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Volumn 2, Issue 4, 2012, Pages 333-348

A model of GDNF Gene therapy in mice with 6-hydroxydopamine lesions: Time course of neurorestorative effects and ERK1/2 activation

Author keywords

GDNF; MAPK; mitogen activated protein kinases; neuroprotection; Neurotoxin; rodent; trophic factor

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LENTIVIRUS VECTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TYROSINE 3 MONOOXYGENASE;

EID: 84874820297     PISSN: 18777171     EISSN: 1877718X     Source Type: Journal    
DOI: 10.3233/JPD-012146     Document Type: Article
Times cited : (13)

References (51)
  • 1
    • 0030031116 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor exerts neurotrophic effects on dopaminergic neurons in vitro and promotes their survival and regrowth after damage by 1-methyl-4-phenylpyridinium
    • Hou JG, Lin L-FH, & Mytilineou C (1996) Glial cell line-derived neurotrophic factor exerts neurotrophic effects on dopaminergic neurons in vitro and protomotes their survival and regrowth after damage by 1-methyl-4- phenylpyridinium. J Neurochem, 66, 74-82. (Pubitemid 26010766)
    • (1996) Journal of Neurochemistry , vol.66 , Issue.1 , pp. 74-82
    • Hou, J.-G.G.1    Lin, L.-F.H.2    Mytilineou, C.3
  • 3
    • 0028874203 scopus 로고
    • GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo
    • Kearns CM, & Gash DM (1995) GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo. Brain Res, 672, 104-111.
    • (1995) Brain Res , vol.672 , pp. 104-111
    • Kearns, C.M.1    Gash, D.M.2
  • 4
    • 0343517507 scopus 로고    scopus 로고
    • Lentiviral vectors as a gene delivery system in the mouse midbrain: Cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF
    • DOI 10.1006/exnr.2000.7409
    • Bensadoun JC, Deglon N, Tseng JL, Ridet JL, Zurn AD, & Aebischer P (2000) Lentiviral vectors as a gene delivery system in the mouse midbrain: Cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF. Exp Neurol, 164, 15-24. (Pubitemid 30490718)
    • (2000) Experimental Neurology , vol.164 , Issue.1 , pp. 15-24
    • Bensadoun, J.-C.1    Deglon, N.2    Tseng, J.L.3    Ridet, J.-L.4    Zurn, A.D.5    Aebischer, P.6
  • 6
    • 0037148074 scopus 로고    scopus 로고
    • Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector
    • Georgievska B, Kirik D, Rosenblad C, Lundberg C, & Björklund A (2002) Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using lentiviral vector. Neuroreport, 13, 75-82. (Pubitemid 34102030)
    • (2002) NeuroReport , vol.13 , Issue.1 , pp. 75-82
    • Georgievska, B.1    Kirik, D.2    Rosenblad, C.3    Lundberg, C.4    Bjorklund, A.5
  • 7
    • 22544461907 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain
    • DOI 10.1038/nm0705-703
    • Love S, Plaha P, Patel NK, Hotton GR, Brooks DJ, & Gill SS (2005) Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain. Nat Med, 11, 703-704. (Pubitemid 41021193)
    • (2005) Nature Medicine , vol.11 , Issue.7 , pp. 703-704
    • Love, S.1    Plaha, P.2    Patel, N.K.3    Hotton, G.R.4    Brooks, D.J.5    Gill, S.S.6
  • 9
    • 0347087435 scopus 로고    scopus 로고
    • Enhancement of Tyrosine Hydroxylase Phosphorylation and Activity by Glial Cell Line-derived Neurotrophic Factor
    • DOI 10.1074/jbc.M310734200
    • Kobori N, Waymire JC, Haycock JW, Clifton GL, & Dash PK (2004) Enhancement of tyrosine hydroxylase phospho-rylation and activity by glial cell line-derived neurotrophic factor. J Biol Chem, 279, 2182-2191. (Pubitemid 38084492)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.3 , pp. 2182-2191
    • Kobori, N.1    Waymire, J.C.2    Haycock, J.W.3    Clifton, G.L.4    Dash, P.K.5
  • 13
    • 0033625038 scopus 로고    scopus 로고
    • GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival
    • Tansey MG, Baloh RH, Mildbrant J, & Johnson EM (2000) GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. Neuon, 25, 611-623.
