Resolution of inflammation: Prostaglandin E2 dissociates nuclear trafficking of individual NF-κB subunits (p65, p50) in stimulated rheumatoid synovial fibroblasts

Journal of Immunology

Volumn 175, Issue 10, 2005, Pages 6924-6930

  Gomez, Paul F ^a,b   Pillinger, Michael H ^a,b,c,d   Attur, Mukundan ^a,b   Marjanovic, Nada ^a,b   Dave, Mander ^a,b   Park, Jean ^a,b   Bingham III, Clifton O ^a,b   Al Mussawir, Hayf ^a,b   Abramson, Steven B ^a,b  

^a NYU HOSPITAL FOR JOINT DISEASES   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CELECOXIB; I KAPPA B ALPHA; IBUPROFEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN E2; PROTEIN P50; PROTEIN SUBUNIT; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING SITE; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REPORTER GENE; RHEUMATOID ARTHRITIS;

EID: 27744552036     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.10.6924     Document Type: Article

References (43)

1. 2 in rheumatoid arthritis synovial fibroblasts via tumor necrosis factor receptOr-55. J. Rheumatol. 30: 1680-1690.
2. Di Battista, J. A., H. Fahmi, Y. He, M. Zhang, J. Martel-Pelletier, and J. P. Pelletier. 2001. Differential regulation of interleukin-1β-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts. Clin. Exp. Rheumatol. 19: S3-S8.
3. Pillinger, M. H., P. B. Rosenthal, S. N. Tolani, B. Apsel, V. Dinsell, J. Greenberg, E. S. Chan, P. F. Gomez, and S. B. Abramson. 2003. Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activation. J. Immunol. 171: 6080-6089.
4. Jackson, J. R., J. A. Minton, M. L. Ho, N. Wei, and J. D. Winkler. 1997. Expression of vascular endothelial growth factor in synovial fibroblasts is induced by hypoxia and interleukin 1β. J. Rheumatol 24: 1253-1259.
5. Barchowsky, A., D. Frleta, and M. P. Vincenti. 2000. Integration of the NF-κB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts. Cytokine 12: 1469-1479.
6. Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16: 225-260.
7. Pessara, U., and N. Koch. 1990. Tumor necrosis factor α regulates expression of the major histocompatibility complex class II-associated invariant chain by binding of an NF-κB-like factor to a promoter element. Mol. Cell. Biol. 10: 4146-4154.
8. Ghosh, S., and M. Karin. 2002. Missing pieces in the NF-κB puzzle. Cell 109(Suppl.): S81-S93.
9. DiDonato, J., F. Mercurio, C. Rosette, J. Wu-Li, H. Suyang, S. Ghosh, and M. Karin. 1996. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16: 1295-1304.
10. Makarov, S. S. 2001. NF-κB in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction. Arthritis Res. 3: 200-206.
11. Vincenti, M. P., C. I. Coon, and C. E. Brinckerhoff. 1998. Nuclear factor κB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1β-stimulated synovial fibroblasts. Arthritis Rheum. 41: 1987-1994.
12. Vincenti, M. P., and C. E. Brinckerhoff. 2002. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res. 4: 157-164.
13. 2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase. FEBS Lett. 547: 75-79.
14. Crofford, L. J., B. Tan, C. J. McCarthy, and T. Hla. 1997. Involvement of nuclear factor κB in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes. Arthritis Rheum. 40: 226-236.
15. Sherman, M. P., E. E. Aeberhard, V. Z. Wong, J. M. Griscavage, and L. J. Ignarro. 1993. Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochem. Biophys. Res. Commun. 191: 1301-1308.
16. Eberhardt, W., D. Kunz, and J. Pfeilschifter. 1994. Pyrrolidine dithiocarbamate differentially affects interleukin 1β- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells. Biochem. Biophys. Res. Commun. 200: 163-170.
17. 2, which inhibits IgM secretion by peritoneal B-1a cells. J. Immunol. 154: 5630-5636.
18. Weissmann, G. 1993. Prostaglandins as modulators rather than mediators of inflammation. J. Lipid Mediat. 6: 275-286.
19. 1 inhibits chemoattractant-induced mitogen-activated protein kinase activity in human neutrophils. Adv. Prostaglandin Thromboxane Leukotrienes Res. 23: 311-316.
20. 1 hybrid mice. 21. Prevention of glomerulonephritis. Arthritis Rheum. 20: 1449-1456.
21. 1 on adjuvant arthritis. Nature 234: 304-305.
22. 1 inhibits collagenase gene expression in rabbit synoviocytes and human fibroblasts. Endocrinology 131: 21-28.
