High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats

Psychopharmacology

Volumn 222, Issue 1, 2012, Pages 89-97

  Dilleen, Ruth ^a,b,e   Pelloux, Yann ^a,b   Mar, Adam C ^a,b   Molander, Anna ^d   Robbins, Trevor W ^a,b   Everitt, Barry J ^a,b   Dalley, Jeffrey W ^a,b,c   Belin, David ^e,f  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UK   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

^d NEUROSEARCH A S   (Denmark)

^e INSERM   (France)

^f UNIVERSITÉ DE POITIERS   (France)

Author keywords

Addiction; Anxiety; Cocaine; Escalation; Heroin; Self administration

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DRUG SELF ADMINISTRATION; ENDOPHENOTYPE; HEROIN DEPENDENCE; MALE; MAZE TEST; NONHUMAN; OPIATE ADDICTION; PREDICTION; PRIORITY JOURNAL; RAT;

ANIMALS; ANXIETY; COCAINE; DISEASE MODELS, ANIMAL; HEROIN; MALE; MAZE LEARNING; RATS; SELF ADMINISTRATION; SUBSTANCE-RELATED DISORDERS;

EID: 84861916259     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2626-4     Document Type: Article

References (51)

1. Ahmed SH, Koob GF (1998) Transition from moderate to excessive drug intake: change in hedonic set point. Science 282(5387):298-300 (Pubitemid 28487203)
2. Ahmed SH, Walker JR, Koob GF (2000) Persistent increase in the motivation to take heroin in rats with a history of drug escalation. Neuropsychopharmacology 22(4):413-421 (Pubitemid 30105769)
3. Ambrose-Lanci LM, Sterling RC, Van Bockstaele EJ (2010) Cocaine withdrawal-induced anxiety in females: impact of circulating estrogen and potential use of delta-opioid receptor agonists for treatment. J Neurosci Res 88(4):816-824
4. Anthony JC, Tien AY, Petronis KR (1989) Epidemiologic evidence on cocaine use and panic attacks. Am J Epidemiol 129(3):543-549
5. APA (2000) Diagnostic and statistical manual of mental Disorders fourth edition, text revision (DSM-IV TR). American Psychiatric Association, Washington
6. Badiani A, Belin D, Epstein D, Calu D, Shaham Y (2011) Opiate versus psychostimulant addiction: the differences do matter. Nat Rev Neurosci 12(11):685-700
7. Bardo MT (1998) Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens. Crit Rev Neurobiol 12(1-2):37-67
8. Belin D, Everitt BJ (2008) Cocaine-seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron 57(3):432-441 (Pubitemid 351179162)
9. Belin D, Mar A, Dalley JW, Robbins TW, Everitt BJ (2008) High impulsivity predicts the switch to compulsive cocaine-taking. Science 320(5881):1352-1355 (Pubitemid 351929473)
10. Belin D, Berson N, Balado E, Piazza PV, Deroche-Gamonet V (2011) High-novelty-preference rats are predisposed to compulsive cocaine self-administration. Neuropsychopharmacology 36(3):569-579
11. Blanchard DC, Blanchard RJ (1999) Cocaine potentiates defensive behaviors related to fear and anxiety. Neurosci Biobehav Rev 23(7):981-991 (Pubitemid 29502403)
12. Blanchard RJ, Kaawaloa JN, Hebert MA, Blanchard DC (1999) Cocaine produces panic-like flight responses in mice in the mouse defense test battery. Pharmacol Biochem Behav 64(3):523-528 (Pubitemid 29488480)
13. Blanchard RJ, Hebert M, Dulloog L, Markham C, Figueira R, Nishimura O, Newsham K, Kaawaloa JN, Blanchard DC (2000) Cocaine-induced sniffing stereotypy changes in response to threat. Pharmacol Biochem Behav 66(2):249-256 (Pubitemid 30394609)
14. Bush D, Vaccarino F (2007) Individual differences in elevated plusmaze exploration predicted progressive-ratio cocaine selfadministration break points in Wistar rats. Psychopharmacology 194(2):211-219 (Pubitemid 47457951)
