-
1
-
-
22244442489
-
The biochemistry of Parkinson's disease
-
Cookson, M. R. (2005) The biochemistry of Parkinson's disease. Annu. Rev. Biochem. 74, 29-52
-
(2005)
Annu. Rev. Biochem.
, vol.74
, pp. 29-52
-
-
Cookson, M.R.1
-
2
-
-
0034077041
-
Mice lacking α-Synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W. H., Castillo, P. E., Shinsky, N., Verdugo, J. M., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., and Rosenthal, A. (2000) Mice lacking α-Synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25, 239-252
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Fariñas, I.3
Choi-Lundberg, D.4
Ho, W.H.5
Castillo, P.E.6
Shinsky, N.7
Verdugo, J.M.8
Armanini, M.9
Ryan, A.10
Hynes, M.11
Phillips, H.12
Sulzer, D.13
Rosenthal, A.14
-
3
-
-
0037109727
-
Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking α-Synuclein
-
Cabin, D. E., Shimazu, K., Murphy, D., Cole, N. B., Gottschalk, W., McIlwain, K. L., Orrison, B., Chen, A., Ellis, C. E., Paylor, R., Lu, B., and Nussbaum, R. L. (2002) Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking α-Synuclein. J. Neurosci. 22, 8797-8807
-
(2002)
J. Neurosci.
, vol.22
, pp. 8797-8807
-
-
Cabin, D.E.1
Shimazu, K.2
Murphy, D.3
Cole, N.B.4
Gottschalk, W.5
McIlwain, K.L.6
Orrison, B.7
Chen, A.8
Ellis, C.E.9
Paylor, R.10
Lu, B.11
Nussbaum, R.L.12
-
4
-
-
73549085595
-
Increased expression of α-Synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
-
Nemani, V. M., Lu, W., Berge, V., Nakamura, K., Onoa, B., Lee, M. K., Chaudhry, F. A., Nicoll, R. A., and Edwards, R. H. (2010) Increased expression of α-Synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron 65, 66-79
-
(2010)
Neuron
, vol.65
, pp. 66-79
-
-
Nemani, V.M.1
Lu, W.2
Berge, V.3
Nakamura, K.4
Onoa, B.5
Lee, M.K.6
Chaudhry, F.A.7
Nicoll, R.A.8
Edwards, R.H.9
-
5
-
-
77953796839
-
A pathologic cascade leading to synaptic dysfunction in α-Synuclein-induced neurodegeneration
-
Scott, D. A., Tabarean, I., Tang, Y., Cartier, A., Masliah, E., and Roy, S. (2010) A pathologic cascade leading to synaptic dysfunction in α-Synuclein-induced neurodegeneration. J. Neurosci. 30, 8083-8095
-
(2010)
J. Neurosci.
, vol.30
, pp. 8083-8095
-
-
Scott, D.A.1
Tabarean, I.2
Tang, Y.3
Cartier, A.4
Masliah, E.5
Roy, S.6
-
6
-
-
0034193399
-
Synucleins are developmentally expressed, and α-Synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
-
Murphy, D. D., Rueter, S. M., Trojanowski, J. Q., and Lee, V. M. (2000) Synucleins are developmentally expressed, and α-Synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J. Neurosci. 20, 3214-3220
-
(2000)
J. Neurosci.
, vol.20
, pp. 3214-3220
-
-
Murphy, D.D.1
Rueter, S.M.2
Trojanowski, J.Q.3
Lee, V.M.4
-
7
-
-
0029820770
-
Characterization of the precursor protein of the non-Aβ component of senile plaques (NACP) in the human central nervous system
-
Irizarry, M. C., Kim, T. W., McNamara, M., Tanzi, R. E., George, J. M., Clayton, D. F., and Hyman, B. T. (1996) Characterization of the precursor protein of the non-Aβ component of senile plaques (NACP) in the human central nervous system. J. Neuropathol. Exp. Neurol. 55, 889-895
-
(1996)
J. Neuropathol. Exp. Neurol.
, vol.55
, pp. 889-895
-
-
Irizarry, M.C.1
Kim, T.W.2
McNamara, M.3
Tanzi, R.E.4
George, J.M.5
Clayton, D.F.6
Hyman, B.T.7
-
8
-
-
0034280435
-
Subcellular localization of wild-type and Parkinson's disease-associated mutant α-Synuclein in human and transgenic mouse brain
-
Kahle, P. J., Neumann, M., Ozmen, L., Muller, V., Jacobsen, H., Schindzielorz, A., Okochi, M., Leimer, U., van Der Putten, H., Probst, A., Kremmer, E., Kretzschmar, H. A., and Haass, C. (2000) Subcellular localization of wild-type and Parkinson's disease-associated mutant α-Synuclein in human and transgenic mouse brain. J. Neurosci. 20, 6365-6373
-
(2000)