23. Suzuki, K., B. E. Rapuano, and R. S. Bockman. 1997. Role of protein kinase A in collagenase-1 gene regulation by prostaglandin E1: studies in a rabbit synoviocyte cell line, HIG-82. J. Bone Miner. Res. 12: 561-567.
24. Georgescu, H. I., D. Mendelow, and C. H. Evans, 1988. HIG-82: an established cell line from rabbit periarticular soft tissue, which retains the "activatable" phenotype. In Vitro Cell Dev. Biol. 24: 1015-1022.
25. Pillinger, M. H., V. Dinsell, B. Apsel, S. N. Tolani, N. Marjanovic, E. S. Chan, P. Gomez, R. Clancy, L. F. Chang, and S. B. Abramson. 2004. Regulation of metalloproteinases and NF-κB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA. Br. J. Pharmacol. 142: 973-982.
26. Clancy, R. M., P. F. Gomez, and S. B. Abramson. 2004. Nitric oxide sustains nuclear factor κB activation in cytokine-stimulated chondrocytes. Osteoarthritis Cartilage 12: 552-558.
27. Alessi, D. R., A. Cuenda, P. Cohen, D. T. Dudley, and A. R. Saltiel. 1995. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270: 27489-27494.
28. Poppers, D. M., P. Schwenger, and J. Vilcek. 2000. Persistent tumor necrosis factor signaling in normal human fibroblasts prevents the complete resynthesis of IκB-α. J. Biol. Chem. 275: 29587-29593.
29. Arend, W. P., M. Malyak, C. F. Bigler, M. F. Smith, Jr., and R. W. Janson. 1991. The biological role of naturally-occurring cytokine inhibitors. Br. J. Rheumatol. 30(Suppl. 2): 49-52.
30. Morita, Y., M. Yamamura, M. Kawashima, T. Aita, S. Harada, H. Okamoto, H. Inoue, and H. Makino. 2001. Differential in vitro effects of 1L-4, 1L-10, and IL-13 on proinflammatory cytokine production and fibroblast proliferation in rheumatoid synovium. Rheumatol. Int. 20: 49-54.
31. Serhan, C. N., and N. Chiang. 2004. Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entree for resoleomics. Rheum. Dis. Clin. North Am. 30: 69-95.
32. Udalova, I. A., A. Richardson, A. Denys, C. Smith, H. Ackerman, B. Foxwell, and D. Kwiatkowski. 2000. Functional consequences of a polymorphism affecting NF-κB p50-p50 binding to the TNF promoter region. Mol. Cell. Biol. 20: 9113-9119.
33. b gene expression in metastatic tumor cells. J. Exp. Med. 177: 1651-1662.
34. + T lymphocytes. Science 256: 1452-1456.
35. Bohuslav, J., V. V. Kravchenko, G. C. Parry, J. H. Erlich, S. Gerondakis, N. Mackman, and R. J. Ulevitch. 1998. Regulation of an essential innate immune response by the p50 subunit of NF-κB. J. Clin. Invest. 102: 1645-1652.
36. Ma, X. Y., H. Wang, B. Ding, H. Zhong, S. Ghosh, and P. Lengyel. 2003. The interferon-inducible p202a protein modulates NF-κB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homodimers while enhancing the binding of p50 homodimers. J. Biol. Chem. 278: 23008-23019.
37. Nakashima, O., Y. Terada, S. Inoshita, M. Kuwahara, S. Sasaki, and F. Marumo. 1999. Inducible nitric oxide synthase can be induced in the absence of active nuclear factor-κB in rat mesangial cells: involvement of the Janus kinase 2 signaling pathway. J. Am. Soc. Nephrol. 10: 721-729.
38. D'Acquisto, F., L. Sautebin, T. Iuvone, M. Di Rosa, and R. Carnuccio. 1998. Prostaglandins prevent inducible nitric oxide synthase protein expression by inhibiting nuclear factor-κB activation in J774 macrophages. FEBS Lett. 440: 76-80.
39. Poligone, B., and A. S. Baldwin. 2001. Positive and negative regulation of NF-κB by COX-2: roles of different prostaglandins. J. Biol. Chem. 276: 38658-38664.
40. Warner, T. D., F. Giuliano, I. Vojnovic, A. Bukasa, J. A. Mitchell, and J. R. Vane. 1999. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc. Natl. Acad. Sci. USA 96: 7563-7568.
41. Jiang, B., P. Brecher, and R. A. Cohen. 2001. Persistent activation of nuclear factor-κB by interleukin-1β and subsequent inducible NO synthase expression requires extracellular signal-regulated kinase. Arterioscler. Thromb. Vasc. Biol. 21: 1915-1920.
42. Jiang, B., S. Xu, X. Hou, D. R. Pimentel, P. Brecher, and R. A. Cohen. 2004. Temporal control of NF-κB activation by ERK differentially regulates interleukin-10-induced gene expression. J. Biol. Chem. 279: 1323-1329.
43. Pillinger, M. H., N. Marjanovic, S. Y. Kim, J. U. Scher, P. Izmirly, S. Tolani, V. Dinsell, Y. C. Lee, M. J. Blaser, and S. B. Abramson. 2005. Matrix metalloproteinase secretion by gastric epithelial cells is regulated by E prostaglandins and mitogen-activated protein kinases. J. Biol. Chem. 280: 9973-9979.