SLC27 fatty acid transport proteins

Molecular Aspects of Medicine

Volumn 34, Issue 2-3, 2013, Pages 516-528

  Anderson, Courtney M ^a   Stahl, Andreas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

FATP; Fatty acid activation; Fatty acid transport proteins; Fatty acid uptake; SLC27

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; CHENODEOXYCHOLIC ACID; DIHYDROPYRIMIDINONE DERIVATIVE; FATTY ACID SYNTHASE; FATTY ACID TRANSPORTER; FATTY ACID TRANSPORTER 1; FATTY ACID TRANSPORTER 2; FATTY ACID TRANSPORTER 3; FATTY ACID TRANSPORTER 4; FATTY ACID TRANSPORTER 5; FATTY ACID TRANSPORTER 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHENOTHIAZINE; PYRIMIDINONE DERIVATIVE; SOLUTE CARRIER FAMILY 27; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL METABOLISM; CELL VIABILITY; DEATH; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; FATTY ACID TRANSPORT; GENETIC POLYMORPHISM; HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; KETOACIDOSIS; METABOLIC DISORDER; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVIEW; SIDE EFFECT; SIGNAL TRANSDUCTION; SLC27A1 GENE; SLC27A2 GENE; SLC27A3 GENE; SLC27A4 GENE; SLC27A5 GENE; SLC27A6 GENE; TISSUE SPECIFICITY; TRANSGENIC MOUSE; WEIGHT GAIN;

ANIMALS; BIOLOGICAL TRANSPORT; FATTY ACID TRANSPORT PROTEINS; FATTY ACIDS; GENE EXPRESSION PROFILING; HUMANS; MICE; MODELS, ANIMAL; MULTIGENE FAMILY; PROTEIN STRUCTURE, TERTIARY;

EID: 84875156452     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2012.07.010     Document Type: Review

References (90)

1. E.Z. Amri, F. Bonino, G. Ailhaud, N.A. Abumrad, and P.A. Grimaldi Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors J. Biol. Chem. 270 5 1995 2367 2371
2. B. Ason, J. Castro-Perez, S. Tep, A. Stefanni, M. Tadin-Strapps, T. Roddy, T. Hankemeier, B. Hubbard, A.B. Sachs, W. Michael Flanagan, N.A. Kuklin, and L.J. Mitnaul ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5) Lipids 46 11 2011 991 1003
3. A. Auinger, U. Helwig, M. Pfeuffer, D. Rubin, M. Luedde, T. Rausche, N. Eddine El Mokhtari, U.R. Folsch, S. Schreiber, N. Frey, and J. Schrezenmeir A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy Br. J. Nutr. 2011 1 7
4. A. Auinger, L. Valenti, M. Pfeuffer, U. Helwig, J. Herrmann, A.L. Fracanzani, P. Dongiovanni, S. Fargion, J. Schrezenmeir, and D. Rubin A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis Horm. Metab. Res. 42 12 2010 854 859
5. C. Binnert, H.A. Koistinen, G. Martin, F. Andreelli, P. Ebeling, V.A. Koivisto, M. Laville, J. Auwerx, and H. Vidal Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans Am. J. Physiol. Endocrinol. Metab. 279 5 2000 E1072 1079
6. P.N. Black, and C.C. DiRusso Vectorial acylation: linking fatty acid transport and activation to metabolic trafficking Novartis Found Symp. 286 2007 127 138 (discussion 138-141, 162-123, 196-203)
7. P.N. Black, and C.C. DiRusso Yeast acyl-CoA synthetases at the crossroads of fatty acid metabolism and regulation Biochim. Biophys. Acta 1771 3 2007 286 298
8. C. Blackburn, B. Guan, J. Brown, C. Cullis, S.M. Condon, T.J. Jenkins, S. Peluso, Y. Ye, R.E. Gimeno, S. Punreddy, Y. Sun, H. Wu, B. Hubbard, V. Kaushik, P. Tummino, P. Sanchetti, D. Yu Sun, T. Daniels, E. Tozzo, S.K. Balani, and P. Raman Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)- ones as inhibitors of the fatty acid transporter FATP4 Bioorg. Med. Chem. Lett. 16 13 2006 3504 3509
