Discovery of a potential anti-inflammatory agent: 3-Oxo-29-noroleana-1, 9(11),12-trien-2,20-dicarbonitrile

Journal of Medicinal Chemistry

Volumn 56, Issue 5, 2013, Pages 1984-1995

  You, Ran ^a   Long, Wenyan ^a   Lai, Zhonghui ^a   Sha, Lei ^a   Wu, Kai ^a   Yu, Xing ^a   Lai, Yisheng ^a   Ji, Hui ^a   Huang, Zhangjian ^a   Zhang, Yihua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

(18 BETA,20 BETA) 2 CYANO 3 OXOOLEANA 1,9(11),12 TRIEN 29 OIC ACID; (18 BETA,20 BETA) 2 HYDROXY 3 OXOOLEANA 1,9(11),12 TRIEN 29 AMIDE; (18 BETA,20 BETA) 2 HYDROXY 3 OXOOLEANA 1,9(11),12 TRIEN 29 OIC ACID; (18 BETA,20 BETA) 2 HYDROXY N METHYL 3 OXOOLEANA 1,9(11),12 TRIEN 29 AMIDE; (18 BETA,20 BETA) 2 IODO 3 OXO 29 NOROLEANA 1,9(11),12 TRIEN 20 CARBONITRILE; (18 BETA,20 BETA) 2 IODO 3 OXOOLEANA 1,9(11),12 TRIEN 29 OIC ACID; (18 BETA,20 BETA) 3 OXO 29 NOROLEANA 1,9(11),12 TRIEN 2,20 DICARBONITRILE; (18 BETA,20 BETA) 3 OXO 29 NOROLEANA 1,9(11),12 TRIEN 20 CARBONITRILE; (18 BETA,20 BETA) 3 OXOOLEANA 1,9(11),12 TRIEN 29 AMIDE; (18 BETA,20 BETA) 3 OXOOLEANA 1,9(11),12 TRIEN 29 OIC ACID; (18 BETA,20 BETA) 3 OXOOLEANA 9(11),12 DIEN 29 OIC ACID; (3 BETA,18 BETA,20 BETA) 3 HYDROXYOLEANA 9(11),12 DIEN 29 OIC ACID; (3 BETA,18 BETA,20 BETA) 3 HYDROXYOLEANA 9(11),12 DIEN29 OIC ACID; (3 BETA,18 BETA,20 BETA) 3,11 DIHYDROXYOLEANA 12 EN- 9 OIC ACID; 1 [(18 BETA,20 BETA) 2 HYDROXY 3 OXOOLEANA 1,9(11),12 TRIEN 29 OYL]IMIDAZOLE; ANTIINFLAMMATORY AGENT; METHYL (18 BETA,20 BETA) 2 CYANO 3 OXOOLEANA 1,9(11),12 TRIEN 29 OATE; METHYL (18 BETA,20 BETA) 2 HYDROXY 3 OXOOLEANA 1,9(11),12 TRIEN 29 OATE; METHYL (18 BETA,20 BETA) 2 IODO 3 OXOOLEANA 1,9(11),12 TRIEN 29 OATE; METHYL (18 BETA,20 BETA) 3 OXOOLEANA 1,9(11),12 TRIEN 29 OATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DEGRADATION; GENE EXPRESSION; MACROPHAGE; MOUSE; NONHUMAN; PHOSPHORYLATION; PROTEIN EXPRESSION; SEPTIC SHOCK;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GLYCYRRHETINIC ACID; I-KAPPA B PROTEINS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; NITRIC OXIDE SYNTHASE TYPE II; RECEPTORS, GLUCOCORTICOID; SHOCK, SEPTIC; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84875162681     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301652t     Document Type: Article

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