Endogenous acetylcholine modulates impulsive action via α4β2 nicotinic acetylcholine receptors in rats

European Journal of Pharmacology

Volumn 641, Issue 2-3, 2010, Pages 148-153

  Tsutsui Kimura, Iku ^a   Ohmura, Yu ^a,b   Izumi, Takeshi ^a   Yamaguchi, Taku ^a   Yoshida, Takayuki ^a   Yoshioka, Mitsuhiro ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

5 choice serial reaction time task; Attention deficit hyperactivity disorder; Impulsive behavior; Impulsivity; Premature responding; Response inhibition

Indexed keywords

ACETYLCHOLINE; NICOTINIC RECEPTOR ALPHA4BETA2;

3 CHOICE SERIAL REACTION TIME TASK; ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HORMONE ACTION; IMPULSIVENESS; LATENT PERIOD; MALE; MOTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION TIME; TRAINING;

ACETYLCHOLINE; ACONITINE; ANIMALS; BEHAVIOR, ANIMAL; CHOICE BEHAVIOR; DIHYDRO-BETA-ERYTHROIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; IMPULSIVE BEHAVIOR; MALE; NICOTINE; RATS; RATS, WISTAR; REACTION TIME; RECEPTORS, NICOTINIC;

EID: 77954083146     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.05.028     Document Type: Article

References (38)