9. H.C. Chiu, A. Kovacs, R.M. Blanton, X. Han, M. Courtois, C.J. Weinheimer, K.A. Yamada, S. Brunet, H. Xu, J.M. Nerbonne, M.J. Welch, N.M. Fettig, T.L. Sharp, N. Sambandam, K.M. Olson, D.S. Ory, and J.E. Schaffer Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy Circ. Res. 96 2 2005 225 233
10. H. Choi, S.J. Kim, S.S. Park, C. Chang, and E. Kim TR4 activates FATP1 gene expression to promote lipid accumulation in 3T3-L1 adipocytes FEBS Lett. 585 17 2011 2763 2767
11. J.Y. Choi, and C.E. Martin The Saccharomyces cerevisiae FAT1 gene encodes an acyl-CoA synthetase that is required for maintenance of very long chain fatty acid levels J. Biol. Chem. 274 8 1999 4671 4683
12. C.T. Coburn, F.F. Knapp Jr.; M. Febbraio, A.L. Beets, R.L. Silverstein, and N.A. Abumrad Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice J. Biol. Chem. 275 42 2000 32523 32529
13. N.R. Coe, A.J. Smith, B.I. Frohnert, P.A. Watkins, and D.A. Bernlohr The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase J. Biol. Chem. 274 51 1999 36300 36304
14. C.C. DiRusso, H. Li, D. Darwis, P.A. Watkins, J. Berger, and P.N. Black Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast J. Biol. Chem. 280 17 2005 16829 16837
15. H. Doege, R.A. Baillie, A.M. Ortegon, B. Tsang, Q. Wu, S. Punreddy, D. Hirsch, N. Watson, R.E. Gimeno, and A. Stahl Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis Gastroenterology 130 4 2006 1245 1258
16. H. Doege, D. Grimm, A. Falcon, B. Tsang, T.A. Storm, H. Xu, A.M. Ortegon, M. Kazantzis, M.A. Kay, and A. Stahl Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia J. Biol. Chem. 283 32 2008 22186 22192
17. N.J. Faergeman, C.C. DiRusso, A. Elberger, J. Knudsen, and P.N. Black Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids J. Biol. Chem. 272 13 1997 8531 8538
18. C.N. Falany, X. Xie, J.B. Wheeler, J. Wang, M. Smith, D. He, and S. Barnes Molecular cloning and expression of rat liver bile acid CoA ligase J. Lipid Res. 43 12 2002 2062 2071
19. A. Falcon, H. Doege, A. Fluitt, B. Tsang, N. Watson, M.A. Kay, and A. Stahl FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase Am. J. Physiol. Endocrinol. Metab. 299 3 2010 E384 393
20. B.A. Fitscher, H.D. Riedel, K.C. Young, and W. Stremmel Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4) Biochim. Biophys. Acta 1443 3 1998 381 385
21. B.I. Frohnert, T.Y. Hui, and D.A. Bernlohr Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene J. Biol. Chem. 274 7 1999 3970 3977
22. K. Gertow, M. Bellanda, P. Eriksson, S. Boquist, A. Hamsten, M. Sunnerhagen, and R.M. Fisher Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome J. Clin. Endocrinol. Metab. 89 1 2004 392 399
23. K. Gertow, K.H. Pietilainen, H. Yki-Jarvinen, J. Kaprio, A. Rissanen, P. Eriksson, A. Hamsten, and R.M. Fisher Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance Diabetologia 47 6 2004 1118 1125
24. K. Gertow, C. Skoglund-Andersson, P. Eriksson, S. Boquist, K. Orth-Gomer, K. Schenck-Gustafsson, A. Hamsten, and R.M. Fisher A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution Atherosclerosis 167 2 2003 265 273
25. R.E. Gimeno, D.J. Hirsch, S. Punreddy, Y. Sun, A.M. Ortegon, H. Wu, T. Daniels, A. Stricker-Krongrad, H.F. Lodish, and A. Stahl Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality J. Biol. Chem. 278 49 2003 49512 49516
