메뉴 건너뛰기




Volumn 8, Issue 3, 2013, Pages

Identification and Characterization of Potential Therapeutic Candidates in Emerging Human Pathogen Mycobacterium abscessus: A Novel Hierarchical In Silico Approach

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; ANTIINFECTIVE AGENT; AZITHROMYCIN; CEFOXITIN; GATIFLOXACIN; IMIPENEM; KATG PROTEIN; MOXIFLOXACIN; TIGECYCLINE; VIRULENCE FACTOR;

EID: 84875093869     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059126     Document Type: Article
Times cited : (92)

References (117)
  • 1
    • 77449132090 scopus 로고    scopus 로고
    • Mycobacterium abscessus: a new player in the mycobacterial field
    • Medjahed H, Gaillard JL, Reyrat JM, (2010) Mycobacterium abscessus: a new player in the mycobacterial field. Trends Microbiol 18: 117-123.
    • (2010) Trends Microbiol , vol.18 , pp. 117-123
    • Medjahed, H.1    Gaillard, J.L.2    Reyrat, J.M.3
  • 2
    • 33744783400 scopus 로고    scopus 로고
    • Mycobacterium abscessus: an emerging rapid-growing potential pathogen
    • Petrini B, (2006) Mycobacterium abscessus: an emerging rapid-growing potential pathogen. APMIS 114: 319-328.
    • (2006) APMIS , vol.114 , pp. 319-328
    • Petrini, B.1
  • 3
    • 70350432979 scopus 로고    scopus 로고
    • Antibiotic treatment of Mycobacterium abscessus lung disease: a retrospective analysis of 65 patients
    • Jeon K, Kwon OJ, Lee NY, Kim BJ, Kook YH, et al. (2009) Antibiotic treatment of Mycobacterium abscessus lung disease: a retrospective analysis of 65 patients. Am J Respir Crit Care Med 180: 896-902.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 896-902
    • Jeon, K.1    Kwon, O.J.2    Lee, N.Y.3    Kim, B.J.4    Kook, Y.H.5
  • 4
    • 79958804692 scopus 로고    scopus 로고
    • Identification of antimicrobial activity among FDA-approved drugs for combating Mycobacterium abscessus and Mycobacterium chelonae
    • Chopra S, Matsuyama K, Hutson C, Madrid P, (2011) Identification of antimicrobial activity among FDA-approved drugs for combating Mycobacterium abscessus and Mycobacterium chelonae. J Antimicrob Chemother 66: 1533-1536.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 1533-1536
    • Chopra, S.1    Matsuyama, K.2    Hutson, C.3    Madrid, P.4
  • 5
    • 69949109997 scopus 로고    scopus 로고
    • Characterization of mycobacteria from a major Brazilian outbreak suggests that revision of the taxonomic status of members of the Mycobacterium chelonae-M. abscessus group is needed
    • Leao SC, Tortoli E, Viana-Niero C, Ueki SY, Lima KV, et al. (2009) Characterization of mycobacteria from a major Brazilian outbreak suggests that revision of the taxonomic status of members of the Mycobacterium chelonae-M. abscessus group is needed. J Clin Microbiol 47: 2691-2698.
    • (2009) J Clin Microbiol , vol.47 , pp. 2691-2698
    • Leao, S.C.1    Tortoli, E.2    Viana-Niero, C.3    Ueki, S.Y.4    Lima, K.V.5
  • 6
    • 67650141987 scopus 로고    scopus 로고
    • Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus
    • Ripoll F, Pasek S, Schenowitz C, Dossat C, Barbe V, et al. (2009) Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus. PLoS One 4: e5660.
    • (2009) PLoS One , vol.4
    • Ripoll, F.1    Pasek, S.2    Schenowitz, C.3    Dossat, C.4    Barbe, V.5
  • 7
    • 33847050904 scopus 로고    scopus 로고
    • An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases
    • Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, et al. (2007) An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 175: 367-416.
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 367-416
    • Griffith, D.E.1    Aksamit, T.2    Brown-Elliott, B.A.3    Catanzaro, A.4    Daley, C.5
  • 8
    • 44449178706 scopus 로고    scopus 로고
    • Differential antibiotic susceptibility of Mycobacterium abscessus variants in biofilms and macrophages compared to that of planktonic bacteria
    • Greendyke R, Byrd TF, (2008) Differential antibiotic susceptibility of Mycobacterium abscessus variants in biofilms and macrophages compared to that of planktonic bacteria. Antimicrob Agents Chemother 52: 2019-2026.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2019-2026
    • Greendyke, R.1    Byrd, T.F.2
  • 9
    • 0034095185 scopus 로고    scopus 로고
    • Mycobacterium abscessus infection in cystic fibrosis. Colonization or infection?
    • Cullen AR, Cannon CL, Mark EJ, Colin AA, (2000) Mycobacterium abscessus infection in cystic fibrosis. Colonization or infection? Am J Respir Crit Care Med 161: 641-645.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 641-645
    • Cullen, A.R.1    Cannon, C.L.2    Mark, E.J.3    Colin, A.A.4
  • 10
    • 65649093032 scopus 로고    scopus 로고
    • A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae
    • Nash KA, Brown-Elliott BA, Wallace RJ Jr, (2009) A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. Antimicrob Agents Chemother 53: 1367-1376.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1367-1376
    • Nash, K.A.1    Brown-Elliott, B.A.2    Wallace Jr., R.J.3
  • 12
    • 79953863902 scopus 로고    scopus 로고
    • In Silico Subtractive Genomics for Target Identification in Human Bacterial Pathogens
    • Barh D, Tiwari S, Jain N, Ali A, Santos AR, et al. (2011) In Silico Subtractive Genomics for Target Identification in Human Bacterial Pathogens. Drug Development Research 72: 162-177.
