Inhibition of lipopolysaccharide-stimulated NO production by a novel synthetic compound CYL-4d in RAW 264.7 macrophages involving the blockade of MEK4/JNK/AP-1 pathway

Biochemical Pharmacology

Volumn 73, Issue 11, 2007, Pages 1796-1806

  Lin, Meng Wei ^a   Tsao, Lo Ti ^b   Chang, Ling Chu ^c   Chen, Ye Long ^d   Huang, Li Jiau ^a   Kuo, Sheng Chu ^a   Tzeng, Cherng Chyi ^d   Lee, Miau Rong ^a   Wang, Jih Pyang ^a,b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Alveolar macrophages; AP 1; BV 2 microglia; CYL 4d; NF B; Nitric oxide; RAW 264.7 macrophages

Indexed keywords

4 [2 (CYCLOHEX 2 ENYLIDENE)HYDRAZINYL]QUINOLIN 2(1H) ONE; ANTIINFLAMMATORY AGENT; CYL 4D; DOUBLE STRANDED RNA; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIGAND; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OLIGONUCLEOTIDE; PEPTIDOGLYCAN; PROTEIN C JUN; QUINOLINE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL IMMORTALIZATION; CELL NUCLEUS; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE ACTIVITY; GENE EXPRESSION; INTRACELLULAR TRANSPORT; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA DEGRADATION; SIGNAL TRANSDUCTION;

ANIMALS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MACROPHAGES, ALVEOLAR; MAP KINASE KINASE 4; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1;

EID: 34247130132     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.02.009     Document Type: Article

References (38)

