Folic acid inhibits endothelial cell migration through inhibiting the RhoA activity mediated by activating the folic acid receptor/cSrc/p190RhoGAP- signaling pathway

Biochemical Pharmacology

Volumn 85, Issue 3, 2013, Pages 376-384

  Hou, Tien Chi ^a   Lin, Jheng Jhe ^b   Wen, Heng Ching ^b   Chen, Li Ching ^b   Hsu, Sung Po ^a,b   Lee, Wen Sen ^a,b,c  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Angiogenesis; Cell migration; cSrc; p190RhoGAP; RhoA

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; FOLATE RECEPTOR; FOLIC ACID; PROTEIN KINASE P60; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA;

ANGIOGENESIS; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DRUG MECHANISM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIAL CELLS; FOLIC ACID; FOLIC ACID TRANSPORTERS; GENE EXPRESSION REGULATION; GENES, SRC; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; PSEUDOPODIA; REPRESSOR PROTEINS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84872683508     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.11.011     Document Type: Article

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