J. Neurosci.
, vol.20
, pp. 6365-6373
-
-
Kahle, P.J.1
Neumann, M.2
Ozmen, L.3
Muller, V.4
Jacobsen, H.5
Schindzielorz, A.6
Okochi, M.7
Leimer, U.8
Van Der Putten, H.9
Probst, A.10
Kremmer, E.11
Kretzschmar, H.A.12
Haass, C.13
-
9
-
-
33845952600
-
Cytosolic proteins regulate α-Synuclein dissociation from presynaptic membranes
-
Wislet-Gendebien, S., D'Souza, C., Kawarai, T., St George-Hyslop, P., Westaway, D., Fraser, P., and Tandon, A. (2006) Cytosolic proteins regulate α-Synuclein dissociation from presynaptic membranes. J. Biol. Chem. 281, 32148-32155
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 32148-32155
-
-
Wislet-Gendebien, S.1
D'Souza, C.2
Kawarai, T.3
St George-Hyslop, P.4
Westaway, D.5
Fraser, P.6
Tandon, A.7
-
10
-
-
28044461467
-
Neural activity controls the synaptic accumulation of α-Synuclein
-
Fortin, D. L., Nemani, V. M., Voglmaier, S. M., Anthony, M. D., Ryan, T. A., and Edwards, R. H. (2005) Neural activity controls the synaptic accumulation of α-Synuclein. J. Neurosci. 25, 10913-10921
-
(2005)
J. Neurosci.
, vol.25
, pp. 10913-10921
-
-
Fortin, D.L.1
Nemani, V.M.2
Voglmaier, S.M.3
Anthony, M.D.4
Ryan, T.A.5
Edwards, R.H.6
-
11
-
-
77952900626
-
α-Synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs
-
Thayanidhi, N., Helm, J. R., Nycz, D. C., Bentley, M., Liang, Y., and Hay, J. C. (2010) α-Synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs. Mol. Biol. Cell 21, 1850-1863
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 1850-1863
-
-
Thayanidhi, N.1
Helm, J.R.2
Nycz, D.C.3
Bentley, M.4
Liang, Y.5
Hay, J.C.6
-
12
-
-
0029904487
-
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
-
Weinreb, P. H., Zhen, W., Poon, A. W., Conway, K. A., and Lansbury, P. T., Jr. (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35, 13709-13715
-
(1996)
Biochemistry
, vol.35
, pp. 13709-13715
-
-
Weinreb, P.H.1
Zhen, W.2
Poon, A.W.3
Conway, K.A.4
Lansbury Jr., P.T.5
-
13
-
-
0032540327
-
Stabilization of α-Synuclein secondary structure upon binding to synthetic membranes
-
Davidson, W. S., Jonas, A., Clayton, D. F., and George, J. M. (1998) Stabilization of α-Synuclein secondary structure upon binding to synthetic membranes. J. Biol. Chem. 273, 9443-9449
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9443-9449
-
-
Davidson, W.S.1
Jonas, A.2
Clayton, D.F.3
George, J.M.4
-
14
-
-
0035815115
-
Conformational properties of α-Synuclein in its free and lipid-associated states
-
Eliezer, D., Kutluay, E., Bussell, R., Jr., and Browne, G. (2001) Conformational properties of α-Synuclein in its free and lipid-associated states. J. Mol. Biol. 307, 1061-1073
-
(2001)
