Discovery of oxysterol-derived pharmacological chaperones for NPC1: Implication for the existence of second sterol-binding site

Chemistry and Biology

Volumn 20, Issue 3, 2013, Pages 391-402

  Ohgane, Kenji ^a   Karaki, Fumika ^a   Dodo, Kosuke ^b   Hashimoto, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; MUTANT PROTEIN; NIEMANN PICK TYPE C1 PROTEIN; OXYSTEROL; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CRYSTAL STRUCTURE; DOSE RESPONSE; ENDOSOME; FIBROBLAST; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LYSOSOME; MOLECULAR WEIGHT; NIEMANN PICK DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CARRIER PROTEINS; DRUG DISCOVERY; FIBROBLASTS; HEK293 CELLS; HUMANS; HYDROXYCHOLESTEROLS; INTRACELLULAR SPACE; MEMBRANE GLYCOPROTEINS; MUTATION; NIEMANN-PICK DISEASE, TYPE C; OXIDATION-REDUCTION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875448226     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2013.02.009     Document Type: Article

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