Characterization and comparison of disulfide linkages and scrambling patterns in therapeutic monoclonal antibodies: Using LC-MS with electron transfer dissociation

Analytical Chemistry

Volumn 83, Issue 8, 2011, Pages 3133-3140

  Wang, Yi ^a   Lu, Qiaozhen ^a   Wu, Shiaw Lin ^a   Karger, Barry L ^a   Hancock, William S ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLISION INDUCED DISSOCIATION; CYS RESIDUES; DISULFIDE LINKAGES; ELECTRON-TRANSFER DISSOCIATION; FUSION PROTEINS; HEAT STRESS; HEAVY CHAIN; LIGHT CHAIN; MISFOLDED PROTEINS; MONOCLONAL ANTIBODIES (MAB); SDS-PAGE; SODIUM DODECYL SULFATE-POLYACRYLAMIDE GEL ELECTROPHORESIS; THERAPEUTIC MONOCLONAL ANTIBODIES;

ELECTROPHORESIS; MONOCLONAL ANTIBODIES; SODIUM SULFATE; STRUCTURAL DESIGN; SURFACE PLASMON RESONANCE;

DISSOCIATION;

DISULFIDE; MONOCLONAL ANTIBODY;

ARTICLE; CHEMISTRY; COMPARATIVE STUDY; ELECTRON TRANSPORT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, LIQUID; DISULFIDES; ELECTRON TRANSPORT; MASS SPECTROMETRY;

EID: 79954492422     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac200128d     Document Type: Article

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