J. Mol. Biol.
, vol.307
, pp. 1061-1073
-
-
Eliezer, D.1
Kutluay, E.2
Bussell Jr., R.3
Browne, G.4
-
15
-
-
2942555022
-
Structure of membrane-boundα-Synuclein studied by site-directed spin labeling
-
Jao, C. C., Der-Sarkissian, A., Chen, J., and Langen, R. (2004) Structure of membrane-boundα-Synuclein studied by site-directed spin labeling. Proc. Natl. Acad. Sci. U.S.A. 101, 8331-8336
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 8331-8336
-
-
Jao, C.C.1
Der-Sarkissian, A.2
Chen, J.3
Langen, R.4
-
16
-
-
53549118872
-
Differential regulation of wild-type and mutant α-Synuclein binding to synaptic membranes by cytosolic factors
-
Wislet-Gendebien, S., Visanji, N. P., Whitehead, S. N., Marsilio, D., Hou, W., Figeys, D., Fraser, P. E., Bennett, S. A., and Tandon, A. (2008) Differential regulation of wild-type and mutant α-Synuclein binding to synaptic membranes by cytosolic factors. BMC Neurosci. 9, 92
-
(2008)
BMC Neurosci
, vol.9
, pp. 92
-
-
Wislet-Gendebien, S.1
Visanji, N.P.2
Whitehead, S.N.3
Marsilio, D.4
Hou, W.5
Figeys, D.6
Fraser, P.E.7
Bennett, S.A.8
Tandon, A.9
-
17
-
-
0026067472
-
A small GTPbinding protein dissociates from synaptic vesicles during exocytosis
-
Fischer von Mollard, G., Südhof, T. C., and Jahn, R. (1991) A small GTPbinding protein dissociates from synaptic vesicles during exocytosis. Nature 349, 79-81
-
(1991)
Nature
, vol.349
, pp. 79-81
-
-
Fischer Von Mollard, G.1
Südhof, T.C.2
Jahn, R.3
-
18
-
-
0032125862
-
Differential regulation of exocytosis by calcium and CAPS in semi-intact synaptosomes
-
Tandon, A., Bannykh, S., Kowalchyk, J. A., Banerjee, A., Martin, T. F., and Balch, W. E. (1998) Differential regulation of exocytosis by calcium and CAPS in semi-intact synaptosomes. Neuron 21, 147-154
-
(1998)
Neuron
, vol.21
, pp. 147-154
-
-
Tandon, A.1
Bannykh, S.2
Kowalchyk, J.A.3
Banerjee, A.4
Martin, T.F.5
Balch, W.E.6
-
19
-
-
0032952414
-
Synphilin-1 associates with α-Synuclein and promotes the formation of cytosolic inclusions
-
Engelender, S., Kaminsky, Z., Guo, X., Sharp, A. H., Amaravi, R. K., Kleiderlein, J. J., Margolis, R. L., Troncoso, J. C., Lanahan, A. A., Worley, P. F., Dawson, V. L., Dawson, T. M., and Ross, C. A. (1999) Synphilin-1 associates with α-Synuclein and promotes the formation of cytosolic inclusions. Nat. Genet. 22, 110-114
-
(1999)
Nat. Genet.
, vol.22
, pp. 110-114
-
-
Engelender, S.1
Kaminsky, Z.2
Guo, X.3
Sharp, A.H.4
Amaravi, R.K.5
Kleiderlein, J.J.6
Margolis, R.L.7
Troncoso, J.C.8
Lanahan, A.A.9
Worley, P.F.10
Dawson, V.L.11
Dawson, T.M.12
Ross, C.A.13
-
20
-
-
0037110754
-
Rab-αGDI activity is regulated by a Hsp90 chaperone complex
-
Sakisaka, T., Meerlo, T., Matteson, J., Plutner, H., and Balch, W. E. (2002) Rab-αGDI activity is regulated by a Hsp90 chaperone complex. EMBO J. 21, 6125-6135
-
(2002)
EMBO J
, vol.21
, pp. 6125-6135
-
-
Sakisaka, T.1
Meerlo, T.2
Matteson, J.3
Plutner, H.4
Balch, W.E.5
-
21
-
-
32344444043
-
Use of Hsp90 inhibitors to disrupt GDI-dependent Rab recycling
-
Chen, C. Y., Sakisaka, T., and Balch, W. E. (2005) Use of Hsp90 inhibitors to disrupt GDI-dependent Rab recycling. Methods Enzymol. 403, 339-347
-
(2005)
Methods Enzymol
, vol.403
, pp. 339-347
-
-
Chen, C.Y.1
Sakisaka, T.2
Balch, W.E.3
-
22
-
-
0038504064
-
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in mammalian brain
-
Chen, F., Tandon, A., Sanjo, N., Gu, Y. J., Hasegawa, H., Arawaka, S., Lee, F. J., Ruan, X., Mastrangelo, P., Erdebil, S., Wang, L., Westaway, D., Mount, H. T., Yankner, B., Fraser, P. E., and St George-Hyslop, P. (2003) Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in mammalian brain. J. Biol. Chem. 278, 19974-19979
