The anti-apoptotic genes Bcl-XL and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells

British Journal of Haematology

Volumn 118, Issue 2, 2002, Pages 521-534

  Konopleva, Marina ^a   Zhao, Shourong ^a   Hu, Wei ^a   Jiang, Shuwei ^a   Snell, Virginia ^a   Weidner, Douglas ^a   Jackson, C Ellen ^a   Zhang, Xin ^a   Champlin, Richard ^a   Estey, Elihu ^a   Reed, John C ^b   Andreeff, Michael ^a,c  

^a UNIVERSITY OF TEXAS   (United States)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

AML; Apoptosis; Bcl 2; Bcl XL; Cell cycle

Indexed keywords

ANTINEOPLASTIC AGENT; ARABINOSIDE; CD34 ANTIGEN; CYTOSINE; PROTEIN BCL 2; PROTEIN BCL XL; RETINOIC ACID;

ADULT; AGED; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; GENE EXPRESSION; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD34; ANTIGENS, CD95; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-X PROTEIN; BETA 2-MICROGLOBULIN; BONE MARROW CELLS; CELL DIVISION; CYTARABINE; DOWN-REGULATION; FLOW CYTOMETRY; GENES, BCL-2; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA, MYELOID; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2; TRETINOIN;

EID: 0036040031     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03637.x     Document Type: Article

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