    • (2000) Neuon , vol.25 , pp. 611-623
    • Tansey, M.G.1    Baloh, R.H.2    Mildbrant, J.3    Johnson, E.M.4
  • 14
    • 0033597817 scopus 로고    scopus 로고
    • Ret-dependent and-independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells
    • Trupp M, Scott R, Whittemore SR, & Ibanez CF (1999) Ret-dependent and-independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells. J Biol Chem, 274, 20885-20894.
    • (1999) J Biol Chem , vol.274 , pp. 20885-20894
    • Trupp, M.1    Scott, R.2    Whittemore, S.R.3    Ibanez, C.F.4
  • 15
    • 0031034813 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation
    • DOI 10.1074/jbc.272.1.249
    • van Weering DH, & Bos JH (1997) Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation. J Biol Chem, 272, 249-254. (Pubitemid 27021152)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.1 , pp. 249-254
    • Van Weering, D.H.J.1    Bos, J.L.2
  • 16
    • 0029846514 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase
    • DOI 10.1074/jbc.271.39.23619
    • Worby CA, Vega QC, Zhao Y, Chao HH-J, Seasholtz AF, & Dixon JE (1996) Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase. J Biol Chem, 271, 23619-23622. (Pubitemid 26327319)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.39 , pp. 23619-23622
    • Worby, C.A.1    Vega, Q.C.2    Zhao, Y.3    Chao, H.H.-J.4    Seasholtz, A.F.5    Dixon, J.E.6
  • 17
    • 0038054032 scopus 로고    scopus 로고
    • Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: Modulation by inhibitors of PI3 kinase and MEK
    • DOI 10.1002/jnr.10632
    • Ugarte SD, Lin E, Klann E, Zigmond MJ, & Perez RG (2003) Effects of GDNF on 6-OHDA-induced death in a dopamin-ergic cell line: Modulation by inhibitors of PI3 kinase and MEK. J Neurosci Res, 73, 105-112. (Pubitemid 36791375)
    • (2003) Journal of Neuroscience Research , vol.73 , Issue.1 , pp. 105-112
    • Ugarte, S.D.1    Lin, E.2    Klann, E.3    Zigmond, M.J.4    Perez, R.G.5
  • 19
    • 70349095592 scopus 로고    scopus 로고
    • Roleofglialcell line-derived neurotrophic factor (GDNF)-neural cell adhesion molecule (NCAM) interactions in induction of neurite outgrowth and identification of a binding site for NCAM in the heel region of GDNF
    • Nielsen J, Gotfryd K, Li S, Kulahin N, Soroka V, Rasmussen KK, Bock E, & Berezin V (2009) Roleofglialcell line-derived neurotrophic factor (GDNF)-neural cell adhesion molecule (NCAM) interactions in induction of neurite outgrowth and identification of a binding site for NCAM in the heel region of GDNF. J Neurosci, 29, 11360-11376.