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19974-19979
-
-
Chen, F.1
Tandon, A.2
Sanjo, N.3
Gu, Y.J.4
Hasegawa, H.5
Arawaka, S.6
Lee, F.J.7
Ruan, X.8
Mastrangelo, P.9
Erdebil, S.10
Wang, L.11
Westaway, D.12
Mount, H.T.13
Yankner, B.14
Fraser, P.E.15
St George-Hyslop, P.16
-
23
-
-
0026463861
-
Amino acid residues in the Ras-like GTPase Rab3A that specify sensitivity to factors that regulate the GTP/GDP cycling of Rab3A
-
Burstein, E. S., Brondyk, W. H., and Macara, I. G. (1992) Amino acid residues in the Ras-like GTPase Rab3A that specify sensitivity to factors that regulate the GTP/GDP cycling of Rab3A. J. Biol. Chem. 267, 22715-22718
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 22715-22718
-
-
Burstein, E.S.1
Brondyk, W.H.2
MacAra, I.G.3
-
24
-
-
0027158878
-
Mutants of Rab3A analogous to oncogenic Ras mutants. Sensitivity to Rab3A-GTPase-activating protein and Rab3A-guanine nucleotide releasing factor
-
Brondyk, W. H., McKiernan, C. J., Burstein, E. S., and Macara, I. G. (1993) Mutants of Rab3A analogous to oncogenic Ras mutants. Sensitivity to Rab3A-GTPase-activating protein and Rab3A-guanine nucleotide releasing factor. J. Biol. Chem. 268, 9410-9415
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 9410-9415
-
-
Brondyk, W.H.1
McKiernan, C.J.2
Burstein, E.S.3
MacAra, I.G.4
-
25
-
-
0037175049
-
Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion
-
Schlüter, O. M., Khvotchev, M., Jahn, R., and Südhof, T. C. (2002) Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion. J. Biol. Chem. 277, 40919-40929
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40919-40929
-
-
Schlüter, O.M.1
Khvotchev, M.2
Jahn, R.3
Südhof, T.C.4
-
26
-
-
2942737775
-
A complete genetic analysis of neuronal Rab3 function
-
Schlüter, O. M., Schmitz, F., Jahn, R., Rosenmund, C., and Südhof, T. C. (2004) A complete genetic analysis of neuronal Rab3 function. J. Neurosci. 24, 6629-6637
-
(2004)
J. Neurosci.
, vol.24
, pp. 6629-6637
-
-
Schlüter, O.M.1
Schmitz, F.2
Jahn, R.3
Rosenmund, C.4
Südhof, T.C.5
-
27
-
-
39349092547
-
Core proteins of the secretory machinery
-
Lang, T., and Jahn, R. (2008) Core proteins of the secretory machinery. Handb. Exp. Pharmacol. 184, 107-127
-
(2008)
Handb. Exp. Pharmacol.
, vol.184
, pp. 107-127
-
-
Lang, T.1
Jahn, R.2
-
28
-
-
0029944499
-
Structure and mutational analysis of Rab GDP-dissociation inhibitor
-
Schalk, I., Zeng, K., Wu, S. K., Stura, E. A., Matteson, J., Huang, M., Tandon, A., Wilson, I. A., and Balch, W. E. (1996) Structure and mutational analysis of Rab GDP-dissociation inhibitor. Nature 381, 42-48
-
(1996)
Nature
, vol.381
, pp. 42-48
-
-
Schalk, I.1
Zeng, K.2
Wu, S.K.3
Stura, E.A.4
Matteson, J.5
Huang, M.6
Tandon, A.7
Wilson, I.A.8
Balch, W.E.9
-
29
-
-
0034157347
-
A new functional domain of guanine nucleotide dissociation inhibitor (α-GDI) involved in Rab recycling
-
Luan, P., Heine, A., Zeng, K., Moyer, B., Greasely, S. E., Kuhn, P., Balch, W. E., and Wilson, I. A. (2000) A new functional domain of guanine nucleotide dissociation inhibitor (α-GDI) involved in Rab recycling. Traffic 1, 270-281
-
(2000)
Traffic
, vol.1
, pp. 270-281
-
-
Luan, P.1
Heine, A.2
Zeng, K.3
Moyer, B.4
Greasely, S.E.5
Kuhn, P.6
Balch, W.E.7
Wilson, I.A.8
-
30
-
-
3242879787
-
α-Synuclein-synaptosomal membrane interactions: Implications for fibrillogenesis
-
Jo, E., Darabie, A. A., Han, K., Tandon, A., Fraser, P. E., and McLaurin, J. (2004) α-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis. Eur. J. Biochem. 271, 3180-3189
-
(2004)
Eur. J. Biochem.
