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Volumn 2012, Issue , 2012, Pages

Hesperidin-3′- O -methylether is more potent than hesperidin in phosphodiesterase inhibition and suppression of ovalbumin-induced airway hyperresponsiveness

Author keywords

[No Author keywords available]

Indexed keywords

AGLYCONE; BETA GLUCOSIDASE; FLAVANONE GLYCOSIDE; HESPERIDIN; HESPERIDIN 3 O METHYLETHER; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G2A; KETAMINE; OVALBUMIN; PHOSPHODIESTERASE; UNCLASSIFIED DRUG; XYLAN;

EID: 84874866580     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/908562     Document Type: Article
Times cited : (9)

References (49)
  • 1
    • 0037163858 scopus 로고    scopus 로고
    • Crystal structure of phosphodiesterase 4D and inhibitor complex
    • DOI 10.1016/S0014-5793(02)03396-3, PII S0014579302033963
    • Lee M. E., Markowitz J., Lee J. O., Lee H., Crystal structure of phosphodiesterase 4D and inhibitor complex. FEBS Letters 2002 530 1-3 53 58 2-s2.0-0037163858 10.1016/S0014-5793(02)03396-3 (Pubitemid 35248185)
    • (2002) FEBS Letters , vol.530 , Issue.1-3 , pp. 53-58
    • Lee, M.E.1    Markowitz, J.2    Lee, J.-O.3    Lee, H.4
  • 2
    • 0025092063 scopus 로고
    • Characterization and selective inhibition of cyclic nucleotide phosphodiesterase isozymes in canine tracheal smooth muscle
    • Torphy T. J., Cieslinski L. B., Characterization and selective inhibition of cyclic nucleotide phosphodiesterase isozymes in canine tracheal smooth muscle. Molecular Pharmacology 1990 37 2 206 214 2-s2.0-0025092063 (Pubitemid 20082984)
    • (1990) Molecular Pharmacology , vol.37 , Issue.2 , pp. 206-214
    • Torphy, T.J.1    Cieslinski, L.B.2
  • 3
    • 0032804309 scopus 로고    scopus 로고
    • Experimental studies on guanosine 3',5'-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs
    • Kapui Z., Schaeffer P., Mikus E. G., Boronkay E., Gyürky J., Herbert J. M., Pascal M., Experimental studies on guanosine 3',5'-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs. Arzneimittel-Forschung/Drug Research 1999 49 8 685 693 2-s2.0-0032804309 (Pubitemid 29400043)
    • (1999) Arzneimittel-Forschung/Drug Research , vol.49 , Issue.8 , pp. 685-693
    • Kapui, Z.1    Schaeffer, P.2    Mikus, E.G.3    Boronkay, E.4    Gyurky, J.5    Herbert, J.-M.6    Pascal, M.7
  • 4
    • 0026741623 scopus 로고
    • Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: Biochemical and pharmacological analysis using selective inhibitors
    • 2-s2.0-0026741623
    • de Boer J., Philpott A. J., Van Amsterdam R. G. M., Shahid M., Zaagsma J., Nicholson C. D., Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: biochemical and pharmacological analysis using selective inhibitors. British Journal of Pharmacology 1992 106 4 1028 1034 2-s2.0-0026741623
    • (1992) British Journal of Pharmacology , vol.106 , Issue.4 , pp. 1028-1034
    • De Boer, J.1    Philpott, A.J.2    Van Amsterdam, R.G.M.3    Shahid, M.4    Zaagsma, J.5    Nicholson, C.D.6
  • 5
    • 0023880662 scopus 로고
    • Differential pharmacologic sensitivity of cyclic nucleotide phosphodiesterase isozymes isolated from cardiac muscle, arterial and airway smooth muscle
    • 2-s2.0-0023880662
