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Volumn 15, Issue 5, 2010, Pages 488-497

Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5

Author keywords

Bile acids; Fatty acid transport proteins; Fluorometric imaging plate reader (FLIPR); High throughput screening; Long chain fatty acids

Indexed keywords

4 ARYL DIHYDROPYRIMIDINONE DERIVATIVE; BILE ACID; CHENODEOXYCHOLIC ACID; FATTY ACID TRANSPORTER; FATTY ACID TRANSPORTER 4; FATTY ACID TRANSPORTER 5; LONG CHAIN FATTY ACID; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

EID: 77953632274     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110369700     Document Type: Article
Times cited : (19)

References (33)
  • 1
    • 0030592967 scopus 로고    scopus 로고
    • A novel adipocyte long chain fatty acid transport protein
    • Schaffer JE: A novel adipocyte long chain fatty acid transport protein. Eur J Med Res 1996 ; 1: 176-180.
    • (1996) Eur J Med Res , vol.1 , pp. 176-180
    • Schaffer, J.E.1
  • 3
    • 0035168901 scopus 로고    scopus 로고
    • A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids
    • Stremmel W., Pohl L., Ring A., Herrmann T.: A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids. Lipids 2001 ; 36: 981-989.
    • (2001) Lipids , vol.36 , pp. 981-989
    • Stremmel, W.1    Pohl, L.2    Ring, A.3    Herrmann, T.4
  • 4
    • 1242317654 scopus 로고    scopus 로고
    • A current review of fatty acid transport proteins (SLC27)
    • Stahl A.: A current review of fatty acid transport proteins (SLC27). Pflugers Arch 2004 ; 447: 722-727.
    • (2004) Pflugers Arch , vol.447 , pp. 722-727
    • Stahl, A.1
  • 5
    • 33745897922 scopus 로고    scopus 로고
    • Translocation of long chain fatty acids across the plasma membrane-lipid rafts and fatty acid transport proteins
    • Ehehalt R., Fullekrug J., Pohl J., Ring A., Herrmann T., Stremmel W.: Translocation of long chain fatty acids across the plasma membrane-lipid rafts and fatty acid transport proteins. Mol Cell Biochem 2006 ; 284: 135-140.
    • (2006) Mol Cell Biochem , vol.284 , pp. 135-140
    • Ehehalt, R.1    Fullekrug, J.2    Pohl, J.3    Ring, A.4    Herrmann, T.5    Stremmel, W.6
  • 6
    • 0001141551 scopus 로고    scopus 로고
    • Fatty acid transporters in animal cells
    • Hui TY, Bernlohr DA: Fatty acid transporters in animal cells. Front Biosci 1997 ; 2: d222 - d231.
    • (1997) Front Biosci , vol.2
    • Hui, T.Y.1    Bernlohr, D.A.2
  • 7
    • 0032559036 scopus 로고    scopus 로고
    • Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)
    • Fitscher BA, Riedel HD, Young KC, Stremmel W.: Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4). Biochim Biophys Acta 1998 ; 1443: 381-385.
    • (1998) Biochim Biophys Acta , vol.1443 , pp. 381-385
    • Fitscher, B.A.1    Riedel, H.D.2    Young, K.C.3    Stremmel, W.4
  • 8
    • 2942711830 scopus 로고    scopus 로고
    • New concepts of cellular fatty acid uptake: Role of fatty acid transport proteins and of caveolae
    • Pohl J., Ring A., Ehehalt R., Herrmann T., Stremmel W.: New concepts of cellular fatty acid uptake: role of fatty acid transport proteins and of caveolae. Proc Nutr Soc 2004 ; 63: 259-262.
    • (2004) Proc Nutr Soc , vol.63 , pp. 259-262
    • Pohl, J.1    Ring, A.2    Ehehalt, R.3    Herrmann, T.4    Stremmel, W.5
  • 10
    • 34248337907 scopus 로고    scopus 로고
    • Fatty acid transport proteins
    • Gimeno RE: Fatty acid transport proteins. Curr Opin Lipidol 2007 ; 18: 271-276.
    • (2007) Curr Opin Lipidol , vol.18 , pp. 271-276
    • Gimeno, R.E.1
  • 11
    • 1542782154 scopus 로고    scopus 로고
    • Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality
    • Gimeno RE, Hirsch DJ, Punreddy S.,, et al. Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem 2003 ; 278: 49512-49516.
    • (2003) J Biol Chem , vol.278 , pp. 49512-49516
    • Gimeno, R.E.1    Hirsch, D.J.2    Punreddy, S.3
  • 12
    • 0037806023 scopus 로고    scopus 로고
    • Characterization of a heart-specific fatty acid transport protein
    • Gimeno RE, Ortegon AM, Patel S.,, et al. Characterization of a heart-specific fatty acid transport protein. J Biol Chem 2003 ; 278: 16039-16044.
