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Volumn 19, Issue 4, 2013, Pages 443-460

Reflections on the history of pre-mRNA processing and highlights of current knowledge: A unified picture

Author keywords

Pre mRNA processing

Indexed keywords

CALCITONIN; CALCITONIN GENE RELATED PEPTIDE; HETEROGENEOUS NUCLEAR RNA; MESSENGER RNA; MESSENGER RNA PRECURSOR;

EID: 84875429298     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.038596.113     Document Type: Review
Times cited : (83)

References (171)
  • 1
    • 0022132080 scopus 로고
    • Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases
    • Allison LA, Movie M, Shales M, Ingles CJ. 1985. Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases. Cell 42: 599-610.
    • (1985) Cell , vol.42 , pp. 599-610
    • Allison, L.A.1    Movie, M.2    Shales, M.3    Ingles, C.J.4
  • 2
    • 0018848546 scopus 로고
    • Synthesis of secreted and membrane-bound immunoglobulin μ heavy chains is directed by mRNAs that differ at their 3′ ends
    • Alt FW, Bothwell AL, Knapp M, Siden E, Mather E, Koshland M, Baltimore D. 1980. Synthesis of secreted and membrane-bound immunoglobulin μ heavy chains is directed by mRNAs that differ at their 3′ ends. Cell 20: 293-301.
    • (1980) Cell , vol.20 , pp. 293-301
    • Alt, F.W.1    Bothwell, A.L.2    Knapp, M.3    Siden, E.4    Mather, E.5    Koshland, M.6    Baltimore, D.7
  • 3
    • 0021715282 scopus 로고
    • Calcitonin/calcitonin gene related peptide transcription: Tissue-specific expression involves selective use of alternative polyadenylation site
    • Amara S, Evans RM, Rosenfeld MG. 1984. Calcitonin/calcitonin gene related peptide transcription: Tissue-specific expression involves selective use of alternative polyadenylation site. Mol Cell Biol 4: 2151-2160.
    • (1984) Mol Cell Biol , vol.4 , pp. 2151-2160
    • Amara, S.1    Evans, R.M.2    Rosenfeld, M.G.3
  • 4
    • 20744451863 scopus 로고    scopus 로고
    • A subset of nuclear receptor coregulators act as coupling proteins during synthesis and maturation of RNA transcripts
    • Auboeuf D, Dowhan DH, Dutertre M, Martin N, Berget SM, O'Malley BW. 2005. A subset of nuclear receptor coregulators act as coupling proteins during synthesis and maturation of RNA transcripts. Mol Cell Biol 25: 5307-5316.
    • (2005) Mol Cell Biol , vol.25 , pp. 5307-5316
    • Auboeuf, D.1    Dowhan, D.H.2    Dutertre, M.3    Martin, N.4    Berget, S.M.5    O'Malley, B.W.6
  • 5
    • 0036784630 scopus 로고    scopus 로고
    • In vivo kinetics of mRNA splicing and transport in mammalian cells
    • Audibert A, Weil D, Dautry F. 2002. In vivo kinetics of mRNA splicing and transport in mammalian cells. Mol Cell Biol 22: 6706-6718.
    • (2002) Mol Cell Biol , vol.22 , pp. 6706-6718
    • Audibert, A.1    Weil, D.2    Dautry, F.3
  • 6
    • 0019312704 scopus 로고
    • Early capping of transcripts from the adenovirus major late transcription unit
    • Babich A, Nevins JR, Darnell JE Jr. 1980. Early capping of transcripts from the adenovirus major late transcription unit. Nature 287: 246-248.
    • (1980) Nature , vol.287 , pp. 246-248
    • Babich, A.1    Nevins, J.R.2    Darnell Jr., J.E.3
  • 7
    • 0016685836 scopus 로고
    • Adenovirus 2 mRNA is transcribed as part of a high molecular weight precursor RNA
    • Bachenheimer S, Darnell JE. 1975. Adenovirus 2 mRNA is transcribed as part of a high molecular weight precursor RNA. Proc Natl Acad Sci 72: 4445-4449.
    • (1975) Proc Natl Acad Sci , vol.72 , pp. 4445-4449
    • Bachenheimer, S.1    Darnell, J.E.2
  • 8
    • 0023988471 scopus 로고
    • A molecular analysis of doublesex, a bifunctional gene that controls both male and female sexual differentiation in Drosophila melanogaster
    • Baker BS, Wolfner MF. 1988. A molecular analysis of doublesex, a bifunctional gene that controls both male and female sexual differentiation in Drosophila melanogaster. Genes Dev 2: 477-489.
    • (1988) Genes Dev , vol.2 , pp. 477-489
    • Baker, B.S.1    Wolfner, M.F.2
  • 9
    • 0024909231 scopus 로고
    • Molecular and genetic aspects of sex determination in Drosophila melanogaster
    • Baker BS, Burtis K, Goralski T, Mattox W, Nagushi R. 1989. Molecular and genetic aspects of sex determination in Drosophila melanogaster. Genome 31: 638-645.
    • (1989) Genome , vol.31 , pp. 638-645
    • Baker, B.S.1    Burtis, K.2    Goralski, T.3    Mattox, W.4    Nagushi, R.5
  • 10
    • 0036591882 scopus 로고    scopus 로고
    • The mRNA assembly line: Transcription and processing machines in the same factory
    • Bentley DL. 2002. The mRNA assembly line: Transcription and processing machines in the same factory. Curr Opin Cell Biol 14: 336-342.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 336-342
    • Bentley, D.L.1
  • 11
    • 19344378943 scopus 로고    scopus 로고
    • Rules of engagement: Co-transcriptional recruitment of pre-mRNA processing factors
    • Bentley DL. 2005. Rules of engagement: Co-transcriptional recruitment of pre-mRNA processing factors. Curr Opin Cell Biol 17: 251-256.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 251-256
    • Bentley, D.L.1
  • 13
    • 0018367819 scopus 로고
    • Structure of late adenovirus 2 heterogeneous nuclear RNA
    • Berget SM, Sharp PA. 1978. Structure of late adenovirus 2 heterogeneous nuclear RNA. J Mol Biol 129: 547-565.
    • (1978) J Mol Biol , vol.129 , pp. 547-565
    • Berget, S.M.1    Sharp, P.A.2
  • 14
    • 0017680534 scopus 로고
    • Spliced segments at the 5′ terminus of adenovirus-2 late mRNA: A role for heterogeneous nuclear RNA in mammalian cells
    • Spring Harb Symp Quant Biol
    • Berget SM, Berk AJ, Harrison T, Sharp PA. 1977a. Spliced segments at the 5′ terminus of adenovirus-2 late mRNA: A role for heterogeneous nuclear RNA in mammalian cells. Cold Spring Harb Symp Quant Biol 42: 523-530.
    • (1977) Cold , vol.42 , pp. 523-530
    • Berget, S.M.1    Berk, A.J.2    Harrison, T.3    Sharp, P.A.4
  • 15
    • 0344622123 scopus 로고
    • Spliced segments at the 5′ terminus of adenovirus 2 late mRNA
    • Berget SM, Moore C, Sharp PA. 1977b. Spliced segments at the 5′ terminus of adenovirus 2 late mRNA. Proc Natl Acad Sci 74: 3171-3175.
    • (1977) Proc Natl Acad Sci , vol.74 , pp. 3171-3175
    • Berget, S.M.1    Moore, C.2    Sharp, P.A.3
  • 16
    • 0024021747 scopus 로고
    • Splice site selection, rate of splicing and alternative splicing on nascent transcripts
    • Beyer AL, Osheim YN. 1988. Splice site selection, rate of splicing and alternative splicing on nascent transcripts. Genes Dev 2: 754-765.