, vol.271
, pp. 3180-3189
-
-
Jo, E.1
Darabie, A.A.2
Han, K.3
Tandon, A.4
Fraser, P.E.5
McLaurin, J.6
-
31
-
-
0034602296
-
α-Synuclein membrane interactions and lipid specificity
-
Jo, E., McLaurin, J., Yip, C. M., St George-Hyslop, P., and Fraser, P. E. (2000) α-Synuclein membrane interactions and lipid specificity. J. Biol. Chem. 275, 34328-34334
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34328-34334
-
-
Jo, E.1
McLaurin, J.2
Yip, C.M.3
St George-Hyslop, P.4
Fraser, P.E.5
-
32
-
-
0034602271
-
Interaction of human α-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis
-
Perrin, R. J., Woods, W. S., Clayton, D. F., and George, J. M. (2000) Interaction of human α-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis. J. Biol. Chem. 275, 34393-34398
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34393-34398
-
-
Perrin, R.J.1
Woods, W.S.2
Clayton, D.F.3
George, J.M.4
-
33
-
-
0035928748
-
Membrane binding and self-association of α-Synucleins
-
Narayanan, V., and Scarlata, S. (2001) Membrane binding and self-association of α-Synucleins. Biochemistry 40, 9927-9934
-
(2001)
Biochemistry
, vol.40
, pp. 9927-9934
-
-
Narayanan, V.1
Scarlata, S.2
-
34
-
-
0141891097
-
The association of α-Synuclein with membranes affects bilayer structure, stability, and fibril formation
-
Zhu, M., Li, J., and Fink, A. L. (2003) The association of α-Synuclein with membranes affects bilayer structure, stability, and fibril formation. J. Biol. Chem. 278, 40186-40197
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 40186-40197
-
-
Zhu, M.1
Li, J.2
Fink, A.L.3
-
35
-
-
80053912079
-
Effect of Ser-129 phosphorylation on interaction of α-Synuclein with synaptic and cellular membranes
-
Visanji, N. P., Wislet-Gendebien, S., Oschipok, L. W., Zhang, G., Aubert, I., Fraser, P. E., and Tandon, A. (2011) Effect of Ser-129 phosphorylation on interaction of α-Synuclein with synaptic and cellular membranes. J. Biol. Chem. 286, 35863-35873
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 35863-35873
-
-
Visanji, N.P.1
Wislet-Gendebien, S.2
Oschipok, L.W.3
Zhang, G.4
Aubert, I.5
Fraser, P.E.6
Tandon, A.7
-
36
-
-
0036307753
-
Defective membrane interactions of familial Parkinson's disease mutant A30P α-Synuclein
-
Jo, E., Fuller, N., Rand, R. P., St George-Hyslop, P., and Fraser, P. E. (2002) Defective membrane interactions of familial Parkinson's disease mutant A30P α-Synuclein. J. Mol. Biol. 315, 799-807
-
(2002)
J. Mol. Biol.
, vol.315
, pp. 799-807
-
-
Jo, E.1
Fuller, N.2
Rand, R.P.3
St George-Hyslop, P.4
Fraser, P.E.5
-
37
-
-
0032500599
-
Binding of α-Synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
-
Jensen, P. H., Nielsen, M. S., Jakes, R., Dotti, C. G., and Goedert, M. (1998) Binding of α-Synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. J. Biol. Chem. 273, 26292-26294
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26292-26294
-
-
Jensen, P.H.1
Nielsen, M.S.2
Jakes, R.3
Dotti, C.G.4
Goedert, M.5
-
38
-
-
1942534598
-
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated α-Synuclein
-
Bussell, R., Jr., and Eliezer, D. (2004) Effects of Parkinson's disease-linked mutations on the structure of lipid-associated α-Synuclein. Biochemistry 43, 4810-4818
-
(2004)
Biochemistry
, vol.43
, pp. 4810-4818
-
-
Bussell Jr., R.1
Eliezer, D.2
-
39
-
-
24744432079
-
A combinatorial code for the interaction of α-Synuclein with membranes
-
Kubo, S., Nemani, V. M., Chalkley, R. J., Anthony, M. D., Hattori, N., Mizuno, Y., Edwards, R. H., and Fortin, D. L. (2005) A combinatorial code for the interaction of α-Synuclein with membranes. J. Biol. Chem. 280, 31664-31672
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31664-31672
-
-
Kubo, S.1
Nemani, V.M.2
Chalkley, R.J.3
Anthony, M.D.4
Hattori, N.5
Mizuno, Y.6
Edwards, R.H.7
Fortin, D.L.8
-
40
-
-
18044381951
-
α-Synuclein binding to rab3a in multiple system atrophy
-
Dalfó, E., and Ferrer, I. (2005) α-Synuclein binding to rab3a in multiple system atrophy. Neurosci. Lett. 380, 170-175
-
(2005)
Neurosci. Lett.
, vol.380
, pp. 170-175
-
-
Dalfó, E.1
Ferrer, I.2
-
41
-
-
2342457804
-
Abnormal α-Synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease
-
Dalfó, E., Barrachina, M., Rosa, J. L., Ambrosio, S., and Ferrer, I. (2004) Abnormal α-Synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease. Neurobiol. Dis. 16, 92-97
-
(2004)
Neurobiol. Dis.
