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Volumn 336, Issue 1, 2005, Pages 11-19

A live-cell high-throughput screening assay for identification of fatty acid uptake inhibitors

Author keywords

Fatty acid transport; High throughput screening; Lipotoxicity; Obesity; Saccharomyces cerevisiae; Trypan blue

Indexed keywords

CELLS; CHEMICAL ACTIVATION; CYTOLOGY; DRUG PRODUCTS; FLUORESCENCE; MAMMALS; SODIUM AZIDE; YEAST;

EID: 9944241271     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ab.2004.09.025     Document Type: Article
Times cited : (42)

References (32)
  • 1
    • 0038729655 scopus 로고    scopus 로고
    • Risks of obesity
    • G.A. Bray Risks of obesity Prim. Care 30 2003 281 299 v-vi
    • (2003) Prim. Care , vol.30 , pp. 281-299
    • Bray, G.A.1
  • 2
    • 0033694535 scopus 로고    scopus 로고
    • Lipotoxic diseases of nonadipose tissues in obesity
    • R.H. Unger, and L. Orci Lipotoxic diseases of nonadipose tissues in obesity Int. J. Obes. Relat. Metab. Disord. 24 Suppl 4 2000 S28 32
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24 , Issue.4
    • Unger, R.H.1    Orci, L.2
  • 4
    • 0033891368 scopus 로고    scopus 로고
    • Obesity: An epidemic in need of therapeutics
    • L.H. VanDer Ploeg Obesity: an epidemic in need of therapeutics Curr. Opin. Chem. Biol. 4 2000 452 460
    • (2000) Curr. Opin. Chem. Biol. , vol.4 , pp. 452-460
    • Vander Ploeg, L.H.1
  • 5
    • 0032434821 scopus 로고    scopus 로고
    • Sibutramine. A review of its contribution to the management of obesity
    • W. Mcneely, and K.L. Goa Sibutramine. A review of its contribution to the management of obesity Drugs 56 1998 1093 1124
    • (1998) Drugs , vol.56 , pp. 1093-1124
    • McNeely, W.1    Goa, K.L.2
  • 6
    • 0032752435 scopus 로고    scopus 로고
    • Orlistat: A review of its use in the management of obesity
    • K.M. Hvizdos, and A. Markham Orlistat: a review of its use in the management of obesity Drugs 58 1999 743 760
    • (1999) Drugs , vol.58 , pp. 743-760
    • Hvizdos, K.M.1    Markham, A.2
  • 7
    • 0037298936 scopus 로고    scopus 로고
    • Treatment of obesity: An update on anti-obesity medications
    • A. Halpern, and M.C. Mancini Treatment of obesity: an update on anti-obesity medications Obes. Rev. 4 2003 25 42
    • (2003) Obes. Rev. , vol.4 , pp. 25-42
    • Halpern, A.1    Mancini, M.C.2
  • 8
    • 3042526304 scopus 로고    scopus 로고
    • Conjugated linoleic acid (CLA) versus saturated fats/cholesterol: Their proportion in fatty and lean meats may affect the risk of developing colon cancer
    • A.R. Eynard, and C.B. Lopez Conjugated linoleic acid (CLA) versus saturated fats/cholesterol: their proportion in fatty and lean meats may affect the risk of developing colon cancer Lipids Health Dis. 2 2003 6
    • (2003) Lipids Health Dis. , vol.2 , pp. 6
    • Eynard, A.R.1    Lopez, C.B.2
  • 9
    • 0033637473 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by dietary fatty acids and eicosanoids
    • D.P. Rose, and J.M. Connolly Regulation of tumor angiogenesis by dietary fatty acids and eicosanoids. Nutr. Cancer 37 2000 119 127
    • (2000) Nutr. Cancer , vol.37 , pp. 119-127
    • Rose, D.P.1    Connolly, J.M.2
  • 11
    • 0038509036 scopus 로고    scopus 로고
    • Lipotoxicity: When tissues overeat
    • J.E. Schaffer Lipotoxicity: when tissues overeat Curr. Opin. Lipidol. 14 2003 281 287
    • (2003) Curr. Opin. Lipidol. , vol.14 , pp. 281-287
    • Schaffer, J.E.1
  • 12
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome
    • R.H. Unger Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome Endocrinology 144 2003 5159 5165
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 13
    • 0030889638 scopus 로고    scopus 로고
    • Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids
    • N.J. Faergeman, C.C. Dirusso, A. Elberger, J. Knudsen, and P.N. Black Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids J. Biol. Chem. 272 1997 8531 8538
    • (1997) J. Biol. Chem. , vol.272 , pp. 8531-8538
    • Faergeman, N.J.1    Dirusso, C.C.2    Elberger, A.3    Knudsen, J.4    Black, P.N.5
  • 14
    • 0028152492 scopus 로고
    • Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein
    • J.E. Schaffer, and H.F. Lodish Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein Cell 79 1994 427 436
    • (1994) Cell , vol.79 , pp. 427-436
    • Schaffer, J.E.1    Lodish, H.F.2
  • 15
    • 0032923359 scopus 로고    scopus 로고
    • Localization of adipocyte long-chain fatty acyl-CoA synthetase at the plasma membrane
    • C.E. Gargiulo, S.M. Stuhlsatz-Krouper, and J.E. Schaffer Localization of adipocyte long-chain fatty acyl-CoA synthetase at the plasma membrane J. Lipid Res. 40 1999 881 892
    • (1999) J. Lipid Res. , vol.40 , pp. 881-892
    • Gargiulo, C.E.1    Stuhlsatz-Krouper, S.M.2    Schaffer, J.E.3
  • 16
    • 0037507257 scopus 로고    scopus 로고
    • Vectorial acylation in Saccharomyces cerevisiae. Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complex
    • Z. Zou, F. Tong, N.J. Faergeman, C. Borsting, P.N. Black, and C.C. DiRusso Vectorial acylation in Saccharomyces cerevisiae. Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complex J. Biol. Chem. 278 2003 16414 16422
    • (2003) J. Biol. Chem. , vol.278 , pp. 16414-16422
    • Zou, Z.1    Tong, F.2    Faergeman, N.J.3    Borsting, C.4    Black, P.N.5    Dirusso, C.C.6
  • 17
    • 0035813196 scopus 로고    scopus 로고
    • The Acyl-CoA synthetases encoded within FAA1 and FAA4 in Saccharomyces cerevisiae function as components of the fatty acid transport system linking import, activation, and intracellular utilization
    • N.J. Faergeman, P.N. Black, X.D. Zhao, J. Knudsen, and C.C. Dirusso The Acyl-CoA synthetases encoded within FAA1 and FAA4 in Saccharomyces cerevisiae function as components of the fatty acid transport system linking import, activation, and intracellular utilization J. Biol. Chem. 276 2001 37051 37059
    • (2001) J. Biol. Chem. , vol.276 , pp. 37051-37059
    • Faergeman, N.J.1    Black, P.N.2    Zhao, X.D.3    Knudsen, J.4    Dirusso, C.C.5
  • 19
    • 0027984281 scopus 로고
    • Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: An assessment of their role in regulating protein N-myristoylation and cellular lipid metabolism
    • D.R. Johnson, L.J. Knoll, D.E. Levin, and J.I. Gordon Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: an assessment of their role in regulating protein N-myristoylation and cellular lipid metabolism J. Cell Biol. 127 1994 751 762
    • (1994) J. Cell Biol. , vol.127 , pp. 751-762
    • Johnson, D.R.1    Knoll, L.J.2    Levin, D.E.3    Gordon, J.I.4
  • 20
    • 0020630726 scopus 로고
    • A fluorescence quenching technique using trypan blue to differentiate between attached and ingested glutaraldehyde-fixed red blood cells in phagocytosing murine macrophages
    • J.D. Loike, and S.C. Silverstein A fluorescence quenching technique using trypan blue to differentiate between attached and ingested glutaraldehyde-fixed red blood cells in phagocytosing murine macrophages J. Immunol. Methods 57 1983 373 379
    • (1983) J. Immunol. Methods , vol.57 , pp. 373-379
    • Loike, J.D.1    Silverstein, S.C.2
  • 21
    • 0028067938 scopus 로고
    • Evaluation of a flow cytometric fluorescence quenching assay of phagocytosis of sensitized sheep erythrocytes by polymorphonuclear leukocytes
    • E.S. Van Amersfoort, and J.A. Van Strijp Evaluation of a flow cytometric fluorescence quenching assay of phagocytosis of sensitized sheep erythrocytes by polymorphonuclear leukocytes Cytometry 17 1994 294 301
    • (1994) Cytometry , vol.17 , pp. 294-301
    • Van Amersfoort, E.S.1    Van Strijp, J.A.2
  • 22
    • 0015230393 scopus 로고
    • Analysis of long-chain free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants
    • A.A. Spector, J.E. Fletcher, and J.D. Ashbrook Analysis of long-chain free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants Biochemistry 10 1971 3229 3232
    • (1971) Biochemistry , vol.10 , pp. 3229-3232
    • Spector, A.A.1    Fletcher, J.E.2    Ashbrook, J.D.3
  • 23
    • 0014935338 scopus 로고
    • Free fatty acid utilization by mammalian cell suspension comparison between individual fatty acids and fatty acid mixtures