    • (1988) Genes Dev , vol.2 , pp. 754-765
    • Beyer, A.L.1    Osheim, Y.N.2
  • 17
    • 0019851631 scopus 로고
    • Correlation of hnRNP structure and nascent transcript cleavage
    • Beyer AL, Bouton AH, Miller OL Jr. 1981. Correlation of hnRNP structure and nascent transcript cleavage. Cell 26: 155-165.
    • (1981) Cell , vol.26 , pp. 155-165
    • Beyer, A.L.1    Bouton, A.H.2    Miller Jr., O.L.3
  • 19
    • 4744373424 scopus 로고    scopus 로고
    • RNA polymerase II carboxy-terminal domain phosphorylation is required for cotranscriptional premRNA splicing and 3′-end formation
    • Bird G, Zorio DA, Bentley DL. 2004. RNA polymerase II carboxy-terminal domain phosphorylation is required for cotranscriptional premRNA splicing and 3′-end formation. Mol Cell Biol 24: 8963-8969.
    • (2004) Mol Cell Biol , vol.24 , pp. 8963-8969
    • Bird, G.1    Zorio, D.A.2    Bentley, D.L.3
  • 20
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms in alternative pre-messenger RNA splicing
    • Black DL. 2003. Mechanisms in alternative pre-messenger RNA splicing. Annu Rev Biochem 72: 291-336.
    • (2003) Annu Rev Biochem , vol.72 , pp. 291-336
    • Black, D.L.1
  • 21
    • 0002578977 scopus 로고
    • La détection histochimique et le microdosage des acides pentosenucléiques (tissus animaux - développement embryonnaire des amphibiens)
    • Brachet J. 1941. La détection histochimique et le microdosage des acides pentosenucléiques (tissus animaux - développement embryonnaire des amphibiens). Enzymologia 10: 87-96.
    • (1941) Enzymologia , vol.10 , pp. 87-96
    • Brachet, J.1
  • 22
    • 84912413711 scopus 로고
    • The biological role of the pentose nucleic acids
    • (ed. E Chargaff, JN Davidson), Academic Press, New York
    • Brachet J. 1955. The biological role of the pentose nucleic acids. In The nucleic acids (ed. E Chargaff, JN Davidson), Vol. 2, pp. 475-519. Academic Press, New York.
    • (1955) The Nucleic Acids , vol.2 , pp. 475-519
    • Brachet, J.1
  • 23
    • 36949088975 scopus 로고
    • An unstable intermediate carrying information from genes to ribosomes for protein synthesis
    • Brenner S, Jacob F, Meselson M. 1961. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature 190: 576-581.
    • (1961) Nature , vol.190 , pp. 576-581
    • Brenner, S.1    Jacob, F.2    Meselson, M.3
  • 24
    • 0021799778 scopus 로고
    • The "spliceosome": Yeast pre-messenger RNA associated with a 40S complex in a splicing-dependent reaction
    • Brody E, Abelson J. 1985. The "spliceosome": Yeast pre-messenger RNA associated with a 40S complex in a splicing-dependent reaction. Science 228: 963-967.
    • (1985) Science , vol.228 , pp. 963-967
    • Brody, E.1    Abelson, J.2
  • 27
    • 70449641057 scopus 로고    scopus 로고
    • Progression through the RNA polymerase II CTD cycle
    • Buratowski S. 2009. Progression through the RNA polymerase II CTD cycle. Mol Cell 36: 541-546.
    • (2009) Mol Cell , vol.36 , pp. 541-546
    • Buratowski, S.1
  • 28
    • 84858193914 scopus 로고    scopus 로고
    • Gene expression: Transcription initiation unwrapped
    • Buratowski S. 2012. Gene expression: Transcription initiation unwrapped. Nature 483: 286-287.
    • (2012) Nature , vol.483 , pp. 286-287
    • Buratowski, S.1
  • 29
    • 0024539898 scopus 로고
    • Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides
    • Burtis KC, Baker BS. 1989. Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. Cell 56: 997-1010.
    • (1989) Cell , vol.56 , pp. 997-1010
    • Burtis, K.C.1    Baker, B.S.2
  • 30
    • 0020956508 scopus 로고
    • RNA splicing: Three themes with variations
    • Cech TR. 1983. RNA splicing: Three themes with variations. Cell 34: 713-716.
    • (1983) Cell , vol.34 , pp. 713-716
    • Cech, T.R.1
  • 31
    • 60149101421 scopus 로고    scopus 로고
    • Crawling out of the RNA world
    • Cech TR. 2009. Crawling out of the RNA world. Cell 136: 599-603.
    • (2009) Cell , vol.136 , pp. 599-603
    • Cech, T.R.1
  • 32
    • 70350569286 scopus 로고    scopus 로고
    • Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches
    • Chen M, Manley JL. 2009. Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches. Nat Rev Mol Cell Biol 10: 741-754.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 741-754
    • Chen, M.1    Manley, J.L.2
  • 33
    • 0018116823 scopus 로고
    • The spliced structures of adenovirus 2 fiber message and other late mRNAs
    • Chow LT, Broker TR. 1978. The spliced structures of adenovirus 2 fiber message and other late mRNAs. Cell 15: 497-510.
    • (1978) Cell , vol.15 , pp. 497-510
    • Chow, L.T.1    Broker, T.R.2
  • 34
    • 0017688583 scopus 로고
    • An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA
    • Chow LT, Gelinas RE, Broker TR, Roberts RJ. 1977a. An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA. Cell 12: 1-8.
    • (1977) Cell , vol.12 , pp. 1-8
    • Chow, L.T.1    Gelinas, R.E.2    Broker, T.R.3    Roberts, R.J.4
  • 35
    • 0017667268 scopus 로고
    • A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids
    • Chow LT, Roberts JM, Lewis JB, Broker TR. 1977b. A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids. Cell 11: 819-836.
    • (1977) Cell , vol.11 , pp. 819-836
    • Chow, L.T.1    Roberts, J.M.2    Lewis, J.B.3    Broker, T.R.4
  • 36
    • 0009370184 scopus 로고
    • A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II
    • Corden JL, Cadena DL, Ahearn JM Jr, Dahmus ME. 1985. A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II. Proc Natl Acad Sci 82: 7934-7938.
    • (1985) Proc Natl Acad Sci , vol.82 , pp. 7934-7938
    • Corden, J.L.1    Cadena, D.L.2    Ahearn Jr., J.M.3    Dahmus, M.E.4
  • 37
    • 41349094797 scopus 로고    scopus 로고
    • Transcription regulation through promoter-proximal pausing of RNA polymerase II
    • Core LJ, Lis JT. 2008. Transcription regulation through promoter-proximal pausing of RNA polymerase II. Science 319: 1791-1792.
    • (2008) Science , vol.319 , pp. 1791-1792
    • Core, L.J.1    Lis, J.T.2
  • 38
    • 57849109058 scopus 로고    scopus 로고
    • Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters
    • Core LJ, Waterfall JJ, Lis JT. 2008. Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science 322: 1845-1848.
    • (2008) Science , vol.322 , pp. 1845-1848
    • Core, L.J.1    Waterfall, J.J.2    Lis, J.T.3
  • 39
    • 0022345860 scopus 로고
    • A mutation in the largest subunit of RNA polymease II alters RNA chain elongation in vitro
    • Coulter DE, Greenleaf SL. 1985. A mutation in the largest subunit of RNA polymease II alters RNA chain elongation in vitro. J Biol Chem 260: 13190-13198.
    • (1985) J Biol Chem , vol.260 , pp. 13190-13198
    • Coulter, D.E.1    Greenleaf, S.L.2
  • 41
    • 0015244734 scopus 로고
    • Polyadenylic acid sequences: Role in conversion of nuclear RNA into messenger RNA
    • Darnell JE, Philipson L, Wall R, Adesnik M. 1971a. Polyadenylic acid sequences: Role in conversion of nuclear RNA into messenger RNA. Science 174: 507-510.