26. R.E. Gimeno, A.M. Ortegon, S. Patel, S. Punreddy, P. Ge, Y. Sun, H.F. Lodish, and A. Stahl Characterization of a heart-specific fatty acid transport protein J. Biol. Chem. 278 18 2003 16039 16044
27. C.E. Hagberg, A. Falkevall, X. Wang, E. Larsson, J. Huusko, I. Nilsson, L.A. van Meeteren, E. Samen, L. Lu, M. Vanwildemeersch, J. Klar, G. Genove, K. Pietras, S. Stone-Elander, L. Claesson-Welsh, S. Yla-Herttuala, P. Lindahl, and U. Eriksson Vascular endothelial growth factor B controls endothelial fatty acid uptake Nature 464 7290 2010 917 921
28. P. Haggarty Placental regulation of fatty acid delivery and its effect on fetal growth- A review Placenta 23 Suppl. A 2002 S28 S38
29. A.M. Hall, B.M. Wiczer, T. Herrmann, W. Stremmel, and D.A. Bernlohr Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice J. Biol. Chem. 280 12 2005 11948 11954
30. L.C. Heather, M.A. Cole, C.A. Lygate, R.D. Evans, D.J. Stuckey, A.J. Murray, S. Neubauer, and K. Clarke Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart Cardiovasc. Res. 72 3 2006 430 437
31. A.K. Heinzer, P.A. Watkins, J.F. Lu, S. Kemp, A.B. Moser, Y.Y. Li, S. Mihalik, J.M. Powers, and K.D. Smith A very long-chain acyl-CoA synthetase-deficient mouse and its relevance to X-linked adrenoleukodystrophy Hum. Mol. Genet. 12 10 2003 1145 1154
32. T. Herrmann, F. Buchkremer, I. Gosch, A.M. Hall, D.A. Bernlohr, and W. Stremmel Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase Gene 270 1-2 2001 31 40
33. T. Herrmann, H.J. Grone, L. Langbein, I. Kaiser, I. Gosch, U. Bennemann, D. Metzger, P. Chambon, A.F. Stewart, and W. Stremmel Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency J. Invest. Dermatol. 125 6 2005 1228 1235
34. T. Herrmann, F. van der Hoeven, H.J. Grone, A.F. Stewart, L. Langbein, I. Kaiser, G. Liebisch, I. Gosch, F. Buchkremer, W. Drobnik, G. Schmitz, and W. Stremmel Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy J. Cell Biol. 161 6 2003 1105 1115
35. D. Hirsch, A. Stahl, and H.F. Lodish A family of fatty acid transporters conserved from mycobacterium to man Proc. Natl. Acad. Sci. USA 95 15 1998 8625 8629
36. G.P. Holloway, C.J. Chou, J. Lally, T. Stellingwerff, A.C. Maher, O. Gavrilova, M. Haluzik, H. Alkhateeb, M.L. Reitman, and A. Bonen Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance Diabetologia 54 6 2011 1457 1467
37. H. Huang, O. Starodub, A. McIntosh, A.B. Kier, and F. Schroeder Liver fatty acid-binding protein targets fatty acids to the nucleus. Real time confocal and multiphoton fluorescence imaging in living cells J. Biol. Chem. 277 32 2002 29139 29151
38. B. Hubbard, H. Doege, S. Punreddy, H. Wu, X. Huang, V.K. Kaushik, R.L. Mozell, J.J. Byrnes, A. Stricker-Krongrad, C.J. Chou, L.A. Tartaglia, H.F. Lodish, A. Stahl, and R.E. Gimeno Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity Gastroenterology 130 4 2006 1259 1269
39. T.Y. Hui, B.I. Frohnert, A.J. Smith, J.E. Schaffer, and D.A. Bernlohr Characterization of the murine fatty acid transport protein gene and its insulin response sequence J. Biol. Chem. 273 42 1998 27420 27429
40. S.S. Jain, A. Chabowski, L.A. Snook, R.W. Schwenk, J.F. Glatz, J.J. Luiken, and A. Bonen Additive effects of insulin and muscle contraction on fatty acid transport and fatty acid transporters, FAT/CD36, FABPpm, FATP1, 4 and 6 FEBS Lett. 583 13 2009 2294 2300