    • A.A. Spector Free fatty acid utilization by mammalian cell suspension comparison between individual fatty acids and fatty acid mixtures Biochim. Biophys. Acta 218 1970 36 43
    • (1970) Biochim. Biophys. Acta , vol.218 , pp. 36-43
    • Spector, A.A.1
  • 24
    • 0028058149 scopus 로고
    • Molecular and biochemical analyses of fatty acid transport, metabolism, and gene regulation in Escherichia coli
    • P.N. Black, and C.C. DiRusso Molecular and biochemical analyses of fatty acid transport, metabolism, and gene regulation in Escherichia coli Biochim. Biophys. Acta 1210 1994 123 145
    • (1994) Biochim. Biophys. Acta , vol.1210 , pp. 123-145
    • Black, P.N.1    Dirusso, C.C.2
  • 25
    • 0029093993 scopus 로고
    • Comparison of the reactivity of tetradecenoic acids, a triacsin, and unsaturated oximes with four purified Saccharomyces cerevisiae fatty acid activation proteins
    • L.J. Knoll, O.F. Schall, I. Suzuki, G.W. Gokel, and J.I. Gordon Comparison of the reactivity of tetradecenoic acids, a triacsin, and unsaturated oximes with four purified Saccharomyces cerevisiae fatty acid activation proteins J. Biol. Chem. 270 1995 20090 20097
    • (1995) J. Biol. Chem. , vol.270 , pp. 20090-20097
    • Knoll, L.J.1    Schall, O.F.2    Suzuki, I.3    Gokel, G.W.4    Gordon, J.I.5
  • 27
    • 0028290824 scopus 로고
    • Energy transduction by cytochrome complexes in mitochondrial and bacterial respiration: The enzymology of coupling electron transfer reactions to transmembrane proton translocation
    • B.L. Trumpower, and R.B. Gennis Energy transduction by cytochrome complexes in mitochondrial and bacterial respiration: the enzymology of coupling electron transfer reactions to transmembrane proton translocation Annu. Rev. Biochem. 63 1994 675 716
    • (1994) Annu. Rev. Biochem. , vol.63 , pp. 675-716
    • Trumpower, B.L.1    Gennis, R.B.2
  • 28
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening Assays
    • J.H. Zhang, T.D. Chung, and K.R. Oldenburg A simple statistical parameter for use in evaluation and validation of high throughput screening Assays J. Biomol. Screen. 4 1999 67 73
    • (1999) J. Biomol. Screen. , vol.4 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.2    Oldenburg, K.R.3
  • 29
    • 0034181706 scopus 로고    scopus 로고
    • Confirmation of primary active substances from high throughput screening of chemical and biological populations: A statistical approach and practical considerations
    • J.H. Zhang, T.D. Chung, and K.R. Oldenburg Confirmation of primary active substances from high throughput screening of chemical and biological populations: a statistical approach and practical considerations J. Comb. Chem. 2 2000 258 265
    • (2000) J. Comb. Chem. , vol.2 , pp. 258-265
    • Zhang, J.H.1    Chung, T.D.2    Oldenburg, K.R.3
  • 30
    • 0037163035 scopus 로고    scopus 로고
    • Fatty acid transport in Saccharomyces cerevisiae. Directed mutagenesis of FAT1 distinguishes the biochemical activities associated with Fat1p
    • Z. Zou, C.C. DiRusso, V. Ctrnacta, and P.N. Black Fatty acid transport in Saccharomyces cerevisiae. Directed mutagenesis of FAT1 distinguishes the biochemical activities associated with Fat1p J. Biol. Chem. 277 2002 31062 31071
    • (2002) J. Biol. Chem. , vol.277 , pp. 31062-31071
    • Zou, Z.1    Dirusso, C.C.2    Ctrnacta, V.3    Black, P.N.4
  • 31
    • 0034922738 scopus 로고    scopus 로고
    • Fatty acid transport: The diffusion mechanism in model and biological membranes
    • J.A. Hamilton, R.A. Johnson, B. Corkey, and F. Kamp Fatty acid transport: the diffusion mechanism in model and biological membranes J. Mol. Neurosci. 16 2001 99 108
    • (2001) J. Mol. Neurosci. , vol.16 , pp. 99-108
    • Hamilton, J.A.1    Johnson, R.A.2    Corkey, B.3    Kamp, F.4
  • 32
    • 0032175112 scopus 로고    scopus 로고
    • Technological advances in high-throughput screening
    • P.B. Fernandes Technological advances in high-throughput screening Curr. Opin. Chem. Biol. 2 1998 597 603
    • (1998) Curr. Opin. Chem. Biol. , vol.2 , pp. 597-603
    • Fernandes, P.B.1


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