Highly impulsive rats: Modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction

DMM Disease Models and Mechanisms

Volumn 6, Issue 2, 2013, Pages 302-311

  Jupp, Bianca ^a,b   Caprioli, Daniele ^a   Dalley, Jeffrey W ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ALCOHOL; AMPHETAMINE; ANXIOLYTIC AGENT; ATOMOXETINE; CITALOPRAM; COCAINE; DIAMORPHINE; DIZOCILPINE; FLUOXETINE; GUANFACINE; KETANSERIN; METHYLPHENIDATE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; NALOXONE; NALTRINDOLE; NICOTINE; OPIATE; OXIDOPAMINE; RACLOPRIDE; RIMONABANT; SULPIRIDE; UNINDEXED DRUG; VOLINANSERIN;

ADDICTION; ANTERIOR CINGULATE; ATTENTION DEFICIT DISORDER; BASOLATERAL AMYGDALA; BEHAVIOR; BRAIN CORTEX; CORPUS STRIATUM; DECISION MAKING; DRUG ABUSE; DRUG DEPENDENCE; ENDOPHENOTYPE; ENVIRONMENTAL ENRICHMENT; ENVIRONMENTAL FACTOR; HEREDITY; HIPPOCAMPUS; HUMAN; IMPULSIVENESS; INSTRUMENTAL CONDITIONING; MATERNAL DEPRIVATION; NEUROBIOLOGY; NEUROPSYCHOLOGICAL TEST; NONHUMAN; NUCLEUS ACCUMBENS; ORBITAL CORTEX; PATHOGENESIS; PLACE PREFERENCE; PRIORITY JOURNAL; RAT; RESPONSE TIME; REVIEW; SUBTHALAMIC NUCLEUS; WITHDRAWAL SYNDROME;

ANIMALS; BEHAVIOR, ADDICTIVE; DISEASE MODELS, ANIMAL; ENDOPHENOTYPES; ENVIRONMENT; HUMANS; NEUROBIOLOGY; QUANTITATIVE TRAIT, HERITABLE; RATS;

EID: 84875192767     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.010934     Document Type: Review

References (156)

1. Abela, A. R., Dougherty, S. D., Fagen, E. D., Hill, C. J. and Chudasama, Y. (2012). Inhibitory control deficits in rats with ventral hippocampal lesions. Cereb. Cortex. [Epub ahead of print] doi.org/10.1093/cercor/bhs121.
2. Adriani, W., Caprioli, A., Granstrem, O., Carli, M. and Laviola, G. (2003). The spontaneously hypertensive-rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopulations. Neurosci. Biobehav. Rev. 27, 639-651. (Pubitemid 37414912)
3. Agnoli, L. and Carli, M. (2012). Dorsal-striatal 5-HT2A and 5-HT2C receptors control impulsivity and perseverative responding in the 5-choice serial reaction time task. Psychopharmacology (Berl.) 219, 633-645.
4. Anker, J. J., Perry, J. L., Gliddon, L. A. and Carroll, M. E. (2009). Impulsivity predicts the escalation of cocaine self-administration in rats. Pharmacol. Biochem. Behav. 93, 343-348.
5. Avila, C., Cuenca, I., Félix, V., Parcet, M. A. and Miranda, A. (2004). Measuring impulsivity in school-aged boys and examining its relationship with ADHD and ODD ratings. J. Abnorm. Child Psychol. 32, 295-304. (Pubitemid 39004757)
6. Baarendse, P. J. and Vanderschuren, L. J. (2012). Dissociable effects of monoamine reuptake inhibitors on distinct forms of impulsive behavior in rats. Psychopharmacology (Berl.) 219, 313-326.
7. Bañuelos, C., Gilbert, R. J., Montgomery, K. S., Fincher, A. S., Wang, H., Frye, G. D., Setlow, B. and Bizon, J. L. (2012). Altered spatial learning and delay discounting in a rat model of human third trimester binge ethanol exposure. Behav. Pharmacol. 23, 54-65.
8. Bari, A., Mar, A. C., Theobald, D. E., Elands, S. A., Oganya, K. C., Eagle, D. M. and Robbins, T. W. (2011). Prefrontal and monoaminergic contributions to stop-signal task performance in rats. J. Neurosci. 31, 9254-9263.
9. Barratt, E. S. (1985). Impulsiveness subtraits, arousal and information processing In Motivation, Emotion and Personality (ed. J. T. Spence and C. T. Itard), pp. 137-146. New York, NY: Elsevier Science.
10. Belin, D., Mar, A. C., Dalley, J. W., Robbins, T. W. and Everitt, B. J. (2008). High impulsivity predicts the switch to compulsive cocaine-taking. Science 320, 1352-1355. (Pubitemid 351929473)
11. Belin, D., Berson, N., Balado, E., Piazza, P. V. and Deroche-Gamonet, V. (2011). High-novelty-preference rats are predisposed to compulsive cocaine self-administration. Neuropsychopharmacology 36, 569-579.
12. Besson, M., Belin, D., McNamara, R., Theobald, D. E., Castel, A., Beckett, V. L., Crittenden, B. M., Newman, A. H., Everitt, B. J., Robbins, T. W. et al. (2010). Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens. Neuropsychopharmacology 35, 560-569.