    • (2011) Drug Development Research , vol.72 , pp. 162-177
    • Barh, D.1    Tiwari, S.2    Jain, N.3    Ali, A.4    Santos, A.R.5
  • 13
    • 40449105405 scopus 로고    scopus 로고
    • Molecular mechanisms of host-pathogen interactions and their potential for the discovery of new drug targets
    • Briken V, (2008) Molecular mechanisms of host-pathogen interactions and their potential for the discovery of new drug targets. Curr Drug Targets 9: 150-157.
    • (2008) Curr Drug Targets , vol.9 , pp. 150-157
    • Briken, V.1
  • 14
    • 62449223765 scopus 로고    scopus 로고
    • targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis
    • Raman K, Yeturu K, Chandra N, (2008) targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol 2: 109.
    • (2008) BMC Syst Biol , vol.2 , pp. 109
    • Raman, K.1    Yeturu, K.2    Chandra, N.3
  • 15
    • 2442636351 scopus 로고    scopus 로고
    • Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery
    • Yeh I, Hanekamp T, Tsoka S, Karp PD, Altman RB, (2004) Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery. Genome Res 14: 917-924.
    • (2004) Genome Res , vol.14 , pp. 917-924
    • Yeh, I.1    Hanekamp, T.2    Tsoka, S.3    Karp, P.D.4    Altman, R.B.5
  • 16
    • 83555161670 scopus 로고    scopus 로고
    • A novel in silico approach to identify potential therapeutic targets in human bacterial pathogens
    • Vetrivel U SG, Dorairaj S, (2011) A novel in silico approach to identify potential therapeutic targets in human bacterial pathogens. HUGO J 5: 25-34.
    • (2011) HUGO J , vol.5 , pp. 25-34
    • Vetrivel, U.S.G.1    Dorairaj, S.2
  • 17
    • 0032728399 scopus 로고    scopus 로고
    • Searching for drug targets in microbial genomes
    • Galperin MY, Koonin EV, (1999) Searching for drug targets in microbial genomes. Curr Opin Biotechnol 10: 571-578.
    • (1999) Curr Opin Biotechnol , vol.10 , pp. 571-578
    • Galperin, M.Y.1    Koonin, E.V.2
  • 18
    • 27644588079 scopus 로고    scopus 로고
    • Potential drug targets in Mycobacterium tuberculosis through metabolic pathway analysis
    • Anishetty S, Pulimi M, Pennathur G, (2005) Potential drug targets in Mycobacterium tuberculosis through metabolic pathway analysis. Comput Biol Chem 29: 368-378.
    • (2005) Comput Biol Chem , vol.29 , pp. 368-378
    • Anishetty, S.1    Pulimi, M.2    Pennathur, G.3
  • 19
    • 79953846232 scopus 로고    scopus 로고
    • Dataset of potential targets for Mycobacterium tuberculosis H37Rv through comparative genome analysis
    • Asif SM, Asad A, Faizan A, Anjali MS, Arvind A, et al. (2009) Dataset of potential targets for Mycobacterium tuberculosis H37Rv through comparative genome analysis. Bioinformation 4: 245-248.
    • (2009) Bioinformation , vol.4 , pp. 245-248
    • Asif, S.M.1    Asad, A.2    Faizan, A.3    Anjali, M.S.4    Arvind, A.5
  • 20
    • 79953851912 scopus 로고    scopus 로고
    • Computational genome analyses of metabolic enzymes in Mycobacterium leprae for drug target identification
    • Shanmugam A, Natarajan J, (2010) Computational genome analyses of metabolic enzymes in Mycobacterium leprae for drug target identification. Bioinformation 4: 392-395.
    • (2010) Bioinformation , vol.4 , pp. 392-395
    • Shanmugam, A.1    Natarajan, J.2
  • 21
    • 84865058687 scopus 로고    scopus 로고
    • Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genes and Therapeutic Candidates
    • Butt AM, Nasrullah I, Tahir S, Tong Y, (2012) Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genes and Therapeutic Candidates. PLoS One 7: e43080.
    • (2012) PLoS One , vol.7
    • Butt, A.M.1    Nasrullah, I.2    Tahir, S.3    Tong, Y.4
  • 22
    • 84861227091 scopus 로고    scopus 로고
    • In silico quest for putative drug targets in Helicobacter pylori HPAG1: molecular modeling of candidate enzymes from lipopolysaccharide biosynthesis pathway
    • Sarkar M, Maganti L, Ghoshal N, Dutta C, (2012) In silico quest for putative drug targets in Helicobacter pylori HPAG1: molecular modeling of candidate enzymes from lipopolysaccharide biosynthesis pathway. J Mol Model 18: 1855-1866.
    • (2012) J Mol Model , vol.18 , pp. 1855-1866
    • Sarkar, M.1    Maganti, L.2    Ghoshal, N.3    Dutta, C.4
  • 23
    • 34248180074 scopus 로고    scopus 로고
    • Metabolic pathway analysis of S. pneumoniae: an in silico approach towards drug-design
    • Singh S, Malik BK, Sharma DK, (2007) Metabolic pathway analysis of S. pneumoniae: an in silico approach towards drug-design. J Bioinform Comput Biol 5: 135-153.
    • (2007) J Bioinform Comput Biol , vol.5 , pp. 135-153
    • Singh, S.1    Malik, B.K.2    Sharma, D.K.3
  • 24
    • 84867059241 scopus 로고    scopus 로고
    • Identification of potential drug targets in Yersinia pestis using metabolic pathway analysis: MurE ligase as a case study
    • Sharma A, Pan A, (2012) Identification of potential drug targets in Yersinia pestis using metabolic pathway analysis: MurE ligase as a case study. Eur J Med Chem 57C: 185-195.