    • (1971) Science , vol.174 , pp. 507-510
    • Darnell, J.E.1    Philipson, L.2    Wall, R.3    Adesnik, M.4
  • 42
    • 0015070067 scopus 로고
    • An adenylic acid-rich sequence in messenger RNA and its possible relationship to reiterated sites in DNA
    • Darnell JE, Wall R, Tushinski RJ. 1971b. An adenylic acid-rich sequence in messenger RNA and its possible relationship to reiterated sites in DNA. Proc Natl Acad Sci 68: 1321-1325.
    • (1971) Proc Natl Acad Sci , vol.68 , pp. 1321-1325
    • Darnell, J.E.1    Wall, R.2    Tushinski, R.J.3
  • 44
    • 34250363024 scopus 로고    scopus 로고
    • SR proteins function in coupling RNAP II transcription to pre-mRNA splicing
    • Das R, Yu J, Zhang Z, Gygi MP, Krainer AR, Gygi SP, Reed R. 2007. SR proteins function in coupling RNAP II transcription to pre-mRNA splicing. Mol Cell 26: 867-881.
    • (2007) Mol Cell , vol.26 , pp. 867-881
    • Das, R.1    Yu, J.2    Zhang, Z.3    Gygi, M.P.4    Krainer, A.R.5    Gygi, S.P.6    Reed, R.7
  • 45
    • 85016842595 scopus 로고
    • The molecular conservation of ribonuleic acid during bacterial growth
    • Davern CI, Meselson M. 1960. The molecular conservation of ribonuleic acid during bacterial growth. J Mol Biol 2: 153-160.
    • (1960) J Mol Biol , vol.2 , pp. 153-160
    • Davern, C.I.1    Meselson, M.2
  • 48
    • 0016318515 scopus 로고
    • Relationship of chain transcription to poly(A) addition and processing of hnRNA in HeLa cells
    • Derman E, Darnell JE. 1974. Relationship of chain transcription to poly(A) addition and processing of hnRNA in HeLa cells. Cell 3: 255-264.
    • (1974) Cell , vol.3 , pp. 255-264
    • Derman, E.1    Darnell, J.E.2
  • 49
    • 0017031323 scopus 로고
    • HnRNA in HeLa cells: Distribution of transcript sizes estimated from nascent molecule profile
    • Derman E, Goldberg S, Darnell JEJ. 1976. hnRNA in HeLa cells: Distribution of transcript sizes estimated from nascent molecule profile. Cell 9: 465-472.
    • (1976) Cell , vol.9 , pp. 465-472
    • Derman, E.1    Goldberg, S.2    Darnell, J.E.J.3
  • 50
    • 80052979140 scopus 로고    scopus 로고
    • Mechanisms and consequences of alternative polyadenylation
    • Di Giammartino DC, Nishida K, Manley JL. 2011. Mechanisms and consequences of alternative polyadenylation. Mol Cell 43: 853-866.
    • (2011) Mol Cell , vol.43 , pp. 853-866
    • Di Giammartino, D.C.1    Nishida, K.2    Manley, J.L.3
  • 51
    • 0018896724 scopus 로고
    • Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways
    • Early P, Rogers J, Davis M, Calame K, Bond M, Wall R, Hood L. 1980. Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways. Cell 20: 313-319.
    • (1980) Cell , vol.20 , pp. 313-319
    • Early, P.1    Rogers, J.2    Davis, M.3    Calame, K.4    Bond, M.5    Wall, R.6    Hood, L.7
  • 52
    • 0001317168 scopus 로고
    • Polynucleotide biosynthesis: Formation of a sequence of adenylate units from adenosine triphosphate by an enzyme from thymus nuclei
    • Edmonds M, Abrams R. 1960. Polynucleotide biosynthesis: Formation of a sequence of adenylate units from adenosine triphosphate by an enzyme from thymus nuclei. J Biol Chem 235: 1142-1149.
    • (1960) J Biol Chem , vol.235 , pp. 1142-1149
    • Edmonds, M.1    Abrams, R.2
  • 53
    • 0015071130 scopus 로고
    • Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly-labeled polyribosomal RNA of HeLa cells: Possible evidence for a precursor relationship
    • Edmonds M, Vaughan MR, Nakazato H. 1971. Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly-labeled polyribosomal RNA of HeLa cells: Possible evidence for a precursor relationship. Proc Natl Acad Sci 68: 1336-1340.
    • (1971) Proc Natl Acad Sci , vol.68 , pp. 1336-1340
    • Edmonds, M.1    Vaughan, M.R.2    Nakazato, H.3
  • 54
    • 0030789131 scopus 로고    scopus 로고
    • Alternative poly(A) site selection in complex transcription units: Means to an end?
    • Edwalds-Gilbert G, Veraldi KL, Milcarek C. 1997. Alternative poly(A) site selection in complex transcription units: Means to an end? Nucleic Acids Res 25: 2547-2561.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2547-2561
    • Edwalds-Gilbert, G.1    Veraldi, K.L.2    Milcarek, C.3
  • 55
    • 0015954151 scopus 로고
    • A tentative initiation inhibitor of chromosomal heterogeneous RNA synthesis
    • Egyhazi E. 1974. A tentative initiation inhibitor of chromosomal heterogeneous RNA synthesis. J Mol Biol 84: 173-183.
    • (1974) J Mol Biol , vol.84 , pp. 173-183
    • Egyhazi, E.1
  • 56
    • 0017851222 scopus 로고
    • DRB-induced termination of late adenovirus transcription
    • Fraser NW, Sehgal PB, Darnell JE. 1978. DRB-induced termination of late adenovirus transcription. Nature 272: 590-593.
    • (1978) Nature , vol.272 , pp. 590-593
    • Fraser, N.W.1    Sehgal, P.B.2    Darnell, J.E.3
  • 57
    • 0018366398 scopus 로고
    • The major late adenovirus type 2 transcription unit: Termination is downstream from the last poly(A) site
    • Fraser NW, Nevins JR, Ziff E, Darnell JE. 1979. The major late adenovirus type 2 transcription unit: Termination is downstream from the last poly(A) site. J Mol Biol 129: 645-656.
    • (1979) J Mol Biol , vol.129 , pp. 645-656
    • Fraser, N.W.1    Nevins, J.R.2    Ziff, E.3    Darnell, J.E.4
  • 58
    • 0029372979 scopus 로고
    • The superfamily of arginine/serine-rich splicing factors
    • Fu XD. 1995. The superfamily of arginine/serine-rich splicing factors. RNA 1: 663-680.
    • (1995) RNA , vol.1 , pp. 663-680
    • Fu, X.D.1
  • 59
    • 0016442397 scopus 로고
    • Reovirus messenger RNA contains a methylated, blocked 5′-terminal structure: M7G(5′)ppp(5′)GmpCp
    • Furuichi Y, Morgan M, Muthukrishnan S, Shatkin AJ. 1975a. Reovirus messenger RNA contains a methylated, blocked 5′-terminal structure: m7G(5′)ppp(5′)GmpCp-. Proc Natl Acad Sci 72: 362-366.
    • (1975) Proc Natl Acad Sci , vol.72 , pp. 362-366
    • Furuichi, Y.1    Morgan, M.2    Muthukrishnan, S.3    Shatkin, A.J.4
  • 61
    • 0023373737 scopus 로고
    • Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted μ-chain expression during B-cell development
    • Galli G, Guise JW, McDevitt MA, Tucker PW, Nevins Jr. 1987. Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted μ-chain expression during B-cell development. Genes Dev 1: 471-481.