, vol.16
, pp. 92-97
-
-
Dalfó, E.1
Barrachina, M.2
Rosa, J.L.3
Ambrosio, S.4
Ferrer, I.5
-
42
-
-
1842563080
-
Abnormal α-Synuclein interactions with Rab proteins in α-Synuclein A30P transgenic mice
-
Dalfó, E., Gómez-Isla, T., Rosa, J. L., Nieto Bodelón, M., Cuadrado Tejedor, M., Barrachina, M., Ambrosio, S., and Ferrer, I. (2004) Abnormal α-Synuclein interactions with Rab proteins in α-Synuclein A30P transgenic mice. J. Neuropathol. Exp. Neurol. 63, 302-313
-
(2004)
J. Neuropathol. Exp. Neurol.
, vol.63
, pp. 302-313
-
-
Dalfó, E.1
Gómez-Isla, T.2
Rosa, J.L.3
Nieto Bodelón, M.4
Cuadrado Tejedor, M.5
Barrachina, M.6
Ambrosio, S.7
Ferrer, I.8
-
43
-
-
38349160161
-
The Parkinson's disease protein α-Synuclein disrupts cellular Rab homeostasis
-
Gitler, A. D., Bevis, B. J., Shorter, J., Strathearn, K. E., Hamamichi, S., Su, L. J., Caldwell, K. A., Caldwell, G. A., Rochet, J. C., McCaffery, J. M., Barlowe, C., and Lindquist, S. (2008) The Parkinson's disease protein α-Synuclein disrupts cellular Rab homeostasis. Proc. Natl. Acad. Sci. U.S.A. 105, 145-150
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 145-150
-
-
Gitler, A.D.1
Bevis, B.J.2
Shorter, J.3
Strathearn, K.E.4
Hamamichi, S.5
Su, L.J.6
Caldwell, K.A.7
Caldwell, G.A.8
Rochet, J.C.9
McCaffery, J.M.10
Barlowe, C.11
Lindquist, S.12
-
44
-
-
33746533924
-
α-Synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
-
Cooper, A. A., Gitler, A. D., Cashikar, A., Haynes, C. M., Hill, K. J., Bhullar, B., Liu, K., Xu, K., Strathearn, K. E., Liu, F., Cao, S., Caldwell, K. A., Caldwell, G. A., Marsischky, G., Kolodner, R. D., Labaer, J., Rochet, J. C., Bonini, N. M., and Lindquist, S. (2006)α-Synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313, 324-328
-
(2006)
Science
, vol.313
, pp. 324-328
-
-
Cooper, A.A.1
Gitler, A.D.2
Cashikar, A.3
Haynes, C.M.4
Hill, K.J.5
Bhullar, B.6
Liu, K.7
Xu, K.8
Strathearn, K.E.9
Liu, F.10
Cao, S.11
Caldwell, K.A.12
Caldwell, G.A.13
Marsischky, G.14
Kolodner, R.D.15
Labaer, J.16
Rochet, J.C.17
Bonini, N.M.18
Lindquist, S.19
-
45
-
-
59649097036
-
Rab11a and HSP90 regulate recycling of extracellular α-Synuclein
-
Liu, J., Zhang, J. P., Shi, M., Quinn, T., Bradner, J., Beyer, R., Chen, S., and Zhang, J. (2009) Rab11a and HSP90 regulate recycling of extracellular α-Synuclein. J. Neurosci. 29, 1480-1485
-
(2009)
J. Neurosci.
, vol.29
, pp. 1480-1485
-
-
Liu, J.1
Zhang, J.P.2
Shi, M.3
Quinn, T.4
Bradner, J.5
Beyer, R.6
Chen, S.7
Zhang, J.8
-
46
-
-
52549126992
-
Regulation of secretory vesicle traffic by Rab small GTPases
-
Fukuda, M. (2008) Regulation of secretory vesicle traffic by Rab small GTPases. Cell. Mol. Life Sci. 65, 2801-2813
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, pp. 2801-2813
-
-
Fukuda, M.1
-
47
-
-
23844445866
-
The structural and mechanistic basis for recycling of Rab proteins between membrane compartments
-
Goody, R. S., Rak, A., and Alexandrov, K. (2005) The structural and mechanistic basis for recycling of Rab proteins between membrane compartments. Cell. Mol. Life Sci. 62, 1657-1670
-
(2005)
Cell. Mol. Life Sci.