1. Marletta M.A. Nitric oxide synthase structure and mechanism. J Biol Chem 268 (1993) 12231-12234
2. Xie Q., and Nathan C. The high-output nitric oxide pathway: role and regulation. J Leukoc Biol 56 (1994) 576-582
3. McCartney-Francis N., Allen J.B., Mizel D.E., Albina J.E., Xie Q.W., Nathan C.F., et al. Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med 178 (1993) 749-754
4. Chen Y.L., Chung C.H., Chen I.L., Chen P.H., and Jeng H.Y. Synthesis and cytotoxic activity evaluation of indolo-, pyrrolo-, and benzofuro-quinolin-2(1H)-ones and 6-anilinoindoloquinoline derivatives. Bioorg Med Chem 10 (2002) 2705-2712
5. Liu S.H., Tzeng H.P., Kuo M.L., and Lin-Shiau S.Y. Inhibition of inducible nitric oxide synthase by β-lapachone in rat alveolar macrophages and aorta. Br J Pharmacol 126 (1999) 746-750
6. 2 and by cyclooxygenase inhibitors. Glia 19 (1997) 152-160
7. Wang M.J., Huang H.M., Chen H.L., Kuo J.S., and Jeng K.C. Dehydroepiandrosterone inhibits lipopolysaccharide-induced nitric oxide production in BV-2 microglia. J Neurochem 77 (2001) 830-838
8. _ΔΔCT method. Methods 25 (2001) 402-408
9. Tsao L.T., Tsai P.S., Lin R.H., Huang L.J., Kuo S.C., and Wang J.P. Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by phenolic (3E)-4-(2-hydroxyphenyl)but-3-en-2-one in RAW 264.7 macrophages. Biochem Pharmacol 70 (2005) 618-626
10. Velasco M., Diaz-Guerra M.J., Diaz-Achirica P., Andreu D., Rivas L., and Bosca L. Macrophage triggering with cecropin A and melittin-derived peptides induces type II nitric oxide synthase expression. J Immunol 158 (1997) 4437-4443
11. Tsi C.J., Chao Y., Chen C.W., and Lin W.W. Aurintricarboxylic acid protects against cell death caused by lipopolysaccharide in macrophages by decreasing inducible nitric-oxide synthase induction via IκB kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kinase inhibition. Mol Pharmacol 62 (2002) 90-101
12. Hatziieremia S., Gray A.I., Ferro V.A., Paul A., and Plevin R. The effects of cardamonin on lipopolysaccharide-induced inflammatory protein production and MAP kinase and NF-κB signalling pathways in monocytes/macrophages. Br J Pharmacol 149 (2006) 188-198
13. Ghosh S., May M.J., and Kopp E.B. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16 (1998) 225-260
14. Tsao L.T., Lee C.Y., Huang L.J., Kuo S.C., and Wang J.P. Inhibition of lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages by a synthetic carbazole, LCY-2-CHO. Biochem Pharmacol 63 (2002) 1961-1968
15. Krens S.F.G., Spaink H.P., and Snaar-Jagalska B.E. Functions of the MAPK family in vertebrate-development. FEBS Lett 580 (2006) 4984-4990
16. Cano E., and Mahadevan L.C. Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 20 (1995) 117-122
17. Derijard B., Hibi M., Wu I.H., Barrett T., Su B., Deng T., et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76 (1994) 1025-1037
18. Carter A.B., Knudtson K.L., Monick M.M., and Hunninghake G.W. The p38 mitogen-activated protein kinase is required for NF-κB-dependent gene expression. The role of TATA-binding protein (TBP). J Biol Chem 274 (1999) 30858-30863
19. Akira S., and Takeda K. Toll-like receptor signalling. Nat Rev Immunol 4 (2004) 499-511
20. Torgerson T.R., Colosia A.D., Donahue J.P., Lin Y.Z., and Hawiger J. Regulation of NF-κB, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-κB p50. J Immunol 161 (1998) 6084-6092
21. Moroianu J. Distinct nuclear import and export pathways mediated by members of the karyopherin β family. J Cell Biochem 70 (1998) 231-239
22. Kolenko V., Bloom T., Rayman P., Bukowski R., His E., and Finke J. Inhibition of NF-κB activity in human T lymphocytes induces caspase-dependent apoptosis without detectable activation of caspase-1 and -3. J Immunol 163 (1999) 590-598
23. Shin H.M., Kim M.H., Kim B.H., Jung S.H., Kim Y.S., Park H.J., et al. Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-κB without affecting IκB degradation. FEBS Lett 571 (2004) 50-54
24. Hambleton J., Weinstein S.L., Lem L., and DeFranco A.L. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci USA 93 (1996) 2774-2778
25. Karin M., Liu Z.G., and Zandi E. AP-1 function and regulation. Curr Opin Cell Biol 9 (1997) 240-246
26. Martin C.B., and Martin B.K. Characterization of the murine C3a receptor enhancer-promoter: expression control by an activator protein 1 sequence and an Ets-like site. J Immunol 175 (2005) 3123-3132
27. Guha M., and Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 13 (2001) 85-94
28. Paul A., Cuenda A., Bryant C.E., Murray J., Chilvers E.R., Cohen P., et al. Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages. Cell Signal 11 (1999) 491-497
29. Uto T., Fujii M., and Hou D.X. 6-(Methylsulfinyl)hexyl isothiocyanate suppresses inducible nitric oxide synthase expression through the inhibition of Janus kinase 2-mediated JNK pathway in lipopolysaccharide-activated murine macrophages. Biochem Pharmacol 70 (2005) 1211-1221
30. Deng T., and Karin M. JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers. Genes Dev 7 (1993) 479-490
31. Lee S.H., Soyoola E., Chanmugam P., Hart S., Sun W., Zhong H., et al. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 267 (1992) 25934-25938
32. Eliopoulos A.G., Dumitru C.D., Wang C.C., Cho J., and Tsichlis P.N. Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals. EMBO J 21 (2002) 4831-4840
33. Wu K.K. Transcription-based COX-2 inhibition: a therapeutic strategy. Thromb Haemost 96 (2006) 417-422
34. Wu K.K., Liou J.Y., and Cieslik K. Transcriptional control of COX-2 via C/EBPβ. Arterioscler Thromb Vasc Biol 25 (2005) 679-685
35. Beinke S., and Ley S.C. Functions of NF-κB1 and NF-κB2 in immune cell biology. Biochem J 382 (2004) 393-409
36. Gonzalez-Scarano F., and Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 22 (1999) 219-240
37. Liu B., and Hong J.S. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 304 (2003) 1-7
38. Sibille Y., and Reynolds H.Y. Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am Rev Respir Dis 141 (1990) 471-501