Induction of apoptosis in human tumour xenografts after oral administration of uracil and tegafur to nude mice bearing tumours

British Journal of Cancer

Volumn 78, Issue 5, 1998, Pages 625-630

  Oki, E ^a   Sakaguchi, Y ^b   Toh, Y ^a   Oda, S ^a   Maehara, Y ^a   Yamamoto, N ^c   Sugimachi, K ^b  

^a KYUSHU UNIVERSITY HOSPITAL   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Apoptosis; Gastrointestinal cancers; Growth inhibition; UFT

Indexed keywords

TEGAFUR; URACIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; COLON ADENOCARCINOMA; CONTROLLED STUDY; GASTROINTESTINAL TUMOR; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PANCREAS CARCINOMA; PRIORITY JOURNAL; STOMACH CARCINOMA; TUMOR XENOGRAFT;

EID: 0031903520     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.552     Document Type: Article

References (30)

1. Barry MA, Behnke CA and Eastman A (1990) Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem Pharmacol 40: 2353-2362
2. Blokhina NG, Vozny EK and Garin AM (1972) Results of treatment of malignant tumours with ftorafur. Cancer 30: 390-392
3. Dive C and Hickman JA (1991) Drug-target interactions: only the first step in the commitment to a programmed cell death? Br J Cancer 64: 192-196
4. Dyson JE, Simmons DM, Daniel J, McLaughlin JM, Quirke P and Bird CC (1986) Kinetic and physical studies of cell death induced by chemotherapeutic agents or hyperthermia. Cell Tissue Kinetics 19: 311-324
5. Fisher DE (1994) Apoptosis in cancer therapy: crossing the threshold. Cell 78: 539-542
6. Fisher TC, Milner AE, Gregory CD, Jackman AL, Aherne GW, Hartley JA, Dive C and Hickman JA (1993) bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways. Cancer Res 53: 3321-3326
7. Fujii S, Ikenaka K, Fukushima M and Shirasaka T (1978) Effect of uracil and its derivatives on antitumour activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil. Gann 69: 763-772
8. Fujii S, Kitano S, Ikenaka K and Shirasaka T (1979) Effect of coadministration of uracil or cytosine on the anti-tumour activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents. Gann 70: 209-214
9. Gavrieli Y, Sherman Y and Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493-501
10. Ikenaka T, Shirasaka T, Kitano S and Fujii S (1979) Effect of uracil on metabolism of 5-fluorouracil in vitro. Jpn J Cancer Res (Gan) 70: 353-359
11. Kerr JF and Searle J (1972) A suggested explanation for the paradoxically slow growth rate of basal-cell carcinomas that contain numerous mitotic figures. J Pathol 107: 41-44
12. Kerr JF, Wyllie AH and Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257
13. Kondo S, Barna BP, Kondo Y, Tanaka Y, Casey G, Liu J, Morimura T, Kaakaji R, Peterson JW, Werbel B and Barnett GH (1996) WAF1/CIP1 increases the susceptibility of p53 non-functional malignant glioma cells to cisplatin-induced apoptosis. Oncogene 13: 1279-1285
14. Lichter AS and Lawrence TS (1995) Recent advances in radiation oncology. New Engl J Med 332: 371-379
15. Lowe SW, Ruley HE, Jacks T and Housman DE (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967
16. Maehara Y, Kusumoto T, Kusumoto H, Anai H and Sugimachi K (1988) UFT is more antineoplastic against gastric carcinoma than 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil and 1-hexylcarbamoyl-5-fluorouracil. Chemotherapy 34: 484-489
17. Maehara Y, Sugimachi K, Akagi M, Kakegawa T, Shimazu H and Tomita M (1992) Early postoperative chemotherapy following noncurative resection for patients with advanced gastric cancer. Br J Cancer 65:413-416
18. Maehara Y, Takeuchi H, Oshiro T, Takahashi I, Inutsuka S, Baba H, Kohnoe S and Sugimachi K (1994) Effect of gastrectomy on the pharmacokinetics of tegafur, uracil, and 5-fluorouracil after oral administration of a 1:4 tegafur and uracil combination. Cancer Chemother Pharm 33: 445-449
19. Meyn RE, Stephens LC, Hunter NR and Milas L (1994) Induction of apoptosis in murine tumours by cyclophosphamide. Cancer Chemother Pharm 33: 410-414
20. Meyn RE, Stephens LC, Hunter NR and Milas L (1995a) Apoptosis in murine tumours treated with chemotherapy agents. Anti-Cancer Drugs 6: 443-450
21. Meyn RE, Stephens LC, Hunter NR and Milas L (1995b) Kinetics of cisplatin-induced apoptosis in murine mammary and ovarian adenocarcinomas. Int J Cancer 60: 725-729
22. Muggia FM, Wu X, Spicer D, Groshen S, Jeffers S, Leichman CG, Leichman L and Chan KK (1996) Phase 1 and pharmacokinetic study of oral UFT, a combinatin of the 5-fluorouracil prodrug tegafur and uracil. Clin Cancer Res 2: 1461-1467
23. Ota K, Taguchi T and Kimura K (1988) Report on nationwide pooled data and cohort investigation in UFT phase II study. Cancer Chemother Pharm 22: 333-338
24. Pazdur R, Lassere Y, Rhodes V, Ajani JA, Sugarman SM, Patt YZ, Jones Jr. DV, Markowitz AB, Abbruzzese JL, Bready B and Levin B (1994) Phase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma. J Clin Oncol 12: 2296-2300
25. Sakaguchi Y, Stephens LC, Makino M, Kaneko T, Strebel FR, Danhauser LL, Jenkins GN and Bull JM (1994) Apoptosis in normal tissues induced by 5-fluorouracil: comparison between bolus injection and prolonged infusion. Anticancer Res 14: 1489-1492
26. Schumacher HJ, Wilson JG and Jordan RL (1969) Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. II. Biochemical aspects. Teratology 2: 99-105
27. Strobel T, Swanson L, Korsmeyer S and Cannistra SA (1996) BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Proc Natl Acad Sci USA 93: 14094-14099
28. Toide H, Akiyoshi H, Minato Y, Okuda H and Fujii S (1977) Comparative studies on the metabolism of 2-(tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil. Gann 68: 553-560
29. Vasey PA, Jones NA, Jenkins S, Dive C and Brown R (1996) Cisplatin, camptothecin, and taxol sensitivities of cells with p53-associated multidrug resistance. Mol Pharmacol 50: 1536-1540
30. Wyllie AH (1992) Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview. Cancer Metastasis Rev 11: 95-103