    • Silver P. J., Hamel L. T., Perrone M. H., Bentley R. G., Bushover C. R., Evans D. B., Differential pharmacologic sensitivity of cyclic nucleotide phosphodiesterase isozymes isolated from cardiac muscle, arterial and airway smooth muscle. European Journal of Pharmacology 1988 150 1-2 85 94 2-s2.0-0023880662
    • (1988) European Journal of Pharmacology , vol.150 , Issue.1-2 , pp. 85-94
    • Silver, P.J.1    Hamel, L.T.2    Perrone, M.H.3    Bentley, R.G.4    Bushover, C.R.5    Evans, D.B.6
  • 6
    • 0038341865 scopus 로고    scopus 로고
    • Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-asthmatics
    • DOI 10.1016/S0960-894X(03)00405-0
    • Kim E., Chun H. O., Jung S. H., Kim J. H., Lee J. M., Suh B. C., Xiang M. X., Rhee C. K., Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-asthmatics. Bioorganic and Medicinal Chemistry Letters 2003 13 14 2355 2358 2-s2.0-0038341865 10.1016/S0960-894X(03)00405-0 (Pubitemid 36724981)
    • (2003) Bioorganic and Medicinal Chemistry Letters , vol.13 , Issue.14 , pp. 2355-2358
    • Kim, E.1    Chun, H.-O.2    Jung, S.-H.3    Kim, J.H.4    Lee, J.-M.5    Suh, B.-C.6    Xiang, M.X.7    Rhee, C.K.8
  • 7
    • 0034024182 scopus 로고    scopus 로고
    • Phosphodiesterase 4 inhibitors and the treatment of asthma: Where are we now and where do we go from here?
    • Giembycz M. A., Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here? Drugs 2000 59 2 193 212 2-s2.0-0034024182 (Pubitemid 30168507)
    • (2000) Drugs , vol.59 , Issue.2 , pp. 193-212
    • Giembycz, M.A.1
  • 10
    • 5144221343 scopus 로고    scopus 로고
    • Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships
    • DOI 10.1016/j.bcp.2004.06.030, PII S0006295204004770
    • Ko W. C., Shih C. M., Lai Y. H., Chen J. H., Huang H. L., Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. Biochemical Pharmacology 2004 68 10 2087 2094 2-s2.0-5144221343 10.1016/j.bcp.2004.06.030 (Pubitemid 39346198)
    • (2004) Biochemical Pharmacology , vol.68 , Issue.10 , pp. 2087-2094
    • Ko, W.-C.1    Shih, C.-M.2    Lai, Y.-H.3    Chen, J.-H.4    Huang, H.-L.5
  • 13
    • 84859419789 scopus 로고    scopus 로고
    • Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model
    • 2-s2.0-79251542073 10.1007/s10753-011-9295-7
    • Wei D., Ci X., Chu X., Wei M., Hua S., Deng X., Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model. Inflammation 2011 1 8 2-s2.0-79251542073 10.1007/s10753-011-9295-7
    • (2011) Inflammation , pp. 1-8
    • Wei, D.1    Ci, X.2    Chu, X.3    Wei, M.4    Hua, S.5    Deng, X.6
  • 14
    • 0037616054 scopus 로고    scopus 로고
    • 3-O-methylquercetin more selectively inhibits phosphodiesterase subtype 3
    • DOI 10.1055/s-2003-38874
    • Ko W. C., Chen M. C., Wang S. H., Lai Y. H., Chen J. H., Lin C. N., 3- O -methylquercetin more selectively inhibits phosphodiesterase subtype 3. Planta Medica 2003 69 4 310 315 2-s2.0-0037616054 10.1055/s-2003-38874 (Pubitemid 36577995)
    • (2003) Planta Medica , vol.69 , Issue.4 , pp. 310-315
    • Ko, W.-C.1    Chen, M.-C.2    Wang, S.-H.3    Lai, Y.-H.4    Chen, J.-H.5    Lin, C.-N.6
  • 15
    • 0015231739 scopus 로고
    • Multiple cyclic nucleotide phosphodiesterase activities from rat brain
    • 2-s2.0-0015231739
    • Thompson W. J., Appleman M. M., Multiple cyclic nucleotide phosphodiesterase activities from rat brain. Biochemistry 1971 10 2 311 316 2-s2.0-0015231739
    • (1971) Biochemistry , vol.10 , Issue.2 , pp. 311-316
    • Thompson, W.J.1    Appleman, M.M.2
  • 16
