메뉴 건너뛰기




Volumn 69, Issue 3, 2009, Pages 1166-1173

p21/Cip1 and p27/Kip1 are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DRINKING WATER; PHYTIC ACID; RETROVIRUS VECTOR; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

EID: 59149098373     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-3115     Document Type: Article
Times cited : (64)

References (41)
  • 2
    • 34548438462 scopus 로고    scopus 로고
    • Therapeutic options for hormone-refractory prostate cancer in 2007
    • Hadaschik BA, Gleave ME. Therapeutic options for hormone-refractory prostate cancer in 2007. Urol Oncol 2007;25:413-9.
    • (2007) Urol Oncol , vol.25 , pp. 413-419
    • Hadaschik, B.A.1    Gleave, M.E.2
  • 3
    • 36849065338 scopus 로고    scopus 로고
    • Putative cancer chemopreventive agents of dietary origin - how safe are they?
    • Verschoyle RD, Steward WP, Gescher AJ. Putative cancer chemopreventive agents of dietary origin - how safe are they? Nutr Cancer 2007;59:152-62.
    • (2007) Nutr Cancer , vol.59 , pp. 152-162
    • Verschoyle, R.D.1    Steward, W.P.2    Gescher, A.J.3
  • 4
    • 0037294160 scopus 로고    scopus 로고
    • Beneficial and adverse effects of chemopreventive agents
    • Lee BM, Park KK. Beneficial and adverse effects of chemopreventive agents. Mutat Res 2003;523-4:265-78.
    • (2003) Mutat Res
    • Lee, B.M.1    Park, K.K.2
  • 5
    • 38349000628 scopus 로고    scopus 로고
    • Cancer chemoprevention through dietary antioxidants: Progress and promise
    • Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal 2008;10:475-510.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 475-510
    • Khan, N.1    Afaq, F.2    Mukhtar, H.3
  • 6
    • 44849135016 scopus 로고    scopus 로고
    • Bioactive food components and cancer risk reduction
    • Stan SD, Kar S, Stoner GD, Singh SV. Bioactive food components and cancer risk reduction. J Cell Biochem 2008;104:339-56.
    • (2008) J Cell Biochem , vol.104 , pp. 339-356
    • Stan, S.D.1    Kar, S.2    Stoner, G.D.3    Singh, S.V.4
  • 7
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003;3:768-80.
    • (2003) Nat Rev Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 8
    • 2942666195 scopus 로고    scopus 로고
    • The traditional diet of Greece and cancer
    • Simopoulos AP. The traditional diet of Greece and cancer. Eur J Cancer Prev 2004;13:219-30.
    • (2004) Eur J Cancer Prev , vol.13 , pp. 219-230
    • Simopoulos, A.P.1
  • 9
    • 0032763994 scopus 로고    scopus 로고
    • Metabolism and cellular functions of IP6: A review
    • Shamsuddin AM. Metabolism and cellular functions of IP6: a review. Anticancer Res 1999;19:3733-6.
    • (1999) Anticancer Res , vol.19 , pp. 3733-3736
    • Shamsuddin, A.M.1
  • 10
    • 0034015892 scopus 로고    scopus 로고
    • The effects of inositol hexaphosphate on the inflammatory response in transformed RAW 264.7 macrophages
    • Johnson M, Tucci M, Benghuzzi H, Cason Z, Hughes J. The effects of inositol hexaphosphate on the inflammatory response in transformed RAW 264.7 macrophages. Biomed Sci Instrum 2000;36:21-6.
    • (2000) Biomed Sci Instrum , vol.36 , pp. 21-26
    • Johnson, M.1    Tucci, M.2    Benghuzzi, H.3    Cason, Z.4    Hughes, J.5
  • 11
    • 0032805781 scopus 로고    scopus 로고
    • Phytate (IP6) is a powerful agent for preventing calcifications in biological fluids: Usefulness in renal lithiasis treatment
    • Grases F, Costa-Bauzá A. Phytate (IP6) is a powerful agent for preventing calcifications in biological fluids: usefulness in renal lithiasis treatment. Anticancer Res 1999;19:3717-22.
    • (1999) Anticancer Res , vol.19 , pp. 3717-3722
    • Grases, F.1    Costa-Bauzá, A.2
  • 12
    • 33750846875 scopus 로고    scopus 로고
    • Protection against cancer by dietary IP6 and inositol
    • Vucenik I, Shamsuddin AM. Protection against cancer by dietary IP6 and inositol. Nutr Cancer 2006;55:109-25.