    • (2012) Eur J Med Chem , vol.57 C , pp. 185-195
    • Sharma, A.1    Pan, A.2
  • 25
    • 10044239624 scopus 로고    scopus 로고
    • A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa
    • Sakharkar KR, Sakharkar MK, Chow VT, (2004) A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa. In Silico Biol 4: 355-360.
    • (2004) In Silico Biol , vol.4 , pp. 355-360
    • Sakharkar, K.R.1    Sakharkar, M.K.2    Chow, V.T.3
  • 26
    • 70450257648 scopus 로고    scopus 로고
    • Protein interaction network analysis-approach for potential drug target identification in Mycobacterium tuberculosis
    • Kushwaha SK, Shakya M, (2010) Protein interaction network analysis-approach for potential drug target identification in Mycobacterium tuberculosis. J Theor Biol 262: 284-294.
    • (2010) J Theor Biol , vol.262 , pp. 284-294
    • Kushwaha, S.K.1    Shakya, M.2
  • 27
    • 75849133666 scopus 로고    scopus 로고
    • Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology
    • Karp PD, Paley SM, Krummenacker M, Latendresse M, Dale JM, et al. (2010) Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology. Brief Bioinform 11: 40-79.
    • (2010) Brief Bioinform , vol.11 , pp. 40-79
    • Karp, P.D.1    Paley, S.M.2    Krummenacker, M.3    Latendresse, M.4    Dale, J.M.5
  • 28
    • 75549090213 scopus 로고    scopus 로고
    • KEGG for representation and analysis of molecular networks involving diseases and drugs
    • Kanehisa M, Goto S, Furumichi M, Tanabe M, Hirakawa M, (2010) KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res 38: D355-360.
    • (2010) Nucleic Acids Res , vol.38
    • Kanehisa, M.1    Goto, S.2    Furumichi, M.3    Tanabe, M.4    Hirakawa, M.5
  • 29
    • 33846057724 scopus 로고    scopus 로고
    • NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins
    • Pruitt KD, Tatusova T, Maglott DR, (2007) NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res 35: D61-65.
    • (2007) Nucleic Acids Res , vol.35
    • Pruitt, K.D.1    Tatusova, T.2    Maglott, D.R.3
  • 30
    • 33947620478 scopus 로고    scopus 로고
    • Targeting bacterial secretion systems: benefits of disarmament in the microcosm
    • Baron C, Coombes B, (2007) Targeting bacterial secretion systems: benefits of disarmament in the microcosm. Infect Disord Drug Targets 7: 19-27.
    • (2007) Infect Disord Drug Targets , vol.7 , pp. 19-27
    • Baron, C.1    Coombes, B.2
  • 31
    • 84861904854 scopus 로고    scopus 로고
    • VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors
    • Chen L, Xiong Z, Sun L, Yang J, Jin Q, (2012) VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors. Nucleic Acids Res 40: D641-645.
    • (2012) Nucleic Acids Res , vol.40
    • Chen, L.1    Xiong, Z.2    Sun, L.3    Yang, J.4    Jin, Q.5
  • 32
    • 0036745538 scopus 로고    scopus 로고
    • Successful treatment with faropenem and clarithromycin of pulmonary Mycobacterium abscessus infection
    • Tanaka E, Kimoto T, Tsuyuguchi K, Suzuki K, Amitani R, (2002) Successful treatment with faropenem and clarithromycin of pulmonary Mycobacterium abscessus infection. J Infect Chemother 8: 252-255.
    • (2002) J Infect Chemother , vol.8 , pp. 252-255
    • Tanaka, E.1    Kimoto, T.2    Tsuyuguchi, K.3    Suzuki, K.4    Amitani, R.5
  • 33
    • 57849097106 scopus 로고    scopus 로고
    • Rapid speciation of 15 clinically relevant mycobacteria with simultaneous detection of resistance to rifampin, isoniazid, and streptomycin in Mycobacterium tuberculosis complex
    • Shenai S, Rodrigues C, Mehta A, (2009) Rapid speciation of 15 clinically relevant mycobacteria with simultaneous detection of resistance to rifampin, isoniazid, and streptomycin in Mycobacterium tuberculosis complex. Int J Infect Dis 13: 46-58.
    • (2009) Int J Infect Dis , vol.13 , pp. 46-58
    • Shenai, S.1    Rodrigues, C.2    Mehta, A.3
  • 34
    • 78651324347 scopus 로고    scopus 로고
    • The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored
    • Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, et al. (2011) The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res 39: D561-568.
    • (2011) Nucleic Acids Res , vol.39
    • Szklarczyk, D.1    Franceschini, A.2    Kuhn, M.3    Simonovic, M.4    Roth, A.5
  • 36
    • 58149197597 scopus 로고    scopus 로고
    • DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes
    • Zhang R, Lin Y, (2009) DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes. Nucleic Acids Res 37: D455-458.
    • (2009) Nucleic Acids Res , vol.37
    • Zhang, R.1    Lin, Y.2
  • 39
    • 56349122532 scopus 로고    scopus 로고
    • New horizons for the infectious diseases specialist: how gut microflora promote health and disease
    • Rabizadeh S, Sears C, (2008) New horizons for the infectious diseases specialist: how gut microflora promote health and disease. Curr Infect Dis Rep 10: 92-98.
    • (2008) Curr Infect Dis Rep , vol.10 , pp. 92-98
    • Rabizadeh, S.1    Sears, C.2
  • 41
    • 77954199597 scopus 로고    scopus 로고
    • PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes
    • Yu NY, Wagner JR, Laird MR, Melli G, Rey S, et al. (2010) PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes. Bioinformatics 26: 1608-1615.
    • (2010) Bioinformatics , vol.26 , pp. 1608-1615
    • Yu, N.Y.1    Wagner, J.R.2    Laird, M.R.3    Melli, G.4    Rey, S.5
  • 42
    • 33746218840 scopus 로고    scopus 로고
    • Prediction of protein subcellular localization
    • Yu CS, Chen YC, Lu CH, Hwang JK, (2006) Prediction of protein subcellular localization. Proteins 64: 643-651.