    • 0024454868 scopus 로고
    • Effects of selective inhibitors on cyclic nucleotide phosphodiesterase of rabbit aorta
    • DOI 10.1016/0006-2952(89)90631-X
    • Ahn H. S., Crim W., Romano M., Sybertz E., Pitts B., Effects of selective inhibitors on cyclic nucleotide phosphodiesterase of rabbit aorta. Biochemical Pharmacology 1989 38 19 3331 3339 2-s2.0-0024454868 10.1016/0006-2952(89)90631-X (Pubitemid 19254124)
    • (1989) Biochemical Pharmacology , vol.38 , Issue.19 , pp. 3331-3339
    • Ahn, H.S.1    Crim, W.2    Romano, M.3    Sybertz, E.4    Pitts, B.5
  • 17
    • 0029088562 scopus 로고
    • Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine
    • 2-s2.0-0029088562 10.1016/0898-6568(95)00042-N
    • Podzuweit T., Nennstiel P., Muller A., Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3- nonyl) adenine. Cellular Signalling 1995 7 7 733 738 2-s2.0-0029088562 10.1016/0898-6568(95)00042-N
    • (1995) Cellular Signalling , vol.7 , Issue.7 , pp. 733-738
    • Podzuweit, T.1    Nennstiel, P.2    Muller, A.3
  • 18
    • 0022454622 scopus 로고
    • Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: A receptor for new cardiotonic drugs
    • Harrison S. A., Reifsnyder D. H., Gallis B., Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs. Molecular Pharmacology 1986 29 5 506 514 2-s2.0-0022454622 (Pubitemid 16068905)
    • (1986) Molecular Pharmacology , vol.29 , Issue.5 , pp. 506-514
    • Harrison, S.A.1    Reifsnyder, D.H.2    Gallis, B.3
  • 19
    • 0023088944 scopus 로고
    • The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors
    • Reeves M. L., Leigh B. K., England P. J., The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors. Biochemical Journal 1987 241 2 535 541 2-s2.0-0023088944 (Pubitemid 17234191)
    • (1987) Biochemical Journal , vol.241 , Issue.2 , pp. 535-541
    • Reeves, M.L.1    Leigh, B.K.2    England, P.J.3
  • 20
    • 0024306482 scopus 로고
    • Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M and B 22,948
    • Gillespie P. G., Beavo J. A., Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M and B 22,948. Molecular Pharmacology 1989 36 5 773 781 2-s2.0-0024306482 (Pubitemid 20008225)
    • (1989) Molecular Pharmacology , vol.36 , Issue.5 , pp. 773-781
    • Gillespie, P.G.1    Beavo, J.A.2
  • 21
    • 0022459284 scopus 로고
    • Stereospecific binding of the antidepressant rolipram to brain protein structures
    • Schneider H. H., Schmiechen R., Brezinski M., Seidler J., Stereospecific binding of the antidepressant rolipram to brain protein structures. European Journal of Pharmacology 1986 127 1-2 105 115 2-s2.0-0022459284 (Pubitemid 16023615)
    • (1986) European Journal of Pharmacology , vol.127 , Issue.1-2 , pp. 105-115
    • Schneider, H.H.1    Schmiechen, R.2    Brezinski, M.3    Seidler, J.4
  • 23
    • 0035155146 scopus 로고    scopus 로고
    • Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge
    • Kanehiro A., Ikemura T., Mäkelä M. J., Lahn M., Joetham A., Dakhama A., Gelfand E. W., Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge. American Journal of Respiratory and Critical Care Medicine 2001 163 1 173 184 2-s2.0-0035155146 (Pubitemid 32095268)
    • (2001) American Journal of Respiratory and Critical Care Medicine , vol.163 , Issue.1 , pp. 173-184
    • Kanehiro, A.1    Ikemura, T.2    Makela, M.J.3    Lahn, M.4    Joetham, A.5    Dakhama, A.6    Gelfand, E.W.7
