메뉴 건너뛰기




Volumn 13, Issue , 2013, Pages

High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 84875483113     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-169     Document Type: Article
Times cited : (44)

References (51)
  • 1
    • 22044442973 scopus 로고    scopus 로고
    • Tyrosine kinases as targets for cancer therapy
    • 10.1056/NEJMra044389, 16014887
    • Krause DS, Van Etten RA. Tyrosine kinases as targets for cancer therapy. N Engl J Med 2005, 353(2):172-187. 10.1056/NEJMra044389, 16014887.
    • (2005) N Engl J Med , vol.353 , Issue.2 , pp. 172-187
    • Krause, D.S.1    Van Etten, R.A.2
  • 2
    • 84964412770 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med 2009, 360(15):1579.
    • (2009) N Engl J Med , vol.360 , Issue.15 , pp. 1579
    • Ciardiello, F.1    Tortora, G.2
  • 3
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • 10.1038/nm1087, 15286780
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004, 10(8):789-799. 10.1038/nm1087, 15286780.
    • (2004) Nat Med , vol.10 , Issue.8 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 4
    • 33845608798 scopus 로고    scopus 로고
    • Classification of colorectal cancer based on correlation of clinical, morphological and molecular features
    • 10.1111/j.1365-2559.2006.02549.x, 17204026
    • Jass JR. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology 2007, 50(1):113-130. 10.1111/j.1365-2559.2006.02549.x, 17204026.
    • (2007) Histopathology , vol.50 , Issue.1 , pp. 113-130
    • Jass, J.R.1
  • 5
    • 34248591612 scopus 로고    scopus 로고
    • Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
    • 10.1038/sj.onc.1210422, 17496923
    • Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007, 26(22):3291-3310. 10.1038/sj.onc.1210422, 17496923.
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3291-3310
    • Roberts, P.J.1    Der, C.J.2
  • 6
  • 8
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • 10.1200/JCO.2008.20.8397, 19114683
    • Bokemeyer C, Bondarenko I, Makhson A, Hartmann JT, Aparicio J, de Braud F, Donea S, Ludwig H, Schuch G, Stroh C. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2009, 27(5):663-671. 10.1200/JCO.2008.20.8397, 19114683.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3    Hartmann, J.T.4    Aparicio, J.5    de Braud, F.6    Donea, S.7    Ludwig, H.8    Schuch, G.9    Stroh, C.10
  • 11
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • 10.1200/JCO.2008.19.8135, 19114685
    • Hecht JR, Mitchell E, Chidiac T, Scroggin C, Hagenstad C, Spigel D, Marshall J, Cohn A, McCollum D, Stella P. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009, 27(5):672-680. 10.1200/JCO.2008.19.8135, 19114685.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3    Scroggin, C.4    Hagenstad, C.5    Spigel, D.6    Marshall, J.7    Cohn, A.8    McCollum, D.9    Stella, P.10
  • 12
    • 34247278727 scopus 로고    scopus 로고
    • Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
    • 10.1038/sj.bjc.6603685, 2360149, 17375050
    • Di Fiore F, Blanchard F, Charbonnier F, Le Pessot F, Lamy A, Galais MP, Bastit L, Killian A, Sesboue R, Tuech JJ. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. Br J Cancer 2007, 96:1166-1169. 10.1038/sj.bjc.6603685, 2360149, 17375050.
    • (2007) Br J Cancer , vol.96 , pp. 1166-1169
    • Di Fiore, F.1    Blanchard, F.2    Charbonnier, F.3    Le Pessot, F.4    Lamy, A.5    Galais, M.P.6    Bastit, L.7    Killian, A.8    Sesboue, R.9    Tuech, J.J.10
  • 13
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • 10.1200/JCO.2007.12.5906, 18202412
    • Lievre A, Bachet JB, Boige V, Cayre A, Le Corre D, Buc E, Ychou M, Bouche O, Landi B, Louvet C. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008, 26(3):374-379. 10.1200/JCO.2007.12.5906, 18202412.
    • (2008) J Clin Oncol , vol.26 , Issue.3 , pp. 374-379
    • Lievre, A.1    Bachet, J.B.2    Boige, V.3    Cayre, A.4    Le Corre, D.5    Buc, E.6    Ychou, M.7    Bouche, O.8    Landi, B.9    Louvet, C.10
  • 17
    • 84856399968 scopus 로고    scopus 로고
    • Comparison of methodologies for KRAS mutation detection in metastatic colorectal cancer
    • 10.1016/j.cancergen.2011.07.003, 21962894
    • Pinto P, Rocha P, Veiga I, Guedes J, Pinheiro M, Peixoto A, Pinto C, Fragoso M, Sanches E, Araujo A. Comparison of methodologies for KRAS mutation detection in metastatic colorectal cancer. Cancer Genet 2011, 204(8):439-446. 10.1016/j.cancergen.2011.07.003, 21962894.