    • (1987) Genes Dev , vol.1 , pp. 471-481
    • Galli, G.1    Guise, J.W.2    McDevitt, M.A.3    Tucker, P.W.4    Nevins, J.R.5
  • 62
    • 0023986659 scopus 로고
    • Poly(A) site choice rather than splice site choice governs the regulated production of IgM heavy-chain RNA
    • Galli G, Guise J, Tucker PW, Nevins Jr. 1988. Poly(A) site choice rather than splice site choice governs the regulated production of IgM heavy-chain RNA. Proc Natl Acad Sci 85: 2439-2443.
    • (1988) Proc Natl Acad Sci , vol.85 , pp. 2439-2443
    • Galli, G.1    Guise, J.2    Tucker, P.W.3    Nevins, J.R.4
  • 63
    • 0017755138 scopus 로고
    • The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: Mapping by effects of ultraviolet irradiation
    • Goldberg S, Weber J, Darnell JE. 1977. The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: Mapping by effects of ultraviolet irradiation. Cell 10: 617-621.
    • (1977) Cell , vol.10 , pp. 617-621
    • Goldberg, S.1    Weber, J.2    Darnell, J.E.3
  • 64
    • 21244493903 scopus 로고    scopus 로고
    • Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complex
    • Gornemann J, Kotovic KM, Hujer K, Neugebauer KM. 2005. Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complex. Mol Cell 19: 53-63.
    • (2005) Mol Cell , vol.19 , pp. 53-63
    • Gornemann, J.1    Kotovic, K.M.2    Hujer, K.3    Neugebauer, K.M.4
  • 66
    • 0013942975 scopus 로고
    • Polyadenylic acid in the cytoplasm of rat liver
    • Hadjivassiliou A, Brawerman G. 1966. Polyadenylic acid in the cytoplasm of rat liver. J Mol Biol 20: 1-7.
    • (1966) J Mol Biol , vol.20 , pp. 1-7
    • Hadjivassiliou, A.1    Brawerman, G.2
  • 67
    • 85010246457 scopus 로고
    • The preparation and physical chemical properties of ribonucleic acid from microsomal particles
    • Hall BD, Doty P. 1959. The preparation and physical chemical properties of ribonucleic acid from microsomal particles. J Mol Biol 1: 111-126.
    • (1959) J Mol Biol , vol.1 , pp. 111-126
    • Hall, B.D.1    Doty, P.2
  • 68
    • 70449300881 scopus 로고
    • Turnover of nuclear and cytoplasmic ribonucleic acid in two types of animal cell, with some further observations on the nucleolus
    • Harris H. 1959. Turnover of nuclear and cytoplasmic ribonucleic acid in two types of animal cell, with some further observations on the nucleolus. Biochem J 73: 362-369.
    • (1959) Biochem J , vol.73 , pp. 362-369
    • Harris, H.1
  • 69
    • 1842267728 scopus 로고
    • Site of synthesis of cytoplasmic ribonucleic acid
    • Harris H, LaCour LF. 1963. Site of synthesis of cytoplasmic ribonucleic acid. Nature 200: 227-229.
    • (1963) Nature , vol.200 , pp. 227-229
    • Harris, H.1    Lacour, L.F.2
  • 70
    • 0031990320 scopus 로고    scopus 로고
    • The function of multisite splicing enhancers
    • Hertel KJ, Maniatis T. 1998. The function of multisite splicing enhancers. Mol Cell 1: 449-455.
    • (1998) Mol Cell , vol.1 , pp. 449-455
    • Hertel, K.J.1    Maniatis, T.2
  • 71
    • 0021111680 scopus 로고
    • Isolation of small nuclear ribonucleoproteins containing U1, U2, U4, U5, and U6 RNAs
    • Hinterberger M, Pettersson I, Steitz JA. 1983. Isolation of small nuclear ribonucleoproteins containing U1, U2, U4, U5, and U6 RNAs. J Biol Chem 258: 2604-2613.
    • (1983) J Biol Chem , vol.258 , pp. 2604-2613
    • Hinterberger, M.1    Pettersson, I.2    Steitz, J.A.3
  • 72
    • 0032480229 scopus 로고    scopus 로고
    • RNA polymerase II is an essential mRNA polyadenylation factor
    • Hirose Y, Manley JL. 1998. RNA polymerase II is an essential mRNA polyadenylation factor. Nature 395: 93-96.
    • (1998) Nature , vol.395 , pp. 93-96
    • Hirose, Y.1    Manley, J.L.2
  • 73
    • 0033563098 scopus 로고    scopus 로고
    • Phosphorylated RNA polymerase II stimulates pre-mRNA splicing
    • Hirose Y, Tacke R, Manley JL. 1999. Phosphorylated RNA polymerase II stimulates pre-mRNA splicing. Genes Dev 13: 1234-1239.
    • (1999) Genes Dev , vol.13 , pp. 1234-1239
    • Hirose, Y.1    Tacke, R.2    Manley, J.L.3
  • 74
    • 0019516850 scopus 로고
    • The primary transcription unit of the mouse β-major globin gene
    • Hofer E, Darnell JE Jr. 1981. The primary transcription unit of the mouse β-major globin gene. Cell 23: 585-593.
    • (1981) Cell , vol.23 , pp. 585-593
    • Hofer, E.1    Darnell Jr., J.E.2
  • 75
    • 76249122261 scopus 로고    scopus 로고
    • The Spen family protein FPA controls alternative cleavage and polyadenylation of RNA
    • Hornyik C, Terzi LC, Simpson GG. 2010. The Spen family protein FPA controls alternative cleavage and polyadenylation of RNA. Dev Cell 18: 202-213.
    • (2010) Dev Cell , vol.18 , pp. 202-213
    • Hornyik, C.1    Terzi, L.C.2    Simpson, G.G.3
  • 77
    • 0041305816 scopus 로고    scopus 로고
    • Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae
    • Howe KJ, Kane CM, Ares M Jr. 2003. Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae. RNA 9: 993-1006.
    • (2003) RNA , vol.9 , pp. 993-1006
    • Howe, K.J.1    Kane, C.M.2    Ares Jr., M.3
  • 78
    • 84867160564 scopus 로고    scopus 로고
    • The RNA polymerase II CTD coordinates transcription and RNA processing
    • Hsin JP, Manley JL. 2012. The RNA polymerase II CTD coordinates transcription and RNA processing. Genes Dev 26: 2119-2137.
    • (2012) Genes Dev , vol.26 , pp. 2119-2137
    • Hsin, J.P.1    Manley, J.L.2
  • 79
    • 0025719396 scopus 로고
    • Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors
    • Huang S, Spector DL. 1991. Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors. Genes Dev 5: 2288-2303.
    • (1991) Genes Dev , vol.5 , pp. 2288-2303
    • Huang, S.1    Spector, D.L.2
  • 81
    • 0020490304 scopus 로고
    • The orderly splicing of the first three leaders of the adenovirus-2 major late transcript
    • Keohavong P, Gattoni R, LeMoullec JM, Jacob M, Stevenin J. 1982. The orderly splicing of the first three leaders of the adenovirus-2 major late transcript. Nucleic Acids Res 10: 1215-1229.
    • (1982) Nucleic Acids Res , vol.10 , pp. 1215-1229
    • Keohavong, P.1    Gattoni, R.2    Lemoullec, J.M.3    Jacob, M.4    Stevenin, J.5
  • 83
    • 84869859046 scopus 로고    scopus 로고
    • Cotranscriptional splicing efficiency differs dramatically between Drosophila and mouse
    • Khodor YL, Menet JS, Tolan M, Rosbash M. 2012. Cotranscriptional splicing efficiency differs dramatically between Drosophila and mouse. RNA 18: 2174-2186.
    • (2012) RNA , vol.18 , pp. 2174-2186
    • Khodor, Y.L.1    Menet, J.S.2    Tolan, M.3    Rosbash, M.4
  • 84
    • 0018286888 scopus 로고
    • Processing of the mouse β-globin mRNA precusor: At least two cleavage ligation reactions are necessary to excise the larger intervening sequence
    • Kinniburgh AJ, Ross J. 1979. Processing of the mouse β-globin mRNA precusor: At least two cleavage ligation reactions are necessary to excise the larger intervening sequence. Cell 17: 915-921.