13. Bevilacqua, L., Doly, S., Kaprio, J., Yuan, Q., Tikkanen, R., Paunio, T., Zhou, Z., Wedenoja, J., Maroteaux, L., Diaz, S. et al. (2010). A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature 468, 1061-1066.
14. Bezdjian, S., Baker, L. A. and Tuvblad, C. (2011). Genetic and environmental influences on impulsivity: a meta-analysis of twin, family and adoption studies. Clin. Psychol. Rev. 31, 1209-1223.
15. Bird, J. and Schenk, S. (2012). Contribution of impulsivity and novelty-seeking to the acquisition and maintenance of MDMA self-administration. Addict. Biol. [Epub ahead of print] doi.org/10.1111/j.1369-1600.2012.00477.x.
16. Bizot, J. C., Thiébot, M. H., Le Bihan, C., Soubrié, P. and Simon, P. (1988). Effects of imipramine-like drugs and serotonin uptake blockers on delay of reward in rats. Possible implication in the behavioral mechanism of action of antidepressants. J. Pharmacol. Exp. Ther. 246, 1144-1151.
17. Bizot, J., Le Bihan, C., Puech, A. J., Hamon, M. and Thiébot, M. (1999). Serotonin and tolerance to delay of reward in rats. Psychopharmacology (Berl.) 146, 400-412. (Pubitemid 29513280)
18. Broos, N., Diergaarde, L., Schoffelmeer, A. N., Pattij, T. and De Vries, T. J. (2012). Trait impulsive choice predicts resistance to extinction and propensity to relapse to cocaine seeking: a bidirectional investigation. Neuropsychopharmacology 37, 1377-1386.
19. Buckholtz, J. W., Treadway, M. T., Cowan, R. L., Woodward, N. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Shelby, E. S., Smith, C. E. et al. (2010). Dopaminergic network differences in human impulsivity. Science 329, 532.
20. Cale, E. M. and Lilienfeld, S. O. (2006). Psychopathy factors and risk for aggressive behavior: a test of the "threatened egotism" hypothesis. Law Hum. Behav. 30, 51-74. (Pubitemid 44257247)
21. Cardinal, R. N., Pennicott, D. R., Sugathapala, C. L., Robbins, T. W. and Everitt, B. J. (2001). Impulsive choice induced in rats by lesions of the nucleus accumbens core. Science 292, 2499-2501. (Pubitemid 32601663)
22. Cardona, D., López-Crespo, G., Sánchez-Amate, M. C., Flores, P. and Sánchez-Santed, F. (2011). Impulsivity as long-term sequelae after chlorpyrifos intoxication: time course and individual differences. Neurotox. Res. 19, 128-137.
23. Carmona, S., Proal, E., Hoekzema, E. A., Gispert, J. D., Picado, M., Moreno, I., Soliva, J. C., Bielsa, A., Rovira, M., Hilferty, J. et al. (2009). Ventro-striatal reductions underpin symptoms of hyperactivity and impulsivity in attention-deficit/hyperactivity disorder. Biol. Psychiatry 66, 972-977.
24. Chamberlain, S. R. and Sahakian, B. J. (2007). The neuropsychiatry of impulsivity. Curr. Opin. Psychiatry 20, 255-261. (Pubitemid 46588298)
25. Cheung, T. H. and Cardinal, R. N. (2005). Hippocampal lesions facilitate instrumental learning with delayed reinforcement but induce impulsive choice in rats. BMC Neurosci. 6, 36.
26. Chudasama, Y., Passetti, F., Rhodes, S. E., Lopian, D., Desai, A. and Robbins, T. W. (2003). Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity. Behav. Brain Res. 146, 105-119. (Pubitemid 37476138)
27. Cocker, P. J., Dinelle, K., Kornelson, R., Sossi, V. and Winstanley, C. A. (2012). Irrational choice under uncertainty correlates with lower striatal D2/3 receptor binding in rats. J. Neurosci. 32, 15450-15457.
28. Cole, B. J. and Robbins, T. W. (1987). Amphetamine impairs the discriminative performance of rats with dorsal noradrenergic bundle lesions on a 5-choice serial reaction time task: new evidence for central dopaminergic-noradrenergic interactions. Psychopharmacology (Berl.) 91, 458-466. (Pubitemid 17038209)
29. Congdon, E., Lesch, K. P. and Canli, T. (2008). Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: implications for impulsivity. Am. J. Med. Genet. 147 B, 27-32.
30. Dalley, J. W. and Roiser, J. P. (2012). Dopamine, serotonin and impulsivity. Neuroscience 215, 42-58.
31. Dalley, J. W., Fryer, T. D., Brichard, L., Robinson, E. S., Theobald, D. E., Lääne, K., Peña, Y., Murphy, E. R., Shah, Y., Probst, K. et al. (2007). Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science 315, 1267-1270. (Pubitemid 46364262)
32. Dalley, J. W., Everitt, B. J. and Robbins, T. W. (2011). Impulsivity, compulsivity, and top-down cognitive control. Neuron 69, 680-694.
33. Daruma, J. and Barnes, P. (1993). A neurodevelopmental view of impulsivity and its relationship to the superfactors of personality. In The Impulsive Client: Theory, Research and Treatment (ed. W. McCown, J. Johnson and M. Shure). Washington, DC: American Psychological Association.
