Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-jB/p53 pathway mediated by folic acid receptor

Angiogenesis

Volumn 15, Issue 4, 2012, Pages 671-683

  Lin, Shyr Yi ^a,b   Lee, Woan Ruoh ^a,b   Su, Yi Fan ^b   Hsu, Sung Po ^b   Lin, Hsu Chen ^d   Ho, Pei Yin ^c   Hou, Tien Chi ^b   Chou, Yu Pei ^b   Kuo, Chun Ting ^b   Lee, Wen Sen ^a,b  

^a TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Angiogenesis; Cell proliferation; Endothelium; Folic acid receptor; Signaling pathway

Indexed keywords

DNA; FOLATE RECEPTOR; FOLIC ACID; HEMOGLOBIN; MATRIGEL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE P60; PROTEIN P21; PROTEIN P27; PROTEIN P53; TRANSCRIPTION FACTOR RELA; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL COUNT; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL NUCLEUS; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; INHIBITION KINETICS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WESTERN BLOTTING;

MUS;

EID: 84875052438     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-012-9289-6     Document Type: Article

References (29)

1. Kim YI (2007) Folate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res 51:267-292.
2. Camilo E, Zimmerman J, Mason JB, Golner B, Russell R, Selhub J, Rosenberg IH (1996) Folate synthesized by bacteria in the human upper small intestine is assimilated by the host. Gastroenterology 110:991-998. (Pubitemid 26113736)
3. Kim YI (2004) Will mandatory folic acid fortification prevent or promote cancer? Am J Clin Nutr 80:1123-1128.
4. Choi SW, Mason JB (2002) Folate status: effects on pathways of colorectal carcinogenesis. J Nutr 132(8 suppl):2413S-2418S. (Pubitemid 34848118)
5. Kim YI (1999) Folate and carcinogenesis: evidence, mechanisms, and implications. J Nutr Biochem 10:66-88.
6. Yu CH, Wu J, Su YF, Ho PY, Liang YC, Sheu MT, Lee WS (2004) Anti-proliferation effect of 3-amino-2-imino-3, 4-dihydro- 2H-1, 3-benzothiazin-4-one (BJ-601) in human vascular endothelial cells: G0/G1 p21-associated cell cycle arrest. Biochem Pharmacol 67:1907-1910.
7. Folkman J (1995) Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N Engl J Med 333:1757-1763.
8. Lee WS, Harder JA, Yoshizumi M, Lee ME, Haber E (1997) Progesterone inhibits arterial smooth muscle cell proliferation. Nat Med 3:1005-1008. (Pubitemid 27391955)
9. Hsu SP, Chen TH, Chou YP, Chen LC, Kuo CT, Lee TS, Lin JJ, Chang NC, Lee WS (2011) Extra-nuclear activation of progesterone receptor in regulating arterial smooth muscle cell migration. Atherosclerosis 217:83-89.
10. Hsu SP, Ho PY, Juan SH, Liang YC, Lee WS (2008) Progesterone inhibits human endothelial cell proliferation through a p53-dependent pathway. Cell Mol Life Sci 65(23):3839-3850.
11. Ho PY, Liang YC, Ho YS, Chen CT, Lee WS (2004) Inhibition of human vascular endothelial cells proliferation by terbinafine. Int J Cancer 111:51-59.
12. Hsu SP, Lee W (2011) Progesterone receptor activation of extranuclear signaling pathways in regulating p53 expression in vascular endothelial cells. Mol Endocrinol 25:421-432.
13. Ho PY, Hsu SP, Liang YC, Kuo ML, Ho YS, Lee WS (2008) Inhibition of the ERK phosphorylation plays a role in terbinafineinduced p21 upregulation and DNA synthesis inhibition in human vascular endothelial cells. Toxicol Appl Pharma 229:86-93.
14. Shupnik MA (2004) Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: implications for cell proliferation. Oncogene 23:7979-7989. (Pubitemid 39480682)
15. Mitra G, Weber M, Stacey D (1993) Multiple pathways for activation of MAP kinases. Cell Mol Biol Res 39:517-523. (Pubitemid 24062081)
16. Troppmair J, Bruder JT, Munoz H, Lloyd PA, Kyriakis J, Banerjee P, Avruch J, Rapp UR (1994) Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. J Biol Chem 269:7030-7035.
17. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816. (Pubitemid 23346377)
18. Toyoshima H, Hunter T (1994) p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78:67-74. (Pubitemid 24228301)
19. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D (1993) p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704. (Pubitemid 24036020)
20. Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell E (1995) Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell 6:387-400.
21. Chen J, Jackson PK, Kirschner MW, Dutta A (1995) Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374:386-388.
22. Lin J, Reichner C, Wu X, Levine AJ (1996) Analysis of wild-type and mutant p21WAF-1 gene activities. Mol Cell Biol 16:1786-1793.
23. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825. (Pubitemid 23346378)
24. el-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, Wiman KG, Mercer WE, Kastan MB, Kurt WK, Elledge SJ, Kinzler KW, Vogelstein B (1994) WAF1/CIP1 is induced in p53- mediated G1 arrest and apoptosis. Cancer Res 54:1169-1174. (Pubitemid 24108052)
25. He G, Siddik ZH, Huang Z, Wang R, Koomen J, Kobavashi R, Khokhar AR, Kuang J (2005) Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene 24:2929-2943. (Pubitemid 40675524)
26. Igata M, Motoshima H, Tsuruzoe K, Kojima K, Matsumura T, Kondo T, Taquchi T, Nakamaru K, Yano M, Kukidome D, Matsumoto K, Tovonaqa T, Asano T, Nishikawa T, Araki E (2005) Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression. Circ Res 97:837-844. (Pubitemid 41447135)
27. Barber RC, Lammer EJ, Shaw GM, Greer KA, Finnell R (1999) The role of folate transport and metabolism in neural tube defect risk. Mol Genet Metab 66:1-9. (Pubitemid 29389923)
28. Kamen BA, Wang MT, Streckfuss AJ, Peryea X, Anderson RG (1988) Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles. J Biol Chem 263:13602-13609.
29. Page ST, Owen WC, Price K, Elwood PC (1993) Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene. J Mol Biol 229:1175-1183. (Pubitemid 23091832)