SCOPUS 정보 검색 플랫폼

Volumn 14, Issue 5, 2013, Pages 625-632

Alanine Scan of the Peptide Antibiotic Feglymycin: Assessment of Amino Acid Side Chains Contributing to Antimicrobial Activity

(6) Hänchen, Anne a Rausch, Saskia a Landmann, Benjamin a Toti, Luigi b Nusser, Antje b Süssmuth, Roderich D a

a TECHNISCHE UNIVERSITÄT BERLIN (Germany)

b SANOFI AVENTIS DEUTSCHLAND GMBH (Germany)

Author keywords

Alanine scan; Antibiotics; Enzyme inhibitors; Peptides; Structure activity relationships

Indexed keywords

3,5 DIHYDROXYPHENYLGLYCINE; ALANINE; BACTERIAL ENZYME; FEGLYMYCIN; MURA; MURC; OXFENICINE; PEPTIDOGLYCAN; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG SCREENING; ENZYME INHIBITION; GLYCOPROTEIN SYNTHESIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

ALANINE; ALKYL AND ARYL TRANSFERASES; ANTI-INFECTIVE AGENTS; MICROBIAL SENSITIVITY TESTS; PEPTIDES; PROTEINS; STAPHYLOCOCCUS AUREUS;

EID: 84874967567 PISSN: 14394227 EISSN: 14397633 Source Type: Journal
DOI: 10.1002/cbic.201300032 Document Type: Article

Times cited : (24)

References (42)

1
- 0033042432
- R. E. W. Hancock, D. S. Chapple, Antimicrob. Agents Chemother. 1999, 43, 1317-1323;
- (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 1317-1323
- Hancock, R.E.W.¹ Chapple, D.S.²

2
- 33746001269
- F. von Nussbaum, M. Brands, B. Hinzen, S. Weigand, D. Häbich, Angew. Chem. 2006, 118, 5194-5254; Angew. Chem. Int. Ed. 2006, 45, 5072-5129;
- (2006) Angew. Chem. 2006, 118, 5194-5254; Angew. Chem. Int. Ed. , vol.45 , pp. 5072-5129
- von Nussbaum, F.¹ Brands, M.² Hinzen, B.³ Weigand, S.⁴ Häbich, D.⁵

3
- 58249108035
- K. C. Nicolaou, J. S. Chen, D. J. Edmonds, A. A. Estrada, Angew. Chem. 2009, 121, 670-732; Angew. Chem. Int. Ed. 2009, 48, 660-719;
- (2009) Angew. Chem. 2009, 121, 670-732; Angew. Chem. Int. Ed. , vol.48 , pp. 660-719
- Nicolaou, K.C.¹ Chen, J.S.² Edmonds, D.J.³ Estrada, A.A.⁴

4
- 59649084249
- E. M. Nolan, C. T. Walsh, ChemBioChem 2009, 10, 34-53.
- (2009) ChemBioChem , vol.10 , pp. 34-53
- Nolan, E.M.¹ Walsh, C.T.²

5
- 0037524493
- D. Schwarzer, R. Finking, M. A. Marahiel, Nat. Prod. Rep. 2003, 20, 275-287;
- (2003) Nat. Prod. Rep. , vol.20 , pp. 275-287
- Schwarzer, D.¹ Finking, R.² Marahiel, M.A.³

6
- 14844362054
- S. A. Sieber, M. A. Marahiel, Chem. Rev. 2005, 105, 715-738;
- (2005) Chem. Rev. , vol.105 , pp. 715-738
- Sieber, S.A.¹ Marahiel, M.A.²