34. Davies, W., Isles, A., Smith, R., Karunadasa, D., Burrmann, D., Humby, T., Ojarikre, O., Biggin, C., Skuse, D., Burgoyne, P. et al. (2005). Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nat. Genet. 37, 625-629. (Pubitemid 40770418)
35. Del Campo, N., Chamberlain, S. R., Sahakian, B. J. and Robbins, T. W. (2011). The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder. Biol. Psychiatry 69, e145-e157.
36. Diergaarde, L., Pattij, T., Poortvliet, I., Hogenboom, F., De Vries, W., Schoffelmeer, A. N. and De Vries, T. J. (2008). Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats. Biol. Psychiatry 63, 301-308.
37. Dilleen, R., Pelloux, Y., Mar, A. C., Molander, A., Robbins, T. W., Everitt, B. J., Dalley, J. W. and Belin, D. (2012). High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats. Psychopharmacology (Berl.) 222, 89-97.
38. Doe, C. M., Relkovic, D., Garfield, A. S., Dalley, J. W., Theobald, D. E., Humby, T., Wilkinson, L. S. and Isles, A. R. (2009). Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Hum. Mol. Genet. 18, 2140-2148.
39. Dougherty, D. M., Mathias, C. W., Marsh, D. M., Papageorgiou, T. D., Swann, A. C. and Moeller, F. G. (2004). Laboratory measured behavioral impulsivity relates to suicide attempt history. Suicide Life Threat. Behav. 34, 374-385. (Pubitemid 39665376)
40. Duclot, F., Hollis, F., Darcy, M. J. and Kabbaj, M. (2011). Individual differences in novelty-seeking behavior in rats as a model for psychosocial stress-related mood disorders. Physiol. Behav. 104, 296-305.
41. Eagle, D. M. and Baunez, C. (2010). Is there an inhibitory-response- control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition. Neurosci. Biobehav. Rev. 34, 50-72.
42. Eagle, D. M., Baunez, C., Hutcheson, D. M., Lehmann, O., Shah, A. P. and Robbins, T. W. (2008). Stop-signal reaction-time task performance: role of prefrontal cortex and subthalamic nucleus. Cereb. Cortex 18, 178-188. (Pubitemid 350233064)
43. Eagle, D. M., Wong, J. C., Allan, M. E., Mar, A. C., Theobald, D. E. and Robbins, T. W. (2011). Contrasting roles for dopamine D1 and D2 receptor subtypes in the dorsomedial striatum but not the nucleus accumbens core during behavioral inhibition in the stop-signal task in rats. J. Neurosci. 31, 7349-7356.
44. Economidou, D., Pelloux, Y., Robbins, T. W., Dalley, J. W. and Everitt, B. J. (2009). High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence. Biol. Psychiatry 65, 851-856.
45. Economidou, D., Theobald, D. E., Robbins, T. W., Everitt, B. J. and Dalley, J. W. (2012). Norepinephrine and dopamine modulate impulsivity on the five-choice serial reaction time task through opponent actions in the shell and core sub-regions of the nucleus accumbens. Neuropsychopharmacology 37, 2057-2066.
46. Eisenberg, D. T., Mackillop, J., Modi, M., Beauchemin, J., Dang, D., Lisman, S. A., Lum, J. K. and Wilson, D. S. (2007). Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study. Behav. Brain Funct. 3, 2.
47. Ersche, K. D., Turton, A. J., Pradhan, S., Bullmore, E. T. and Robbins, T. W. (2010). Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits. Biol. Psychiatry 68, 770-773.
48. Ersche, K. D., Jones, P. S., Williams, G. B., Turton, A. J., Robbins, T. W. and Bullmore, E. T. (2012). Abnormal brain structure implicated in stimulant drug addiction. Science 335, 601-604.
49. Evenden, J. L. (1999). Varieties of impulsivity. Psychopharmacology (Berl.) 146, 348-361. (Pubitemid 29513276)
50. Evenden, J. L. and Ryan, C. N. (1996). The pharmacology of impulsive behaviour in rats: the effects of drugs on response choice with varying delays of reinforcement. Psychopharmacology (Berl.) 128, 161-170. (Pubitemid 26383303)
51. Everitt, B. J. and Robbins, T. W. (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 8, 1481-1489. (Pubitemid 41573659)
52. Everitt, B. J., Belin, D., Economidou, D., Pelloux, Y., Dalley, J. W. and Robbins, T. W. (2008). Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos. Trans. R. Soc. Lond. B Biol. Sci. 363, 3125-3135.
53. Eysenck, H. J. and Eysenck, S. B. G. (1984). The Manual of the Eysenck Personality Inventory. London, UK: University of London Press.
54. Fernando, A. B., Economidou, D., Theobald, D. E., Zou, M. F., Newman, A. H., Spoelder, M., Caprioli, D., Moreno, M., Hipólito, L., Aspinall, A. T. et al. (2012). Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists. Psychopharmacology (Berl.) 219, 341-352.
55. Flagel, S. B., Robinson, T. E., Clark, J. J., Clinton, S. M., Watson, S. J., Seeman, P., Phillips, P. E. and Akil, H. (2010). An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction. Neuropsychopharmacology 35, 388-400.