15. Bystritsky A, Ackerman DL, Pasnau RO (1991) Low dose desipramine treatment of cocaine-related panic attacks. J Nerv Ment Dis 179(12):755-758
16. Cruz FC, Quadros IM, Hogenelst K, Planeta CS, Miczek KA (2011) Social defeat stress in rats: escalation of cocaine and "speedball" binge self-administration, but not heroin. Psychopharmacology (Berl) 215:165-175
17. Dalley JW, Fryer T, Brichard L, Robinson E, Theobald DE, Laane K, Pena Y, Murphy E, Shah Y, Probst K, Abakumova I, Aigbirhio F, Richards H, Hong Y, Baron J, Everitt BJ, Robbins TW (2007) Nucleus accumbens d2/3 receptors predict trait impulsivity and cocaine reinforcement. Science 315(5816):1267-1270 (Pubitemid 46364262)
18. David V, Gold LH, Koob GF, Cazala P (2001) Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice. Neuropsychopharmacology 24(3):300-318 (Pubitemid 32144814)
19. Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci U S A 85 (14):5274-5278
20. Ettenberg A, Pettit HO, Bloom FE, Koob GF (1982) Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems. Psychopharmacology 78(3):204-209 (Pubitemid 13250843)
21. Ettenberg A, Raven MA, Danluck DA, Necessary BD (1999) Evidence for opponent-process actions of intravenous cocaine. Pharmacol Biochem Behav 64(3):507-512 (Pubitemid 29488477)
22. Goeders NE (1991) Cocaine differentially affects benzodiazepine receptors in discrete regions of the rat brain: persistence and potential mechanisms mediating these effects. J Pharmacol Exp Ther 259(2):574-581
23. Gunnarsdottir ED, Pingitore RA, Spring BJ, Konopka LM, Crayton JW, Milo T, Shirazi P (2000) Individual differences among cocaine users. Addict Behav 25(5):641-652 (Pubitemid 30609670)
24. Harro J, Kiivet RA, Lang A, Vasar E (1990) Rats with anxious or non-anxious type of exploratory behaviour differ in their brain cck-8 and benzodiazepine receptor characteristics. Behav Brain Res 39(1):63-71 (Pubitemid 20182172)
25. Homberg JR, van den Akker M, Raaso HS, Wardeh G, Binnekade R, Schoffelmeer AN, de Vries TJ (2002) Enhanced motivation to self-administer cocaine is predicted by self-grooming behaviour and relates to dopamine release in the rat medial prefrontal cortex and amygdala. Eur J Neurosci 15(9):1542-1550 (Pubitemid 35477985)
26. Johnson SW, North RA (1992) Opioids excite dopamine neurons by hyperpolarization of local interneurons. J Neurosci 12(2):483-488
27. Khantzian EJ (1985) The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. Am J Psychiatry 142(11):1259-1264
28. Koob GF, Moal ML (1997) Drug abuse: hedonic homeostatic dysregulation. Science 278(5335):52-58 (Pubitemid 27446270)
29. Le Merrer J, Cagniard B, Cazala P (2006) Modulation of anxiety by mu-opioid receptors of the lateral septal region in mice. Pharmacol Biochem Behav 83(3):465-479 (Pubitemid 43736964)
30. Lejuez CW, Paulson A, Daughters SB, Bornovalova MA, Zvolensky MJ (2006). The association between heroin use and anxiety sensitivity among inner-city individuals in residential drug use treatment. Behav Res Ther 44(5), 5, 667-677
31. Lejuez CW, Zvolensky MJ, Daughters SB, Bornovalova MA, Paulson A, Tull MT, Ettinger K, Otto MW (2008) Anxiety sensitivity: a unique predictor of dropout among inner-city heroin and crack/cocaine users in residential substance use treatment. Behav Res Ther 46(7):811-818
