메뉴 건너뛰기




Volumn 182, Issue 4, 2013, Pages 1055-1064

Wounds that will not heal: Pervasive cellular reprogramming in cancer

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; GELATINASE B; MATRIX METALLOPROTEINASE 14; STROMELYSIN;

EID: 84875123308     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.01.009     Document Type: Review
Times cited : (82)

References (119)
  • 2
    • 84875189433 scopus 로고
    • Mechanical irritation as etiologic factor of cancer: Clinical observation
    • N.M. Alter Mechanical irritation as etiologic factor of cancer: clinical observation Am J Pathol 1 1925 511 518.3
    • (1925) Am J Pathol , vol.1 , pp. 511-5183
    • Alter, N.M.1
  • 3
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal: Similarities between tumor stroma generation and wound healing
    • H.F. Dvorak Tumors: wounds that do not heal: similarities between tumor stroma generation and wound healing N Engl J Med 315 1986 1650 1659
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 4
    • 0015489740 scopus 로고
    • Molecular repair, wound healing, and carcinogenesis: Tumor production a possible overhealing?
    • A. Haddow Molecular repair, wound healing, and carcinogenesis: tumor production a possible overhealing? Adv Cancer Res 16 1972 181 234
    • (1972) Adv Cancer Res , vol.16 , pp. 181-234
    • Haddow, A.1
  • 5
    • 84875189557 scopus 로고
    • A quantitative study of wound healing in the rat, I: Cell movements and cell layers during wound healing
    • H. Akaiwa A quantitative study of wound healing in the rat, I: cell movements and cell layers during wound healing J Med Res 40 1919 311 351
    • (1919) J Med Res , vol.40 , pp. 311-351
    • Akaiwa, H.1
  • 6
    • 9444258150 scopus 로고
    • A comparative study of the mechanism of wound healing
    • L. Loeb A comparative study of the mechanism of wound healing J Med Res 41 1920 247 281
    • (1920) J Med Res , vol.41 , pp. 247-281
    • Loeb, L.1
  • 7
    • 0037926778 scopus 로고    scopus 로고
    • Rous-Whipple Award Lecture: How tumors make bad blood vessels and stroma
    • H.F. Dvorak Rous-Whipple Award Lecture: how tumors make bad blood vessels and stroma Am J Pathol 162 2003 1747 1757
    • (2003) Am J Pathol , vol.162 , pp. 1747-1757
    • Dvorak, H.F.1
  • 8
    • 0015329548 scopus 로고
    • Participation of components of the blood coagulation system in the inflammatory response
    • D.G. McKay Participation of components of the blood coagulation system in the inflammatory response Am J Pathol 67 1972 181 210
    • (1972) Am J Pathol , vol.67 , pp. 181-210
    • McKay, D.G.1
  • 10
    • 0020264236 scopus 로고
    • Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization
    • R.A. Clark, J.M. Lanigan, P. DellaPelle, E. Manseau, H.F. Dvorak, and R.B. Colvin Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization J Invest Dermatol 79 1982 264 269
    • (1982) J Invest Dermatol , vol.79 , pp. 264-269
    • Clark, R.A.1    Lanigan, J.M.2    Dellapelle, P.3    Manseau, E.4    Dvorak, H.F.5    Colvin, R.B.6
  • 11
    • 0020688930 scopus 로고
    • Fibrin as a component of the tumor stroma: Origins and biological significance
    • H.F. Dvorak, D.R. Senger, and A.M. Dvorak Fibrin as a component of the tumor stroma: origins and biological significance Cancer Metastasis Rev 2 1983 41 73
    • (1983) Cancer Metastasis Rev , vol.2 , pp. 41-73
    • Dvorak, H.F.1    Senger, D.R.2    Dvorak, A.M.3
  • 12
    • 34548849117 scopus 로고    scopus 로고
    • The role of complement in inflammatory diseases from behind the scenes into the spotlight
    • M.M. Markiewski, and J.D. Lambris The role of complement in inflammatory diseases from behind the scenes into the spotlight Am J Pathol 171 2007 715 727
    • (2007) Am J Pathol , vol.171 , pp. 715-727
    • Markiewski, M.M.1    Lambris, J.D.2
  • 13
    • 47749139256 scopus 로고    scopus 로고