56. Fletcher, P. J., Rizos, Z., Noble, K. and Higgins, G. A. (2011). Impulsive action induced by amphetamine, cocaine and MK801 is reduced by 5-HT (2C) receptor stimulation and 5-HT (2A) receptor blockade. Neuropharmacology 61, 468-477.
57. García-Lecumberri, C., Torres, I., Martín, S., Crespo, J. A., Miguéns, M., Nicanor, C., Higuera-Matas, A. and Ambrosio, E. (2011). Strain differences in the dose-response relationship for morphine self-administration and impulsive choice between Lewis and Fischer 344 rats. J. Psychopharmacol. 25, 783-791.
58. Ghahremani, D. G., Lee, B., Robertson, C. L., Tabibnia, G., Morgan, A. T., De Shetler, N., Brown, A. K., Monterosso, J. R., Aron, A. R., Mandelkern, M. A. et al. (2012). Striatal dopamine D2/D3 receptors mediate response inhibition and related activity in frontostriatal neural circuitry in humans. J. Neurosci. 32, 7316-7324.
59. Giorgi, O., Piras, G. and Corda, M. G. (2007). The psychogenetically selected Roman high-and low-avoidance rat lines: a model to study the individual vulnerability to drug addiction. Neurosci. Biobehav. Rev. 31, 148-163. (Pubitemid 44880079)
60. Grottick, A. J. and Higgins, G. A. (2000). Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task. Behav. Brain Res. 117, 197-208.
61. Gubner, N. R., Wilhelm, C. J., Phillips, T. J. and Mitchell, S. H. (2010). Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains. Alcohol. Clin. Exp. Res. 34, 1353-1362.
62. Harvey, R. C., Sen, S., Deaciuc, A., Dwoskin, L. P. and Kantak, K. M. (2011). Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function. Neuropsychopharmacology 36, 837-847.
63. Homberg, J. R., Pattij, T., Janssen, M. C., Ronken, E., De Boer, S. F., Schoffelmeer, A. N. and Cuppen, E. (2007). Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility. Eur. J. Neurosci. 26, 2066-2073. (Pubitemid 47493211)
64. Hoyle, E., Genn, R. F., Fernandes, C. and Stolerman, I. P. (2006). Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task. Psychopharmacology (Berl.) 189, 211-223. (Pubitemid 44691543)
65. Ibias, J. and Pellón, R. (2011). Schedule-induced polydipsia in the spontaneously hypertensive rat and its relation to impulsive behaviour. Behav. Brain Res. 223, 58-69.
66. Isles, A. R., Humby, T., Walters, E. and Wilkinson, L. S. (2004). Common genetic effects on variation in impulsivity and activity in mice. J. Neurosci. 24, 6733-6740. (Pubitemid 38993893)
67. Kertzman, S., Grinspan, H., Birger, M. and Kotler, M. (2006). Computerized neuropsychological examination of impulsiveness: A selective review. Isr. J. Psychiatry Relat. Sci. 43, 74-80. (Pubitemid 44090648)
68. Kirby, K. N. and Petry, N. M. (2004). Heroin and cocaine abusers have higher discount rates for delayed rewards than alcoholics or non-drug-using controls. Addiction 99, 461-471. (Pubitemid 38496662)
69. Kolokotroni, K. Z., Rodgers, R. J. and Harrison, A. A. (2011). Acute nicotine increases both impulsive choice and behavioural disinhibition in rats. Psychopharmacology (Berl.) 217, 455-473.
70. Lee, B., London, E. D., Poldrack, R. A., Farahi, J., Nacca, A., Monterosso, J. R., Mumford, J. A., Bokarius, A. V., Dahlbom, M., Mukherjee, J. et al. (2009). Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity. J. Neurosci. 29, 14734-14740.
71. Levy, D. J. and Glimcher, P. W. (2012). The root of all value: a neural common currency for choice. Curr. Opin. Neurobiol. [Epub ahead of print] doi.org/10.1016/j.conb.2012.06.001.
72. Lindström, M. B., Ryding, E., Bosson, P., Ahnlide, J. A., Rosén, I. and Träskman-Bendz, L. (2004). Impulsivity related to brain serotonin transporter binding capacity in suicide attempters. Eur. Neuropsychopharmacol. 14, 295-300. (Pubitemid 38649086)
73. Liu, L., Guan, L. L., Chen, Y., Ji, N., Li, H. M., Li, Z. H., Qian, Q. J., Yang, L., Glatt, S. J., Faraone, S. V. et al. (2011). Association analyses of MAOA in Chinese Han subjects with attention-deficit/hyperactivity disorder: family-based association test, case-control study, and quantitative traits of impulsivity. Am. J. Med. Genet. 156 B, 737-748.
74. Logan, G. D., Schachar, R. J. and Tannock, R. (1997). Impulsivity and inhibitory control. Psychol. Sci. 8, 60-64.
75. Logue, S. F., Swartz, R. J. and Wehner, J. M. (1998). Genetic correlation between performance on an appetitive-signaled nosepoke task and voluntary ethanol consumption. Alcohol. Clin. Exp. Res. 22, 1912-1920. (Pubitemid 29031007)
76. Lombardo, L. E., Bearden, C. E., Barrett, J., Brumbaugh, M. S., Pittman, B., Frangou, S. and Glahn, D. C. (2012). Trait impulsivity as an endophenotype for bipolar I disorder. Bipolar Disord. 14, 565-570.
