Transcriptional analysis of the three Nlrp1 paralogs in mice

BMC Genomics

Volumn 14, Issue 1, 2013, Pages

  Sastalla, Inka ^a   Crown, Devorah ^a   Masters, Seth L ^b   McKenzie, Andrew ^a   Leppla, Stephen H ^a   Moayeri, Mahtab ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Anthrax toxins; Bacillus anthracis; Inflammasome; Lethal toxin; Nlrp1; Splice variants

Indexed keywords

ANTHRAX LETHAL TOXIN; ANTHRAX TOXIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PROTEIN NLRP1A; PROTEIN NLRP1B; PROTEIN NLRP1C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; CELL SPECIFICITY; CONTROLLED STUDY; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; RNA SPLICING; SEQUENCE HOMOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALTERNATIVE SPLICING; ANIMALS; ANTIGENS, BACTERIAL; APOPTOSIS REGULATORY PROTEINS; BACTERIAL TOXINS; INFLAMMASOMES; MICE; MICE, INBRED STRAINS;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); MURINAE; MUS; RODENTIA;

EID: 84875075579     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-14-188     Document Type: Article

References (32)

1. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003, 21:335-376. 10.1146/annurev.immunol.21.120601.141126, 12524386.
2. Martinon F, Mayor A, Tschopp J. The inflammasomes: guardians of the body. Annu Rev Immunol 2009, 27:229-265. 10.1146/annurev.immunol.021908.132715, 19302040.
3. D'Osualdo A, Weichenberger CX, Wagner RN, Godzik A, Wooley J, Reed JC. CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain. PLoS One 2011, 6(11):e27396. 10.1371/journal.pone.0027396, 3210808, 22087307.
4. Frew BC, Joag VR, Mogridge J. Proteolytic processing of Nlrp1b is required for inflammasome activity. PLoS Pathog 2012, 8(4):e1002659. 10.1371/journal.ppat.1002659, 3334886, 22536155.
5. Srinivasula SM, Poyet JL, Razmara M, Datta P, Zhang Z, Alnemri ES. The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem 2002, 277(24):21119-21122. 10.1074/jbc.C200179200, 11967258.
6. Moayeri M, Sastalla I, Leppla SH. Anthrax and the inflammasome. Microbes Infect 2012, 14(5):392-400. 10.1016/j.micinf.2011.12.005, 22207185.
7. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006, 440(7081):237-241. 10.1038/nature04516, 16407889.
8. Li H, Willingham SB, Ting JP, Re F. Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol 2008, 181(1):17-21. 2587213, 18566365.
9. Jin C, Flavell RA. Molecular mechanism of NLRP3 inflammasome activation. J Clin Immunol 2010, 30(5):628-631. 10.1007/s10875-010-9440-3, 20589420.
10. Kofoed EM, Vance RE. Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 2011, 477(7366):592-595. 10.1038/nature10394, 3184209, 21874021.
11. Zhao Y, Yang J, Shi J, Gong YN, Lu Q, Xu H, Liu L, Shao F. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 2011, 477(7366):596-600. 10.1038/nature10510, 21918512.
12. Leppla SH. Bacillus anthracis toxins. The Comprehensive Sourcebook of Bacterial Protein Toxins 2006, 323-347. Burlington, MA: Academic Press, Alouf JE, Popoff MR, 3.
13. Duesbery NS, Webb CP, Leppla SH, Gordon VM, Klimpel KR, Copeland TD, Ahn NG, Oskarsson MK, Fukasawa K, Paull KD. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science 1998, 280(5364):734-737. 10.1126/science.280.5364.734, 9563949.
14. Fink SL, Bergsbaken T, Cookson BT. Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms. Proc Natl Acad Sci U S A 2008, 105(11):4312-4317. 10.1073/pnas.0707370105, 2393760, 18337499.