    • Cancer as an overhealing wound: An old hypothesis revisited
    • M. Schäfer, and S. Werner Cancer as an overhealing wound: an old hypothesis revisited Nat Rev Mol Cell Biol 9 2008 628 638
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 628-638
    • Schäfer, M.1    Werner, S.2
  • 14
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • J. Folkman Tumor angiogenesis: therapeutic implications N Engl J Med 285 1971 1182 1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 15
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • D.R. Senger, S.J. Galli, A.M. Dvorak, C.A. Perruzzi, V.S. Harvey, and H.F. Dvorak Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid Science 219 1983 983 985
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 16
    • 70449491904 scopus 로고    scopus 로고
    • Orchestration of macrophage polarization
    • A. Mantovani, and M. Locati Orchestration of macrophage polarization Blood 114 2009 3135 3136
    • (2009) Blood , vol.114 , pp. 3135-3136
    • Mantovani, A.1    Locati, M.2
  • 17
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: Mechanism and functions
    • S. Gordon, and F.O. Martinez Alternative activation of macrophages: mechanism and functions Immunity 32 2010 593 604
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 18
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    • G. Solinas, G. Germano, A. Mantovani, and P. Allavena Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation J Leukoc Biol 86 2009 1065 1073
    • (2009) J Leukoc Biol , vol.86 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3    Allavena, P.4
  • 20
    • 62549109923 scopus 로고    scopus 로고
    • High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors
    • L.S. Ojalvo, W. King, D. Cox, and J.W. Pollard High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors Am J Pathol 174 2009 1048 1064
    • (2009) Am J Pathol , vol.174 , pp. 1048-1064
    • Ojalvo, L.S.1    King, W.2    Cox, D.3    Pollard, J.W.4
  • 21
    • 70350529527 scopus 로고    scopus 로고
    • Functional plasticity of macrophages: In situ reprogramming of tumor-associated macrophages
    • R.D. Stout, S.K. Watkins, and J. Suttles Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages J Leukoc Biol 86 2009 1105 1109
    • (2009) J Leukoc Biol , vol.86 , pp. 1105-1109
    • Stout, R.D.1    Watkins, S.K.2    Suttles, J.3
  • 22
    • 80052138920 scopus 로고    scopus 로고
    • Cancer-promoting tumor-associated macrophages: New vistas and open questions
    • A. Mantovani, G. Germano, F. Marchesi, M. Locatelli, and S.K. Biswas Cancer-promoting tumor-associated macrophages: new vistas and open questions Eur J Immunol 41 2011 2522 2525
    • (2011) Eur J Immunol , vol.41 , pp. 2522-2525
    • Mantovani, A.1    Germano, G.2    Marchesi, F.3    Locatelli, M.4    Biswas, S.K.5
  • 23
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • D.M. Mosser, and J.P. Edwards Exploring the full spectrum of macrophage activation Nat Rev Immunol 8 2008 958 969
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 24
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies
    • L. Bingle, N.J. Brown, and C.E. Lewis The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies J Pathol 196 2002 254 265
    • (2002) J Pathol , vol.196 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 26
    • 78650547508 scopus 로고    scopus 로고
    • Tumor-associated macrophages in breast cancer as potential biomarkers for new treatments and diagnostics
    • R.A. Mukhtar, O. Nseyo, M.J. Campbell, and L.J. Esserman Tumor-associated macrophages in breast cancer as potential biomarkers for new treatments and diagnostics Expert Rev Mol Diagn 11 2011 91 100
    • (2011) Expert Rev Mol Diagn , vol.11 , pp. 91-100
    • Mukhtar, R.A.1    Nseyo, O.2    Campbell, M.J.3    Esserman, L.J.4
  • 29