77. Loos, M., Van der Sluis, S., Bochdanovits, Z., Van Zutphen, I. J., Pattij, T., Stiedl, O., Neuro-BSIK Mouse Phenomics consortium, Smit, A. B. and Spijker, S. (2009). Activity and impulsive action are controlled by different genetic and environmental factors. Genes Brain Behav. 8, 817-828.
78. Loos, M., Pattij, T., Janssen, M. C., Counotte, D. S., Schoffelmeer, A. N., Smit, A. B., Spijker, S. and Van Gaalen, M. M. (2010). Dopamine receptor D1/D5 gene expression in the medial prefrontal cortex predicts impulsive choice in rats. Cereb. Cortex 20, 1064-1070.
79. Lovic, V., Keen, D., Fletcher, P. J. and Fleming, A. S. (2011). Early-life maternal separation and social isolation produce an increase in impulsive action but not impulsive choice. Behav. Neurosci. 125, 481-491.
80. Mar, A. C., Walker, A. L., Theobald, D. E., Eagle, D. M. and Robbins, T. W. (2011). Dissociable effects of lesions to orbitofrontal cortex subregions on impulsive choice in the rat. J. Neurosci. 31, 6398-6404.
81. Marusich, J. A. and Bardo, M. T. (2009). Differences in impulsivity on a delay-discounting task predict self-administration of a low unit dose of methylphenidate in rats. Behav. Pharmacol. 20, 447-454.
82. McNamara, R., Dalley, J. W., Robbins, T. W., Everitt, B. J. and Belin, D. (2010). Traitlike impulsivity does not predict escalation of heroin self-administration in the rat. Psychopharmacology (Berl.) 212, 453-464.
83. Mendez, I. A., Simon, N. W., Hart, N., Mitchell, M. R., Nation, J. R., Wellman, P. J. and Setlow, B. (2010). Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task. Behav. Neurosci. 124, 470-477.
84. Meyer, J. H., Wilson, A. A., Rusjan, P., Clark, M., Houle, S., Woodside, S., Arrowood, J., Martin, K. and Colleton, M. (2008). Serotonin2A receptor binding potential in people with aggressive and violent behaviour. J. Psychiatry Neurosci. 33, 499-508.
85. Michaelides, M., Thanos, P. K., Kim, R., Cho, J., Ananth, M., Wang, G. J. and Volkow, N. D. (2012). PET imaging predicts future body weight and cocaine preference. Neuroimage 59, 1508-1513.
86. Moeller, F. G., Barratt, E. S., Dougherty, D. M., Schmitz, J. M. and Swann, A. C. (2001). Psychiatric aspects of impulsivity. Am. J. Psychiatry 158, 1783-1793. (Pubitemid 33054770)
87. Molander, A. C., Mar, A., Norbury, A., Steventon, S., Moreno, M., Caprioli, D., Theobald, D. E., Belin, D., Everitt, B. J., Robbins, T. W. et al. (2011). High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress. Psychopharmacology (Berl.) 215, 721-731.
88. Monterosso, J. and Ainslie, G. (1999). Beyond discounting: possible experimental models of impulse control. Psychopharmacology (Berl.) 146, 339-347. (Pubitemid 29513275)
89. Moreno, M., Cardona, D., Gómez, M. J., Sánchez-Santed, F., Tobeña, A., Fernández-Teruel, A., Campa, L., Suñol, C., Escarabajal, M. D., Torres, C. et al. (2010). Impulsivity characterization in the Roman high-and low-avoidance rat strains: behavioral and neurochemical differences. Neuropsychopharmacology 35, 1198-1208.
90. Moreno, M., Gutiérrez-Ferre, V. E., Ruedas, L., Campa, L., Suñol, C. and Flores, P. (2012). Poor inhibitory control and neurochemical differences in high compulsive drinker rats selected by schedule-induced polydipsia. Psychopharmacology (Berl.) 219, 661-672.
91. Moreno-López, L., Catena, A., Fernández-Serrano, M. J., Delgado-Rico, E., Stamatakis, E. A., Pérez-García, M. and Verdejo-García, A. (2012). Trait impulsivity and prefrontal gray matter reductions in cocaine dependent individuals. Drug Alcohol Depend. 125, 208-214.
92. Muir, J. L., Everitt, B. J. and Robbins, T. W. (1996). The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction time task. Cereb. Cortex 6, 470-481.
93. Murphy, E. R., Fernando, A. B., Urcelay, G. P., Robinson, E. S., Mar, A. C., Theobald, D. E., Dalley, J. W. and Robbins, T. W. (2012). Impulsive behaviour induced by both NMDA receptor antagonism and GABAA receptor activation in rat ventromedial prefrontal cortex. Psychopharmacology (Berl.) 219, 401-410.