    • (2009) J Neurosci , vol.29 , pp. 11360-11376
    • Nielsen, J.1    Gotfryd, K.2    Li, S.3    Kulahin, N.4    Soroka, V.5    Rasmussen, K.K.6    Bock, E.7    Berezin, V.8
  • 21
    • 3242762057 scopus 로고    scopus 로고
    • Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system
    • DOI 10.1523/JNEUROSCI.1122-04.2004
    • Georgievska B, Kirik D, & Björklund A (2004) Overex-pression of glial cell line-revide neurotrophic factor using a lentiviral vector induces time-and dose-dependent down-regulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system. J Neurosci, 24, 6437-6445. (Pubitemid 38971690)
    • (2004) Journal of Neuroscience , vol.24 , Issue.29 , pp. 6437-6445
    • Georgievska, B.1    Kirik, D.2    Bjorklund, A.3
  • 22
    • 0036434879 scopus 로고    scopus 로고
    • Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer
    • DOI 10.1006/exnr.2002.8006
    • Georgievska B, Kirik D, & Bjorklund A (2002) Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer. Exp Neurol, 177, 461-474. (Pubitemid 35366135)
    • (2002) Experimental Neurology , vol.177 , Issue.2 , pp. 461-474
    • Georgievska, B.1    Kirik, D.2    Bjorklund, A.3
  • 24
    • 2342459797 scopus 로고    scopus 로고
    • A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: Relation to motor and cellular parameters of nigrostriatal function
    • DOI 10.1016/j.nbd.2004.01.007, PII S0969996104000178
    • Lundblad M, Picconi B, Lindgren H, & Censi MA (2004) A modelof L-DOPA-induceddyskinesia in 6-hydroxydopamine lesioned mice: Relation to motor and cellular parameters of nigrostriatal function. Neurobiol Dis, 16, 110-123. (Pubitemid 38569802)
    • (2004) Neurobiology of Disease , vol.16 , Issue.1 , pp. 110-123
    • Lundblad, M.1    Picconi, B.2    Lindgren, H.3    Cenci, M.A.4
  • 25
    • 79954630030 scopus 로고    scopus 로고
    • Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease
    • Francardo V, Recchia A, Popovic N, Andersson D, Nissbrandt H, & Cenci MA (2011) Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease. Neurobiol Dis, 42, 327-340.
    • (2011) Neurobiol Dis , vol.42 , pp. 327-340
    • Francardo, V.1    Recchia, A.2    Popovic, N.3    Andersson, D.4    Nissbrandt, H.5    Cenci, M.A.6
  • 27
    • 0033083082 scopus 로고    scopus 로고
    • Stereological methods for estimating the total number of neurons and synapses: Issues of precision and bias
    • DOI 10.1016/S0166-2236(98)01362-9
    • West MJ (1999) Stereological methods for estimating the total number of neurons and synapses: Issues of precision and bias. Trends Neurosci, 22, 51-61. (Pubitemid 29125550)
    • (1999) Trends in Neurosciences , vol.22 , Issue.2 , pp. 51-61
    • West, M.J.1
  • 28
    • 0029939740 scopus 로고    scopus 로고
    • Estimation of the number of somatostatin neurons in the striatum: An in situ hybridization study using the optical fractionator method
    • DOI 10.1002/(SICI)1096-9861(19960617)370:1<11::AID-CNE2>3.0.CO;2-O
    • West MJ, Ostergaard K, Andreassen OA, & Finsen B (1996) Estimation of the number of somatostatin neurons in the striatum: An in situ hybridization study using the optical fractionator method. J Comp Neurol, 370, 11-22. (Pubitemid 26192341)
    • (1996) Journal of Comparative Neurology , vol.370 , Issue.1 , pp. 11-22
    • West, M.J.1    Ostergaard, K.2    Andreassen, O.A.3    Finsen, B.4
  • 29
    • 48249129178 scopus 로고    scopus 로고
    • Activation of the extracellular signal-regulated kinases 1 and 2 by glial cell line-derived neurotrophic factor and its relation to neuroprotection in a mouse model of Parkinson's disease
    • Lindgren N, Leak RK, Carlson KM, Smith AD, & Zigmond MJ (2008) Activation of the extracellular signal-regulated kinases 1 and 2 by glial cell line-derived neurotrophic factor and its relation to neuroprotection in a mouse model of Parkinson's disease. J Neurosci Res, 86, 2039-2049.