    • (2006) Proteins , vol.64 , pp. 643-651
    • Yu, C.S.1    Chen, Y.C.2    Lu, C.H.3    Hwang, J.K.4
  • 44
    • 58149193234 scopus 로고    scopus 로고
    • STRING 8-a global view on proteins and their functional interactions in 630 organisms
    • Jensen LJ, Kuhn M, Stark M, Chaffron S, Creevey C, et al. (2009) STRING 8-a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res 37: D412-416.
    • (2009) Nucleic Acids Res , vol.37
    • Jensen, L.J.1    Kuhn, M.2    Stark, M.3    Chaffron, S.4    Creevey, C.5
  • 45
    • 79551587720 scopus 로고    scopus 로고
    • Cytoscape 2.8: new features for data integration and network visualization
    • Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T, (2011) Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics 27: 431-432.
    • (2011) Bioinformatics , vol.27 , pp. 431-432
    • Smoot, M.E.1    Ono, K.2    Ruscheinski, J.3    Wang, P.L.4    Ideker, T.5
  • 46
    • 61649095940 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis interactome analysis unravels potential pathways to drug resistance
    • Raman K, Chandra N, (2008) Mycobacterium tuberculosis interactome analysis unravels potential pathways to drug resistance. BMC Microbiol 8: 234.
    • (2008) BMC Microbiol , vol.8 , pp. 234
    • Raman, K.1    Chandra, N.2
  • 47
    • 11144234660 scopus 로고    scopus 로고
    • Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae
    • Said MR, Begley TJ, Oppenheim AV, Lauffenburger DA, Samson LD, (2004) Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 101: 18006-18011.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 18006-18011
    • Said, M.R.1    Begley, T.J.2    Oppenheim, A.V.3    Lauffenburger, D.A.4    Samson, L.D.5
  • 48
    • 65349157710 scopus 로고    scopus 로고
    • Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis
    • Cui T, Zhang L, Wang X, He ZG, (2009) Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis. BMC Genomics 10: 118.
    • (2009) BMC Genomics , vol.10 , pp. 118
    • Cui, T.1    Zhang, L.2    Wang, X.3    He, Z.G.4
  • 49
    • 36549003965 scopus 로고    scopus 로고
    • InterPro and InterProScan: tools for protein sequence classification and comparison
    • Mulder N, Apweiler R, (2007) InterPro and InterProScan: tools for protein sequence classification and comparison. Methods Mol Biol 396: 59-70.
    • (2007) Methods Mol Biol , vol.396 , pp. 59-70
    • Mulder, N.1    Apweiler, R.2
  • 50
    • 78651287426 scopus 로고    scopus 로고
    • DrugBank 3.0: a comprehensive resource for 'omics' research on drugs
    • Knox C, Law V, Jewison T, Liu P, Ly S, et al. (2011) DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 39: D1035-1041.
    • (2011) Nucleic Acids Res , vol.39
    • Knox, C.1    Law, V.2    Jewison, T.3    Liu, P.4    Ly, S.5
  • 51
    • 17244362388 scopus 로고    scopus 로고
    • Mechanistic basis of enzyme-targeted drugs
    • Robertson JG, (2005) Mechanistic basis of enzyme-targeted drugs. Biochemistry 44: 5561-5571.
    • (2005) Biochemistry , vol.44 , pp. 5561-5571
    • Robertson, J.G.1
  • 52
  • 53
    • 84859267371 scopus 로고    scopus 로고
    • Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery
    • Zhu F, Shi Z, Qin C, Tao L, Liu X, et al. (2012) Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res 40: D1128-1136.
    • (2012) Nucleic Acids Res , vol.40
    • Zhu, F.1    Shi, Z.2    Qin, C.3    Tao, L.4    Liu, X.5
  • 54
    • 33745607880 scopus 로고    scopus 로고
    • Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis
    • Hasan S, Daugelat S, Rao PS, Schreiber M, (2006) Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. PLoS Comput Biol 2: e61.
    • (2006) PLoS Comput Biol , vol.2
    • Hasan, S.1    Daugelat, S.2    Rao, P.S.3    Schreiber, M.4
  • 55
  • 56
    • 33745202607 scopus 로고    scopus 로고
    • In silico identification of potential therapeutic targets in the human pathogen Helicobacter pylori
    • Dutta A, Singh SK, Ghosh P, Mukherjee R, Mitter S, et al. (2006) In silico identification of potential therapeutic targets in the human pathogen Helicobacter pylori. In Silico Biol 6: 43-47.
    • (2006) In Silico Biol , vol.6 , pp. 43-47
    • Dutta, A.1    Singh, S.K.2    Ghosh, P.3    Mukherjee, R.4    Mitter, S.5
  • 57
    • 70449380022 scopus 로고    scopus 로고
    • In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae
    • Barh D, Kumar A, (2009) In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae. In Silico Biol 9: 225-231.
    • (2009) In Silico Biol , vol.9 , pp. 225-231
    • Barh, D.1    Kumar, A.2
  • 58
    • 58149183707 scopus 로고    scopus 로고
    • A systematic survey of mini-proteins in bacteria and archaea
    • Wang F, Xiao J, Pan L, Yang M, Zhang G, et al. (2008) A systematic survey of mini-proteins in bacteria and archaea. PLoS One 3: e4027.
    • (2008) PLoS One , vol.3
    • Wang, F.1    Xiao, J.2    Pan, L.3    Yang, M.4    Zhang, G.5
  • 59
    • 66249139112 scopus 로고    scopus 로고
    • Choke point analysis of metabolic pathways in E.histolytica: a computational approach for drug target identification
    • Singh S, Malik BK, Sharma DK, (2007) Choke point analysis of metabolic pathways in E.histolytica: a computational approach for drug target identification. Bioinformation 2: 68-72.