    • (2003) J Biol Chem , vol.278 , pp. 16039-16044
    • Gimeno, R.E.1    Ortegon, A.M.2    Patel, S.3
  • 13
    • 26444485985 scopus 로고    scopus 로고
    • Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
    • Koonen DP, Glatz JF, Bonen A., Luiken JJ: Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle. Biochim Biophys Acta 2005 ; 1736: 163-180.
    • (2005) Biochim Biophys Acta , vol.1736 , pp. 163-180
    • Koonen, D.P.1    Glatz, J.F.2    Bonen, A.3    Luiken, J.J.4
  • 14
    • 33644746164 scopus 로고    scopus 로고
    • Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes
    • Richards MR, Harp JD, Ory DS, Schaffer JE: Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes. J Lipid Res 2006 ; 47: 665-672.
    • (2006) J Lipid Res , vol.47 , pp. 665-672
    • Richards, M.R.1    Harp, J.D.2    Ory, D.S.3    Schaffer, J.E.4
  • 15
    • 57649180527 scopus 로고    scopus 로고
    • Transport of fatty acids across the human placenta: A review
    • Duttaroy AK: Transport of fatty acids across the human placenta: a review. Prog Lipid Res 2009 ; 48: 52-61.
    • (2009) Prog Lipid Res , vol.48 , pp. 52-61
    • Duttaroy, A.K.1
  • 16
    • 0036228690 scopus 로고    scopus 로고
    • Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes
    • Stahl A., Evans JG, Pattel S., Hirsch D., Lodish HF: Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes. Dev Cell 2002 ; 2: 477-488.
    • (2002) Dev Cell , vol.2 , pp. 477-488
    • Stahl, A.1    Evans, J.G.2    Pattel, S.3    Hirsch, D.4    Lodish, H.F.5
  • 17
    • 0029953711 scopus 로고    scopus 로고
    • Physiological concentrations of insulin and T3 stimulate 3T3-L1 adipocyte acyl-CoA synthetase gene transcription
    • Kansara MS, Mehra AK, Von Hagen J., Kabotyansky E., Smith PJ: Physiological concentrations of insulin and T3 stimulate 3T3-L1 adipocyte acyl-CoA synthetase gene transcription. Am J Physiol 1996 ; 270 (pt 1). E873 - E881.
    • (1996) Am J Physiol , vol.270 , Issue.1
    • Kansara, M.S.1    Mehra, A.K.2    Von Hagen, J.3    Kabotyansky, E.4    Smith, P.J.5
  • 18
    • 0036087336 scopus 로고    scopus 로고
    • Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats
    • Steinberg GR, Bonen A., Dyck DJ: Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats. Am J Physiol Endocrinol Metab 2002 ; 282: E593 - E600.
    • (2002) Am J Physiol Endocrinol Metab , vol.282
    • Steinberg, G.R.1    Bonen, A.2    Dyck, D.J.3
  • 20
    • 17144370240 scopus 로고    scopus 로고
    • Fatty acid transport proteins and insulin resistance
    • Fisher RM, Gertow K.: Fatty acid transport proteins and insulin resistance. Curr Opin Lipidol 2005 ; 16: 173-178.
    • (2005) Curr Opin Lipidol , vol.16 , pp. 173-178
    • Fisher, R.M.1    Gertow, K.2
  • 21
    • 33645994508 scopus 로고    scopus 로고
    • Targeted deletion of FATP5 reveals multiple functions in liver metabolism: Alterations in hepatic lipid homeostasis
    • Doege H., Baillie RA, Ortegon AM,, et al. Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis. Gastroenterology 2006 ; 130: 1245-1258.
    • (2006) Gastroenterology , vol.130 , pp. 1245-1258
    • Doege, H.1    Baillie, R.A.2    Ortegon, A.M.3
  • 22
    • 0037477788 scopus 로고    scopus 로고
    • Mice with targeted disruption of the fatty acid transport protein 4 (FATP 4, Slc27a4) gene show features of lethal restrictive dermopathy
    • Herrmann T., van der Hoeven F., Grone HJ,, et al. Mice with targeted disruption of the fatty acid transport protein 4 (FATP 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol 2003 ; 161: 1105-1115.
    • (2003) J Cell Biol , vol.161 , pp. 1105-1115
    • Herrmann, T.1    Van Der Hoeven, F.2    Grone, H.J.3
  • 23
    • 33645994830 scopus 로고    scopus 로고
    • Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity
    • Hubbard B., Doege H., Punreddy S.,, et al. Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology 2006 ; 130: 1259-1269.
    • (2006) Gastroenterology , vol.130 , pp. 1259-1269
    • Hubbard, B.1    Doege, H.2    Punreddy, S.3
  • 24
    • 24144441290 scopus 로고    scopus 로고