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • K.L. Talks, H. Turley, K.C. Gatter, P.H. Maxwell, C.W. Pugh, P.J. Ratcliffe, and A.L. Harris The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages Am J Pathol 157 2000 411 421
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6    Harris, A.L.7
  • 30
    • 0023838315 scopus 로고
    • Evidence for the nonmuscle nature of the "myofibroblast" of granulation tissue and hypertropic scar: An immunofluorescence study
    • R.J. Eddy, J.A. Petro, and J.J. Tomasek Evidence for the nonmuscle nature of the "myofibroblast" of granulation tissue and hypertropic scar: an immunofluorescence study Am J Pathol 130 1988 252 260
    • (1988) Am J Pathol , vol.130 , pp. 252-260
    • Eddy, R.J.1    Petro, J.A.2    Tomasek, J.J.3
  • 37
    • 0033134111 scopus 로고    scopus 로고
    • Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue
    • F. Grinnell, M. Zhu, M.A. Carlson, and J.M. Abrams Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue Exp Cell Res 248 1999 608 619
    • (1999) Exp Cell Res , vol.248 , pp. 608-619
    • Grinnell, F.1    Zhu, M.2    Carlson, M.A.3    Abrams, J.M.4
  • 38
    • 81255205399 scopus 로고    scopus 로고
    • Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
    • M. Labelle, S. Begum, and R.O. Hynes Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis Cancer Cell 20 2011 576 590
    • (2011) Cancer Cell , vol.20 , pp. 576-590
    • Labelle, M.1    Begum, S.2    Hynes, R.O.3
  • 39
    • 84455171408 scopus 로고    scopus 로고
    • Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells
    • J.A. Cho, H. Park, E.H. Lim, and K.W. Lee Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells Int J Oncol 40 2012 130 138
    • (2012) Int J Oncol , vol.40 , pp. 130-138
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Lee, K.W.4
  • 40
    • 78649958307 scopus 로고    scopus 로고
    • Cancer exosomes trigger fibroblast to myofibroblast differentiation
    • J. Webber, R. Steadman, M.D. Mason, Z. Tabi, and A. Clayton Cancer exosomes trigger fibroblast to myofibroblast differentiation Cancer Res 70 2010 9621 9630
    • (2010) Cancer Res , vol.70 , pp. 9621-9630
    • Webber, J.1    Steadman, R.2    Mason, M.D.3    Tabi, Z.4    Clayton, A.5
  • 42
    • 0034799176 scopus 로고    scopus 로고
    • Renal fibrosis: Collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation
    • M. Zeisberg, G. Bonner, Y. Maeshima, P. Colorado, G.A. Muller, F. Strutz, and R. Kalluri Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation Am J Pathol 159 2001 1313 1321
    • (2001) Am J Pathol , vol.159 , pp. 1313-1321
    • Zeisberg, M.1    Bonner, G.2    Maeshima, Y.3    Colorado, P.4    Muller, G.A.5    Strutz, F.6    Kalluri, R.7
  • 43
    • 73549087447 scopus 로고    scopus 로고
    • Endothelial-mesenchymal transition as a novel mechanism for generating myofibroblasts during diabetic nephropathy
    • A. Kizu, D. Medici, and R. Kalluri Endothelial-mesenchymal transition as a novel mechanism for generating myofibroblasts during diabetic nephropathy Am J Pathol 175 2009 1371 1373
    • (2009) Am J Pathol , vol.175 , pp. 1371-1373
    • Kizu, A.1    Medici, D.2    Kalluri, R.3
  • 45
    • 0028535872 scopus 로고
    • Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair
    • R. Bucala, L.A. Spiegel, J. Chesney, M. Hogan, and A. Cerami Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair Mol Med 1 1994 71 81
    • (1994) Mol Med , vol.1 , pp. 71-81
    • Bucala, R.1    Spiegel, L.A.2    Chesney, J.3    Hogan, M.4    Cerami, A.5
  • 46
    • 60549104810 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Flip side of the coin
    • P.J. Mishra, J.W. Glod, and D. Banerjee Mesenchymal stem cells: flip side of the coin Cancer Res 69 2009 1255 1258
    • (2009) Cancer Res , vol.69 , pp. 1255-1258
    • Mishra, P.J.1    Glod, J.W.2    Banerjee, D.3
  • 49
    • 0028179175 scopus 로고
    • Induction of alpha-smooth muscle actin expression in cultured human brain pericytes by transforming growth factor-beta 1