41. Z. Jia, C.L. Moulson, Z. Pei, J.H. Miner, and P.A. Watkins Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts J. Biol. Chem. 282 28 2007 20573 20583
42. M. Kazantzis, and A. Stahl Fatty acid transport proteins, implications in physiology and disease Biochim Biophys Acta 1821 5 2011 852 857
43. J.K. Kim, R.E. Gimeno, T. Higashimori, H.J. Kim, H. Choi, S. Punreddy, R.L. Mozell, G. Tan, A. Stricker-Krongrad, D.J. Hirsch, J.J. Fillmore, Z.X. Liu, J. Dong, G. Cline, A. Stahl, H.F. Lodish, and G.I. Shulman Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle J. Clin. Invest. 113 5 2004 756 763
44. J. Klar, M. Schweiger, R. Zimmerman, R. Zechner, H. Li, H. Torma, A. Vahlquist, B. Bouadjar, N. Dahl, and J. Fischer Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome Am. J. Hum. Genet. 85 2 2009 248 253
45. S.A. Kliewer, B.M. Forman, B. Blumberg, E.S. Ong, U. Borgmeyer, D.J. Mangelsdorf, K. Umesono, and R.M. Evans Differential expression and activation of a family of murine peroxisome proliferator-activated receptors Proc. Natl. Acad. Sci. USA 91 15 1994 7355 7359
46. J. Krammer, M. Digel, F. Ehehalt, W. Stremmel, J. Fullekrug, and R. Ehehalt Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells Int. J. Med. Sci. 8 7 2011 599 614
47. E.D. Labonte, L.M. Camarota, J.C. Rojas, R.J. Jandacek, D.E. Gilham, J.P. Davies, Y.A. Ioannou, P. Tso, D.Y. Hui, and P.N. Howles Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice Am. J. Physiol. Gastrointest. Liver Physiol. 295 4 2008 G776 783
48. M. Lafontan, and M. Berlan Fat cell adrenergic receptors and the control of white and brown fat cell function J. Lipid Res. 34 7 1993 1057 1091
49. L.S. Lenz, J. Marx, W. Chamulitrat, I. Kaiser, H.J. Grone, G. Liebisch, G. Schmitz, C. Elsing, B.K. Straub, J. Fullekrug, W. Stremmel, and T. Herrmann Adipocyte-specific inactivation of Acyl-CoA synthetase fatty acid transport protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of complex lipids under high fat diet J. Biol. Chem. 286 41 2011 35578 35587
50. S.E. Lewis, L.L. Listenberger, D.S. Ory, and J.E. Schaffer Membrane topology of the murine fatty acid transport protein 1 J. Biol. Chem. 276 40 2001 37042 37050
51. H. Li, P.N. Black, A. Chokshi, A. Sandoval-Alvarez, R. Vatsyayan, W. Sealls, and C.C. DiRusso High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemias J. Lipid Res. 49 1 2008 230 244
52. H. Li, P.N. Black, and C.C. DiRusso A live-cell high-throughput screening assay for identification of fatty acid uptake inhibitors Anal. Biochem. 336 1 2005 11 19
53. M.H. Lin, K.W. Chang, S.C. Lin, and J.H. Miner Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling Dev. Biol. 344 2 2010 707 719
54. S. Lobo, B.M. Wiczer, A.J. Smith, A.M. Hall, and D.A. Bernlohr Fatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4 J. Lipid Res. 48 3 2007 609 620
55. M.Z. Man, T.Y. Hui, J.E. Schaffer, H.F. Lodish, and D.A. Bernlohr Regulation of the murine adipocyte fatty acid transporter gene by insulin Mol. Endocrinol. 10 8 1996 1021 1028
56. G. Martin, K. Schoonjans, A.M. Lefebvre, B. Staels, and J. Auwerx Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators J. Biol. Chem. 272 45 1997 28210 28217