    • (2011) Cancer Genet , vol.204 , Issue.8 , pp. 439-446
    • Pinto, P.1    Rocha, P.2    Veiga, I.3    Guedes, J.4    Pinheiro, M.5    Peixoto, A.6    Pinto, C.7    Fragoso, M.8    Sanches, E.9    Araujo, A.10
  • 18
    • 0026847151 scopus 로고
    • Typing of human papillomaviruses by polymerase chain reaction amplification with L1 consensus primers and RFLP analysis
    • 10.1016/0890-8508(92)90059-7, 1355266
    • Lungu O, Wright TC, Silverstein S. Typing of human papillomaviruses by polymerase chain reaction amplification with L1 consensus primers and RFLP analysis. Mol Cell Probes 1992, 6(2):145-152. 10.1016/0890-8508(92)90059-7, 1355266.
    • (1992) Mol Cell Probes , vol.6 , Issue.2 , pp. 145-152
    • Lungu, O.1    Wright, T.C.2    Silverstein, S.3
  • 20
    • 48649092117 scopus 로고    scopus 로고
    • High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer
    • 10.1309/LWDY1AXHXUULNVHQ, 18628094
    • Simi L, Pratesi N, Vignoli M, Sestini R, Cianchi F, Valanzano R, Nobili S, Mini E, Pazzagli M, Orlando C. High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer. Am J Clin Pathol 2008, 130(2):247-253. 10.1309/LWDY1AXHXUULNVHQ, 18628094.
    • (2008) Am J Clin Pathol , vol.130 , Issue.2 , pp. 247-253
    • Simi, L.1    Pratesi, N.2    Vignoli, M.3    Sestini, R.4    Cianchi, F.5    Valanzano, R.6    Nobili, S.7    Mini, E.8    Pazzagli, M.9    Orlando, C.10
  • 21
    • 20144378490 scopus 로고    scopus 로고
    • Human malignant melanoma: detection of BRAF- and c-kit-activating mutations by high-resolution amplicon melting analysis
    • 10.1016/j.humpath.2005.03.015, 15948115
    • Willmore-Payne C, Holden JA, Tripp S, Layfield LJ. Human malignant melanoma: detection of BRAF- and c-kit-activating mutations by high-resolution amplicon melting analysis. Hum Pathol 2005, 36(5):486-493. 10.1016/j.humpath.2005.03.015, 15948115.
    • (2005) Hum Pathol , vol.36 , Issue.5 , pp. 486-493
    • Willmore-Payne, C.1    Holden, J.A.2    Tripp, S.3    Layfield, L.J.4
  • 22
    • 64249106774 scopus 로고    scopus 로고
    • Evaluation of high-resolution melting analysis as a diagnostic tool to detect the BRAF V600E mutation in colorectal tumors
    • 10.2353/jmoldx.2009.080100, 2665863, 19213871
    • Pichler M, Balic M, Stadelmeyer E, Ausch C, Wild M, Guelly C, Bauemhofer T, Samonigg H, Hoefler G, Dandachi N. Evaluation of high-resolution melting analysis as a diagnostic tool to detect the BRAF V600E mutation in colorectal tumors. J Mol Diagn 2009, 11(2):140-147. 10.2353/jmoldx.2009.080100, 2665863, 19213871.
    • (2009) J Mol Diagn , vol.11 , Issue.2 , pp. 140-147
    • Pichler, M.1    Balic, M.2    Stadelmeyer, E.3    Ausch, C.4    Wild, M.5    Guelly, C.6    Bauemhofer, T.7    Samonigg, H.8    Hoefler, G.9    Dandachi, N.10
  • 24
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
    • 10.1016/S1470-2045(10)70130-3, 20619739
    • De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, Kalogeras KT, Kotoula V, Papamichael D, Laurent-Puig P. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010, 11(8):753-762. 10.1016/S1470-2045(10)70130-3, 20619739.
    • (2010) Lancet Oncol , vol.11 , Issue.8 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3    De Schutter, J.4    Biesmans, B.5    Fountzilas, G.6    Kalogeras, K.T.7    Kotoula, V.8    Papamichael, D.9    Laurent-Puig, P.10
  • 25
    • 68749119351 scopus 로고    scopus 로고
    • KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer
    • 10.1038/sj.bjc.6605177, 2736831, 19603018
    • Loupakis F, Ruzzo A, Cremolini C, Vincenzi B, Salvatore L, Santini D, Masi G, Stasi I, Canestrari E, Rulli E. KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer. Br J Cancer 2009, 101(4):715-721. 10.1038/sj.bjc.6605177, 2736831, 19603018.