    • (1979) Cell , vol.17 , pp. 915-921
    • Kinniburgh, A.J.1    Ross, J.2
  • 85
    • 0018220351 scopus 로고
    • The sequence of the chromosomal mouse β-globin major gene: Homologies in capping, splicing and poly(A) sites
    • Konkel DA, Tilghman SM, Leder P. 1978. The sequence of the chromosomal mouse β-globin major gene: Homologies in capping, splicing and poly(A) sites. Cell 15: 1125-1132.
    • (1978) Cell , vol.15 , pp. 1125-1132
    • Konkel, D.A.1    Tilghman, S.M.2    Leder, P.3
  • 86
    • 19344363974 scopus 로고    scopus 로고
    • Promoter usage and alternative splicing
    • Kornblihtt AR. 2005. Promoter usage and alternative splicing. Curr Opin Cell Biol 17: 262-268.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 262-268
    • Kornblihtt, A.R.1
  • 87
    • 85012585566 scopus 로고
    • Molecular characterization of ribonucleic acid from Escherichia coli ribosomes: I. Isolation and molecular weights
    • Kurland CG. 1960. Molecular characterization of ribonucleic acid from Escherichia coli ribosomes: I. Isolation and molecular weights. J Mol Biol 2: 83-91.
    • (1960) J Mol Biol , vol.2 , pp. 83-91
    • Kurland, C.G.1
  • 88
    • 0018139189 scopus 로고
    • Mapping the spliced and unspliced late lytic SV40 RNAs
    • Lai CJ, Dhar R, Khoury G. 1978. Mapping the spliced and unspliced late lytic SV40 RNAs. Cell 14: 971-982.
    • (1978) Cell , vol.14 , pp. 971-982
    • Lai, C.J.1    Dhar, R.2    Khoury, G.3
  • 89
    • 34548367537 scopus 로고    scopus 로고
    • Concurrent splicing and transcription are not sufficient to enhance splicing efficiency
    • Lazarev D, Manley JL. 2007. Concurrent splicing and transcription are not sufficient to enhance splicing efficiency. RNA 13: 1546-1557.
    • (2007) RNA , vol.13 , pp. 1546-1557
    • Lazarev, D.1    Manley, J.L.2
  • 90
    • 39149089317 scopus 로고    scopus 로고
    • Structural insights into the exon junction complex
    • Le Hir H, Andersen GR. 2008. Structural insights into the exon junction complex. Curr Opin Struct Biol 18: 112-119.
    • (2008) Curr Opin Struct Biol , vol.18 , pp. 112-119
    • Le Hir, H.1    Andersen, G.R.2
  • 91
    • 0015069455 scopus 로고
    • A polynucleotide segment rich in adenylic acid in the rapidly-labeled polyribosomal component in mouse sarcoma 180 ascites cells
    • Lee SEY, Mendicki J, Brawerman G. 1971. A polynucleotide segment rich in adenylic acid in the rapidly-labeled polyribosomal component in mouse sarcoma 180 ascites cells. Proc Natl Acad Sci 68: 1331-1335.
    • (1971) Proc Natl Acad Sci , vol.68 , pp. 1331-1335
    • Lee, S.E.Y.1    Mendicki, J.2    Brawerman, G.3
  • 92
    • 0023652355 scopus 로고
    • Splice commitment dictates neuron-specific alternative RNA processing in calcitonin/CGRP gene expesssion
    • Leff SE, Evans RM, Rosenfeld MG. 1987. Splice commitment dictates neuron-specific alternative RNA processing in calcitonin/CGRP gene expesssion. Cell 48: 517-524.
    • (1987) Cell , vol.48 , pp. 517-524
    • Leff, S.E.1    Evans, R.M.2    Rosenfeld, M.G.3
  • 93
    • 0025169502 scopus 로고
    • Splicing precedes polyadenylation during Drosophila E74A transcription
    • Lemaire MF, Thummel CS. 1990. Splicing precedes polyadenylation during Drosophila E74A transcription. Mol Cell Biol 10: 6059-6063.
    • (1990) Mol Cell Biol , vol.10 , pp. 6059-6063
    • Lemaire, M.F.1    Thummel, C.S.2
  • 95
    • 72849106592 scopus 로고    scopus 로고
    • RNA processing and its regulation: Global insights into biological networks
    • Licatalosi DD, Darnell RB. 2010. RNA processing and its regulation: Global insights into biological networks. Nat Rev Genet 11: 75-87.
    • (2010) Nat Rev Genet , vol.11 , pp. 75-87
    • Licatalosi, D.D.1    Darnell, R.B.2
  • 97
    • 33748351186 scopus 로고    scopus 로고
    • Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells
    • Listerman I, Sapra AK, Neugebauer KM. 2006. Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells. Nat Struct Mol Biol 13: 815-822.
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 815-822
    • Listerman, I.1    Sapra, A.K.2    Neugebauer, K.M.3
  • 98
    • 0031840978 scopus 로고    scopus 로고
    • Regulation of alternative polyadenylation by U1 snRNPs and SRp20
    • Lou H, Neugebauer KM, Gagel RF, Berget SM. 1998. Regulation of alternative polyadenylation by U1 snRNPs and SRp20. Mol Cell Biol 18: 4977-4985.
    • (1998) Mol Cell Biol , vol.18 , pp. 4977-4985
    • Lou, H.1    Neugebauer, K.M.2    Gagel, R.F.3    Berget, S.M.4
  • 99
    • 0029858338 scopus 로고    scopus 로고
    • Assembly of specific SR protein complexes on distinct regulatory elements of the doublesex splicing enhancer
    • Lynch KW, Maniatis T. 1996. Assembly of specific SR protein complexes on distinct regulatory elements of the doublesex splicing enhancer. Genes Dev 10: 2089-2101.
    • (1996) Genes Dev , vol.10 , pp. 2089-2101
    • Lynch, K.W.1    Maniatis, T.2
  • 100
    • 77958111633 scopus 로고    scopus 로고
    • The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
    • Malik S, Roeder RG. 2010. The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet 11: 761-772.
    • (2010) Nat Rev Genet , vol.11 , pp. 761-772
    • Malik, S.1    Roeder, R.G.2
  • 101
    • 0037041395 scopus 로고    scopus 로고
    • An extensive network of coupling among gene expression machines
    • Maniatis T, Reed R. 2002. An extensive network of coupling among gene expression machines. Nature 416: 499-506.
    • (2002) Nature , vol.416 , pp. 499-506
    • Maniatis, T.1    Reed, R.2
  • 102
    • 0037062982 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing and proteosome expansion in metazoans
    • Maniatis T, Tasic B. 2002. Alternative pre-mRNA splicing and proteosome expansion in metazoans. Nature 418: 236-243.
    • (2002) Nature , vol.418 , pp. 236-243
    • Maniatis, T.1    Tasic, B.2
  • 103
    • 0020699579 scopus 로고
    • Alternative splicing pathways exist in the formation of adenoviral late messenger RNAs
    • Mariman EC, van Beek-Reinders RJ, van Venrooij WJ. 1983. Alternative splicing pathways exist in the formation of adenoviral late messenger RNAs. J Mol Biol 163: 239-256.
    • (1983) J Mol Biol , vol.163 , pp. 239-256
    • Mariman, E.C.1    Van Beek-Reinders, R.J.2    Van Venrooij, W.J.3
  • 104
    • 15244358670 scopus 로고    scopus 로고
    • Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo
    • Mason PB, Struhl K. 2005. Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo. Mol Cell 17: 831-840.