  • 25
    • 0032811720 scopus 로고    scopus 로고
    • Flow cytometric detection of antigen-specific cytokine responses in lung T cells in a murine model of pulmonary inflammation
    • DOI 10.1016/S0022-1759(99)00049-6, PII S0022175999000496
    • Winterrowd G. E., Chin J. E., Flow cytometric detection of antigen-specific cytokine responses in lung T cells in a murine model of pulmonary inflammation. Journal of Immunological Methods 1999 226 1-2 105 118 2-s2.0-0032811720 10.1016/S0022-1759(99)00049-6 (Pubitemid 29336535)
    • (1999) Journal of Immunological Methods , vol.226 , Issue.1-2 , pp. 105-118
    • Winterrowd, G.E.1    Chin, J.E.2
  • 27
    • 0035253291 scopus 로고    scopus 로고
    • Asthma
    • DOI 10.1056/NEJM200102013440507
    • Busse W. W., Lemanske R. F., Asthma. New England Journal of Medicine 2001 344 5 350 362 2-s2.0-0035253291 10.1056/NEJM200102013440507 (Pubitemid 32107645)
    • (2001) New England Journal of Medicine , vol.344 , Issue.5 , pp. 350-362
    • Busse, W.W.1    Lemanske Jr., R.F.2
  • 28
    • 11844276029 scopus 로고    scopus 로고
    • Lipoprotein I, a TLR2/4 ligand modulates Th2-driven allergic immune responses
    • Revets H., Pynaert G., Grooten J., De Baetselier P., Lipoprotein I, a TLR2/4 ligand modulates Th2-driven allergic immune responses. Journal of Immunology 2005 174 2 1097 1103 2-s2.0-11844276029 (Pubitemid 40094307)
    • (2005) Journal of Immunology , vol.174 , Issue.2 , pp. 1097-1103
    • Revets, H.1    Pynaert, G.2    Grooten, J.3    De Baetselier, P.4
  • 29
    • 33745698831 scopus 로고    scopus 로고
    • Regulatory T cells, a potent immunoregulatory target for CAM researchers: The ultimate antagonist (I)
    • DOI 10.1093/ecam/nek022
    • Vojdani A., Erde J., Regulatory T cells, a potent immunoregulatory target for CAM researchers: the ultimate antagonist (I). Evidence-based Complementary and Alternative Medicine 2006 3 1 25 30 2-s2.0-33745698831 10.1093/ecam/nek022 (Pubitemid 43999648)
    • (2006) Evidence-based Complementary and Alternative Medicine , vol.3 , Issue.1 , pp. 25-30
    • Vojdani, A.1    Erde, J.2
  • 30
    • 0023269443 scopus 로고
    • Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by T(H)1 clones
    • Cher D. J., Mosmann T. R., Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by Th1 clones. Journal of Immunology 1987 138 11 3688 3694 2-s2.0-0023269443 (Pubitemid 17078235)
    • (1987) Journal of Immunology , vol.138 , Issue.11 , pp. 3688-3694
    • Cher, D.J.1    Mosmann, T.R.2
  • 31
    • 0023548365 scopus 로고
    • Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans
    • Bokkenheuser V. D., Shackleton C. H. L., Winter J., Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans. Biochemical Journal 1987 248 3 953 956 2-s2.0-0023548365 (Pubitemid 18012735)
    • (1987) Biochemical Journal , vol.248 , Issue.3 , pp. 953-956
    • Bokkenheuser, V.D.1    Shackleton, C.H.L.2    Winter, J.3
  • 32
    • 81055127631 scopus 로고    scopus 로고
    • Hesperetin-7,3'- O -dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio
    • 10.1186/1423-0127-18-84
    • Yang Y. L., Hsu H. T., Wang K. H., Hesperetin-7,3'- O -dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio. Journal of Biomedical Science 2011 18 1 84 10.1186/1423-0127-18-84
    • (2011) Journal of Biomedical Science , vol.18 , Issue.1 , pp. 84
