The HSP90 inhibitor NVP-AUY922-AG inhibits the PI3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells

British Journal of Haematology

Volumn 161, Issue 1, 2013, Pages 57-67

  Walsby, Elisabeth J ^a   Lazenby, Michelle ^a   Pepper, Chris J ^a   Knapper, Steven ^a   Burnett, Alan K ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Acute myeloid leukaemia (AML); Cell signalling; Chemotherapy; HSP90; Synergy

Indexed keywords

CASPASE 3; CHAPERONE; CYTARABINE; HEAT SHOCK PROTEIN 90 INHIBITOR; LIPOCORTIN 5; NVP AUG922 AG; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; APOPTOSIS; ARTICLE; BONE MARROW CULTURE; CELL DEATH; CLINICAL ARTICLE; DRUG MECHANISM; FEMALE; HUMAN; IN VITRO STUDY; MALE; PRIORITY JOURNAL; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; ANNEXIN A5; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CASPASE 3; CYTARABINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; FEMALE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; I-KAPPA B KINASE; ISOXAZOLES; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; RESORCINOLS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; YOUNG ADULT;

EID: 84875050569     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12215     Document Type: Article

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