1. Alkondon M., Albuquerque E.X. The nicotinic acetylcholine receptor subtypes and their function in the hippocampus and cerebral cortex. Prog. Brain Res. 2004, 145:109-120.
2. Beane M., Marrocco R.T. Norepinephrine and acetylcholine mediation of the components of reflexive attention: implications for attention deficit disorders. Prog. Neurobiol. 2004, 74:167-181.
3. Blondel A., Sanger D.J., Moser P.C. Characterisation of the effects of nicotine in the five-choice serial reaction time task in rats: antagonist studies. Psychopharmacology 2000, 149:293-305.
4. Broersen L.M., Uylings H.B. Visual attention task performance in Wistar and Lister hooded rats: response inhibition deficits after medial prefrontal cortex lesions. Neuroscience 1999, 94:47-57.
5. Brookes K., Xu X., Chen W., Zhou K., Neale B., Lowe N. The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol. Psychiatry 2006, 11:934-953.
6. Chudasama Y., Passetti F., Rhodes S.E., Lopian D., Desai A., Robbins T.W. Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity. Behav. Brain Res. 2003, 146:105-119.
7. Cole B.J., Robbins T.W. Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats: implications for theories of selective attention and arousal. Behav. Brain Res. 1989, 33:165-179.
8. Cordero-Erausquin M., Marubio L.M., Klink R., Changeux J.P. Nicotinic receptor function: new perspectives from knockout mice. Trends Pharmacol. Sci. 2000, 21:211-217.
9. Court J., Clementi F. Distribution of nicotinic subtypes in human brain. Alzheimer Dis. Assoc. Disord. 1995, 9(Suppl. 2):6-14.
10. Curzon P., Brion J.D., Decker M.W. Effect of intraventricular injections of dihydro-beta-erythroidine (DH beta E) on spatial memory in the rat. Brain Res. 1996, 714:185-191.
11. Dallery J., Locey M.L. Effects of acute and chronic nicotine on impulsive choice in rats. Behav. Pharmacol. 2005, 16:15-23.
12. Dougherty D.M., Bjork J.M., Huckabee H.C., Moeller F.G., Swann A.C. Laboratory measures of aggression and impulsivity in women with borderline personality disorder. Psychiatry Res. 1999, 85:315-326.
13. Enticott P.G., Ogloff J.R., Bradshaw J.L. Response inhibition and impulsivity in schizophrenia. Psychiatry Res. 2008, 157:251-254.
14. Galzi J.L., Changeux J.P. Neuronal nicotinic receptors: molecular organization and regulations. Neuropharmacology 1995, 34:563-582.
15. Grottick A.J., Higgins G.A. Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task. Behav. Brain Res. 2000, 117:197-208.
16. Guan L., Wang B., Chen Y., Yang L., Li J., Qian Q., Wang Z., Faraone S.V., Wang Y. A high-density single-nucleotide polymorphism screen of 23 candidate genes in attention deficit hyperactivity disorder: suggesting multiple susceptibility genes among Chinese Han population. Mol. Psychiatry 2009, 14:546-554.
17. Harvey S.C., Luetje C.W. Determinants of competitive antagonist sensitivity on neuronal nicotinic receptor beta subunits. J. Neurosci. 1996, 16:3798-3806.
18. Kent L., Middle F., Hawi Z., Fitzgerald M., Gill M., Feehan C., Craddock N. Nicotinic acetylcholine receptor alpha4 subunit gene polymorphism and attention deficit hyperactivity disorder. Psychiatr. Genet. 2001, 11:37-40.
19. Khiroug S.S., Khiroug L., Yakel J.L. Rat nicotinic acetylcholine receptor alpha2beta2 channels: comparison of functional properties with alpha4beta2 channels in Xenopus oocytes. Neuroscience 2004, 124:817-822.
20. Léna C., Changeux J.P. Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders. Curr. Opin. Neurobiol. 1997, 7:674-682.
21. Liang Y., Boules M., Shaw A.M., Williams K., Fredrickson P., Richelson E. Effect of a novel neurotensin analog, NT69 L, on nicotine-induced alterations in monoamine levels in rat brain. Brain Res. 2008, 1231:6-15.
22. Murphy E.R., Dalley J.W., Robbins T.W. Local glutamate receptor antagonism in the rat prefrontal cortex disrupts response inhibition in a visuospatial attentional task. Psychopharmacology 2005, 179:99-107.
23. Ohmura Y., Takahashi T., Kitamura N. Discounting delayed and probabilistic monetary gains and losses by smokers of cigarettes. Psychopharmacology 2005, 182:508-515.
24. Ohmura Y., Yamaguchi T., Futami Y., Togashi H., Izumi T., Matsumoto M., Yoshida T., Yoshioka M. Corticotropin releasing factor enhances attentional function as assessed by the five-choice serial reaction time task in rats. Behav. Brain Res. 2009, 198:429-433.
25. Pattij T., Janssen M.C., Vanderschuren L.J., Schoffelmeer A.N., van Gaalen M.M. Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response control. Psychopharmacology 2007, 191:587-598.
26. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1996, Academic Press, San Diego, London. 3rd edn.
27. Potter A.S., Newhouse P.A. Effects of acute nicotine administration on behavioral inhibition in adolescents with attention-deficit/hyperactivity disorder. Psychopharmacology 2004, 176:182-194.
28. Potter A.S., Newhouse P.A. Acute nicotine improves cognitive deficits in young adults with attention-deficit/hyperactivity disorder. Pharmacol. Biochem. Behav. 2008, 88:407-417.
29. Robbins T.W. The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology 2002, 163:362-380.
30. Solanto M.V. Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research. Behav. Brain Res. 2002, 130:65-71.
31. Todd R.D., Lobos E.A., Sun L.W., Neuman R.J. Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit/hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems. Mol. Psychiatry 2003, 8:103-108.
32. Tsutsui-Kimura I., Ohmura Y., Izumi T., Yamaguchi T., Yoshida T., Yoshioka M. The effects of serotonin and/or noradrenaline reuptake inhibitors on impulsive-like action assessed by the 3-choice serial reaction time task: a simple and valid model of impulsive action using rats. Behav. Pharmacol. 2009, 20:474-483.
33. Turek J.W., Kang C.H., Campbell J.E., Arneric S.P., Sullivan J.P. A sensitive technique for the detection of the alpha 7 neuronal nicotinic acetylcholine receptor antagonist, methyllycaconitine, in rat plasma and brain. J. Neurosci. Methods 1995, 61:113-118.
34. van Gaalen M.M., Brueqqeman R.J., Bronius P.F., Schoffelmeer A.N., Vanderschuren L.J. Behavioral disinhibition requires dopamine receptor activation. Psychopharmacology 2006, 187:73-85.
35. Ward J.M., Cockcroft V.B., Lunt G.G., Smillie F.S., Wonnacott S. Methyllycaconitine: a selective probe for neuronal alpha-bungarotoxin binding sites. FEBS Lett. 1990, 270:45-48.
36. Wilkinson R.T. Interaction of noise with knowledge of results and sleep deprivation. J. Exp. Psychol. 1963, 66:332-337.
37. Xi Z.X., Spiller K., Gardner E.L. Mechanism-based medication development for the treatment of nicotine dependence. Acta. Pharmacol. Sin. 2009, 30:723-739.
38. Yakir A., Rigbi A., Kanyas K., Pollak Y., Kahana G., Karni O., Eitan R., Kertzman S., Lerer B. Why do young women smoke? III. Attention and impulsivity as neurocognitive predisposing factors. Eur. Neuropsychopharmacol. 2007, 17:339-351.