    • Real-time quantification of fatty acid uptake using a novel fluorescence assay
    • Liao J., Sportsman R., Harris J., Stahl A.: Real-time quantification of fatty acid uptake using a novel fluorescence assay. J Lipid Res 2005 ; 46: 597-602.
    • (2005) J Lipid Res , vol.46 , pp. 597-602
    • Liao, J.1    Sportsman, R.2    Harris, J.3    Stahl, A.4
  • 25
    • 28444448016 scopus 로고    scopus 로고
    • Leptin-mediated inhibition of the insulin-stimulated increase in fatty acid uptake in differentiated 3T3-L1 adipocytes
    • Ho M., Foxall S., Higginbottom M.,, et al. Leptin-mediated inhibition of the insulin-stimulated increase in fatty acid uptake in differentiated 3T3-L1 adipocytes. Metabolism 2006 ; 55: 8-12.
    • (2006) Metabolism , vol.55 , pp. 8-12
    • Ho, M.1    Foxall, S.2    Higginbottom, M.3
  • 26
    • 0033197543 scopus 로고    scopus 로고
    • Identification of the major intestinal fatty acid transport protein
    • Stahl A., Hirsch DJ, Gimeno RE,, et al. Identification of the major intestinal fatty acid transport protein. Mol Cell 1999 ; 4: 299-308.
    • (1999) Mol Cell , vol.4 , pp. 299-308
    • Stahl, A.1    Hirsch, D.J.2    Gimeno, R.E.3
  • 27
    • 9944241271 scopus 로고    scopus 로고
    • A live-cell high-throughput screening assay for identification of fatty acid uptake inhibitors
    • Li H., Black PN, DiRusso CC: A live-cell high-throughput screening assay for identification of fatty acid uptake inhibitors. Anal Biochem 2005 ; 336: 11-19.
    • (2005) Anal Biochem , vol.336 , pp. 11-19
    • Li, H.1    Black, P.N.2    Dirusso, C.C.3
  • 28
    • 38049141096 scopus 로고    scopus 로고
    • High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemias
    • Li H., Black PN, Chokshi A.,, et al. High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemias. J Lipid Res 2008 ; 49: 230-244.
    • (2008) J Lipid Res , vol.49 , pp. 230-244
    • Li, H.1    Black, P.N.2    Chokshi, A.3
  • 29
    • 33646829619 scopus 로고    scopus 로고
    • Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)- ones as inhibitors of the fatty acid transporter FATP4
    • Blackburn C., Guan B., Brown J.,, et al. Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4. Bioorg Med Chem Lett 2006 ; 16: 3504-3509.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 3504-3509
    • Blackburn, C.1    Guan, B.2    Brown, J.3
  • 30
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • Zhang JH, Chung TD, Oldenburg KR: A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 1999 ; 4: 67-73.
    • (1999) J Biomol Screen , vol.4 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.2    Oldenburg, K.R.3
  • 31
    • 75549086552 scopus 로고    scopus 로고
    • Bile acids and metabolic regulation: Mechanisms and clinical responses to bile acid sequestration
    • Staels B., Fonseca VA: Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration. Diabetes Care 2009 ; 32 (suppl 2). S237 - S245.
    • (2009) Diabetes Care , vol.32 , Issue.2
    • Staels, B.1    Fonseca, V.A.2
  • 32
    • 34247611341 scopus 로고    scopus 로고
    • Validation of high throughput screening assays against three subtypes of Cav3 T-type channels using molecular and pharmacologic approaches
    • Xie XM, Van Deusen AL, Vitko I., Barrett PQ, Huynh N., Cheng H.,, et al. Validation of high throughput screening assays against three subtypes of Cav3 T-type channels using molecular and pharmacologic approaches. Assay Drug Dev Technol 2007 ; 5: 191-203.
    • (2007) Assay Drug Dev Technol , vol.5 , pp. 191-203
    • Xie, X.M.1    Van Deusen, A.L.2    Vitko, I.3    Barrett, P.Q.4    Huynh, N.5    Cheng, H.6
  • 33
    • 50149085495 scopus 로고    scopus 로고
    • Fatty acid transport and activation and the expression patterns of genes involved in fatty acid trafficking
    • Sandoval A., Fraisl P., Arias-Barrau E.,, et al. Fatty acid transport and activation and the expression patterns of genes involved in fatty acid trafficking. Arch Biochem Biophys 2008 ; 477: 363-371.
    • (2008) Arch Biochem Biophys , vol.477 , pp. 363-371
    • Sandoval, A.1    Fraisl, P.2    Arias-Barrau, E.3


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