    • (2005) Mol Cell , vol.17 , pp. 831-840
    • Mason, P.B.1    Struhl, K.2
  • 105
    • 68749113985 scopus 로고    scopus 로고
    • Widespread shortening of 3′ UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells
    • Mayr C, Bartel DP. 2009. Widespread shortening of 3′ UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell 138: 673-684.
    • (2009) Cell , vol.138 , pp. 673-684
    • Mayr, C.1    Bartel, D.P.2
  • 108
    • 0014688424 scopus 로고
    • Visualization of nucleolar genes
    • Miller OL, Beatty BR. 1969. Visualization of nucleolar genes. Science 164: 955-957.
    • (1969) Science , vol.164 , pp. 955-957
    • Miller, O.L.1    Beatty, B.R.2
  • 109
    • 77956183151 scopus 로고    scopus 로고
    • The carboxy terminal domain of RNA polymerase II and alternative splicing
    • Munoz MM, de la Mata M, Kornblihtt AR. 2010. The carboxy terminal domain of RNA polymerase II and alternative splicing. Trends Biochem Sci 35: 497-504.
    • (2010) Trends Biochem Sci , vol.35 , pp. 497-504
    • Munoz, M.M.1    De La Mata, M.2    Kornblihtt, A.R.3
  • 110
    • 0032104190 scopus 로고    scopus 로고
    • A rule for termination-codon position within intron-containing genes: When nonsense affects RNA abundance
    • Nagy E, Maquat LE. 1998. A rule for termination-codon position within intron-containing genes: When nonsense affects RNA abundance. Trends Biochem Sci 23: 198-199.
    • (1998) Trends Biochem Sci , vol.23 , pp. 198-199
    • Nagy, E.1    Maquat, L.E.2
  • 111
    • 0015935203 scopus 로고
    • Localization of the polyadenylate sequences in messenger ribonucleic acid and in the heterogeneous nuclear ribonucleic acid of HeLa cells
    • Nakazato H, KoppDW, Edmonds M. 1973. Localization of the polyadenylate sequences in messenger ribonucleic acid and in the heterogeneous nuclear ribonucleic acid of HeLa cells. J Biol Chem 248: 1472-1476.
    • (1973) J Biol Chem , vol.248 , pp. 1472-1476
    • Nakazato, H.1    Kopp, D.W.2    Edmonds, M.3
  • 112
    • 0017891514 scopus 로고
    • Groups of adenovirus type 2 mRNAs derived from a large primary transcript
    • Nevins JR, Darnell JE. 1978a. Groups of adenovirus type 2 mRNAs derived from a large primary transcript. J Virol 25: 811-823.
    • (1978) J Virol , vol.25 , pp. 811-823
    • Nevins, J.R.1    Darnell, J.E.2
  • 113
    • 0018233483 scopus 로고
    • Steps in the processing of Ad2 mRNA: Poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing
    • Nevins JR, Darnell JE. 1978b. Steps in the processing of Ad2 mRNA: Poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing. Cell 15: 1477-1493.
    • (1978) Cell , vol.15 , pp. 1477-1493
    • Nevins, J.R.1    Darnell, J.E.2
  • 114
    • 75849145292 scopus 로고    scopus 로고
    • Expansion of the eukaryotic proteome by alternative splicing
    • Nilsen TW, Graveley BR. 2010. Expansion of the eukaryotic proteome by alternative splicing. Nature 463: 457-463.
    • (2010) Nature , vol.463 , pp. 457-463
    • Nilsen, T.W.1    Graveley, B.R.2
  • 115
    • 0037044769 scopus 로고    scopus 로고
    • Transcriptional activators differ in their abilities to control alternative splicing
    • Nogues G, Kadener S, Cramer P, Bentley D, Kornblihtt AR. 2002. Transcriptional activators differ in their abilities to control alternative splicing. J Biol Chem 277: 43110-43114.
    • (2002) J Biol Chem , vol.277 , pp. 43110-43114
    • Nogues, G.1    Kadener, S.2    Cramer, P.3    Bentley, D.4    Kornblihtt, A.R.5
  • 116
    • 78649289872 scopus 로고    scopus 로고
    • Global analysis of nascent RNA reveals transcriptional pausing in terminal exons
    • Oesterreich FC, Preibisch S, Neugebauer KM. 2010. Global analysis of nascent RNA reveals transcriptional pausing in terminal exons. Mol Cell 40: 571-581.
    • (2010) Mol Cell , vol.40 , pp. 571-581
    • Oesterreich, F.C.1    Preibisch, S.2    Neugebauer, K.M.3
  • 118
    • 70349125488 scopus 로고    scopus 로고
    • Co-transcriptional splicing of constitutive and alternative exons
    • Pandya-Jones A, Black DL. 2009. Co-transcriptional splicing of constitutive and alternative exons. RNA 15: 1896-1908.
    • (2009) RNA , vol.15 , pp. 1896-1908
    • Pandya-Jones, A.1    Black, D.L.2
  • 119
    • 0000315576 scopus 로고
    • Polyribosomes in normal and poliovirus infected HeLa cells and their relationship to messenger RNA
    • Penman S, Scherrer K, Becker Y, Darnell JE. 1963. Polyribosomes in normal and poliovirus infected HeLa cells and their relationship to messenger RNA. Proc Natl Acad Sci 49: 654-662.
    • (1963) Proc Natl Acad Sci , vol.49 , pp. 654-662
    • Penman, S.1    Scherrer, K.2    Becker, Y.3    Darnell, J.E.4
  • 120
    • 0000362243 scopus 로고
    • The cellular sites of synthesis of ribosomal and 4S RNA
    • Perry RP. 1962. The cellular sites of synthesis of ribosomal and 4S RNA. Proc Natl Acad Sci 48: 2179-2186.
    • (1962) Proc Natl Acad Sci , vol.48 , pp. 2179-2186
    • Perry, R.P.1
  • 121
    • 0014859062 scopus 로고
    • Inhibition of RNA synthesis by actinomycin D: Characteristic dose-response of different RNA species
    • Perry RP, Kelley DE. 1970. Inhibition of RNA synthesis by actinomycin D: Characteristic dose-response of different RNA species. J Cell Physiol 76: 127-139.
    • (1970) J Cell Physiol , vol.76 , pp. 127-139
    • Perry, R.P.1    Kelley, D.E.2
  • 122
    • 0016373910 scopus 로고
    • Existence of methylated messenger RNA in mouse L cells
    • Perry RP, Kelley DE. 1974. Existence of methylated messenger RNA in mouse L cells. Cell 1: 37-41.
    • (1974) Cell , vol.1 , pp. 37-41
    • Perry, R.P.1    Kelley, D.E.2
  • 123
    • 33751090746 scopus 로고    scopus 로고
    • Phosphorylation and functions of the RNA polymerase II CTD
    • Phatnani HP, Greenleaf AL. 2006. Phosphorylation and functions of the RNA polymerase II CTD. Genes Dev 20: 2922-2936.
    • (2006) Genes Dev , vol.20 , pp. 2922-2936
    • Phatnani, H.P.1    Greenleaf, A.L.2
  • 124
    • 0015151126 scopus 로고
    • Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication
    • Philipson L, Wall R, Glickman G, Darnell JE Jr. 1971. Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication. Proc Natl Acad Sci 68: 2806-2809.
    • (1971) Proc Natl Acad Sci , vol.68 , pp. 2806-2809
    • Philipson, L.1    Wall, R.2    Glickman, G.3    Darnell Jr., J.E.4
  • 125
    • 0016438549 scopus 로고
    • Short-lived messenger RNA in HeLa cells and its impact on the kinetics of accumulation of cytoplasmic polyadenylate
    • Puckett L, Chambers S, Darnell JE. 1975. Short-lived messenger RNA in HeLa cells and its impact on the kinetics of accumulation of cytoplasmic polyadenylate. Proc Natl Acad Sci 72: 389-393.
