Identification of potential drug targets in Yersinia pestis using metabolic pathway analysis: MurE ligase as a case study

European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 185-195

  Sharma, Aditya ^a,b   Pan, Archana ^a  

^a PONDICHERRY UNIVERSITY   (India)

^b DELHI TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

Docking; Drug target; Metabolic pathways; MurE ligase; Plague; Yersinia pestis

Indexed keywords

ANTIINFECTIVE AGENT; LIGASE; MURE LIGASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENOME; BACTERIAL METABOLISM; BACTERIAL SURVIVAL; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HUMAN; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PLAGUE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; YERSINIA PESTIS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG DESIGN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGASES; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PLAGUE; SEQUENCE ALIGNMENT; SMALL MOLECULE LIBRARIES; SPECIES SPECIFICITY; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; YERSINIA PESTIS;

EID: 84867059241     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.09.018     Document Type: Article

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