    • (2007) Bioinformation , vol.2 , pp. 68-72
    • Singh, S.1    Malik, B.K.2    Sharma, D.K.3
  • 60
    • 82355185742 scopus 로고    scopus 로고
    • Bacterial mer operon-mediated detoxification of mercurial compounds: a short review
    • Mathema VB, Thakuri BC, Sillanpaa M, (2011) Bacterial mer operon-mediated detoxification of mercurial compounds: a short review. Arch Microbiol 193: 837-844.
    • (2011) Arch Microbiol , vol.193 , pp. 837-844
    • Mathema, V.B.1    Thakuri, B.C.2    Sillanpaa, M.3
  • 61
    • 14944375311 scopus 로고    scopus 로고
    • New targets and screening approaches in antimicrobial drug discovery
    • Brown ED, Wright GD, (2005) New targets and screening approaches in antimicrobial drug discovery. Chem Rev 105: 759-774.
    • (2005) Chem Rev , vol.105 , pp. 759-774
    • Brown, E.D.1    Wright, G.D.2
  • 62
    • 0037223505 scopus 로고    scopus 로고
    • Structure and function of the Mur enzymes: development of novel inhibitors
    • El Zoeiby A, Sanschagrin F, Levesque RC, (2003) Structure and function of the Mur enzymes: development of novel inhibitors. Mol Microbiol 47: 1-12.
    • (2003) Mol Microbiol , vol.47 , pp. 1-12
    • El Zoeiby, A.1    Sanschagrin, F.2    Levesque, R.C.3
  • 63
    • 0036790373 scopus 로고    scopus 로고
    • Two-component and phosphorelay signal-transduction systems as therapeutic targets
    • Stephenson K, Hoch JA, (2002) Two-component and phosphorelay signal-transduction systems as therapeutic targets. Curr Opin Pharmacol 2: 507-512.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 507-512
    • Stephenson, K.1    Hoch, J.A.2
  • 64
    • 0030003383 scopus 로고    scopus 로고
    • Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin
    • Eisenreich W, Menhard B, Hylands PJ, Zenk MH, Bacher A, (1996) Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin. Proc Natl Acad Sci U S A 93: 6431-6436.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 6431-6436
    • Eisenreich, W.1    Menhard, B.2    Hylands, P.J.3    Zenk, M.H.4    Bacher, A.5
  • 65
    • 0027368126 scopus 로고
    • Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate
    • Rohmer M, Knani M, Simonin P, Sutter B, Sahm H, (1993) Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate. Biochem J 295 (Pt 2): 517-524.
    • (1993) Biochem J , vol.295 , Issue.Pt 2 , pp. 517-524
    • Rohmer, M.1    Knani, M.2    Simonin, P.3    Sutter, B.4    Sahm, H.5
  • 66
    • 0033813444 scopus 로고    scopus 로고
    • Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis
    • Cunningham FX Jr, Lafond TP, Gantt E, (2000) Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis. J Bacteriol 182: 5841-5848.
    • (2000) J Bacteriol , vol.182 , pp. 5841-5848
    • Cunningham Jr., F.X.1    Lafond, T.P.2    Gantt, E.3
  • 67
    • 0024421915 scopus 로고
    • Inhibition of bacterial isoprenoid synthesis by fosmidomycin, a phosphonic acid-containing antibiotic
    • Shigi Y, (1989) Inhibition of bacterial isoprenoid synthesis by fosmidomycin, a phosphonic acid-containing antibiotic. J Antimicrob Chemother 24: 131-145.
    • (1989) J Antimicrob Chemother , vol.24 , pp. 131-145
    • Shigi, Y.1
  • 69
    • 0034804919 scopus 로고    scopus 로고
    • Lipid biosynthesis as a target for antibacterial agents
    • Heath RJ, White SW, Rock CO, (2001) Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res 40: 467-497.
    • (2001) Prog Lipid Res , vol.40 , pp. 467-497
    • Heath, R.J.1    White, S.W.2    Rock, C.O.3
  • 70
    • 4544275674 scopus 로고    scopus 로고
    • Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems
    • Schweizer E, Hofmann J, (2004) Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems. Microbiol Mol Biol Rev 68: 501-517.
    • (2004) Microbiol Mol Biol Rev , vol.68 , pp. 501-517
    • Schweizer, E.1    Hofmann, J.2
  • 72
    • 0034664991 scopus 로고    scopus 로고
    • Tetrahydrofolate and tetrahydromethanopterin compared: functionally distinct carriers in C1 metabolism
    • Maden BE, (2000) Tetrahydrofolate and tetrahydromethanopterin compared: functionally distinct carriers in C1 metabolism. Biochem J 350 Pt 3: 609-629.
    • (2000) Biochem J 350 Pt , vol.3 , pp. 609-629
    • Maden, B.E.1
  • 73
    • 77951995416 scopus 로고    scopus 로고
    • Folate Biosynthesis - Reappraisal of Old and Novel Targets in the Search for New Antimicrobials
    • Swarbrick J IP, Simpsona JS, Macreadiec I, (2008) Folate Biosynthesis - Reappraisal of Old and Novel Targets in the Search for New Antimicrobials. The Open Enzyme Inhibition Journal 1: 12-33.
    • (2008) The Open Enzyme Inhibition Journal , vol.1 , pp. 12-33
    • Swarbrick, J.I.P.1    Simpsona, J.S.2    Macreadiec, I.3
  • 74
    • 0035996799 scopus 로고    scopus 로고
    • The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery
    • Bermingham A, Derrick JP, (2002) The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery. Bioessays 24: 637-648.