    • (2009) Br J Cancer , vol.101 , Issue.4 , pp. 715-721
    • Loupakis, F.1    Ruzzo, A.2    Cremolini, C.3    Vincenzi, B.4    Salvatore, L.5    Santini, D.6    Masi, G.7    Stasi, I.8    Canestrari, E.9    Rulli, E.10
  • 26
    • 79251634728 scopus 로고    scopus 로고
    • The importance of evaluation of DNA amplificability in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissues
    • 10.1093/jjco/hyq173, 20926413
    • Okayama N, Nishioka M, Hazama S, Sakai K, Suehiro Y, Maekawa M, Sakamoto J, Iwamoto S, Kato T, Mishima H. The importance of evaluation of DNA amplificability in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissues. Jpn J Clin Oncol 2011, 41(2):165-171. 10.1093/jjco/hyq173, 20926413.
    • (2011) Jpn J Clin Oncol , vol.41 , Issue.2 , pp. 165-171
    • Okayama, N.1    Nishioka, M.2    Hazama, S.3    Sakai, K.4    Suehiro, Y.5    Maekawa, M.6    Sakamoto, J.7    Iwamoto, S.8    Kato, T.9    Mishima, H.10
  • 27
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
    • 10.1200/JCO.2008.21.6796, 19884556
    • Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, Lecomte T, Rougier P, Lievre A, Landi B, Boige V. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol 2009, 27(35):5924-5930. 10.1200/JCO.2008.21.6796, 19884556.
    • (2009) J Clin Oncol , vol.27 , Issue.35 , pp. 5924-5930
    • Laurent-Puig, P.1    Cayre, A.2    Manceau, G.3    Buc, E.4    Bachet, J.B.5    Lecomte, T.6    Rougier, P.7    Lievre, A.8    Landi, B.9    Boige, V.10
  • 29
    • 17844362179 scopus 로고    scopus 로고
    • Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study
    • 10.1016/S1470-2045(05)70102-9, 15863375
    • Moroni M, Veronese S, Benvenuti S, Marrapese G, Sartore-Bianchi A, Di Nicolantonio F, Gambacorta M, Siena S, Bardelli A. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 2005, 6(5):279-286. 10.1016/S1470-2045(05)70102-9, 15863375.
    • (2005) Lancet Oncol , vol.6 , Issue.5 , pp. 279-286
    • Moroni, M.1    Veronese, S.2    Benvenuti, S.3    Marrapese, G.4    Sartore-Bianchi, A.5    Di Nicolantonio, F.6    Gambacorta, M.7    Siena, S.8    Bardelli, A.9
  • 30
  • 31
    • 42149083899 scopus 로고    scopus 로고
    • Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers
    • 10.1002/ijc.23388, 18224685
    • Barault L, Veyrie N, Jooste V, Lecorre D, Chapusot C, Ferraz JM, Lievre A, Cortet M, Bouvier AM, Rat P. Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. Int J Cancer 2008, 122(10):2255-2259. 10.1002/ijc.23388, 18224685.
    • (2008) Int J Cancer , vol.122 , Issue.10 , pp. 2255-2259
    • Barault, L.1    Veyrie, N.2    Jooste, V.3    Lecorre, D.4    Chapusot, C.5    Ferraz, J.M.6    Lievre, A.7    Cortet, M.8    Bouvier, A.M.9    Rat, P.10
  • 34
    • 77952536391 scopus 로고    scopus 로고
    • Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes
    • 10.1371/journal.pone.0008802, 2809099, 20098682
    • Lurkin I, Stoehr R, Hurst CD, van Tilborg AA, Knowles MA, Hartmann A, Zwarthoff EC. Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes. PLoS One 2010, 5(1):e8802. 10.1371/journal.pone.0008802, 2809099, 20098682.
    • (2010) PLoS One , vol.5 , Issue.1
    • Lurkin, I.1    Stoehr, R.2    Hurst, C.D.3    van Tilborg, A.A.4    Knowles, M.A.5    Hartmann, A.6    Zwarthoff, E.C.7
  • 36
    • 70350028742 scopus 로고    scopus 로고
    • Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer
    • 10.1371/journal.pone.0007287, 2750753, 19806185
    • Sartore-Bianchi A, Di Nicolantonio F, Nichelatti M, Molinari F, De Dosso S, Saletti P, Martini M, Cipani T, Marrapese G, Mazzucchelli L. Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer. PLoS One 2009, 4(10):e7287. 10.1371/journal.pone.0007287, 2750753, 19806185.
