; SULFONAMIDES; TANDEM MASS SPECTROMETRY;

EID: 78649274348     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx1001496     Document Type: Article

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