, vol.62
, pp. 1657-1670
-
-
Goody, R.S.1
Rak, A.2
Alexandrov, K.3
-
48
-
-
0025901047
-
Isoprenoid modification of Rab proteins terminating in CC or CXC motifs
-
Khosravi-Far, R., Lutz, R. J., Cox, A. D., Conroy, L., Bourne, J. R., Sinensky, M., Balch, W. E., Buss, J. E., and Der, C. J. (1991) Isoprenoid modification of Rab proteins terminating in CC or CXC motifs. Proc. Natl. Acad. Sci. U.S.A. 88, 6264-6268
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 6264-6268
-
-
Khosravi-Far, R.1
Lutz, R.J.2
Cox, A.D.3
Conroy, L.4
Bourne, J.R.5
Sinensky, M.6
Balch, W.E.7
Buss, J.E.8
Der, C.J.9
-
49
-
-
0025830577
-
C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester
-
Farnsworth, C. C., Kawata, M., Yoshida, Y., Takai, Y., Gelb, M. H., and Glomset, J. A. (1991) C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester. Proc. Natl. Acad. Sci. U.S.A. 88, 6196-6200
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 6196-6200
-
-
Farnsworth, C.C.1
Kawata, M.2
Yoshida, Y.3
Takai, Y.4
Gelb, M.H.5
Glomset, J.A.6
-
50
-
-
0026668873
-
The geranylgeranyl moiety but not the methyl moiety of the smg-25A/rab3A protein is essential for the interactions with membrane and its inhibitory GDP/GTP exchange protein
-
Musha, T., Kawata, M., and Takai, Y. (1992) The geranylgeranyl moiety but not the methyl moiety of the smg-25A/rab3A protein is essential for the interactions with membrane and its inhibitory GDP/GTP exchange protein. J. Biol. Chem. 267, 9821-9825
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 9821-9825
-
-
Musha, T.1
Kawata, M.2
Takai, Y.3
-
51
-
-
0037334826
-
Geranylgeranyl switching regulates GDI-Rab GTPase recycling
-
An, Y., Shao, Y., Alory, C., Matteson, J., Sakisaka, T., Chen, W., Gibbs, R. A., Wilson, I. A., and Balch, W. E. (2003) Geranylgeranyl switching regulates GDI-Rab GTPase recycling. Structure 11, 347-357
-
(2003)
Structure
, vol.11
, pp. 347-357
-
-
An, Y.1
Shao, Y.2
Alory, C.3
Matteson, J.4
Sakisaka, T.5
Chen, W.6
Gibbs, R.A.7
Wilson, I.A.8
Balch, W.E.9
-
52
-
-
0033591317
-
Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo. Rabindependent binding to membranes and role of Rab recycling factors
-
Luan, P., Balch, W. E., Emr, S. D., and Burd, C. G. (1999) Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo. Rabindependent binding to membranes and role of Rab recycling factors. J. Biol. Chem. 274, 14806-14817
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 14806-14817
-
-
Luan, P.1
Balch, W.E.2
Emr, S.D.3
Burd, C.G.4
-
53
-
-
14644415031
-
The synaptic vesicle protein CSPα prevents presynaptic degeneration
-
Fernández-Chacón, R., Wölfel, M., Nishimune, H., Tabares, L., Schmitz, F., Castellano-Muñoz, M., Rosenmund, C., Montesinos, M. L., Sanes, J. R., Schneggenburger, R., and Südhof, T. C. (2004) The synaptic vesicle protein CSPα prevents presynaptic degeneration. Neuron 42, 237-251
-
(2004)
Neuron
, vol.42
, pp. 237-251
-
-
Fernández-Chacón, R.1
Wölfel, M.2
Nishimune, H.3
Tabares, L.4
Schmitz, F.5
Castellano-Muñoz, M.6
Rosenmund, C.7
Montesinos, M.L.8
Sanes, J.R.9
Schneggenburger, R.10
Südhof, T.C.11
-
54
-
-
27544507306
-
α-Synuclein cooperates with CSPα in preventing neurodegeneration
-
Chandra, S., Gallardo, G., Fernández-Chacón, R., Schlüter, O. M., and Südhof, T. C. (2005) α-Synuclein cooperates with CSPα in preventing neurodegeneration. Cell 123, 383-396
-
(2005)
Cell
, vol.123
, pp. 383-396
-
-
Chandra, S.1
Gallardo, G.2
Fernández-Chacón, R.3
Schlüter, O.M.4
Südhof, T.C.5
-
55
-
-
77957347060
-
α-Synuclein promotes SNARE-complex assembly in vivo and in vitro
-
Burré, J., Sharma, M., Tsetsenis, T., Buchman, V., Etherton, M. R., and Südhof, T. C. (2010) α-Synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 329, 1663-1667
