Accelerated cytotoxic mechanism screening of hydralazine using an in vitro hepatocyte inflammatory cell peroxidase model

Chemical Research in Toxicology

Volumn 21, Issue 4, 2008, Pages 904-910

  Tafazoli, Shahrzad ^a   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOBENZOTRIAZOLE; BUTYLATED HYDROXYANISOLE; CYTOCHROME P450 INHIBITOR; GALLIC ACID; GLUTATHIONE; HYDRALAZINE; HYDROGEN PEROXIDE; MYELOPEROXIDASE; PROPYLTHIOURACIL; TEMPOL;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SENSITIVITY; IN VITRO STUDY; INFLAMMATORY CELL; KUPFFER CELL; LC 50; LIPID PEROXIDATION; LIVER CELL; MALE; NEUTROPHIL; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PROTEIN CARBONYLATION; RAT; TOXICITY TESTING;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CELL SURVIVAL; CELLS, CULTURED; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEPATOCYTES; HYDRALAZINE; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PEROXIDASE; PROTEIN CARBONYLATION; RATS; RATS, SPRAGUE-DAWLEY; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

RATTUS;

EID: 43149087329     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx700371x     Document Type: Article

References (38)

1. Itoh, S., Ichinoe, A., Tsukada, Y., and Itoh, Y. (1981) Hydralazine-induced hepatitis. Hepatogastroenterology 28, 13-16.
2. Murata, K., Hamada, M., Sugimoto, K., and Nakano, T. (2007) A novel mechanism for drug-induced liver failure: Inhibition of histone acetylation by hydralazine derivatives. J. Hepatol. 46, 322-329.
3. Bourdi, M., Gautier, J. C., Mircheva, J., Larrey, D., Guillouzo, A., Andre, C., Belloc, C., and Beaune, P. H. (1992) Anti-liver microsomes autoantibodies and dihydralazine-induced hepatitis: specificity of autoantibodies and inductive capacity of the drug. Mol. Pharmacol. 42, 280-285.
4. Cameron, H. A., and Ramsay, L. E. (1984) The lupus syndrome induced by hydralazine: a common complication with low dose treatment. Br. Med. J. (Clin. Res. Ed.) 289, 410-412.
5. Hofstra, A. H., Matassa, L. C., and Uetrecht, J. P. (1991) Metabolism of hydralazine by activated leukocytes: Implications for hydralazine induced lupus. J. Rheumatol. 18, 1673-1680.
6. Hofstra, A. H., and Uetrecht, J. P. (1993) Reactive intermediates in the oxidation of hydralazine by HOCl: The major oxidant generated by neutrophils. Chem.-Biol. Interact. 89, 183-196.
7. Sinha, B. K. (1983) Enzymatic activation of hydrazine derivatives. A spin-trapping study. J. Biol. Chem. 258, 796-801.
8. Wong, P. K., Poyer, J. L., DuBose, C. M., and Floyd, R. A. (1988) Hydralazine-dependent carbon dioxide free radical formation by metabolizing mitochondria. J. Biol. Chem. 263, 11296-11301.
9. Yamamoto, K., and Kawanishi, S. (1991) Free radical production and site-specific DNA damage induced by hydralazine in the presence of metal ions or peroxidase/hydrogen peroxide. Biochem. Pharmacol. 41, 905-914.
10. Martelli, A., Allavena, A., Campari, G. B., Canonero, R., Ghia, M., Mattioli, F., Mereto, E., Robbiano, L., and Brambilla, G. (1995) In vitro and in vivo testing of hydralazine genotoxicity. J. Pharmacol. Exp. Ther. 273, 113-120.
11. Parodi, S., De Flora, S., Cavanna, M., Pino, A., Robbiano, L., Bennicelli, C., and Brambilla, G. (1981) DNA-damaging activity in vivo and bacterial mutagenicity of sixteen hydrazine derivatives as related quantitatively to their carcinogenicity. Cancer Res. 41, 1469-1482.
12. Toth, B. (1978) Tumorigenic effect of 1 hydrazinophthalazine hydrochloride in mice. J. Natl. Cancer Inst. 61, 1363-1365.
13. LaCagnin, L. B., Colby, H. D., and O'Donnell, J. P. (1986) The oxidative metabolism of hydralazine by rat liver microsomes. Drug Metab. Dispos. 14, 549-554.
14. Deng, X., Luyendyk, J. P., Zou, W., Lu, J., Malle, E., Ganey, P. E., and Roth, R. A. (2007) Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine. J. Pharmacol. Exp. Ther. 322, 852-861.
15. Shaw, P. J., Hopfensperger, M. J., Ganey, P. E., and Roth, R. A. (2007) Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. Toxicol. Sci. 100, 259-266.
