Myeloperoxidase-generated phenothiazine cation radicals inactivate Trypanosoma cruzi dihydrolipoamide dehydrogenase

Revista Argentina de Microbiologia

Volumn 34, Issue 2, 2002, Pages 83-94

  Gutierrez Correa J ^a   Stoppani, A O M ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Cation radical; Dihydrolipoamide dehydrogenase; Horseradish peroxidase; Myeloperoxidase; Myoglobin; Phenothiazines; Trypanosoma cruzi

Indexed keywords

ACETYLCYSTEINE; ALIMEMAZINE; AROMATIC AMINO ACID; ASCORBIC ACID; CHLORPROMAZINE; DIHYDROLIPOAMIDE DEHYDROGENASE; FLUPHENAZINE; GLUTATHIONE; HYDROGEN PEROXIDE; MYELOPEROXIDASE; MYOGLOBIN; NITRILE; PENICILLAMINE; PEPTIDE DERIVATIVE; PERICIAZINE; PERPHENAZINE; PHENOTHIAZINE; PROCHLORPERAZINE; PROMAZINE; PROMETHAZINE; PROPIONYLPROMAZINE; RADICAL; SCAVENGER; THIOL DERIVATIVE; THIORIDAZINE; TRIFLUOPERAZINE; TRIFLUPROMAZINE; TRYPTOPHAN; TYROSINE;

ARTICLE; DRUG ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; MOLECULAR STABILITY; NONHUMAN; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

AMINO ACIDS, AROMATIC; ANIMALS; ASCORBIC ACID; CATIONS; DIHYDROLIPOAMIDE DEHYDROGENASE; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; FREE RADICALS; HUMANS; HYDROGEN PEROXIDE; PEROXIDASE; PHENOTHIAZINES; PROTOZOAN PROTEINS; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 0036342382     PISSN: 03257541     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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