    • (2006) Nutr Cancer , vol.55 , pp. 109-125
    • Vucenik, I.1    Shamsuddin, A.M.2
  • 13
    • 33748583748 scopus 로고    scopus 로고
    • Effects of inositol hexaphosphate on proliferation of HT-29 human colon carcinoma cell line
    • Tian Y, Song Y. Effects of inositol hexaphosphate on proliferation of HT-29 human colon carcinoma cell line. World J Gastroenterol 2006;12:4137-42.
    • (2006) World J Gastroenterol , vol.12 , pp. 4137-4142
    • Tian, Y.1    Song, Y.2
  • 15
    • 45849124466 scopus 로고    scopus 로고
    • Purified and endogenous phytic acid in wheat bran affects early biomarkers of colon cancer risk
    • Jenab M, Thompson LU. Purified and endogenous phytic acid in wheat bran affects early biomarkers of colon cancer risk. IARC Sci Publ 2002;156:387-9.
    • (2002) IARC Sci Publ , vol.156 , pp. 387-389
    • Jenab, M.1    Thompson, L.U.2
  • 16
    • 0032217237 scopus 로고    scopus 로고
    • IP6 in treatment of liver cancer. II. Intra-tumoral injection of IP6 regresses pre-existing human liver cancer xenotransplanted in nude mice
    • Vucenik I, Zhang ZS, Shamsuddin AM. IP6 in treatment of liver cancer. II. Intra-tumoral injection of IP6 regresses pre-existing human liver cancer xenotransplanted in nude mice. Anticancer Res 1998;18:4091-6.
    • (1998) Anticancer Res , vol.18 , pp. 4091-4096
    • Vucenik, I.1    Zhang, Z.S.2    Shamsuddin, A.M.3
  • 17
    • 22944459874 scopus 로고    scopus 로고
    • Prostate cancer and inositol hexaphosphate: Efficacy and mechanisms
    • Singh RP, Agarwal R. Prostate cancer and inositol hexaphosphate: efficacy and mechanisms. Anticancer Res 2005;25:2891-903.
    • (2005) Anticancer Res , vol.25 , pp. 2891-2903
    • Singh, R.P.1    Agarwal, R.2
  • 18
    • 0034746736 scopus 로고    scopus 로고
    • G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6)
    • El-Sherbiny YM, Cox MC, Ismail ZA, Shamsuddin AM, Vucenik I. G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6). Anticancer Res 2001;21:2393-403.
    • (2001) Anticancer Res , vol.21 , pp. 2393-2403
    • El-Sherbiny, Y.M.1    Cox, M.C.2    Ismail, Z.A.3    Shamsuddin, A.M.4    Vucenik, I.5
  • 19
    • 0038575866 scopus 로고    scopus 로고
    • Inositol hexaphosphate (IP6) enhances the antiproliferative effects of adriamycin and tamoxifen in breast cancer
    • Tantivejkul K, Vucenik I, Eiseman J, Shamsuddin AM. Inositol hexaphosphate (IP6) enhances the antiproliferative effects of adriamycin and tamoxifen in breast cancer. Breast Cancer Res Treat 2003;79:301-12.
    • (2003) Breast Cancer Res Treat , vol.79 , pp. 301-312
    • Tantivejkul, K.1    Vucenik, I.2    Eiseman, J.3    Shamsuddin, A.M.4
  • 20
    • 0037360095 scopus 로고    scopus 로고
    • Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: Modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes
    • Singh RP, Agarwal C, Agarwal R. Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. Carcinogenesis 2003;24:555-63.
    • (2003) Carcinogenesis , vol.24 , pp. 555-563
    • Singh, R.P.1    Agarwal, C.2    Agarwal, R.3
  • 21
    • 6944232245 scopus 로고    scopus 로고
    • Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells
    • Agarwal C, Dhanalakshmi S, Singh RP, Agarwal R. Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells. Neoplasia 2004;6:646-59.
    • (2004) Neoplasia , vol.6 , pp. 646-659
    • Agarwal, C.1    Dhanalakshmi, S.2    Singh, R.P.3    Agarwal, R.4
  • 22
    • 1642453720 scopus 로고    scopus 로고
    • In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: Induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor
    • Singh RP, Sharma G, Mallikarjuna GU, Dhanalakshmi S, Agarwal C, Agarwal R. In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor. Clin Cancer Res 2004;10:244-50.
