α-synuclein binds the KATP channel at insulin-secretory granules and inhibits insulin secretion

American Journal of Physiology - Endocrinology and Metabolism

Volumn 300, Issue 2, 2011, Pages

  Geng, Xuehui ^a   Lou, Haiyan ^a   Wang, Jian ^a   Li, Lehong ^a   Swanson, Alexandra L ^a   Sun, Ming ^a   Beers Stolz, Donna ^a   Watkins, Simon ^a   Perez, Ruth G ^a   Drain, Peter ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; ATP sensitive K+ channels; Diabetes; Glucose sensitive insulin secretion; Kir6.2; Parkinson's disease; SUR1; Vesicle

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ALPHA SYNUCLEIN; C PEPTIDE; GLUCOSE; INSULIN; INSULIN ANTIBODY; SULFONYLUREA;

ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECRETORY GRANULE; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; WESTERN BLOTTING;

ALPHA-SYNUCLEIN; ANIMALS; CYTOPLASM; DNA; DOWN-REGULATION; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; KATP CHANNELS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SECRETORY VESICLES;

EID: 79251553739     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00262.2010     Document Type: Article

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