    • M.M. Verbeek, I. Otte-Holler, P. Wesseling, D.J. Ruiter, and R.M. de Waal Induction of alpha-smooth muscle actin expression in cultured human brain pericytes by transforming growth factor-beta 1 Am J Pathol 144 1994 372 382
    • (1994) Am J Pathol , vol.144 , pp. 372-382
    • Verbeek, M.M.1    Otte-Holler, I.2    Wesseling, P.3    Ruiter, D.J.4    De Waal, R.M.5
  • 50
    • 0029997830 scopus 로고    scopus 로고
    • Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: A key event in hepatic fibrogenesis
    • A.M. Gressner Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis Kidney Int Suppl 54 1996 S39 S45
    • (1996) Kidney Int Suppl , vol.54
    • Gressner, A.M.1
  • 51
    • 77957331903 scopus 로고    scopus 로고
    • Epigenetic repression of matrix metalloproteinases in myofibroblastic hepatic stellate cells through histone deacetylases 4: Implication in tissue fibrosis
    • L. Qin, and Y.P. Han Epigenetic repression of matrix metalloproteinases in myofibroblastic hepatic stellate cells through histone deacetylases 4: implication in tissue fibrosis Am J Pathol 177 2010 1915 1928
    • (2010) Am J Pathol , vol.177 , pp. 1915-1928
    • Qin, L.1    Han, Y.P.2
  • 52
    • 80054908979 scopus 로고    scopus 로고
    • Myofibroblast-mediated adventitial remodeling: An underestimated player in arterial pathology
    • M. Coen, G. Gabbiani, and M.L. Bochaton-Piallat Myofibroblast-mediated adventitial remodeling: an underestimated player in arterial pathology Arterioscler Thromb Vasc Biol 31 2011 2391 2396
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2391-2396
    • Coen, M.1    Gabbiani, G.2    Bochaton-Piallat, M.L.3
  • 53
    • 55249103431 scopus 로고    scopus 로고
    • Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
    • E.M. Zeisberg, S.E. Potenta, H. Sugimoto, M. Zeisberg, and R. Kalluri Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition J Am Soc Nephrol 19 2008 2282 2287
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2282-2287
    • Zeisberg, E.M.1    Potenta, S.E.2    Sugimoto, H.3    Zeisberg, M.4    Kalluri, R.5
  • 54
    • 80052851503 scopus 로고    scopus 로고
    • Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders
    • S. Piera-Velazquez, Z. Li, and S.A. Jimenez Role of endothelial- mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders Am J Pathol 179 2011 1074 1080
    • (2011) Am J Pathol , vol.179 , pp. 1074-1080
    • Piera-Velazquez, S.1    Li, Z.2    Jimenez, S.A.3
  • 55
    • 84555179609 scopus 로고    scopus 로고
    • Extracellular matrix degradation and remodeling in development and disease
    • pii:a005058
    • P. Lu, K. Takai, V.M. Weaver, and Z. Werb Extracellular matrix degradation and remodeling in development and disease Cold Spring Harbor Perspect Biol 3 2011 pii:a005058
    • (2011) Cold Spring Harbor Perspect Biol , vol.3
    • Lu, P.1    Takai, K.2    Weaver, V.M.3    Werb, Z.4
  • 56
    • 73549107232 scopus 로고    scopus 로고
    • Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders
    • S.L. Nishimura Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders Am J Pathol 175 2009 1362 1370
    • (2009) Am J Pathol , vol.175 , pp. 1362-1370
    • Nishimura, S.L.1
  • 57
    • 27644538315 scopus 로고    scopus 로고
    • Integrin-mediated activation of latent transforming growth factor beta
    • D. Sheppard Integrin-mediated activation of latent transforming growth factor beta Cancer Metastasis Rev 24 2005 395 402
    • (2005) Cancer Metastasis Rev , vol.24 , pp. 395-402
    • Sheppard, D.1
  • 58
    • 17844386070 scopus 로고    scopus 로고
    • Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element
    • J.J. Tomasek, J. McRae, G.K. Owens, and C.J. Haaksma Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element Am J Pathol 166 2005 1343 1351
    • (2005) Am J Pathol , vol.166 , pp. 1343-1351