7
- 0035905507
- D. Bischoff, S. Pelzer, B. Bister, G. J. Nicholson, M. Schirle, S. Stockert, W. Wohlleben, G. Jung, R. D. Süssmuth, Angew. Chem. 2001, 113, 4824-4827; Angew. Chem. Int. Ed. 2001, 40, 4688-4691.
- (2001) Angew. Chem. 2001, 113, 4824-4827; Angew. Chem. Int. Ed. , vol.40 , pp. 4688-4691
- Bischoff, D.¹ Pelzer, S.² Bister, B.³ Nicholson, G.J.⁴ Schirle, M.⁵ Stockert, S.⁶ Wohlleben, W.⁷ Jung, G.⁸ Süssmuth, R.D.⁹

8
- 0033516914
- K. C. Nicolaou, C. N. C. Boddy, S. Bräse, N. Winssinger, Angew. Chem. 1999, 111, 2230-2287; Angew. Chem. Int. Ed. 1999, 38, 2096-2152;
- (1999) Angew. Chem. 1999, 111, 2230-2287; Angew. Chem. Int. Ed. , vol.38 , pp. 2096-2152
- Nicolaou, K.C.¹ Boddy, C.N.C.² Bräse, S.³ Winssinger, N.⁴

9
- 53549095165
- F. Wolter, S. Schoof, R. D. Süssmuth, Top. Curr. Chem. 2007, 267, 143-185.
- (2007) Top. Curr. Chem. , vol.267 , pp. 143-185
- Wolter, F.¹ Schoof, S.² Süssmuth, R.D.³

10
- 0021233768
- B. Cavalleri, H. Pagani, G. Volpe, E. Selva, F. Parenti, J. Antibiot. 1984, 37, 309-317;
- (1984) J. Antibiot. , vol.37 , pp. 309-317
- Cavalleri, B.¹ Pagani, H.² Volpe, G.³ Selva, E.⁴ Parenti, F.⁵

11
- 0021190177
- R. Pallanza, M. Berti, R. Scotti, E. Randisi, V. Arioli, J. Antibiot. 1984, 37, 318-324;
- (1984) J. Antibiot. , vol.37 , pp. 318-324
- Pallanza, R.¹ Berti, M.² Scotti, R.³ Randisi, E.⁴ Arioli, V.⁵

12
- 0036948308
- D. G. McCafferty, P. Cudic, B. A. Frankel, S. Barkallah, R. G. Kruger, W. Li, Pept. Sci. 2002, 66, 261-284;
- (2002) Pept. Sci. , vol.66 , pp. 261-284
- McCafferty, D.G.¹ Cudic, P.² Frankel, B.A.³ Barkallah, S.⁴ Kruger, R.G.⁵ Li, W.⁶

13
- 14844340653
- S. Walker, L. Chen, Y. Hu, Y. Rew, D. Shin, D. L. Boger, Chem. Rev. 2005, 105, 449-475.
- (2005) Chem. Rev. , vol.105 , pp. 449-475
- Walker, S.¹ Chen, L.² Hu, Y.³ Rew, Y.⁴ Shin, D.⁵ Boger, D.L.⁶

14
- 0036308911
- J. Schimana, K. Gebhardt, A. Höltzel, D. G. Schmid, R. Süssmuth, J. Müller, R. Pukall, H.-P. Fiedler, J. Antibiot. 2002, 55, 565-570;
- (2002) J. Antibiot. , vol.55 , pp. 565-570
- Schimana, J.¹ Gebhardt, K.² Höltzel, A.³ Schmid, D.G.⁴ Süssmuth, R.⁵ Müller, J.⁶ Pukall, R.⁷ Fiedler, H.-P.⁸

15
- 0036304338
- A. Höltzel, D. G. Schmid, G. J. Nicholson, S. Stevanovic, J. Schimana, K. Gebhardt, H.-P. Fiedler, G. Jung, J. Antibiot. 2002, 55, 571-577;
- (2002) J. Antibiot. , vol.55 , pp. 571-577
- Höltzel, A.¹ Schmid, D.G.² Nicholson, G.J.³ Stevanovic, S.⁴ Schimana, J.⁵ Gebhardt, K.⁶ Fiedler, H.-P.⁷ Jung, G.⁸