    • (2008) J Neurosci Res , vol.86 , pp. 2039-2049
    • Lindgren, N.1    Leak, R.K.2    Carlson, K.M.3    Smith, A.D.4    Zigmond, M.J.5
  • 30
    • 4344713871 scopus 로고    scopus 로고
    • Regulation of striatal tyrosine hydroxylase phosphorylation by acute and chronic haloperidol
    • DOI 10.1111/j.1460-9568.2004.03547.x
    • Håkansson K, Pozzi L, Usiello A, Haycock JW, Borelli F, & Fisone G (2004) Regulation of striatal tyrosine hydroxy-lase phosphorylation by acute and chronic haloperidol. Eur J Neurosci, 20, 1108-1112. (Pubitemid 39141317)
    • (2004) European Journal of Neuroscience , vol.20 , Issue.4 , pp. 1108-1112
    • Hakansson, K.1    Pozzi, L.2    Usiello, A.3    Haycock, J.4    Borrelli, E.5    Fisone, G.6
  • 31
    • 0036460132 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinases 1 and 2 by depolarization stimulates tyrosine hydroxylase phosphorylation and dopamine synthesis in rat brain
    • DOI 10.1046/j.1460-9568.2002.01901.x
    • Lindgren N, Goiny M, Herrera-Marschitz M, Haycock JW, Hökfelt T, & Fisone G (2002) Activation of extracellular signal-regulated kinases 1 and 2 by depolarization stimulates tyrosine hydroxylase phosphorylation and dopamine synthesis in rat brain. Eur J Neurosci, 15, 769-773. (Pubitemid 35471943)
    • (2002) European Journal of Neuroscience , vol.15 , Issue.4 , pp. 769-773
    • Lindgren, N.1    Goiny, M.2    Herrera-Marschitz, M.3    Haycock, J.W.4    Hokfelt, T.5    Fisone, G.6
  • 32
    • 39449113020 scopus 로고    scopus 로고
    • Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and α-synuclein-deleted mice
    • DOI 10.1016/j.expneurol.2007.10.012, PII S0014488607004025
    • Alvarez-Fischer D, Henze C, Strenzke C, Westrich J, Ferger B, Hoglinger GU, Oertel WH, & Hartmann A (2008) Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice. Exp Neurol, 210, 182-193. (Pubitemid 351265366)
    • (2008) Experimental Neurology , vol.210 , Issue.1 , pp. 182-193
    • Alvarez-Fischer, D.1    Henze, C.2    Strenzke, C.3    Westrich, J.4    Ferger, B.5    Hoglinger, G.U.6    Oertel, W.H.7    Hartmann, A.8
  • 34
    • 0037267170 scopus 로고    scopus 로고
    • Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system
    • DOI 10.1046/j.1460-9568.2003.02456.x
    • Rosenblad C, Georgievska B, & Kirik D (2003) Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system. Eur J Neurosci, 17, 260-270. (Pubitemid 36459505)
    • (2003) European Journal of Neuroscience , vol.17 , Issue.2 , pp. 260-270
    • Rosenblad, C.1    Georgievska, B.2    Kirik, D.3
  • 35
    • 0034097605 scopus 로고    scopus 로고
    • Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
    • DOI 10.1006/exnr.1999.7296
    • Rosenblad C, Kirik D, & Björklund A (2000) Sequential administrationofGDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model. Exp Neurol, 161, 503-516. (Pubitemid 30137010)
    • (2000) Experimental Neurology , vol.161 , Issue.2 , pp. 503-516
    • Rosenblad, C.1    Kirik, D.2    Bjorklund, A.3
  • 36
    • 0034571915 scopus 로고    scopus 로고
    • Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice
    • Bezard E, Dovero S, Imbert C, Boraud T, & Gross CE (2000) Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice. Synapse, 38, 363-368.
    • (2000) Synapse , vol.38 , pp. 363-368
    • Bezard, E.1    Dovero, S.2    Imbert, C.3    Boraud, T.4    Gross, C.E.5
  • 37
    • 84857782774 scopus 로고    scopus 로고
    • Efficient gene therapy for Parkinson's disease using astrocytes as hosts for localized neurotrophic factor delivery
    • Drinkut A, Tereshchenko Y, Schulz JB, Bahr M, & Kugler S (2012) Efficient gene therapy for Parkinson's disease using astrocytes as hosts for localized neurotrophic factor delivery. Mol Ther, 20, 534-543.