    • Tomasek, J.J.1    McRae, J.2    Owens, G.K.3    Haaksma, C.J.4
  • 59
    • 73649131572 scopus 로고    scopus 로고
    • Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation
    • R.M. Simpson, S. Meran, D. Thomas, P. Stephens, T. Bowen, R. Steadman, and A. Phillips Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation Am J Pathol 175 2009 1915 1928
    • (2009) Am J Pathol , vol.175 , pp. 1915-1928
    • Simpson, R.M.1    Meran, S.2    Thomas, D.3    Stephens, P.4    Bowen, T.5    Steadman, R.6    Phillips, A.7
  • 60
    • 67649981446 scopus 로고    scopus 로고
    • Modulation of TGFbeta1-dependent myofibroblast differentiation by hyaluronan
    • J. Webber, R.H. Jenkins, S. Meran, A. Phillips, and R. Steadman Modulation of TGFbeta1-dependent myofibroblast differentiation by hyaluronan Am J Pathol 175 2009 148 160
    • (2009) Am J Pathol , vol.175 , pp. 148-160
    • Webber, J.1    Jenkins, R.H.2    Meran, S.3    Phillips, A.4    Steadman, R.5
  • 61
    • 79955966781 scopus 로고    scopus 로고
    • Hyaluronan facilitates transforming growth factor-beta1-dependent proliferation via CD44 and epidermal growth factor receptor interaction
    • S. Meran, D.D. Luo, R. Simpson, J. Martin, A. Wells, R. Steadman, and A.O. Phillips Hyaluronan facilitates transforming growth factor-beta1-dependent proliferation via CD44 and epidermal growth factor receptor interaction J Biol Chem 286 2011 17618 17630
    • (2011) J Biol Chem , vol.286 , pp. 17618-17630
    • Meran, S.1    Luo, D.D.2    Simpson, R.3    Martin, J.4    Wells, A.5    Steadman, R.6    Phillips, A.O.7
  • 64
    • 33744776333 scopus 로고    scopus 로고
    • Caveolin-1 mutations in human breast cancer: Functional association with estrogen receptor alpha-positive status
    • T. Li, F. Sotgia, M.A. Vuolo, M. Li, W.C. Yang, R.G. Pestell, J.A. Sparano, and M.P. Lisanti Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status Am J Pathol 168 2006 1998 2013
    • (2006) Am J Pathol , vol.168 , pp. 1998-2013
    • Li, T.1    Sotgia, F.2    Vuolo, M.A.3    Li, M.4    Yang, W.C.5    Pestell, R.G.6    Sparano, J.A.7    Lisanti, M.P.8
  • 65
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • P. Carmeliet, and R.K. Jain Molecular mechanisms and clinical applications of angiogenesis Nature 473 2011 298 307
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 66
    • 0345275943 scopus 로고    scopus 로고
    • Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair
    • J.I. Virag, and C.E. Murry Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair Am J Pathol 163 2003 2433 2440
    • (2003) Am J Pathol , vol.163 , pp. 2433-2440
    • Virag, J.I.1    Murry, C.E.2
  • 67
    • 35948945337 scopus 로고    scopus 로고
    • Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
    • E.M. Zeisberg, S. Potenta, L. Xie, M. Zeisberg, and R. Kalluri Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts Cancer Res 67 2007 10123 10128
    • (2007) Cancer Res , vol.67 , pp. 10123-10128
    • Zeisberg, E.M.1    Potenta, S.2    Xie, L.3    Zeisberg, M.4    Kalluri, R.5
  • 68
  • 69
    • 77955496673 scopus 로고    scopus 로고
    • Pericytes and vessel maturation during tumor angiogenesis and metastasis
    • A. Raza, M.J. Franklin, and A.Z. Dudek Pericytes and vessel maturation during tumor angiogenesis and metastasis Am J Hematol 85 2010 593 598
    • (2010) Am J Hematol , vol.85 , pp. 593-598
    • Raza, A.1    Franklin, M.J.2    Dudek, A.Z.3
  • 70
    • 57149113728 scopus 로고    scopus 로고
    • Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    • S.L. Lin, T. Kisseleva, D.A. Brenner, and J.S. Duffield Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney Am J Pathol 173 2008 1617 1627
    • (2008) Am J Pathol , vol.173 , pp. 1617-1627
    • Lin, S.L.1    Kisseleva, T.2    Brenner, D.A.3    Duffield, J.S.4
  • 71
    • 0036124520 scopus 로고    scopus 로고
    • Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    • S. Morikawa, P. Baluk, T. Kaidoh, A. Haskell, R.K. Jain, and D.M. McDonald Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors Am J Pathol 160 2002 985 1000
    • (2002) Am J Pathol , vol.160 , pp. 985-1000
    • Morikawa, S.1    Baluk, P.2    Kaidoh, T.3    Haskell, A.4    Jain, R.K.5    McDonald, D.M.6
  • 72
    • 0018608109 scopus 로고
    • Some characteristics of metastasis in man
    • E.V. Sugarbaker Some characteristics of metastasis in man Am J Pathol 97 1979 623 632
    • (1979) Am J Pathol , vol.97 , pp. 623-632
    • Sugarbaker, E.V.1
  • 74
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • S. Valastyan, and R.A. Weinberg Tumor metastasis: molecular insights and evolving paradigms Cell 147 2011 275 292
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 75
    • 84867984708 scopus 로고    scopus 로고
    • Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer
    • N.P. Gunasinghe, A. Wells, E.W. Thompson, and H.J. Hugo Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer Cancer Metastasis Rev 31 2012 469 478
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 469-478
    • Gunasinghe, N.P.1    Wells, A.2    Thompson, E.W.3    Hugo, H.J.4
  • 76
    • 84866325625 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition under control: Global programs to regulate epithelial plasticity
    • M.A. Nieto, and A. Cano The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity Semin Cancer Biol 22 2012 361 368
    • (2012) Semin Cancer Biol , vol.22 , pp. 361-368
    • Nieto, M.A.1    Cano, A.2
  • 77
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • R. Kalluri, and R.A. Weinberg The basics of epithelial-mesenchymal transition J Clin Invest 119 2009 1420 1428
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 78
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • K. Polyak, and R.A. Weinberg Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits Nat Rev Cancer 9 2009 265 273
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 79
    • 65649153358 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: A cancer researcher's conceptual friend and foe
    • M.W. Klymkowsky, and P. Savagner Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe Am J Pathol 174 2009 1588 1593
    • (2009) Am J Pathol , vol.174 , pp. 1588-1593
    • Klymkowsky, M.W.1    Savagner, P.2
  • 80
    • 84866324123 scopus 로고    scopus 로고
    • Cancer stem cells and epithelial-mesenchymal transition: Concepts and molecular links
    • C. Scheel, and R.A. Weinberg Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links Semin Cancer Biol 22 2012 396 403
    • (2012) Semin Cancer Biol , vol.22 , pp. 396-403
    • Scheel, C.1    Weinberg, R.A.2
  • 81
    • 84869223135 scopus 로고    scopus 로고
    • Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin
    • N.S. Nagathihalli, P.P. Massion, A.L. Gonzalez, P. Lu, and P.K. Datta Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin Mol Cancer Ther 11 2012 2362 2372
    • (2012) Mol Cancer Ther , vol.11 , pp. 2362-2372
    • Nagathihalli, N.S.1    Massion, P.P.2    Gonzalez, A.L.3    Lu, P.4    Datta, P.K.5
  • 82
    • 0018750015 scopus 로고
    • Epithelial-mesenchymal transformation in chick atrioventricular cushion morphogenesis
    • D.L. Bolender, and R.R. Markwald Epithelial-mesenchymal transformation in chick atrioventricular cushion morphogenesis Scan Electron Microsc 3 1979 313 321
    • (1979) Scan Electron Microsc , Issue.3 , pp. 313-321
    • Bolender, D.L.1    Markwald, R.R.2
  • 83
    • 0036488589 scopus 로고    scopus 로고
    • Role of integrins in cell invasion and migration
    • J.D. Hood, and D.A. Cheresh Role of integrins in cell invasion and migration Nat Rev Cancer 2 2002 91 100
    • (2002) Nat Rev Cancer , vol.2 , pp. 91-100
    • Hood, J.D.1    Cheresh, D.A.2
  • 84
    • 0026040340 scopus 로고
    • Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast: Correlations with their functions as receptors and cell adhesion molecules