16
- 4344563166
- P. Kulanthaivel, A. J. Kreuzman, M. A. Strege, M. D. Belvo, T. A. Smitka, M. Clemens, J. R. Swartling, K. L. Minton, F. Zheng, E. L. Angleton, D. Mullen, L. N. Jungheim, V. J. Klimkowski, T. I. Nicas, R. C. Thompson, S.-B. Peng, J. Biol. Chem. 2004, 279, 36250-36258;
- (2004) J. Biol. Chem. , vol.279 , pp. 36250-36258
- Kulanthaivel, P.¹ Kreuzman, A.J.² Strege, M.A.³ Belvo, M.D.⁴ Smitka, T.A.⁵ Clemens, M.⁶ Swartling, J.R.⁷ Minton, K.L.⁸ Zheng, F.⁹ Angleton, E.L.¹⁰ Mullen, D.¹¹ Jungheim, L.N.¹² Klimkowski, V.J.¹³ Nicas, T.I.¹⁴ Thompson, R.C.¹⁵ Peng, S.-B.¹⁶

17
- 78649362890
- P. A. Smith, T. C. Roberts, F. E. Romesberg, Chem. Biol. 2010, 17, 1223-1231;
- (2010) Chem. Biol. , vol.17 , pp. 1223-1231
- Smith, P.A.¹ Roberts, T.C.² Romesberg, F.E.³

18
- 80455129410
- J. Liu, C. Luo, P. A. Smith, J. K. Chin, M. G. P. Page, M. Paetzel, F. E. Romesberg, J. Am. Chem. Soc. 2011, 133, 17869-17877.
- (2011) J. Am. Chem. Soc. , vol.133 , pp. 17869-17877
- Liu, J.¹ Luo, C.² Smith, P.A.³ Chin, J.K.⁴ Page, M.G.P.⁵ Paetzel, M.⁶ Romesberg, F.E.⁷

19
- 84874999886
- Hoechst AG), EP 0 848 064 A1
- J. Aszodi, D. Isert, M. Knauf, D. Le Beller, G. Riess, W. Stahl, L. Vértesy, J. Wink (Hoechst AG), EP 0 848 064 A1, 1999;
- (1999)
- Aszodi, J.¹ Isert, D.² Knauf, M.³ Le Beller, D.⁴ Riess, G.⁵ Stahl, W.⁶ Vértesy, L.⁷ Wink, J.⁸

20
- 17144468641
- L. Vértesy, W. Aretz, M. Knauf, A. Markus, M. Vogel, J. Wink, J. Antibiot. 1999, 52, 374-382.
- (1999) J. Antibiot. , vol.52 , pp. 374-382
- Vértesy, L.¹ Aretz, W.² Knauf, M.³ Markus, A.⁴ Vogel, M.⁵ Wink, J.⁶

21
- 14844296372
- G. Bunkóczi, L. Vértesy, G. M. Sheldrick, Angew. Chem. 2005, 117, 1364-1366; Angew. Chem. Int. Ed. 2005, 44, 1340-1342.
- (2005) Angew. Chem. 2005, 117, 1364-1366; Angew. Chem. Int. Ed. , vol.44 , pp. 1340-1342
- Bunkóczi, G.¹ Vértesy, L.² Sheldrick, G.M.³

22
- 0032573081
- B. M. Burkhart, N. Li, D. A. Langs, W. A. Pangborn, W. L. Duax, Proc. Natl. Acad. Sci. USA 1998, 95, 12950-12955.
- (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 12950-12955
- Burkhart, B.M.¹ Li, N.² Langs, D.A.³ Pangborn, W.A.⁴ Duax, W.L.⁵