15. Newman ZL, Printz MP, Liu S, Crown D, Breen L, Miller-Randolph S, Flodman P, Leppla SH, Moayeri M. Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1. PLoS Pathog 2010, 6(5):e1000906. 10.1371/journal.ppat.1000906, 2873920, 20502689.
16. Levinsohn JL, Newman ZL, Hellmich KA, Fattah R, Getz MA, Liu S, Sastalla I, Leppla SH, Moayeri M. Anthrax lethal factor cleavage of Nlrp1b is required for activation of the inflammasome. PLoS Pathog 2012, 8(3):e1002638. 10.1371/journal.ppat.1002638, 3315489, 22479187.
17. Boyden ED, Dietrich WF. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 2006, 38(2):240-244. 10.1038/ng1724, 16429160.
18. Masters SL, Gerlic M, Metcalf D, Preston S, Pellegrini M, O'Donnell JA, McArthur K, Baldwin TM, Chevrier S, Nowell CJ. NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells. Immunity 2012, 37(6):1009-1023. 10.1016/j.immuni.2012.08.027, 23219391.
19. Moayeri M, Crown D, Newman ZL, Okugawa S, Eckhaus M, Cataisson C, Liu S, Sastalla I, Leppla SH. Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment. PLoS Pathog 2010, 6(12):e1001222. 10.1371/journal.ppat.1001222, 3000361, 21170303.
20. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997, 25(17):3389-3402. 10.1093/nar/25.17.3389, 146917, 9254694.
21. Terra JK, France B, Cote CK, Jenkins A, Bozue JA, Welkos SL, Bhargava R, Ho CL, Mehrabian M, Pan C. Allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to Bacillus anthracis. PLoS Pathog 2011, 7(12):e1002469. 10.1371/journal.ppat.1002469, 3248472, 22241984.
22. Friedlander AM. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J Biol Chem 1986, 261(16):7123-7126.
23. Conant GC, Wolfe KH. Turning a hobby into a job: how duplicated genes find new functions. Nat Rev Genet 2008, 9(12):938-950. 10.1038/nrg2482, 19015656.
24. Meyers BC, Kozik A, Griego A, Kuang H, Michelmore RW. Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis. Plant Cell 2003, 15(4):809-834. 10.1105/tpc.009308, 152331, 12671079.
25. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C. Inhibition of death receptor signals by cellular FLIP. Nature 1997, 388(6638):190-195. 10.1038/40657, 9217161.
26. Kataoka T. The caspase-8 modulator c-FLIP. Crit Rev Immunol 2005, 25(1):31-58. 10.1615/CritRevImmunol.v25.i1.30, 15833082.
27. Im SS, Yousef L, Blaschitz C, Liu JZ, Edwards RA, Young SG, Raffatellu M, Osborne TF. Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a. Cell Metab 2011, 13(5):540-549. 10.1016/j.cmet.2011.04.001, 3090630, 21531336.
28. Moayeri M, Martinez NW, Wiggins J, Young HA, Leppla SH. Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun 2004, 72(8):4439-4447. 10.1128/IAI.72.8.4439-4447.2004, 470648, 15271901.
29. Earl PL, Americo JL, Moss B. Lethal Monkeypox Virus Infection of CAST/EiJ Mice is Associated with a Deficient Interferon-gamma Response. J Virol 2012,
30. Mankan AK, Dau T, Jenne D, Hornung V. The NLRP3/ASC/Caspase-1 axis regulates IL-1beta processing in neutrophils. Eur J Immunol 2012, 42(3):710-715. 10.1002/eji.201141921, 22213227.
31. Wang ET, Sandberg R, Luo S, Khrebtukova I, Zhang L, Mayr C, Kingsmore SF, Schroth GP, Burge CB. Alternative isoform regulation in human tissue transcriptomes. Nature 2008, 456(7221):470-476. 10.1038/nature07509, 2593745, 18978772.
32. Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 2008, 40(12):1413-1415. 10.1038/ng.259, 18978789.