    • G.K. Koukoulis, I. Virtanen, M. Korhonen, L. Laitinen, V. Quaranta, and V.E. Gould Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast: correlations with their functions as receptors and cell adhesion molecules Am J Pathol 139 1991 787 799
    • (1991) Am J Pathol , vol.139 , pp. 787-799
    • Koukoulis, G.K.1    Virtanen, I.2    Korhonen, M.3    Laitinen, L.4    Quaranta, V.5    Gould, V.E.6
  • 85
    • 0025037292 scopus 로고
    • Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast
    • M.M. Zutter, G. Mazoujian, and S.A. Santoro Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast Am J Pathol 137 1990 863 870
    • (1990) Am J Pathol , vol.137 , pp. 863-870
    • Zutter, M.M.1    Mazoujian, G.2    Santoro, S.A.3
  • 86
    • 1642587815 scopus 로고    scopus 로고
    • Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase
    • A. Oloumi, T. McPhee, and S. Dedhar Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase Biochim Biophys Acta 1691 2004 1 15
    • (2004) Biochim Biophys Acta , vol.1691 , pp. 1-15
    • Oloumi, A.1    McPhee, T.2    Dedhar, S.3
  • 87
    • 76849100707 scopus 로고    scopus 로고
    • Focal adhesion kinase: A prominent determinant in breast cancer initiation, progression and metastasis
    • M. Luo, and J.L. Guan Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis Cancer Lett 289 2010 127 139
    • (2010) Cancer Lett , vol.289 , pp. 127-139
    • Luo, M.1    Guan, J.L.2
  • 93
    • 0037326569 scopus 로고    scopus 로고
    • The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: A comparison with Snail and E47 repressors
    • V. Bolos, H. Peinado, M.A. Perez-Moreno, M.F. Fraga, M. Esteller, and A. Cano The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors J Cell Sci 116 2003 499 511
    • (2003) J Cell Sci , vol.116 , pp. 499-511
    • Bolos, V.1    Peinado, H.2    Perez-Moreno, M.A.3    Fraga, M.F.4    Esteller, M.5    Cano, A.6
  • 94
    • 77956338683 scopus 로고    scopus 로고
    • Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
    • T. Lin, A. Ponn, X. Hu, B.K. Law, and J. Lu Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition Oncogene 29 2010 4896 4904
    • (2010) Oncogene , vol.29 , pp. 4896-4904
    • Lin, T.1    Ponn, A.2    Hu, X.3    Law, B.K.4    Lu, J.5
  • 95
    • 84859731270 scopus 로고    scopus 로고
    • G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer
    • C. Dong, Y. Wu, J. Yao, Y. Wang, Y. Yu, P.G. Rychahou, B.M. Evers, and B.P. Zhou G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer J Clin Invest 122 2012 1469 1486
    • (2012) J Clin Invest , vol.122 , pp. 1469-1486
    • Dong, C.1    Wu, Y.2    Yao, J.3    Wang, Y.4    Yu, Y.5    Rychahou, P.G.6    Evers, B.M.7    Zhou, B.P.8
  • 96
    • 84857495668 scopus 로고    scopus 로고
    • Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics
    • Y. Mizuguchi, S. Specht, J.G. Lunz 3rd, K. Isse, N. Corbitt, T. Takizawa, and A.J. Demetris Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics PLoS One 7 2012 e32449
    • (2012) PLoS One , vol.7 , pp. 32449
    • Mizuguchi, Y.1    Specht, S.2    Lunz III, J.G.3    Isse, K.4    Corbitt, N.5    Takizawa, T.6    Demetris, A.J.7
  • 98
    • 77956547097 scopus 로고    scopus 로고
    • Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
    • D. Iliopoulos, M. Lindahl-Allen, C. Polytarchou, H.A. Hirsch, P.N. Tsichlis, and K. Struhl Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells Mol Cell 39 2010 761 772
    • (2010) Mol Cell , vol.39 , pp. 761-772
    • Iliopoulos, D.1    Lindahl-Allen, M.2    Polytarchou, C.3    Hirsch, H.A.4    Tsichlis, P.N.5    Struhl, K.6
  • 99
    • 0036190459 scopus 로고    scopus 로고
    • CtBP, an unconventional transcriptional corepressor in development and oncogenesis
    • G. Chinnadurai CtBP, an unconventional transcriptional corepressor in development and oncogenesis Mol Cell 9 2002 213 224