    • (2009) PLoS One , vol.4 , Issue.10
    • Sartore-Bianchi, A.1    Di Nicolantonio, F.2    Nichelatti, M.3    Molinari, F.4    De Dosso, S.5    Saletti, P.6    Martini, M.7    Cipani, T.8    Marrapese, G.9    Mazzucchelli, L.10
  • 37
    • 0030772378 scopus 로고    scopus 로고
    • The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants
    • 10.1126/science.277.5324.333, 9219684
    • Scheffzek K, Ahmadian MR, Kabsch W, Wiesmuller L, Lautwein A, Schmitz F, Wittinghofer A. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 1997, 277(5324):333-338. 10.1126/science.277.5324.333, 9219684.
    • (1997) Science , vol.277 , Issue.5324 , pp. 333-338
    • Scheffzek, K.1    Ahmadian, M.R.2    Kabsch, W.3    Wiesmuller, L.4    Lautwein, A.5    Schmitz, F.6    Wittinghofer, A.7
  • 38
    • 36749036721 scopus 로고    scopus 로고
    • Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf
    • 10.1016/j.str.2007.10.011, 2273997, 18073111
    • Buhrman G, Wink G, Mattos C. Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf. Structure 2007, 15(12):1618-1629. 10.1016/j.str.2007.10.011, 2273997, 18073111.
    • (2007) Structure , vol.15 , Issue.12 , pp. 1618-1629
    • Buhrman, G.1    Wink, G.2    Mattos, C.3
  • 40
    • 0026026818 scopus 로고
    • The GTPase superfamily: conserved structure and molecular mechanism
    • 10.1038/349117a0, 1898771
    • Bourne HR, Sanders DA, McCormick F. The GTPase superfamily: conserved structure and molecular mechanism. Nature 1991, 349(6305):117-127. 10.1038/349117a0, 1898771.
    • (1991) Nature , vol.349 , Issue.6305 , pp. 117-127
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 46
    • 34248369435 scopus 로고    scopus 로고
    • Rare cancer-specific mutations in PIK3CA show gain of function
    • 10.1073/pnas.0701005104, 1838453, 17376864
    • Gymnopoulos M, Elsliger MA, Vogt PK. Rare cancer-specific mutations in PIK3CA show gain of function. Proc Natl Acad Sci USA 2007, 104(13):5569-5574. 10.1073/pnas.0701005104, 1838453, 17376864.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.13 , pp. 5569-5574
    • Gymnopoulos, M.1    Elsliger, M.A.2    Vogt, P.K.3
  • 47
    • 40649096375 scopus 로고    scopus 로고
    • Helical domain and kinase domain mutations in p110 alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
    • 10.1073/pnas.0712169105, 2268191, 18268322
    • Zhao L, Vogt PK. Helical domain and kinase domain mutations in p110 alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms. Proc Natl Acad Sci USA 2008, 105(7):2652-2657. 10.1073/pnas.0712169105, 2268191, 18268322.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.7 , pp. 2652-2657
    • Zhao, L.1    Vogt, P.K.2
  • 48
    • 14144252004 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
    • 10.1073/pnas.0408864102, 545580, 15647370
    • Kang SY, Bader AG, Vogt PK. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci USA 2005, 102(3):802-807. 10.1073/pnas.0408864102, 545580, 15647370.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.3 , pp. 802-807
    • Kang, S.Y.1    Bader, A.G.2    Vogt, P.K.3
  • 49
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • 10.1038/nrc1753, 16341083
    • Bader AG, Kang SY, Zhao L, Vogt PK. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005, 5(12):921-929. 10.1038/nrc1753, 16341083.
    • (2005) Nat Rev Cancer , vol.5 , Issue.12 , pp. 921-929
    • Bader, A.G.1    Kang, S.Y.2    Zhao, L.3    Vogt, P.K.4
  • 51
    • 79960932729 scopus 로고    scopus 로고
    • BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a meta-analysis
    • 10.1007/s11033-010-0351-4, 20857202
    • Mao C, Liao RY, Qiu LX, Wang XW, Ding H, Chen Q. BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a meta-analysis. Mol Biol Rep 2011, 38(4):2219-2223. 10.1007/s11033-010-0351-4, 20857202.
    • (2011) Mol Biol Rep , vol.38 , Issue.4 , pp. 2219-2223
    • Mao, C.1    Liao, R.Y.2    Qiu, L.X.3    Wang, X.W.4    Ding, H.5    Chen, Q.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.