16. Luyendyk, J. P., Lehman-McKeeman, L. D., Nelson, D. M., Bhaskaran, V. M., Reilly, T. P., Car, B. D., Cantor, G. H., Maddox, J. F., Ganey, P. E., and Roth, R. A. (2006) Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: Comparison with famotidine. Toxicol. Sci. 90, 569-585.
17. Quinn, M. T., Amnions, M. C., and Deleo, F. R. (2006) The expanding role of NADPH oxidases in health and disease: No longer just agents of death and destruction. Clin. Sci. (London) 111, 1-20.
18. Kawahara, T., Kohjima, M., Kuwano, Y., Mino, H., Teshima-Kondo, S., Takeya, R., Tsunawaki, S., Wada, A., Sumimoto, H., and Rokutan, K. (2005) Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells. Am. J. Physiol. Cell Physiol. 288, C450-C457.
19. Tafazoli, S., and O'Brien, P. J. (2005) Peroxidases: A role in the metabolism and side effects of drugs. Drug Discovery Today 10, 617-625.
20. Tafazoli, S., Spehar, D. D., and O'Brien, P. J. (2005) Oxidative stress mediated idiosyncratic drug toxicity. Drug Metab Rev. 37, 311-325.
21. Tafazoli, S., Wright, J. S., and O'Brien, P. J. (2005) Prooxidant and antioxidant activity of vitamin E analogues and troglitazone. Chem. Res. Toxicol. 18, 1567-1574.
22. O'Brien, P. J., Tafazoli, S., Chan, K., Mashregi, M., Mehta, R., and Shangari, N. (2007) In A Hepatocyte Inflammation Model for Carbonyl Induced Liver Injury: Drugs, Diabetes, Solvents, Chlorination (Weiner, H., Maser, E., Lindahl, R., and Plapp, B., Eds.) pp 105-112, Purdue University Press, West Lafayette, IN.
23. Moldeus, P., Hogberg, J., and Orrenius, S. (1978) Isolation and use of liver cells. Methods Enzymol. 52, 60-71.
24. 2 fluxes within cells. J. Biochem. Biophys. Methods 31, 59-67.
25. 2 induce apoptosis through Fenton chemistry independent of the cellular thiol state. Free Radical Biol. Med. 30, 1008-1018.
26. Tafazoli, S., and O'Brien, P. J. (2004) Prooxidant activity and cytotoxic effects of indole-3 acetic acid derivative radicals. Chem. Res. Toxicol. 17, 1350-1355.
27. Smith, M. T., Thor, H., Hartizell, P., and Orrenius, S. (1982) The measurement of lipid peroxidation in isolated hepatocytes. Biochem. Pharmacol. 31, 19-26.
28. Reed, D. J., Babson, J. R., Beatty, P. W., Brodie, A. E., Ellis, W. W., and Potter, D. W. (1980) High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Anal. Biochem. 106, 55-62.
29. Hartley, D. P., Kroll, D. J., and Petersen, D. R. (1997) Prooxidant-initiated lipid peroxidation in isolated rat hepatocytes: Detection of 4-hydroxynonenal- and malondialdehyde-protein adducts. Chem. Res. Toxicol. 10, 895-905.
30. Anari, M. R., Khan, S., Jatoe, S. D., and O'Brien, P. J. (1997) Cytochrome P450 dependent xenobiotic activation by physiological hydroperoxides in intact hepatocytes. Eur. J. Drug Metab. Pharmacokinet. 22, 305-310.
31. Ortiz de Montellano, P. R., and Mathews, J. M. (1981) Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1- aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct. Biochem. J. 195, 761-764.
32. Galati, G., Tafazoli, S., Sabzevari, O., Chan, T. S., and O'Brien, P. J. (2002) Idiosyncratic NSAID drug induced oxidative stress. Chem.-Biol. Interact. 142, 25-41.
33. O'Brien, P. J. (1988) Radical formation during the peroxidase catalyzed metabolism of carcinogens and xenobiotics: The reactivity of these radicals with GSH, DNA, and unsaturated lipid. Free Radical Biol. Med. 4, 169-183.
34. Weglarz, L., Drozdz, M., Wardas, M., and Goss, M. (1989) Activities of antioxidant enzymes in fibroblasts cultured in vitro in the presence of hydralazine. Biomed. Biochim. Acta 48, 489-493.
35. Cohen, G., and Hochstein, P. (1964) Generation of hydrogen peroxide in erythrocytes by hemolytic agents. Biochemistry 3, 895-900.
36. Ortiz de Montellano, P. R., and Kerr, D. E. (1983) Inactivation of catalase by Phenylhydrazine. Formation of a stable aryl-iron heme complex. J. Biol. Chem. 258, 10558-10563.
37. Runge-Morris, M., and Novak, R. F. (1993) Effects of phenelzine and hydralazine on hydrogen peroxide production and proteolysis in human red blood cells. J. Pharmacol. Exp. Ther. 267, 1401-1406.
38. Misra, H. P., and Fridovich, I. (1976) The oxidation of Phenylhydrazine: Superoxide and mechanism. Biochemistry 15, 681-687.