94. Nader, M. A. and Czoty, P. W. (2005). PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. Am. J. Psychiatry 162, 1473-1482. (Pubitemid 41105561)
95. Nader, M. A., Morgan, D., Gage, H. D., Nader, S. H., Calhoun, T. L., Buchheimer, N., Ehrenkaufer, R. and Mach, R. H. (2006). PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys. Nat. Neurosci. 9, 1050-1056. (Pubitemid 44264918)
96. Nikiforuk, A., Popik, P., Drescher, K. U., Van Gaalen, M., Relo, A. L., Mezler, M., Marek, G., Schoemaker, H., Gross, G. and Bespalov, A. (2010). Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats. J. Pharmacol. Exp. Ther. 335, 665-673.
97. Oberlin, B. G. and Grahame, N. J. (2009). High-alcohol preferring mice are more impulsive than low-alcohol preferring mice as measured in the delay discounting task. Alcohol. Clin. Exp. Res. 33, 1294-1303.
98. Ohno, Y., Okano, M., Masui, A., Imaki, J., Egawa, M., Yoshihara, C., Tatara, A., Mizuguchi, Y., Sasa, M. and Shimizu, S. (2012). Region-specific elevation of D1 receptor-mediated neurotransmission in the nucleus accumbens of SHR, a rat model of attention deficit/hyperactivity disorder. Neuropharmacology 63, 547-554.
99. Oswald, L. M., Wong, D. F., Zhou, Y., Kumar, A., Brasic, J., Alexander, M., Ye, W., Kuwabara, H., Hilton, J. and Wand, G. S. (2007). Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine release. Neuroimage 36, 153-166. (Pubitemid 46617942)
100. Paine, T. A., Dringenberg, H. C. and Olmstead, M. C. (2003). Effects of chronic cocaine on impulsivity: relation to cortical serotonin mechanisms. Behav. Brain Res. 147, 135-147. (Pubitemid 37491422)
101. Paine, T. A., Tomasiewicz, H. C., Zhang, K. and Carlezon, W. A., Jr (2007). Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague-Dawley rats. Biol. Psychiatry 62, 687-693. (Pubitemid 47314378)
102. Paterson, N. E., Ricciardi, J., Wetzler, C. and Hanania, T. (2011). Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone. Neurosci. Res. 69, 41-50.
103. Pattij, T. and Vanderschuren, L. J. (2008). The neuropharmacology of impulsive behaviour. Trends Pharmacol. Sci. 29, 192-199.
104. Pattij, T., Janssen, M. C., Schepers, I., González-Cuevas, G., De Vries, T. J. and Schoffelmeer, A. N. (2007a). Effects of the cannabinoid CB1 receptor antagonist rimonabant on distinct measures of impulsive behavior in rats. Psychopharmacology (Berl.) 193, 85-96. (Pubitemid 46906632)
105. Pattij, T., Janssen, M. C., Vanderschuren, L. J., Schoffelmeer, A. N. and Van Gaalen, M. M. (2007b). Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response control. Psychopharmacology (Berl.) 191, 587-598. (Pubitemid 46355887)
106. Peña-Oliver, Y., Buchman, V. L., Dalley, J. W., Robbins, T. W., Schumann, G., Ripley, T. L., King, S. L. and Stephens, D. N. (2012). Deletion of alpha-synuclein decreases impulsivity in mice. Genes Brain Behav. 11, 137-146.
107. Perry, J. C. and Körner, A. C. (2011). Impulsive phenomena, the impulsive character (der Triebhafte Charakter) and DSM personality disorders. J. Pers. Disord. 25, 586-606.
108. Perry, J. L., Larson, E. B., German, J. P., Madden, G. J. and Carroll, M. E. (2005). Impulsivity (delay discounting) as a predictor of acquisition of IV cocaine self-administration in female rats. Psychopharmacology (Berl.) 178, 193-201. (Pubitemid 40379214)
109. Perry, J. L., Stairs, D. J. and Bardo, M. T. (2008). Impulsive choice and environmental enrichment: effects of d-amphetamine and methylphenidate. Behav. Brain Res. 193, 48-54.
110. Pezze, M. A., Dalley, J. W. and Robbins, T. W. (2007). Differential roles of dopamine D1 and D2 receptors in the nucleus accumbens in attentional performance on the five-choice serial reaction time task. Neuropsychopharmacology 32, 273-283. (Pubitemid 46106934)
111. Piazza, P. V., Deminière, J. M., Maccari, S., Mormède, P., Le Moal, M. and Simon, H. (1990). Individual reactivity to novelty predicts probability of amphetamine self-administration. Behav. Pharmacol. 1, 339-345.
112. Porrino, L. J., Daunais, J. B., Smith, H. R. and Nader, M. A. (2004). The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration. Neurosci. Biobehav. Rev. 27, 813-820. (Pubitemid 38199611)
113. Pothuizen, H. H., Jongen-Rêlo, A. L., Feldon, J. and Yee, B. K. (2005). Double dissociation of the effects of selective nucleus accumbens core and shell lesions on impulsive-choice behaviour and salience learning in rats. Eur. J. Neurosci. 22, 2605-2616. (Pubitemid 41759003)
114. Poulos, C. X., Le, A. D. and Parker, J. L. (1995). Impulsivity predicts individual susceptibility to high levels of alcohol self-administration. Behav. Pharmacol. 6, 810-814.
115. Radwanska, K. and Kaczmarek, L. (2012). Characterization of an alcohol addiction-prone phenotype in mice. Addict. Biol. 17, 601-612.