    • (1975) Proc Natl Acad Sci , vol.72 , pp. 389-393
    • Puckett, L.1    Chambers, S.2    Darnell, J.E.3
  • 126
    • 66049162655 scopus 로고    scopus 로고
    • Execution of nonsense-mediated mRNA decay: What defines a substrate?
    • Rebbapragada I, Lykke-Andersen J. 2009. Execution of nonsense-mediated mRNA decay: What defines a substrate? Curr Opin Cell Biol 21: 394-402.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 394-402
    • Rebbapragada, I.1    Lykke-Andersen, J.2
  • 127
    • 0038699144 scopus 로고    scopus 로고
    • Coupling transcripiton, splicing and mRNA export
    • Reed R. 2003. Coupling transcripiton, splicing and mRNA export. Curr Opin Cell Biol 15: 326-331.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 326-331
    • Reed, R.1
  • 128
    • 0022516779 scopus 로고
    • A role for exon sequences and slice site proximity in splice site selection
    • Reed R, Maniatis T. 1986. A role for exon sequences and slice site proximity in splice site selection. Cell 46: 681-690.
    • (1986) Cell , vol.46 , pp. 681-690
    • Reed, R.1    Maniatis, T.2
  • 129
    • 66149187105 scopus 로고    scopus 로고
    • Transcription termination by nuclear RNA polymerases
    • Richard P, Manley JL. 2009. Transcription termination by nuclear RNA polymerases. Genes Dev 23: 1247-1269.
    • (2009) Genes Dev , vol.23 , pp. 1247-1269
    • Richard, P.1    Manley, J.L.2
  • 131
    • 0014683539 scopus 로고
    • Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms
    • Roeder RG, Rutter WJ. 1969. Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms. Nature 224: 234-237.
    • (1969) Nature , vol.224 , pp. 234-237
    • Roeder, R.G.1    Rutter, W.J.2
  • 132
    • 0018892655 scopus 로고
    • Two mRNAs with different 3′ ends encode membranebound and secreted forms of immunoglobulin μ chain
    • Rogers J, Early P, Carter C, Calame K, Bond M, Hood L, Wall R. 1980. Two mRNAs with different 3′ ends encode membranebound and secreted forms of immunoglobulin μ chain. Cell 20: 303-312.
    • (1980) Cell , vol.20 , pp. 303-312
    • Rogers, J.1    Early, P.2    Carter, C.3    Calame, K.4    Bond, M.5    Hood, L.6    Wall, R.7
  • 133
    • 76249094361 scopus 로고    scopus 로고
    • Alternative polyadenylation blooms
    • Rosonina E, Manley JL. 2010. Alternative polyadenylation blooms. Dev Cell 18: 172-174.
    • (2010) Dev Cell , vol.18 , pp. 172-174
    • Rosonina, E.1    Manley, J.L.2
  • 136
    • 0017391317 scopus 로고
    • 3′ terminal addition to HeLa cell nuclear and cytoplasmic poly(A)
    • Sawicki S, JelinekW, Darnell JE. 1977. 3′ terminal addition to HeLa cell nuclear and cytoplasmic poly(A). J Mol Biol 113: 219-235.
    • (1977) J Mol Biol , vol.113 , pp. 219-235
    • Sawicki, S.1    Jelinek, W.2    Darnell, J.E.3
  • 137
    • 0001394554 scopus 로고
    • Sedimentation characteristics of rapidly labeled RNA from HeLa cells
    • Scherrer K, Darnell JE Jr. 1962. Sedimentation characteristics of rapidly labeled RNA from HeLa cells. Biochem Biophys Res Commun 7: 486-490.
    • (1962) Biochem Biophys Res Commun , vol.7 , pp. 486-490
    • Scherrer, K.1    Darnell Jr., J.E.2
  • 138
    • 0010951416 scopus 로고
    • Demonstration of an unstable RNA and precursor to ribosomal RNA in HeLa cells
    • Scherrer K, Latham H, Darnell JE Jr. 1963. Demonstration of an unstable RNA and precursor to ribosomal RNA in HeLa cells. Proc Natl Acad Sci 49: 240-248.
    • (1963) Proc Natl Acad Sci , vol.49 , pp. 240-248
    • Scherrer, K.1    Latham, H.2    Darnell Jr., J.E.3
  • 139
    • 0018251899 scopus 로고
    • The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells
    • Schibler U, Marcu KB, Perry RP. 1978. The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells. Cell 15: 1495-1509.
    • (1978) Cell , vol.15 , pp. 1495-1509
    • Schibler, U.1    Marcu, K.B.2    Perry, R.P.3
  • 140
    • 84913713685 scopus 로고
    • 5,6-Dichloro-I-b-D-ribofuranosylbenzimidazole inhibits initiation of nuclear heterogeneousRNAchains in HeLa cells
    • Sehgal PG, Derman E, Molloy GR, Tamm I, Darnell JE. 1976. 5,6-Dichloro-I-b-D-ribofuranosylbenzimidazole inhibits initiation of nuclear heterogeneousRNAchains in HeLa cells. Science 94: 431-433.
    • (1976) Science , vol.94 , pp. 431-433
    • Sehgal, P.G.1    Derman, E.2    Molloy, G.R.3    Tamm, I.4    Darnell, J.E.5
  • 141
    • 0018398747 scopus 로고
    • Early Ad-2 transcription units: Only promoter-proximal RNA continues to be made in the presence of DRB
    • Sehgal PB, Fraser N, Darnell JE. 1979. Early Ad-2 transcription units: Only promoter-proximal RNA continues to be made in the presence of DRB. Virology 94: 185-191.
    • (1979) Virology , vol.94 , pp. 185-191
    • Sehgal, P.B.1    Fraser, N.2    Darnell, J.E.3
  • 142
    • 0026261876 scopus 로고
    • Five easy pieces
    • Sharp PA. 1991. Five easy pieces. Science 254: 663.
    • (1991) Science , vol.254 , pp. 663
    • Sharp, P.A.1
  • 143
    • 0016272591 scopus 로고
    • Methylated messenger RNA synthesis in vitro by purified reovirus
    • Shatkin AJ. 1974. Methylated messenger RNA synthesis in vitro by purified reovirus. Proc Natl Acad Sci 71: 3204-3207.
    • (1974) Proc Natl Acad Sci , vol.71 , pp. 3204-3207
    • Shatkin, A.J.1
  • 145
    • 0036347305 scopus 로고    scopus 로고
    • What messenger RNA capping tells us about eukaryotic evolution
    • Shuman S. 2002. What messenger RNA capping tells us about eukaryotic evolution. Nat Rev Mol Cell Biol 3: 619-625.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 619-625
    • Shuman, S.1
  • 146
    • 70350754211 scopus 로고    scopus 로고
    • Rates of in situ transcription and splicing in large human genes
    • Singh J, Padgett RA. 2009. Rates of in situ transcription and splicing in large human genes. Nat Struct Mol Biol 16: 1128-1133.
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 1128-1133
    • Singh, J.1    Padgett, R.A.2
  • 147
    • 84869090905 scopus 로고    scopus 로고
    • The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus
    • Singh G, Kucukural A, Cenik C, Leszyk JS, Shaffer SA, Weng Z, Moore MJ. 2012. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. Cell 151: 750-764.
    • (2012) Cell , vol.151 , pp. 750-764
    • Singh, G.1    Kucukural, A.2    Cenik, C.3    Leszyk, J.S.4    Shaffer, S.A.5    Weng, Z.6    Moore, M.J.7
  • 148
    • 1842361706 scopus 로고
    • The metabolism of the nucleic acids
    • (ed. E Chargaff, JN Davidson), Academic Press, New York
    • Smellie RMS. 1955. The metabolism of the nucleic acids. In The nucleic acids (ed. E Chargaff, JN Davidson), Vol. 2, pp. 394-429. Academic Press, New York.