    • (2004) Clin Cancer Res , vol.10 , pp. 244-250
    • Singh, R.P.1    Sharma, G.2    Mallikarjuna, G.U.3    Dhanalakshmi, S.4    Agarwal, C.5    Agarwal, R.6
  • 23
    • 49649098564 scopus 로고    scopus 로고
    • Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice
    • Raina K, Rajamanickam S, Singh RP, Agarwal R. Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice. Clin Cancer Res 2008;14:3177-84.
    • (2008) Clin Cancer Res , vol.14 , pp. 3177-3184
    • Raina, K.1    Rajamanickam, S.2    Singh, R.P.3    Agarwal, R.4
  • 24
    • 0036581949 scopus 로고    scopus 로고
    • Phytochemicals as cell cycle modulators-a less toxic approach in halting human cancers
    • Singh RP, Dhanalakshmi S, Agarwal R. Phytochemicals as cell cycle modulators-a less toxic approach in halting human cancers. Cell Cycle 2002;1:156-61.
    • (2002) Cell Cycle , vol.1 , pp. 156-161
    • Singh, R.P.1    Dhanalakshmi, S.2    Agarwal, R.3
  • 25
    • 47249113042 scopus 로고    scopus 로고
    • Downregulation of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype
    • Roy S, Singh RP, Agarwal C, Siriwardana S, Sclafani R, Agarwal R. Downregulation of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype. Cell Cycle 2008;7:1828-35.
    • (2008) Cell Cycle , vol.7 , pp. 1828-1835
    • Roy, S.1    Singh, R.P.2    Agarwal, C.3    Siriwardana, S.4    Sclafani, R.5    Agarwal, R.6
  • 26
    • 33244472101 scopus 로고    scopus 로고
    • Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: A comparison of flavanone silibinin with flavanolignan mixture silymarin
    • Deep G, Singh RP, Agarwal C, Kroll DJ, Agarwal R. Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene 2006;25:1053-69.
    • (2006) Oncogene , vol.25 , pp. 1053-1069
    • Deep, G.1    Singh, R.P.2    Agarwal, C.3    Kroll, D.J.4    Agarwal, R.5
  • 27
    • 0036606413 scopus 로고    scopus 로고
    • Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels
    • Singh RP, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C, Agarwal R. Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels. Cancer Res 2002;62:3063-9.
    • (2002) Cancer Res , vol.62 , pp. 3063-3069
    • Singh, R.P.1    Dhanalakshmi, S.2    Tyagi, A.K.3    Chan, D.C.4    Agarwal, C.5    Agarwal, R.6
  • 28
    • 36949029439 scopus 로고    scopus 로고
    • Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft
    • Singh RP, Deep G, Blouin MJ, Pollak MN, Agarwal R. Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft. Carcinogenesis 2007;28:2567-74.
    • (2007) Carcinogenesis , vol.28 , pp. 2567-2574
    • Singh, R.P.1    Deep, G.2    Blouin, M.J.3    Pollak, M.N.4    Agarwal, R.5
  • 29
    • 33645802169 scopus 로고    scopus 로고
    • Cyclin-dependent kinase pathways as targets for cancer treatment
    • Shapiro GI. Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol 2006;24:1770-83.
    • (2006) J Clin Oncol , vol.24 , pp. 1770-1783
    • Shapiro, G.I.1
  • 30
    • 33749657631 scopus 로고    scopus 로고
    • Targeting cyclins and cyclin-dependent kinases in cancer: Lessons from mice, hopes for therapeutic applications in human
    • Lee YM, Sicinski P. Targeting cyclins and cyclin-dependent kinases in cancer: lessons from mice, hopes for therapeutic applications in human. Cell Cycle 2006;5:2110-4.
    • (2006) Cell Cycle , vol.5 , pp. 2110-2114
    • Lee, Y.M.1    Sicinski, P.2
  • 31
    • 33645285867 scopus 로고    scopus 로고
    • Traffic safety for the cell: Influence of cyclin-dependent kinase activity on genomic stability
    • Enders GH, Maude SL. Traffic safety for the cell: influence of cyclin-dependent kinase activity on genomic stability. Gene 2006;371:1-6.