    • (2002) Bioessays , vol.24 , pp. 637-648
    • Bermingham, A.1    Derrick, J.P.2
  • 75
    • 33645472239 scopus 로고    scopus 로고
    • Role of two-component systems in the virulence of Streptococcus pneumoniae
    • Paterson GK, Blue CE, Mitchell TJ, (2006) Role of two-component systems in the virulence of Streptococcus pneumoniae. J Med Microbiol 55: 355-363.
    • (2006) J Med Microbiol , vol.55 , pp. 355-363
    • Paterson, G.K.1    Blue, C.E.2    Mitchell, T.J.3
  • 76
    • 0031863584 scopus 로고    scopus 로고
    • Two-component signal transduction as a target for microbial anti-infective therapy
    • Barrett JF, Hoch JA, (1998) Two-component signal transduction as a target for microbial anti-infective therapy. Antimicrob Agents Chemother 42: 1529-1536.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 1529-1536
    • Barrett, J.F.1    Hoch, J.A.2
  • 77
    • 0035092543 scopus 로고    scopus 로고
    • Evaluation of the characteristics of safety withdrawal of prescription drugs from worldwide pharmaceuticals markets -1960 to 1999
    • Fung M TA, Mybeck K, Wu JH, Hornbuckle K, Muniz E, (2001) Evaluation of the characteristics of safety withdrawal of prescription drugs from worldwide pharmaceuticals markets -1960 to 1999. Drug Inf J 35: 293-317.
    • (2001) Drug Inf J , vol.35 , pp. 293-317
    • Fung, M.T.A.1    Mybeck, K.2    Wu, J.H.3    Hornbuckle, K.4    Muniz, E.5
  • 80
    • 0032831519 scopus 로고    scopus 로고
    • Acute liver injury associated with the use of ebrotidine, a new H2-receptor antagonist
    • Andrade RJ, Lucena MI, Martin-Vivaldi R, Fernandez MC, Nogueras F, et al. (1999) Acute liver injury associated with the use of ebrotidine, a new H2-receptor antagonist. J Hepatol 31: 641-646.
    • (1999) J Hepatol , vol.31 , pp. 641-646
    • Andrade, R.J.1    Lucena, M.I.2    Martin-Vivaldi, R.3    Fernandez, M.C.4    Nogueras, F.5
  • 81
    • 0024795368 scopus 로고
    • Evaluation of the efficacy and safety of NSAIDs. A new methodological approach
    • Fenner H (1989) Evaluation of the efficacy and safety of NSAIDs. A new methodological approach. Scand J Rheumatol Suppl 80: 32-39.
    • (1989) Scand J Rheumatol , Issue.SUPPL. 80 , pp. 32-39
    • Fenner, H.1
  • 82
    • 0029129057 scopus 로고
    • Drug safety discontinuations in the United Kingdom, the United States, and Spain from 1974 through 1993: a regulatory perspective
    • Bakke OM, Manocchia M, de Abajo F, Kaitin KI, Lasagna L, (1995) Drug safety discontinuations in the United Kingdom, the United States, and Spain from 1974 through 1993: a regulatory perspective. Clin Pharmacol Ther 58: 108-117.
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 108-117
    • Bakke, O.M.1    Manocchia, M.2    de Abajo, F.3    Kaitin, K.I.4    Lasagna, L.5
  • 83
    • 77952847965 scopus 로고    scopus 로고
    • Drugs associated with hepatotoxicity and their reporting frequency of liver adverse events in VigiBase: unified list based on international collaborative work
    • Suzuki A, Andrade RJ, Bjornsson E, Lucena MI, Lee WM, et al. (2010) Drugs associated with hepatotoxicity and their reporting frequency of liver adverse events in VigiBase: unified list based on international collaborative work. Drug Saf 33: 503-522.
    • (2010) Drug Saf , vol.33 , pp. 503-522
    • Suzuki, A.1    Andrade, R.J.2    Bjornsson, E.3    Lucena, M.I.4    Lee, W.M.5
  • 84
    • 0033929411 scopus 로고    scopus 로고
    • An open clinical trial of sulphamethoxypyridazine in the treatment of mucous membrane pemphigoid
    • Thornhill M, Pemberton M, Buchanan J, Theaker E, (2000) An open clinical trial of sulphamethoxypyridazine in the treatment of mucous membrane pemphigoid. Br J Dermatol 143: 117-126.
    • (2000) Br J Dermatol , vol.143 , pp. 117-126
    • Thornhill, M.1    Pemberton, M.2    Buchanan, J.3    Theaker, E.4
  • 85
    • 0033549087 scopus 로고    scopus 로고
    • The safety of newly approved medicines: do recent market removals mean there is a problem?
    • Friedman MA, Woodcock J, Lumpkin MM, Shuren JE, Hass AE, et al. (1999) The safety of newly approved medicines: do recent market removals mean there is a problem? JAMA 281: 1728-1734.
    • (1999) JAMA , vol.281 , pp. 1728-1734
    • Friedman, M.A.1    Woodcock, J.2    Lumpkin, M.M.3    Shuren, J.E.4    Hass, A.E.5
  • 86
    • 34548602369 scopus 로고    scopus 로고
    • Serious adverse drug events reported to the Food and Drug Administration, 1998-2005
    • Moore TJ, Cohen MR, Furberg CD, (2007) Serious adverse drug events reported to the Food and Drug Administration, 1998-2005. Arch Intern Med 167: 1752-1759.
    • (2007) Arch Intern Med , vol.167 , pp. 1752-1759
    • Moore, T.J.1    Cohen, M.R.2    Furberg, C.D.3
  • 88
    • 59849113547 scopus 로고    scopus 로고
    • Microbes in gastrointestinal health and disease
    • Neish AS, (2009) Microbes in gastrointestinal health and disease. Gastroenterology 136: 65-80.