116. Reist, C., Mazzanti, C., Vu, R., Fujimoto, K. and Goldman, D. (2004). Interrelationships of intermediate phenotypes for serotonin function, impulsivity, and a 5-HT2A candidate allele: His452Tyr. Mol. Psychiatry 9, 871-878. (Pubitemid 39294643)
117. Riccio, C. A., Reynolds, C. R., Lowe, P. and Moore, J. J. (2002). The continuous performance test: a window on the neural substrates for attention? Arch. Clin. Neuropsychol. 17, 235-272. (Pubitemid 34201745)
118. Richards, J. B., Zhang, L., Mitchell, S. H. and De Wit, H. (1999). Delay or probability discounting in a model of impulsive behavior: effect of alcohol. J. Exp. Anal. Behav. 71, 121-143.
119. Robbins, T. W. (2002). The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology (Berl.) 163, 362-380.
120. Robinson, E. S., Dalley, J. W., Theobald, D. E., Glennon, J. C., Pezze, M. A., Murphy, E. R. and Robbins, T. W. (2008a). Opposing roles for 5-HT2A and 5-HT2C receptors in the nucleus accumbens on inhibitory response control in the 5-choice serial reaction time task. Neuropsychopharmacology 33, 2398-2406.
121. Robinson, E. S., Eagle, D. M., Mar, A. C., Bari, A., Banerjee, G., Jiang, X., Dalley, J. W. and Robbins, T. W. (2008b). Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat. Neuropsychopharmacology 33, 1028-1037. (Pubitemid 351367544)
122. Robinson, E. S., Eagle, D. M., Economidou, D., Theobald, D. E., Mar, A. C., Murphy, E. R., Robbins, T. W. and Dalley, J. W. (2009). Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: specific deficits in 'waiting' versus 'stopping'. Behav. Brain Res. 196, 310-316.
123. Roesch, M. R., Takahashi, Y., Gugsa, N., Bissonette, G. B. and Schoenbaum, G. (2007). Previous cocaine exposure makes rats hypersensitive to both delay and reward magnitude. J. Neurosci. 27, 245-250. (Pubitemid 46089978)
124. Rogers, R. D., Baunez, C., Everitt, B. J. and Robbins, T. W. (2001). Lesions of the medial and lateral striatum in the rat produce differential deficits in attentional performance. Behav. Neurosci. 115, 799-811. (Pubitemid 32738326)
125. Sagvolden, T. and Xu, T. (2008). l-Amphetamine improves poor sustained attention while d-amphetamine reduces overactivity and impulsiveness as well as improves sustained attention in an animal model of Attention-Deficit/ Hyperactivity Disorder (ADHD). Behav. Brain Funct. 4, 3.
126. Schippers, M. C., Binnekade, R., Schoffelmeer, A. N., Pattij, T. and De Vries, T. J. (2012). Unidirectional relationship between heroin self-administration and impulsive decision-making in rats. Psychopharmacology (Berl.) 219, 443-452.
127. Schneider, T., Ilott, N., Brolese, G., Bizarro, L., Asherson, P. J. and Stolerman, I. P. (2011). Prenatal exposure to nicotine impairs performance of the 5-choice serial reaction time task in adult rats. Neuropsychopharmacology 36, 1114-1125.
128. Schneider, T., Bizarro, L., Asherson, P. J. and Stolerman, I. P. (2012). Hyperactivity, increased nicotine consumption and impaired performance in the five-choice serial reaction time task in adolescent rats prenatally exposed to nicotine. Psychopharmacology (Berl.) 223, 401-415.
129. Semenova, S. and Markou, A. (2007). The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task. Neuropharmacology 52, 863-872. (Pubitemid 46227477)
130. Sukhotina, I. A., Dravolina, O. A., Novitskaya, Y., Zvartau, E. E., Danysz, W. and Bespalov, A. Y. (2008). Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in rats. Psychopharmacology (Berl.) 196, 211-220.
131. Sullivan, P. F., Daly, M. J. and O'Donovan, M. (2012). Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat. Rev. Genet. 13, 537-551.
132. Sweitzer, M. M., Halder, I., Flory, J. D., Craig, A. E., Gianaros, P. J., Ferrell, R. E. and Manuck, S. B. (2012). Polymorphic variation in the dopamine D4 receptor predicts delay discounting as a function of childhood socioeconomic status: evidence for differential susceptibility. Soc. Cogn. Affect. Neurosci. [Epub ahead of print] doi.org/10.1093/scan/nss020.
133. Szerman, N., Peris, L., Mesías, B., Colis, P., Rosa, J. and Prieto, A. (2005). Reboxetine for the treatment of patients with Cocaine Dependence Disorder. Hum. Psychopharmacol. 20, 189-192. (Pubitemid 40561853)
134. Talpos, J. C., Wilkinson, L. S. and Robbins, T. W. (2006). A comparison of multiple 5-HT receptors in two tasks measuring impulsivity. J. Psychopharmacol. 20, 47-58.
135. Tsutsui-Kimura, I., Ohmura, Y., Izumi, T., Yamaguchi, T., Yoshida, T. and Yoshioka, M. (2010a). Endogenous acetylcholine modulates impulsive action via alpha4beta2 nicotinic acetylcholine receptors in rats. Eur. J. Pharmacol. 641, 148-153.