    • (2012) Mol Ther , vol.20 , pp. 534-543
    • Drinkut, A.1    Tereshchenko, Y.2    Schulz, J.B.3    Bahr, M.4    Kugler, S.5
  • 38
    • 84859157176 scopus 로고    scopus 로고
    • Optimized quantities of GDNF overex-pressed by engineered astrocytes are critical for protection of neuroblastoma cells against 6-OHDA toxicity
    • Safi R, Gardaneh M, Panahi Y, Maghsoudi N, Zaefizadeh M, & Gharib E (2012) Optimized quantities of GDNF overex-pressed by engineered astrocytes are critical for protection of neuroblastoma cells against 6-OHDA toxicity. J Mol Neu-rosci, 46, 654-665.
    • (2012) J Mol Neu-rosci , vol.46 , pp. 654-665
    • Safi, R.1    Gardaneh, M.2    Panahi, Y.3    Maghsoudi, N.4    Zaefizadeh, M.5    Gharib, E.6
  • 39
    • 29144536727 scopus 로고    scopus 로고
    • Ex vivo gene delivery of GDNF using primary astrocytes transduced with a lentiviral vector provides neuroprotection in a rat model of Parkinson's disease
    • DOI 10.1111/j.1460-9568.2005.04503.x
    • Ericson C, Georgievska B, & Lundberg C (2005) Ex vivogene delivery of GDNF using primary astrocytes transduced with a lentiviral vector provides neuroprotection in a rat model of Parkinson's disease. Eur J Neurosci, 22, 2755-2764. (Pubitemid 41811272)
    • (2005) European Journal of Neuroscience , vol.22 , Issue.11 , pp. 2755-2764
    • Ericson, C.1    Georgievska, B.2    Lundberg, C.3
  • 40
    • 0034659835 scopus 로고    scopus 로고
    • Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: Intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
    • Kirik D, Rosenblad C, Björklund A, & Mandel RJ (2000) Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: Intrastriatal but not intanigral transduction promotes functional regeneration in the lesioned nigrostriatal system. J Neurosci, 20, 4686-4700. (Pubitemid 30396634)
    • (2000) Journal of Neuroscience , vol.20 , Issue.12 , pp. 4686-4700
    • Kirik, D.1    Rosenblad, C.2    Bjorklund, A.3    Mandel, R.J.4
  • 41
    • 68549096006 scopus 로고    scopus 로고
    • Bilateral effects of unilateral GDNF administration on dopamine-and GABA-regulating proteins in the rat nigrostriatal system
    • Salvatore MF, Gerhardt GA, Dayton RD, Klein RL, & Stanford JA (2009) Bilateral effects of unilateral GDNF administration on dopamine-and GABA-regulating proteins in the rat nigrostriatal system. Exp Neurol, 219, 197-207.
    • (2009) Exp Neurol , vol.219 , pp. 197-207
    • Salvatore, M.F.1    Gerhardt, G.A.2    Dayton, R.D.3    Klein, R.L.4    Stanford, J.A.5
  • 42
    • 0035837429 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway respectively in PC12 cells
    • DOI 10.1016/S0306-4522(01)00093-8, PII S0306452201000938
    • Chen Z, Chai Y, Cao L, Huang A, Cui R, Lu C, & He C (2001) Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the phosphatidylinosi-tol 3-kinase and mitogen-activated protein kinase pathway respectively in PC12 cells. Neuroscience, 104, 593-598. (Pubitemid 32493747)
    • (2001) Neuroscience , vol.104 , Issue.2 , pp. 593-598
    • Chen, Z.-Y.1    Chai, Y.-F.2    Cao, L.3    Huang, A.-J.4    Cui, R.-Y.5    Lu, C.-L.6    He, C.7
  • 44
    • 0033597817 scopus 로고    scopus 로고
    • Ret-dependent and-independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells
    • Trupp M, Scott R, Whittemore SR, & Ibanez CF (1999) Ret-dependent and-independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells. J Biol Chem, 274, 20885-20894.