57. A. Meirhaeghe, G. Martin, M. Nemoto, S. Deeb, D. Cottel, J. Auwerx, P. Amouyel, and N. Helbecque Intronic polymorphism in the fatty acid transport protein 1 gene is associated with increased plasma triglyceride levels in a French population Arterioscler. Thromb. Vasc. Biol. 20 5 2000 1330 1334
58. E.M. Melton, R.L. Cerny, P.A. Watkins, C.C. DiRusso, and P.N. Black Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol J. Biol. Chem. 286 35 2011 30670 30679
59. S.J. Mihalik, S.J. Steinberg, Z. Pei, J. Park, D.G. Kim, A.K. Heinzer, G. Dacremont, R.J. Wanders, D.A. Cuebas, K.D. Smith, and P.A. Watkins Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling J. Biol. Chem. 277 27 2002 24771 24779
60. K. Milger, T. Herrmann, C. Becker, D. Gotthardt, J. Zickwolf, R. Ehehalt, P.A. Watkins, W. Stremmel, and J. Fullekrug Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4 J. Cell Sci. 119 Pt 22 2006 4678 4688
61. T. Mishima, J.H. Miner, M. Morizane, A. Stahl, and Y. Sadovsky The expression and function of fatty acid transport protein-2 and -4 in the murine placenta PLoS One 6 10 2011 e25865
62. R.W. Mitchell, N.H. On, M.R. Del Bigio, D.W. Miller, and G.M. Hatch Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells J. Neurochem. 117 4 2011 735 746
63. H. Mitsuyoshi, K. Yasui, Y. Harano, M. Endo, K. Tsuji, M. Minami, Y. Itoh, T. Okanoue, and T. Yoshikawa Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease Hepatol. Res. 39 4 2009 366 373
64. C.L. Moulson, M.H. Lin, J.M. White, E.P. Newberry, N.O. Davidson, and J.H. Miner Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4/Fatp4 mutant mice J. Biol. Chem. 282 21 2007 15912 15920
65. C.L. Moulson, D.R. Martin, J.J. Lugus, J.E. Schaffer, A.C. Lind, and J.H. Miner Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development Proc. Natl. Acad. Sci. USA 100 9 2003 5274 5279
66. J.W. Newcomer Abnormalities of glucose metabolism associated with atypical antipsychotic drugs J. Clin. Psychiatry 65 Suppl 18 2004 36 46
67. J.G. Nickerson, H. Alkhateeb, C.R. Benton, J. Lally, J. Nickerson, X.X. Han, M.H. Wilson, S.S. Jain, L.A. Snook, J.F. Glatz, A. Chabowski, J.J. Luiken, and A. Bonen Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal muscle J. Biol. Chem. 284 24 2009 16522 16530
68. L. Ordovás, R. Roy, P. Zaragoza, and C. Rodellar Structural and functional characterization of the bovine solute carrier family 27 member 1 (SLC27A1) gene Cytogenet. Genome Res. 115 2 2006 115 122
69. Z. Pei, P. Fraisl, J. Berger, Z. Jia, S. Forss-Petter, and P.A. Watkins Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells J. Biol. Chem. 279 52 2004 54454 54462
70. M.R. Richards, J.D. Harp, D.S. Ory, and J.E. Schaffer Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes J. Lipid Res. 47 3 2006 665 672
71. M.R. Richards, L.L. Listenberger, A.A. Kelly, S.E. Lewis, D.S. Ory, and J.E. Schaffer Oligomerization of the murine fatty acid transport protein 1 J. Biol. Chem. 278 12 2003 10477 10483
72. A. Sandoval, A. Chokshi, E.D. Jesch, P.N. Black, and C.C. Dirusso Identification and characterization of small compound inhibitors of human FATP2 Biochem. Pharmacol. 79 7 2010 990 999
73. A. Sandoval, P. Fraisl, E. Arias-Barrau, C.C. Dirusso, D. Singer, W. Sealls, and P.N. Black Fatty acid transport and activation and the expression patterns of genes involved in fatty acid trafficking Arch. Biochem. Biophys. 477 2 2008 363 371