    • Yang, Y.L.1    Hsu, H.T.2    Wang, K.H.3
  • 33
    • 0028158941 scopus 로고
    • Effects of naturally occurring flavonoids on mitogen-induced lymphocyte proliferation and mixed lymphocyte culture
    • DOI 10.1016/0024-3205(94)00787-X
    • Namgoong S. Y., Son K. H., Chang H. W., Kang S. S., Kim H. P., Effects of naturally occurring flavonoids on mitogen-induced lymphocyte proliferation and mixed lymphocyte culture. Life Sciences 1994 54 5 313 320 2-s2.0-0028158941 10.1016/0024-3205(94)00787-X (Pubitemid 24049591)
    • (1994) Life Sciences , vol.54 , Issue.5 , pp. 313-320
    • Namgoong, S.Y.1    Son, K.H.2    Chang, H.W.3    Kang, S.S.4    Kim, H.P.5
  • 35
    • 0037385864 scopus 로고    scopus 로고
    • Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13
    • DOI 10.1165/rcmb.2002-0032OC
    • Vargaftig B. B., Singer M., Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. American Journal of Respiratory Cell and Molecular Biology 2003 28 4 410 419 2-s2.0-0037385864 10.1165/rcmb.2002-0032OC (Pubitemid 36399362)
    • (2003) American Journal of Respiratory Cell and Molecular Biology , vol.28 , Issue.4 , pp. 410-419
    • Vargaftig, B.B.1    Singer, M.2
  • 37
    • 0030028768 scopus 로고    scopus 로고
    • Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    • DOI 10.1084/jem.183.1.195
    • Foster P. S., Hogan S. P., Ramsay A. J., Matthaei K. I., Young I. G., Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. Journal of Experimental Medicine 1996 183 1 195 201 2-s2.0-0030028768 10.1084/jem.183.1.195 (Pubitemid 26028759)
    • (1996) Journal of Experimental Medicine , vol.183 , Issue.1 , pp. 195-201
    • Foster, P.S.1    Hogan, S.P.2    Ramsay, A.J.3    Matthaei, K.I.4    Young, I.G.5
  • 40
    • 33645827963 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase δ attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
    • DOI 10.1096/fj.05-5045com
    • Lee K. S., Lee H. K., Hayflick J. S., Lee Y. C., Puri K. D., Inhibition of phosphoinositide 3-kinase δ attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. FASEB Journal 2006 20 3 455 465 2-s2.0-33645827963 10.1096/fj.05-5045com (Pubitemid 44933322)
    • (2006) FASEB Journal , vol.20 , Issue.3 , pp. 455-465
    • Lee, K.S.1    Lee, H.K.2    Hayflick, J.S.3    Lee, Y.C.4    Puri, K.D.5
  • 41
    • 0031852973 scopus 로고    scopus 로고
    • Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13
    • DOI 10.1084/jem.188.2.399
    • Emson C. L., Bell S. E., Jones A., Wisden W., McKenzie A. N. J., Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13. Journal of Experimental Medicine 1998 188 2 399 404 2-s2.0-0031852973 10.1084/jem.188.2.399 (Pubitemid 28357768)
    • (1998) Journal of Experimental Medicine , vol.188 , Issue.2 , pp. 399-404
    • Emson, C.L.1    Bell, S.E.2    Jones, A.3    Wisden, W.4    McKenzie, A.N.J.5
  • 42
    • 0030933777 scopus 로고    scopus 로고
    • The immunoglobulin class switch: Beyond 'accessibility'
    • DOI 10.1016/S1074-7613(00)80324-6
    • Snapper C. M., Marcu K. B., Zelazowski P., The immunoglobulin class switch: beyond 'accessibility'. Immunity 1997 6 3 217 223 2-s2.0-0030933777 10.1016/S1074-7613(00)80324-6 (Pubitemid 27148588)
    • (1997) Immunity , vol.6 , Issue.3 , pp. 217-223
    • Snapper, C.M.1    Marcu, K.B.2    Zelazowski, P.3
  • 43
    • 0032858194 scopus 로고    scopus 로고