23
- 77956621008
- T. Hamada, S. Matsunaga, M. Fujiwara, K. Fujita, H. Hirota, R. Schmucki, P. Güntert, N. Fusetani, J. Am. Chem. Soc. 2010, 132, 12941-12945.
- (2010) J. Am. Chem. Soc. , vol.132 , pp. 12941-12945
- Hamada, T.¹ Matsunaga, S.² Fujiwara, M.³ Fujita, K.⁴ Hirota, H.⁵ Schmucki, R.⁶ Güntert, P.⁷ Fusetani, N.⁸

24
- 61349158601
- F. Dettner, A. Hänchen, D. Schols, L. Toti, A. Nußer, R. D. Süssmuth, Angew. Chem. 2009, 121, 1888-1893; Angew. Chem. Int. Ed. 2009, 48, 1856-1861.
- (2009) Angew. Chem. 2009, 121, 1888-1893; Angew. Chem. Int. Ed. , vol.48 , pp. 1856-1861
- Dettner, F.¹ Hänchen, A.² Schols, D.³ Toti, L.⁴ Nußer, A.⁵ Süssmuth, R.D.⁶

25
- 84867193540
- G. Férir, A. Hänchen, K. O. François, B. Hoorelbeke, D. Huskens, F. Dettner, R. D. Süssmuth, D. Schols, Virology 2012, 433, 308-319.
- (2012) Virology , vol.433 , pp. 308-319
- Férir, G.¹ Hänchen, A.² François, K.O.³ Hoorelbeke, B.⁴ Huskens, D.⁵ Dettner, F.⁶ Süssmuth, R.D.⁷ Schols, D.⁸

26
- 73649122749
- T. Schneider, H.-G. Sahl, Int. J. Med. Microbiol. 2010, 300, 161-169.
- (2010) Int. J. Med. Microbiol. , vol.300 , pp. 161-169
- Schneider, T.¹ Sahl, H.-G.²

27
- 79955949528
- S. Rausch, A. Hänchen, A. Denisiuk, M. Löhken, T. Schneider, R. D. Süssmuth, ChemBioChem 2011, 12, 1171-1173.
- (2011) ChemBioChem , vol.12 , pp. 1171-1173
- Rausch, S.¹ Hänchen, A.² Denisiuk, A.³ Löhken, M.⁴ Schneider, T.⁵ Süssmuth, R.D.⁶

28
- 0035806048
- F. Reck, S. Marmor, S. Fisher, M. A. Wuonola, Bioorg. Med. Chem. Lett. 2001, 11, 1451-1454;
- (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 1451-1454
- Reck, F.¹ Marmor, S.² Fisher, S.³ Wuonola, M.A.⁴

29
- 38949165234
- R. Frlan, A. Kovač, D. Blanot, S. Gobec, S. Pečar, A. Obreza, Molecules 2008, 13, 11-30.
- (2008) Molecules , vol.13 , pp. 11-30
- Frlan, R.¹ Kovač, A.² Blanot, D.³ Gobec, S.⁴ Pečar, S.⁵ Obreza, A.⁶

30
- 0038682513
- C. J. Leitheiser, K. L. Smith, M. J. Rishel, S. Hashimoto, K. Konishi, C. J. Thomas, C. Li, M. M. McCormick, S. M. Hecht, J. Am. Chem. Soc. 2003, 125, 8218-8227;
- (2003) J. Am. Chem. Soc. , vol.125 , pp. 8218-8227
- Leitheiser, C.J.¹ Smith, K.L.² Rishel, M.J.³ Hashimoto, S.⁴ Konishi, K.⁵ Thomas, C.J.⁶ Li, C.⁷ McCormick, M.M.⁸ Hecht, S.M.⁹

31
- 34548380947
- J. Nam, D. Shin, Y. Rew, D. L. Boger, J. Am. Chem. Soc. 2007, 129, 8747-8755;
- (2007) J. Am. Chem. Soc. , vol.129 , pp. 8747-8755
- Nam, J.¹ Shin, D.² Rew, Y.³ Boger, D.L.⁴