    • (2006) Gene , vol.371 , pp. 1-6
    • Enders, G.H.1    Maude, S.L.2
  • 32
    • 33644830944 scopus 로고    scopus 로고
    • Targeting the cell cycle: A new approach to cancer therapy
    • Schwartz GK, Shah MA. Targeting the cell cycle: a new approach to cancer therapy. J Clin Oncol 2005;23:9408-21.
    • (2005) J Clin Oncol , vol.23 , pp. 9408-9421
    • Schwartz, G.K.1    Shah, M.A.2
  • 33
    • 0027494237 scopus 로고
    • p53 oncogene mutations in three human prostate cancer cell lines
    • Carroll AG, Voeller HJ, Sugars L, Gelmann EP. p53 oncogene mutations in three human prostate cancer cell lines. Prostate 1993;23:123-34.
    • (1993) Prostate , vol.23 , pp. 123-134
    • Carroll, A.G.1    Voeller, H.J.2    Sugars, L.3    Gelmann, E.P.4
  • 34
    • 0025068887 scopus 로고
    • Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene
    • Bookstein R, Shew JY, Chen PL, Scully P, Lee WH. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science 1990;247:712-5.
    • (1990) Science , vol.247 , pp. 712-715
    • Bookstein, R.1    Shew, J.Y.2    Chen, P.L.3    Scully, P.4    Lee, W.H.5
  • 35
    • 42149088906 scopus 로고    scopus 로고
    • Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone-refractory prostate cancer
    • Uzzo RG, Haas NB, Crispen PL, Kolenko VM. Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone-refractory prostate cancer. Cancer 2008;112:1660-71.
    • (2008) Cancer , vol.112 , pp. 1660-1671
    • Uzzo, R.G.1    Haas, N.B.2    Crispen, P.L.3    Kolenko, V.M.4
  • 36
    • 0031283291 scopus 로고    scopus 로고
    • p27Kip1 overexpression causes apoptotic death of mammalian cells
    • Wang X, Gorospe M, Huang Y, Holbrook NJ. p27Kip1 overexpression causes apoptotic death of mammalian cells. Oncogene 1997;15:2991-7.
    • (1997) Oncogene , vol.15 , pp. 2991-2997
    • Wang, X.1    Gorospe, M.2    Huang, Y.3    Holbrook, N.J.4
  • 37
    • 11244346059 scopus 로고    scopus 로고
    • TNF receptor 1 is involved in the induction of apoptosis by the cyclin dependent kinase inhibitor p27Kip1 in the prostate cancer cell line PC-3
    • Jaruga-Killeen E, Rayford W. TNF receptor 1 is involved in the induction of apoptosis by the cyclin dependent kinase inhibitor p27Kip1 in the prostate cancer cell line PC-3. FASEB J 2005;19:139-41.
    • (2005) FASEB J , vol.19 , pp. 139-141
    • Jaruga-Killeen, E.1    Rayford, W.2
  • 38
    • 12844262761 scopus 로고    scopus 로고
    • A novel apoptosis pathway activated by the carboxyl terminus of p21
    • Dong C, Li Q, Lyu SC, Krensky AM, Clayberger C. A novel apoptosis pathway activated by the carboxyl terminus of p21. Blood 2005;105:1187-94.
    • (2005) Blood , vol.105 , pp. 1187-1194
    • Dong, C.1    Li, Q.2    Lyu, S.C.3    Krensky, A.M.4    Clayberger, C.5
  • 39
    • 33645808244 scopus 로고    scopus 로고
    • Natural flavonoids targeting deregulated cell cycle progression in cancer cells
    • Singh RP, Agarwal R. Natural flavonoids targeting deregulated cell cycle progression in cancer cells. Curr Drug Targets 2006;7:345-54.
    • (2006) Curr Drug Targets , vol.7 , pp. 345-354
    • Singh, R.P.1    Agarwal, R.2
  • 40
    • 0032980308 scopus 로고    scopus 로고
    • The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer
    • Tsihlias J, Kapusta L, Slingerland J. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Annu Rev Med 1999;50:401-23.
    • (1999) Annu Rev Med , vol.50 , pp. 401-423
    • Tsihlias, J.1    Kapusta, L.2    Slingerland, J.3
  • 41
    • 41149150219 scopus 로고    scopus 로고
    • The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy
    • Chu IM, Hengst L, Slingerland JM. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 2008;8:253-67.
    • (2008) Nat Rev Cancer , vol.8 , pp. 253-267
    • Chu, I.M.1    Hengst, L.2    Slingerland, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.