    • (1955) The Nucleic Acids , vol.2 , pp. 394-429
    • Smellie, R.M.S.1
  • 149
    • 0013934675 scopus 로고
    • Rapidly labeled HeLa cell nuclear RNA. II. Base composition and cellular localization of a heterogeneous RNA fraction
    • Soeiro R, Birnboim HC, Darnell JE. 1966. Rapidly labeled HeLa cell nuclear RNA. II. Base composition and cellular localization of a heterogeneous RNA fraction. J Mol Biol 19: 362-372.
    • (1966) J Mol Biol , vol.19 , pp. 362-372
    • Soeiro, R.1    Birnboim, H.C.2    Darnell, J.E.3
  • 151
    • 84910724673 scopus 로고
    • RNAsplicing
    • (ed. M Inouye, BS Ducock), Academic Press, New York
    • Steitz J. 1987. RNAsplicing. In Molecular biology of RNA: New perspectives (ed. M Inouye, BS Ducock), pp. 69-80. Academic Press, New York.
    • (1987) Molecular Biology of RNA: New Perspectives , pp. 69-80
    • Steitz, J.1
  • 152
    • 33846702294 scopus 로고    scopus 로고
    • Ratcheting mRNA out of the nucleus
    • Stewart M. 2007. Ratcheting mRNA out of the nucleus. Mol Cell 25: 327-330.
    • (2007) Mol Cell , vol.25 , pp. 327-330
    • Stewart, M.1
  • 153
    • 0032246188 scopus 로고    scopus 로고
    • Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation
    • Takagaki Y, Manley JL. 1998. Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation. Mol Cell 2: 761-771.
    • (1998) Mol Cell , vol.2 , pp. 761-771
    • Takagaki, Y.1    Manley, J.L.2
  • 154
    • 0030606286 scopus 로고    scopus 로고
    • The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation
    • Takagaki Y, Seipelt RL, Peterson ML, Manley JL. 1996. The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. Cell 87: 941-952.
    • (1996) Cell , vol.87 , pp. 941-952
    • Takagaki, Y.1    Seipelt, R.L.2    Peterson, M.L.3    Manley, J.L.4
  • 155
    • 2342540912 scopus 로고    scopus 로고
    • The ever-increasing complexities of the exon junction complex
    • Tange TO, Nott A, Moore MJ. 2004. The ever-increasing complexities of the exon junction complex. Curr Opin Cell Biol 16: 279-284.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 279-284
    • Tange, T.O.1    Nott, A.2    Moore, M.J.3
  • 156
    • 33845643952 scopus 로고    scopus 로고
    • A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional
    • Tardiff DF, Lacadie SA, Rosbash M. 2006. A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional. Mol Cell 24: 917-929.
    • (2006) Mol Cell , vol.24 , pp. 917-929
    • Tardiff, D.F.1    Lacadie, S.A.2    Rosbash, M.3
  • 158
    • 33747881750 scopus 로고    scopus 로고
    • The general transcription machinery and general cofactors
    • Thomas MC, Chiang CM. 2006. The general transcription machinery and general cofactors. Crit Rev Biochem Mol Biol 41: 105-178.
    • (2006) Crit Rev Biochem Mol Biol , vol.41 , pp. 105-178
    • Thomas, M.C.1    Chiang, C.M.2
  • 159
    • 13744254695 scopus 로고    scopus 로고
    • A large-scale analysis of mRNA polyadenylation of human and mouse genes
    • Tian B, Hu J, Zhang H, Lutz CS. 2005. A large-scale analysis of mRNA polyadenylation of human and mouse genes. Nucleic Acids Res 33: 201-212.
    • (2005) Nucleic Acids Res , vol.33 , pp. 201-212
    • Tian, B.1    Hu, J.2    Zhang, H.3    Lutz, C.S.4
  • 162
    • 60349104299 scopus 로고    scopus 로고
    • The spliceosome: Design principles of a dynamic RNP machine
    • Wahl MC, Will CL, Luhrmann R. 2009. The spliceosome: Design principles of a dynamic RNP machine. Cell 136: 701-718.
    • (2009) Cell , vol.136 , pp. 701-718
    • Wahl, M.C.1    Will, C.L.2    Luhrmann, R.3
  • 163
    • 85172052285 scopus 로고    scopus 로고
    • Prologue to the first edition
    • (ed. RF Gesteland et al.), 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Watson JD. 2006. Prologue to the first edition. In The RNA world (ed. RF Gesteland et al.), 3rd ed., pp. xv-xxiii. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (2006) The RNA World
    • Watson, J.D.1
  • 164
    • 0017401131 scopus 로고
    • The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: Mapping of nascent RNA molecules labeled in isolated nuclei
    • Weber J, Jelinek W, Darnell JE. 1977. The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: Mapping of nascent RNA molecules labeled in isolated nuclei. Cell 10: 811-816.
    • (1977) Cell , vol.10 , pp. 811-816
    • Weber, J.1    Jelinek, W.2    Darnell, J.E.3
  • 165
    • 0018898480 scopus 로고
    • Order of polyadenylic acid addition and splicing events in early adenovirus mRNA formation
    • Weber J, Blanchard J-M, Ginsberg HM, Darnell JE. 1980. Order of polyadenylic acid addition and splicing events in early adenovirus mRNA formation. J Virol 33: 286-291.
    • (1980) J Virol , vol.33 , pp. 286-291
    • Weber, J.1    Blanchard, J.-M.2    Ginsberg, H.M.3    Darnell, J.E.4
  • 166
    • 0011104884 scopus 로고
    • Methylation of newly synthesized viral messenger RNA by an enzyme in vaccinia virus
    • Wei C-M, Moss B. 1974. Methylation of newly synthesized viral messenger RNA by an enzyme in vaccinia virus. Proc Natl Acad Sci 71: 3014-3018.
    • (1974) Proc Natl Acad Sci , vol.71 , pp. 3014-3018
    • Wei, C.-M.1    Moss, B.2
  • 167
    • 0016770156 scopus 로고
    • Methylated nucleotides block 5′ terminus of HeLa cell messenger RNA
    • Wei C-M, Gershowitz A, Moss B. 1975. Methylated nucleotides block 5′ terminus of HeLa cell messenger RNA. Cell 4: 379-386.
    • (1975) Cell , vol.4 , pp. 379-386
    • Wei, C.-M.1    Gershowitz, A.2    Moss, B.3
  • 168
    • 33746641324 scopus 로고    scopus 로고
    • Nucleosome displacement in transcription
    • Workman JL. 2006. Nucleosome displacement in transcription. Genes Dev 20: 2009-2017.
    • (2006) Genes Dev , vol.20 , pp. 2009-2017
    • Workman, J.L.1
  • 169
    • 0028090567 scopus 로고
    • Physical isolation of nascent RNA chains transcribed by RNA polymerase II: Evidence for co-transcriptional splicing
    • Wuarin J, Schibler U. 1994. Physical isolation of nascent RNA chains transcribed by RNA polymerase II: Evidence for co-transcriptional splicing. Mol Cell Biol 14: 7219-7225.
    • (1994) Mol Cell Biol , vol.14 , pp. 7219-7225
    • Wuarin, J.1    Schibler, U.2
  • 170
    • 78649813424 scopus 로고    scopus 로고
    • A model in vitro system for cotranscriptional splicing
    • Yu Y, Das R, Folco EG, Reed R. 2010. A model in vitro system for cotranscriptional splicing. Nucleic Acids Res 38: 7570-7578.
    • (2010) Nucleic Acids Res , vol.38 , pp. 7570-7578
    • Yu, Y.1    Das, R.2    Folco, E.G.3    Reed, R.4


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