    • (1999) J Biol Chem , vol.274 , pp. 20885-20894
    • Trupp, M.1    Scott, R.2    Whittemore, S.R.3    Ibanez, C.F.4
  • 45
    • 0037033036 scopus 로고    scopus 로고
    • Phosphorylation-induced conformational changes in a mitogen-activated protein kinase substrate: Implications for tyrosine hydroxylase activation
    • DOI 10.1074/jbc.M208755200
    • Stultz CM, Levin AD, & Edelman ER (2002) Phosphorylation-induced conformational changes in a mitogen-activated protein kinase substrate. Implications for tyrosine hydroxylase activation. J Biol Chem, 277, 47653-47661. (Pubitemid 36159287)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.49 , pp. 47653-47661
    • Stultz, C.M.1    Levin, A.D.2    Edelman, E.R.3
  • 46
    • 0027508290 scopus 로고
    • Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2
    • DOI 10.1111/j.1432-1033.1993.tb18297.x
    • Sutherland C, Alterio J, Campbell DG, Le Bourdelles B, Mallet J, Haavik J, & Cohen P (1993) Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2. Eur J Biochem, 217, 715-722. (Pubitemid 23311985)
    • (1993) European Journal of Biochemistry , vol.217 , Issue.2 , pp. 715-722
    • Sutherland, C.1    Alterio, J.2    Campbell, D.G.3    Le Bourdelles, B.4    Mallet, J.5    Haavik, J.6    Cohen, P.7
  • 47
    • 0025991739 scopus 로고
    • Phosphorylation of human recombinant tyrosine hydroxylase isoforms 1 and 2: An additional phosphorylated residue in isoform 2, generated through alternative splicing
    • Le Bourdelles B, Horellou P, Le Caer JP, Denefle P, Latta M, Haavik J, Guibert B, Mayaux JF, & Mallet J (1991) Phospho-rylation of human recombinant tyrosine hydroxylase isoforms 1 and 2: An additional phosphorylated residue in isoform 2, generated through alternative splicing. J Biol Chem, 266, 17124-17130. (Pubitemid 21907914)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.26 , pp. 17124-17130
    • Le Bourdelles, B.1    Horellou, P.2    Le Caer, J.-P.3    Denefle, P.4    Latta, M.5    Haavik, J.6    Guibert, B.7    Mayaux, J.-F.8    Mallet, J.9
  • 50
    • 0032424146 scopus 로고    scopus 로고
    • Dopamine D1 and D2 receptor-mediated acute and long-lasting behavioral effects of glial cell line-derived neurotrophic factor administered into the striatum
    • DOI 10.1006/exnr.1998.6952
    • Kobayashi S, Ogren SO, Hoffer BJ, & Olson L (1998) Dopamine D1 and D2 receptor-mediated acute and long-lasting behavioral effects of glial cell line-derived neu-rotrophic factor administered into the striatum. Exp Neurol, 154, 302-314. (Pubitemid 29044203)
    • (1998) Experimental Neurology , vol.154 , Issue.2 , pp. 302-314
    • Kobayashi, S.1    Ogren, S.O.2    Hoffer, B.J.3    Olson, L.4
  • 51
    • 33751209456 scopus 로고    scopus 로고
    • Bilateral effects of unilateral intrastriatal GDNF on locomotor-excited and nonlocomotor-related striatal neurons in aged F344 rats
    • DOI 10.1016/j.neurobiolaging.2005.10.015, PII S0197458005003441
    • Stanford JA, Salvatore MF, Joyce BM, Zhang H, Gash DM, & Gerhardt GA (2007) Bilateral effects of unilateral intrastri-atal GDNF on locomotor-excited and nonlocomotor-related striatal neurons in aged F344 rats. Neurobiol Aging, 28, 156-165. (Pubitemid 44791630)
    • (2007) Neurobiology of Aging , vol.28 , Issue.1 , pp. 156-165
    • Stanford, J.A.1    Salvatore, M.F.2    Joyce, B.M.3    Zhang, H.4    Gash, D.M.5    Gerhardt, G.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.