    • (2002) Mol Cell , vol.9 , pp. 213-224
    • Chinnadurai, G.1
  • 103
    • 77953210095 scopus 로고    scopus 로고
    • On the stem cell origin of cancer
    • 2584-2494
    • S. Sell On the stem cell origin of cancer Am J Pathol 176 2010 2584-2494
    • (2010) Am J Pathol , vol.176
    • Sell, S.1
  • 105
    • 0037017867 scopus 로고    scopus 로고
    • Differential effects of reproductive factors on the risk of pre- and postmenopausal breast cancer: Results from a large cohort of French women
    • F. Clavel-Chapelon Differential effects of reproductive factors on the risk of pre- and postmenopausal breast cancer: results from a large cohort of French women Br J Cancer 86 2002 723 727
    • (2002) Br J Cancer , vol.86 , pp. 723-727
    • Clavel-Chapelon, F.1
  • 107
    • 0026525841 scopus 로고
    • Effect of family history, body-fat distribution, and reproductive factors on the risk of postmenopausal breast cancer
    • T.A. Sellers, L.H. Kushi, J.D. Potter, S.A. Kaye, C.L. Nelson, P.G. McGovern, and A.R. Folsom Effect of family history, body-fat distribution, and reproductive factors on the risk of postmenopausal breast cancer N Engl J Med 326 1992 1323 1329
    • (1992) N Engl J Med , vol.326 , pp. 1323-1329
    • Sellers, T.A.1    Kushi, L.H.2    Potter, J.D.3    Kaye, S.A.4    Nelson, C.L.5    McGovern, P.G.6    Folsom, A.R.7
  • 108
  • 110
    • 33144465789 scopus 로고    scopus 로고
    • Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis
    • S.M. McDaniel, K.K. Rumer, S.L. Biroc, R.P. Metz, M. Singh, W. Porter, and P. Schedin Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis Am J Pathol 168 2006 608 620
    • (2006) Am J Pathol , vol.168 , pp. 608-620
    • McDaniel, S.M.1    Rumer, K.K.2    Biroc, S.L.3    Metz, R.P.4    Singh, M.5    Porter, W.6    Schedin, P.7
  • 111
    • 77749264278 scopus 로고    scopus 로고
    • Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species
    • J. O'Brien, T. Lyons, J. Monks, M.S. Lucia, R.S. Wilson, L. Hines, Y.G. Man, V. Borges, and P. Schedin Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species Am J Pathol 176 2010 1241 1255
    • (2010) Am J Pathol , vol.176 , pp. 1241-1255
    • O'Brien, J.1    Lyons, T.2    Monks, J.3    Lucia, M.S.4    Wilson, R.S.5    Hines, L.6    Man, Y.G.7    Borges, V.8    Schedin, P.9
  • 115
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome: Biological and translational implications
    • S.B. Baylin, and P.A. Jones A decade of exploring the cancer epigenome: biological and translational implications Nat Rev Cancer 11 2011 726 734
    • (2011) Nat Rev Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 116
    • 79961023271 scopus 로고    scopus 로고
    • Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
    • O.G. McDonald, H. Wu, W. Timp, A. Doi, and A.P. Feinberg Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition Nat Struct Mol Biol 18 2011 867 874
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 867-874
    • McDonald, O.G.1    Wu, H.2    Timp, W.3    Doi, A.4    Feinberg, A.P.5
  • 117
    • 59149083658 scopus 로고    scopus 로고
    • Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells
    • B. Wen, H. Wu, Y. Shinkai, R.A. Irizarry, and A.P. Feinberg Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells Nat Genet 41 2009 246 250
    • (2009) Nat Genet , vol.41 , pp. 246-250
    • Wen, B.1    Wu, H.2    Shinkai, Y.3    Irizarry, R.A.4    Feinberg, A.P.5
  • 118
    • 84859977895 scopus 로고    scopus 로고
    • Sirtuins mediate mammalian metabolic responses to nutrient availability
    • A. Chalkiadaki, and L. Guarente Sirtuins mediate mammalian metabolic responses to nutrient availability Nat Rev Endocrinol 8 2012 287 296
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 287-296
    • Chalkiadaki, A.1    Guarente, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.