74. J.E. Schaffer, and H.F. Lodish Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein Cell 79 3 1994 427 436
75. M. Schmuth, A.M. Ortegon, M. Mao-Qiang, P.M. Elias, K.R. Feingold, and A. Stahl Differential expression of fatty acid transport proteins in epidermis and skin appendages J. Invest. Dermatol. 125 6 2005 1174 1181
76. R.W. Schwenk, G.P. Holloway, J.J. Luiken, A. Bonen, and J.F. Glatz Fatty acid transport across the cell membrane: regulation by fatty acid transporters Prostaglandins Leukot. Essent Fatty Acids 82 4-6 2010 149 154
77. J. Shim, C.L. Moulson, E.P. Newberry, M.H. Lin, Y. Xie, S.M. Kennedy, J.H. Miner, and N.O. Davidson Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice J. Lipid Res. 50 3 2009 491 500
78. M. Sobol, N. Dahl, and J. Klar FATP4 missense and nonsense mutations cause similar features in ichthyosis prematurity syndrome BMC Res. Notes 4 2011 90
79. A. Stahl, J.G. Evans, S. Pattel, D. Hirsch, and H.F. Lodish Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes Dev. Cell 2 4 2002 477 488
80. A. Stahl, D.J. Hirsch, R.E. Gimeno, S. Punreddy, P. Ge, N. Watson, S. Patel, M. Kotler, A. Raimondi, L.A. Tartaglia, and H.F. Lodish Identification of the major intestinal fatty acid transport protein Mol. Cell 4 3 1999 299 308
81. S.J. Steinberg, S.J. Mihalik, D.G. Kim, D.A. Cuebas, and P.A. Watkins The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase J. Biol. Chem. 275 21 2000 15605 15608
82. S.J. Steinberg, S.J. Wang, M.C. McGuinness, and P.A. Watkins Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein Mol. Genet. Metab. 68 1 1999 32 42
83. W. Stremmel, L. Pohl, A. Ring, and T. Herrmann A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids Lipids 36 9 2001 981 989
84. A. Uchiyama, T. Aoyama, K. Kamijo, Y. Uchida, N. Kondo, T. Orii, and T. Hashimoto Molecular cloning of cDNA encoding rat very long-chain acyl-CoA synthetase J. Biol. Chem. 271 48 1996 30360 30365
85. P.A. Watkins, J.F. Lu, S.J. Steinberg, S.J. Gould, K.D. Smith, and L.T. Braiterman Disruption of the Saccharomyces cerevisiae FAT1 gene decreases very long-chain fatty acyl-CoA synthetase activity and elevates intracellular very long-chain fatty acid concentrations J. Biol. Chem. 273 29 1998 18210 18219
86. Q. Wu, M. Kazantzis, H. Doege, A.M. Ortegon, B. Tsang, A. Falcon, and A. Stahl Fatty acid transport protein 1 is required for nonshivering thermogenesis in brown adipose tissue Diabetes 55 12 2006 3229 3237
87. Q. Wu, A.M. Ortegon, B. Tsang, H. Doege, K.R. Feingold, and A. Stahl FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity Mol. Cell. Biol. 26 9 2006 3455 3467
88. W. Zhou, P. Madrid, A. Fluitt, A. Stahl, and X.S. Xie Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5 J. Biomol. Screen. 15 5 2010 488 497
89. Z. Zou, C.C. DiRusso, V. Ctrnacta, and P.N. Black Fatty acid transport in Saccharomyces cerevisiae. Directed mutagenesis of FAT1 distinguishes the biochemical activities associated with Fat1p J. Biol. Chem. 277 34 2002 31062 31071
90. Z. Zou, F. Tong, N.J. Faergeman, C. Borsting, P.N. Black, and C.C. DiRusso Vectorial acylation in Saccharomyces cerevisiae. Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complex J. Biol. Chem. 278 18 2003 16414 16422