    • Molecular processes that regulate class switching
    • 2-s2.0-0032858194
    • Stavnezer J., Molecular processes that regulate class switching. Current Topics in Microbiology and Immunology 1999 245 127 168 2-s2.0-0032858194
    • (1999) Current Topics in Microbiology and Immunology , vol.245 , pp. 127-168
    • Stavnezer, J.1
  • 44
    • 0036154530 scopus 로고    scopus 로고
    • Immunopharmacological potential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide-mediated proinflammatory cytokine (interleukin-6 and tumor necrosis factor- α) biosynthesis in alveolar epithelial cells
    • Haddad J. J., Land S. C., Tarnow-Mordi W. O., Zembala M., Kowalczyk D., Lauterbach R., Immunopharmacological potential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide-mediated proinflammatory cytokine (interleukin-6 and tumor necrosis factor- α) biosynthesis in alveolar epithelial cells. Journal of Pharmacology and Experimental Therapeutics 2002 300 2 559 566
    • (2002) Journal of Pharmacology and Experimental Therapeutics , vol.300 , Issue.2 , pp. 559-566
    • Haddad, J.J.1    Land, S.C.2    Tarnow-Mordi, W.O.3    Zembala, M.4    Kowalczyk, D.5    Lauterbach, R.6
  • 45
    • 0036151665 scopus 로고    scopus 로고
    • Immunopharmacological potential of selective phosphodiesterase inhibition. II. Evidence for the involvement of an inhibitory-κB/nuclear factor-κB-sensitive pathway in alveolar epithelial cells
    • DOI 10.1124/jpet.300.2.567
    • Haddad J. J., Land S. C., Tarnow-Mordi W. O., Zembala M., Kowalczyk D., Lauterbach R., Immunopharmacological potential of selective phosphodiesterase inhibition. II. Evidence for the involvement of an inhibitory- B/nuclear factor- B-sensitive pathway in alveolar epithelial cells. Journal of Pharmacology and Experimental Therapeutics 2002 300 2 567 576 2-s2.0-0036151665 10.1124/jpet.300.2.567 (Pubitemid 34106249)
    • (2002) Journal of Pharmacology and Experimental Therapeutics , vol.300 , Issue.2 , pp. 567-576
    • Haddad, J.J.1    Land, S.C.2    Tarnow-Mordi, W.O.3    Zembala, M.4    Kowalczyk, D.5    Lauterbach, R.6
  • 47
    • 84863270633 scopus 로고    scopus 로고
    • Hesperetin, a selective phosphodiesterase 4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without influencing xylazine/ketamine-induced anesthesia
    • 472897 10.1155/2012/472897
    • Shih C. H., Lin L. H., Hsu H. T., Hesperetin, a selective phosphodiesterase 4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without influencing xylazine/ketamine-induced anesthesia. Evidence-Based Complementary and Alternative Medicine 2012 2012 10 472897 10.1155/2012/472897
    • (2012) Evidence-Based Complementary and Alternative Medicine , vol.2012 , pp. 10
    • Shih, C.H.1    Lin, L.H.2    Hsu, H.T.3
  • 48
    • 0035216330 scopus 로고    scopus 로고
    • PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway
    • 2-s2.0-0035216330 10.1016/S0028-3908(00)00142-8
    • Robichaud A., Savoie C., Stamatiou P. B., Tattersall F. D., Chan C. C., PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway. Neuropharmacology 2001 40 2 262 269 2-s2.0-0035216330 10.1016/S0028-3908(00) 00142-8
    • (2001) Neuropharmacology , vol.40 , Issue.2 , pp. 262-269
    • Robichaud, A.1    Savoie, C.2    Stamatiou, P.B.3    Tattersall, F.D.4    Chan, C.C.5


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