    • (2009) Gastroenterology , vol.136 , pp. 65-80
    • Neish, A.S.1
  • 89
    • 0032054355 scopus 로고    scopus 로고
    • Host-microbial symbiosis in the mammalian intestine: exploring an internal ecosystem
    • Hooper LV, Bry L, Falk PG, Gordon JI, (1998) Host-microbial symbiosis in the mammalian intestine: exploring an internal ecosystem. Bioessays 20: 336-343.
    • (1998) Bioessays , vol.20 , pp. 336-343
    • Hooper, L.V.1    Bry, L.2    Falk, P.G.3    Gordon, J.I.4
  • 91
    • 0022505159 scopus 로고
    • Gastrointestinal microflora in mammalian nutrition
    • Savage DC, (1986) Gastrointestinal microflora in mammalian nutrition. Annu Rev Nutr 6: 155-178.
    • (1986) Annu Rev Nutr , vol.6 , pp. 155-178
    • Savage, D.C.1
  • 92
    • 0037425743 scopus 로고    scopus 로고
    • Gut flora in health and disease
    • Guarner F, Malagelada JR, (2003) Gut flora in health and disease. Lancet 361: 512-519.
    • (2003) Lancet , vol.361 , pp. 512-519
    • Guarner, F.1    Malagelada, J.R.2
  • 93
    • 83555179128 scopus 로고    scopus 로고
    • Mycoplasma genitalium: a comparative genomics study of metabolic pathways for the identification of drug and vaccine targets
    • Butt AM, Tahir S, Nasrullah I, Idrees M, Lu J, et al. (2012) Mycoplasma genitalium: a comparative genomics study of metabolic pathways for the identification of drug and vaccine targets. Infect Genet Evol 12: 53-62.
    • (2012) Infect Genet Evol , vol.12 , pp. 53-62
    • Butt, A.M.1    Tahir, S.2    Nasrullah, I.3    Idrees, M.4    Lu, J.5
  • 94
    • 0344670556 scopus 로고    scopus 로고
    • Bacterial Pathogenesis
    • In: Baron S, editor 4th ed. Galveston (TX)
    • Peterson JW (1996) Bacterial Pathogenesis. In: Baron S, editor. Medical Microbiology. 4th ed. Galveston (TX).
    • (1996) Medical Microbiology
    • Peterson, J.W.1
  • 95
    • 34447512704 scopus 로고    scopus 로고
    • Understanding network concepts in modules
    • Dong J, Horvath S, (2007) Understanding network concepts in modules. BMC Syst Biol 1: 24.
    • (2007) BMC Syst Biol , vol.1 , pp. 24
    • Dong, J.1    Horvath, S.2
  • 96
    • 6344282706 scopus 로고    scopus 로고
    • Heme O synthase and heme A synthase from Bacillus subtilis and Rhodobacter sphaeroides interact in Escherichia coli
    • Brown BM, Wang Z, Brown KR, Cricco JA, Hegg EL, (2004) Heme O synthase and heme A synthase from Bacillus subtilis and Rhodobacter sphaeroides interact in Escherichia coli. Biochemistry 43: 13541-13548.
    • (2004) Biochemistry , vol.43 , pp. 13541-13548
    • Brown, B.M.1    Wang, Z.2    Brown, K.R.3    Cricco, J.A.4    Hegg, E.L.5
  • 97
    • 0027256676 scopus 로고
    • Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria
    • Tam R, Saier MH Jr, (1993) Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria. Microbiol Rev 57: 320-346.
    • (1993) Microbiol Rev , vol.57 , pp. 320-346
    • Tam, R.1    Saier Jr., M.H.2
  • 99
    • 65549133009 scopus 로고    scopus 로고
    • A protein linkage map of the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis
    • Teutschbein J, Schumann G, Mollmann U, Grabley S, Cole ST, et al. (2009) A protein linkage map of the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis. Microbiol Res 164: 253-259.
    • (2009) Microbiol Res , vol.164 , pp. 253-259
    • Teutschbein, J.1    Schumann, G.2    Mollmann, U.3    Grabley, S.4    Cole, S.T.5
  • 100
    • 0242268398 scopus 로고    scopus 로고
    • Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system
    • Stanley SA, Raghavan S, Hwang WW, Cox JS, (2003) Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system. Proc Natl Acad Sci U S A 100: 13001-13006.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13001-13006
    • Stanley, S.A.1    Raghavan, S.2    Hwang, W.W.3    Cox, J.S.4
  • 101
    • 29644438456 scopus 로고    scopus 로고
    • Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence
    • Brodin P, Majlessi L, Marsollier L, de Jonge MI, Bottai D, et al. (2006) Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect Immun 74: 88-98.
    • (2006) Infect Immun , vol.74 , pp. 88-98
    • Brodin, P.1    Majlessi, L.2    Marsollier, L.3    de Jonge, M.I.4    Bottai, D.5
  • 102
    • 0030848288 scopus 로고    scopus 로고
    • Structures of Cys319 variants and acetohydroxamate-inhibited Klebsiella aerogenes urease
    • Pearson MA, Michel LO, Hausinger RP, Karplus PA, (1997) Structures of Cys319 variants and acetohydroxamate-inhibited Klebsiella aerogenes urease. Biochemistry 36: 8164-8172.
    • (1997) Biochemistry , vol.36 , pp. 8164-8172
    • Pearson, M.A.1    Michel, L.O.2    Hausinger, R.P.3    Karplus, P.A.4
  • 103
    • 0035937403 scopus 로고    scopus 로고
    • Structural mechanism for rifampicin inhibition of bacterial rna polymerase
    • Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, et al. (2001) Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell 104: 901-912.