32
- 71749096205
- X. Fang, J. Nam, D. Shin, Y. Rew, D. L. Boger, S. Walker, Bioorg. Med. Chem. Lett. 2009, 19, 6189-6191.
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 6189-6191
- Fang, X.¹ Nam, J.² Shin, D.³ Rew, Y.⁴ Boger, D.L.⁵ Walker, S.⁶

33
- 20344399399
- Y.-h. Ye, H. Li, X. Jiang, Pept. Sci. 2005, 80, 172-178.
- (2005) Pept. Sci. , vol.80 , pp. 172-178
- Ye, Y.-h.¹ Li, H.² Jiang, X.³

34
- 18744403986
- R. Kaul, S. Surprenant, W. D. Lubell, J. Org. Chem. 2005, 70, 3838-3844.
- (2005) J. Org. Chem. , vol.70 , pp. 3838-3844
- Kaul, R.¹ Surprenant, S.² Lubell, W.D.³

35
- 0034771092
- G. Han, M. Tamaki, V. J. Hruby, J. Peptide Res. 2001, 58, 338-341.
- (2001) J. Peptide Res. , vol.58 , pp. 338-341
- Han, G.¹ Tamaki, M.² Hruby, V.J.³

36
- 14844299308
- K. C. Nicolaou, A. A. Estrada, M. Zak, S. H. Lee, B. S. Safina, Angew. Chem. 2005, 117, 1402-1406; Angew. Chem. Int. Ed. 2005, 44, 1378-1382.
- (2005) Angew. Chem. 2005, 117, 1402-1406; Angew. Chem. Int. Ed. , vol.44 , pp. 1378-1382
- Nicolaou, K.C.¹ Estrada, A.A.² Zak, M.³ Lee, S.H.⁴ Safina, B.S.⁵

37
- 0025675921
- P. E. Reynolds, E. A. Somner, Drugs Exp. Clin. Res. 1990, 16, 385-389.
- (1990) Drugs Exp. Clin. Res. , vol.16 , pp. 385-389
- Reynolds, P.E.¹ Somner, E.A.²

38
- 0034640026
- M.-C. Lo, H. Men, A. Branstrom, J. Helm, N. Yao, R. Goldman, S. Walker, J. Am. Chem. Soc. 2000, 122, 3540-3541;
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 3540-3541
- Lo, M.-C.¹ Men, H.² Branstrom, A.³ Helm, J.⁴ Yao, N.⁵ Goldman, R.⁶ Walker, S.⁷

39
- 0038298097
- Y. Hu, J. S. Helm, L. Chen, X.-Y. Ye, S. Walker, J. Am. Chem. Soc. 2003, 125, 8736-8737.
- (2003) J. Am. Chem. Soc. , vol.125 , pp. 8736-8737
- Hu, Y.¹ Helm, J.S.² Chen, L.³ Ye, X.-Y.⁴ Walker, S.⁵

40
- 33645517614
- X. Fang, K. Tiyanont, Y. Zhang, J. Wanner, D. Boger, S. Walker, Mol. BioSyst. 2006, 2, 69-76.
- (2006) Mol. BioSyst. , vol.2 , pp. 69-76
- Fang, X.¹ Tiyanont, K.² Zhang, Y.³ Wanner, J.⁴ Boger, D.⁵ Walker, S.⁶

41
- 84874975730
- Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically"; approved standard 7th ed., M07-A7 No. 2, Clinical and Laboratory Standards Institute (CLSI)
- "Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically"; approved standard 7th ed., M07-A7 Vol. 26 No. 2, Clinical and Laboratory Standards Institute (CLSI);
- , vol.26

42
- 39449086721
- I. Wiegand, K. Hilpert, R. E. W. Hancock, Nat. Protoc. 2008, 3, 163-175.
- (2008) Nat. Protoc. , vol.3 , pp. 163-175
- Wiegand, I.¹ Hilpert, K.² Hancock, R.E.W.³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.