136. Tsutsui-Kimura, I., Ohmura, Y., Izumi, T., Yamaguchi, T., Yoshida, T. and Yoshioka, M. (2010b). Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex. Psychopharmacology (Berl.) 209, 351-359.
137. Uslaner, J. M. and Robinson, T. E. (2006). Subthalamic nucleus lesions increase impulsive action and decrease impulsive choice - mediation by enhanced incentive motivation? Eur. J. Neurosci. 24, 2345-2354. (Pubitemid 44622355)
138. Van Den Bergh, F. S., Bloemarts, E., Chan, J. S., Groenink, L., Olivier, B. and Oosting, R. S. (2006a). Spontaneously hypertensive rats do not predict symptoms of attention-deficit hyperactivity disorder. Pharmacol. Biochem. Behav. 83, 380-390. (Pubitemid 43736958)
139. Van Den Bergh, F. S., Bloemarts, E., Groenink, L., Olivier, B. and Oosting, R. S. (2006b). Delay aversion: effects of 7-OH-DPAT, 5-HT1A/1B-receptor stimulation and D-cycloserine. Pharmacol. Biochem. Behav. 85, 736-743. (Pubitemid 46157138)
140. Verdejo-García, A., Lawrence, A. J. and Clark, L. (2008). Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. Neurosci. Biobehav. Rev. 32, 777-810.
141. Wade, T. R., De Wit, H. and Richards, J. B. (2000). Effects of dopaminergic drugs on delayed reward as a measure of impulsive behavior in rats. Psychopharmacology (Berl.) 150, 90-101. (Pubitemid 30350818)
142. Whiteside, S. P. and Lynam, D. R. (2003). Understanding the role of impulsivity and externalizing psychopathology in alcohol abuse: application of the UPPS impulsive behavior scale. Exp. Clin. Psychopharmacol. 11, 210-217. (Pubitemid 36961191)
143. Wilbertz, G., Van Elst, L. T., Delgado, M. R., Maier, S., Feige, B., Philipsen, A. and Blechert, J. (2012). Orbitofrontal reward sensitivity and impulsivity in adult attention deficit hyperactivity disorder. Neuroimage 60, 353-361.
144. Williams, J. and Taylor, E. (2006). The evolution of hyperactivity, impulsivity and cognitive diversity. J. R. Soc. Interface 3, 399-413. (Pubitemid 46682095)
145. Wilson, T. D. and Dunn, E. W. (2004). Self-knowledge: its limits, value, and potential for improvement. Annu. Rev. Psychol. 55, 493-518.
146. Winstanley, C. A. (2011). The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders. Br. J. Pharmacol. 164, 1301-1321.
147. Winstanley, C. A., Chudasama, Y., Dalley, J. W., Theobald, D. E., Glennon, J. C. and Robbins, T. W. (2003). Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats. Psychopharmacology (Berl.) 167, 304-314. (Pubitemid 36712978)
148. Winstanley, C. A., Theobald, D. E., Cardinal, R. N. and Robbins, T. W. (2004a). Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice. J. Neurosci. 24, 4718-4722. (Pubitemid 38668195)
149. Winstanley, C. A., Theobald, D. E., Dalley, J. W., Glennon, J. C. and Robbins, T. W. (2004b). 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion. Psychopharmacology (Berl.) 176, 376-385. (Pubitemid 40012745)
150. Winstanley, C. A., Theobald, D. E., Dalley, J. W. and Robbins, T. W. (2005). Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders. Neuropsychopharmacology 30, 669-682. (Pubitemid 40397073)
151. Winstanley, C. A., Bachtell, R. K., Theobald, D. E., Laali, S., Green, T. A., Kumar, A., Chakravarty, S., Self, D. W. and Nestler, E. J. (2009). Increased impulsivity during withdrawal from cocaine self-administration: role for DeltaFosB in the orbitofrontal cortex. Cereb. Cortex 19, 435-444.
152. Wiskerke, J., Schetters, D., Van Es, I. E., Van Mourik, Y., Den Hollander, B. R., Schoffelmeer, A. N. and Pattij, T. (2011). μ-Opioid receptors in the nucleus accumbens shell region mediate the effects of amphetamine on inhibitory control but not impulsive choice. J. Neurosci. 31, 262-272.
153. Womersley, J. S., Hsieh, J. H., Kellaway, L. A., Gerhardt, G. A. and Russell, V. A. (2011). Maternal separation affects dopamine transporter function in the spontaneously hypertensive rat: an in vivo electrochemical study. Behav. Brain Funct. 7, 49.
154. Wooters, T. E. and Bardo, M. T. (2011). Methylphenidate and fluphenazine, but not amphetamine, differentially affect impulsive choice in spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rats. Brain Res. 1396, 45-53.
155. Yates, J. R., Marusich, J. A., Gipson, C. D., Beckmann, J. S. and Bardo, M. T. (2012). High impulsivity in rats predicts amphetamine conditioned place preference. Pharmacol. Biochem. Behav. 100, 370-376.
156. Zhu, J., Apparsundaram, S., Bardo, M. T. and Dwoskin, L. P. (2005). Environmental enrichment decreases cell surface expression of the dopamine transporter in rat medial prefrontal cortex. J. Neurochem. 93, 1434-1443. (Pubitemid 40853266)