    • (2001) Cell , vol.104 , pp. 901-912
    • Campbell, E.A.1    Korzheva, N.2    Mustaev, A.3    Murakami, K.4    Nair, S.5
  • 105
    • 40549117568 scopus 로고    scopus 로고
    • In vitro antimicrobial susceptibility of Mycobacterium abscessus in Korea
    • Park S, Kim S, Park EM, Kim H, Kwon OJ, et al. (2008) In vitro antimicrobial susceptibility of Mycobacterium abscessus in Korea. J Korean Med Sci 23: 49-52.
    • (2008) J Korean Med Sci , vol.23 , pp. 49-52
    • Park, S.1    Kim, S.2    Park, E.M.3    Kim, H.4    Kwon, O.J.5
  • 106
    • 77955302040 scopus 로고    scopus 로고
    • Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis
    • Prayle A, Watson A, Fortnum H, Smyth A, (2010) Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis. Thorax 65: 654-658.
    • (2010) Thorax , vol.65 , pp. 654-658
    • Prayle, A.1    Watson, A.2    Fortnum, H.3    Smyth, A.4
  • 107
    • 61549089404 scopus 로고    scopus 로고
    • Effects of treatment with antimicrobial agents on the human colonic microflora
    • Rafii F, Sutherland JB, Cerniglia CE, (2008) Effects of treatment with antimicrobial agents on the human colonic microflora. Ther Clin Risk Manag 4: 1343-1358.
    • (2008) Ther Clin Risk Manag , vol.4 , pp. 1343-1358
    • Rafii, F.1    Sutherland, J.B.2    Cerniglia, C.E.3
  • 108
    • 0020400173 scopus 로고
    • The effect of short-term cefoxitin prophylaxis on the colonic microflora in patients undergoing colorectal surgery
    • Kager L, Malmborg AS, Nord CE, Pieper R, (1982) The effect of short-term cefoxitin prophylaxis on the colonic microflora in patients undergoing colorectal surgery. Infection 10: 338-340.
    • (1982) Infection , vol.10 , pp. 338-340
    • Kager, L.1    Malmborg, A.S.2    Nord, C.E.3    Pieper, R.4
  • 109
    • 0029028953 scopus 로고
    • Safety profile of meropenem: international clinical experience based on the first 3125 patients treated with meropenem
    • Norrby SR, Newell PA, Faulkner KL, Lesky W (1995) Safety profile of meropenem: international clinical experience based on the first 3125 patients treated with meropenem. J Antimicrob Chemother 36 Suppl A: 207-223.
    • (1995) J Antimicrob Chemother , vol.36 , Issue.SUPPL. A , pp. 207-223
    • Norrby, S.R.1    Newell, P.A.2    Faulkner, K.L.3    Lesky, W.4
  • 110
    • 0031713220 scopus 로고    scopus 로고
    • Imipenem and meropenem: Comparison of in vitro activity, pharmacokinetics, clinical trials and adverse effects
    • Canadian Carbapenem Discussion G
    • Zhanel GG, Simor AE, Vercaigne L, Mandell L, Canadian Carbapenem Discussion G, (1998) Imipenem and meropenem: Comparison of in vitro activity, pharmacokinetics, clinical trials and adverse effects. Can J Infect Dis 9: 215-228.
    • (1998) Can J Infect Dis , vol.9 , pp. 215-228
    • Zhanel, G.G.1    Simor, A.E.2    Vercaigne, L.3    Mandell, L.4
  • 111
    • 0025317344 scopus 로고
    • Seizure activity with imipenem therapy: incidence and risk factors
    • Job ML, Dretler RH, (1990) Seizure activity with imipenem therapy: incidence and risk factors. DICP 24: 467-469.
    • (1990) DICP , vol.24 , pp. 467-469
    • Job, M.L.1    Dretler, R.H.2
  • 112
    • 33749984264 scopus 로고    scopus 로고
    • Long term effects of azithromycin in patients with cystic fibrosis: A double blind, placebo controlled trial
    • Clement A, Tamalet A, Leroux E, Ravilly S, Fauroux B, et al. (2006) Long term effects of azithromycin in patients with cystic fibrosis: A double blind, placebo controlled trial. Thorax 61: 895-902.
    • (2006) Thorax , vol.61 , pp. 895-902
    • Clement, A.1    Tamalet, A.2    Leroux, E.3    Ravilly, S.4    Fauroux, B.5
  • 113
    • 33749525173 scopus 로고    scopus 로고
    • Effect of tigecycline on normal oropharyngeal and intestinal microflora
    • Nord CE, Sillerstrom E, Wahlund E, (2006) Effect of tigecycline on normal oropharyngeal and intestinal microflora. Antimicrob Agents Chemother 50: 3375-3380.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3375-3380
    • Nord, C.E.1    Sillerstrom, E.2    Wahlund, E.3
  • 115
    • 36148942465 scopus 로고    scopus 로고
    • Moxifloxacin in the management of exacerbations of chronic bronchitis and COPD
    • Miravitlles M, (2007) Moxifloxacin in the management of exacerbations of chronic bronchitis and COPD. Int J Chron Obstruct Pulmon Dis 2: 191-204.
    • (2007) Int J Chron Obstruct Pulmon Dis , vol.2 , pp. 191-204
    • Miravitlles, M.1
  • 116
    • 79958808865 scopus 로고    scopus 로고
    • Hepatic safety of antibiotics used in primary care
    • Andrade RJ, Tulkens PM, (2011) Hepatic safety of antibiotics used in primary care. J Antimicrob Chemother 66: 1431-1446.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 1431-1446
    • Andrade, R.J.1    Tulkens, P.M.2
  • 117
    • 0035209650 scopus 로고    scopus 로고
    • Gatifloxacin-associated acute hepatitis
    • Henann NE, Zambie MF, (2001) Gatifloxacin-associated acute hepatitis. Pharmacotherapy 21: 1579-1582.
    • (2001) Pharmacotherapy , vol.21 , pp. 1579-1582
    • Henann, N.E.1    Zambie, M.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.