-
(2010)
Science
, vol.329
, pp. 1663-1667
-
-
Burré, J.1
Sharma, M.2
Tsetsenis, T.3
Buchman, V.4
Etherton, M.R.5
Südhof, T.C.6
-
56
-
-
84857059950
-
CSPα knockout causes neurodegeneration by impairing SNAP-25 function
-
Sharma, M., Burré, J., Bronk, P., Zhang, Y., Xu, W., and Südhof, T. C. (2012) CSPα knockout causes neurodegeneration by impairing SNAP-25 function. EMBO J. 31, 829-841
-
(2012)
EMBO J
, vol.31
, pp. 829-841
-
-
Sharma, M.1
Burré, J.2
Bronk, P.3
Zhang, Y.4
Xu, W.5
Südhof, T.C.6
-
57
-
-
78650505099
-
CSPα promotes SNARE complex assembly by chaperoning SNAP-25 during synaptic activity
-
Sharma, M., Burré, J., and Südhof, T. C. (2011) CSPα promotes SNARE complex assembly by chaperoning SNAP-25 during synaptic activity. Nat. Cell Biol. 13, 30-39
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 30-39
-
-
Sharma, M.1
Burré, J.2
Südhof, T.C.3
-
58
-
-
77954215793
-
α-Synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis
-
Darios, F., Ruipérez, V., López, I., Villanueva, J., Gutierrez, L. M., and Davletov, B. (2010) α-Synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis. EMBO Rep. 11, 528-533
-
(2010)
EMBO Rep
, vol.11
, pp. 528-533
-
-
Darios, F.1
Ruipérez, V.2
López, I.3
Villanueva, J.4
Gutierrez, L.M.5
Davletov, B.6
-
59
-
-
33751113009
-
α-Synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis
-
Larsen, K. E., Schmitz, Y., Troyer, M. D., Mosharov, E., Dietrich, P., Quazi, A. Z., Savalle, M., Nemani, V., Chaudhry, F. A., Edwards, R. H., Stefanis, L., and Sulzer, D. (2006)α-Synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. J. Neurosci. 26, 11915-11922
-
(2006)
J. Neurosci.
, vol.26
, pp. 11915-11922
-
-
Larsen, K.E.1
Schmitz, Y.2
Troyer, M.D.3
Mosharov, E.4
Dietrich, P.5
Quazi, A.Z.6
Savalle, M.7
Nemani, V.8
Chaudhry, F.A.9
Edwards, R.H.10
Stefanis, L.11
Sulzer, D.12
-
60
-
-
0036786216
-
Evidence that α-Synuclein functions as a negative regulator of Ca2+-dependent α-granule release from human platelets
-
Park, S. M., Jung, H. Y., Kim, H. O., Rhim, H., Paik, S. R., Chung, K. C., Park, J. H., and Kim, J. (2002) Evidence that α-Synuclein functions as a negative regulator of Ca2+-dependent α-granule release from human platelets. Blood 100, 2506-2514
-
(2002)
Blood
, vol.100
, pp. 2506-2514
-
-
Park, S.M.1
Jung, H.Y.2
Kim, H.O.3
Rhim, H.4
Paik, S.R.5
Chung, K.C.6
Park, J.H.7
Kim, J.8
-
61
-
-
79251553739
-
α-Synuclein binds the KATP channel at insulin-secretory granules and inhibits insulin secretion
-
Geng, X., Lou, H., Wang, J., Li, L., Swanson, A. L., Sun, M., Beers-Stolz, D., Watkins, S., Perez, R. G., and Drain, P. (2011) α-Synuclein binds the KATP channel at insulin-secretory granules and inhibits insulin secretion. Am. J. Physiol. Endocrinol. Metab. 300, E276-E286
-
(2011)
Am. J. Physiol. Endocrinol. Metab.
, vol.300
-
-
Geng, X.1
Lou, H.2
Wang, J.3
Li, L.4
Swanson, A.L.5
Sun, M.6
Beers-Stolz, D.7
Watkins, S.8
Perez, R.G.9
Drain, P.10
-
62
-
-
77954368879
-
Regulation of Weibel-Palade body exocytosis by α-Synuclein in endothelial cells
-
Kim, K. S., Park, J. Y., Jou, I., and Park, S. M. (2010) Regulation of Weibel-Palade body exocytosis by α-Synuclein in endothelial cells. J. Biol. Chem. 285, 21416-21425
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 21416-21425
-
-
Kim, K.S.1
Park, J.Y.2
Jou, I.3
Park, S.M.4
-
63
-
-
84864258151
-
α-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis
-
Scott, D., and Roy, S. (2012) α-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis. J. Neurosci. 32, 10129-10135
-
(2012)
J. Neurosci.
, vol.32
, pp. 10129-10135
-
-
Scott, D.1
Roy, S.2
|