32. Maier EY, Ledesma RT, Seiwell AP, Duvauchelle CL (2008) Diazepam alters cocaine self-administration, but not cocaine-stimulated locomotion or nucleus accumbens dopamine. Pharmacol Biochem Behav 91(1):202-207
33. McNamara R, Dalley JW, Robbins TW, Everitt BJ, Belin D (2010) Trait-like impulsivity does not predict escalation of heroin self-administration in the rat. Psychopharmacology 212(4):453-464
34. Molander AC, Mar A, Norbury A, Steventon S, Moreno M, Caprioli D, Theobald DE, Belin D, Everitt BJ, Robbins TW, Dalley JW (2011) High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress. Psychopharmacology (Berl) 215(4):721-731
35. Nestler EJ (2005) Is there a common molecular pathway for addiction? Nat Neurosci 8(11):1445-1449
36. Norton GR (2001) Substance use/abuse and anxiety sensitivity what are the relationships? Addict Behav 26:935-946
37. Pelloux Y, Costentin J, Duterte-Boucher D (2009) Anxiety increases the place conditioning induced by cocaine in rats. Behav Brain Res 197(2):311-316
38. Pellow S, Chopin P, File SE, Briley M (1985) Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14(3):149-167 (Pubitemid 16239568)
39. Pettit HO, Ettenberg A, Bloom FE, Koob GF (1984) Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology (Berl) 84(2):167-173 (Pubitemid 14006568)
40. Rago L, Adojaan A, Harro J, Kiivet RA (1991) Correlation between exploratory activity in an elevated plus-maze and number of central and peripheral benzodiazepine binding sites. Naunyn Schmiedebergs Arch Pharmacol 343(3):301-306
41. Rogerio R, Takahashi RN (1992) Anxiogenic properties of cocaine in the rat evaluated with the elevated plus-maze. Pharmacol Biochem Behav 43(2):631-633
42. Salas-Ramirez KY, Frankfurt M, Alexander A, Luine VN, Friedman E (2010) Prenatal cocaine exposure increases anxiety, impairs cognitive function and increases dendritic spine density in adult rats: influence of sex. Neuroscience 169(3):1287-1295
43. Schulteis G, Yackey M, Risbrough V, Koob GF (1998) Anxiogenic-like effects of spontaneous and naloxone-precipitated opiate withdrawal in the elevated plus-maze. Pharmacol Biochem Behav 60 (3):727-731 (Pubitemid 28341934)
44. Schwarting RK, Thiel CM, Muller CP, Huston JP (1998) Relationship between anxiety and serotonin in the ventral striatum. NeuroReport 9(6):1025-1029 (Pubitemid 28266616)
45. Sherman JE, Zinser MC, Sideroff SI, Baker TB (1989) Subjective dimensions of heroin urges: influence of heroin-related and affectively negative stimuli. Addict Behav 14(6):611-623 (Pubitemid 20049858)
46. Sinha R (2001) How does stress increase risk of drug abuse and relapse? Psychopharmacology (Berl) 158(4):343-359
47. Van Ree JM, Ramsey N (1987) The dopamine hypothesis of opiate reward challenged. Eur J Pharmacol 134(2):239-243 (Pubitemid 17015957)
48. Walker QD, Schramm-Sapyta NL, Caster JM, Waller ST, Brooks MP, Kuhn CM (2009) Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults. Pharmacol Biochem Behav 91(3):398-408
49. Waters RP, See RE (2011) Chronic cocaine self-administration attenuates the anxiogenic-like and stress potentiating effects of the benzodiazepine inverse agonist, fg 7142. Pharmacol Biochem Behav 99(3):408-413
50. Wise RA (1996) Neurobiology of addiction. Curr Opin Neurobiol 6:243-251
51. Zhou Y, Spangler R, Ho A, Kreek MJ (2003) Increased crh mrna levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine. Brain Res Mol Brain Res 114(1):73-79 (Pubitemid 36627998)