Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway respectively in PC12 cells

Neuroscience

Volumn 104, Issue 2, 2001, Pages 593-598

  Chen, Z Y ^a   Chai, Y F ^a,b   Cao, L ^a   Huang, A J ^a   Cui, R Y ^b   Lu, C L ^a   He, C ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Differentiation; Glial cell line derived neurotrophic factor; Glial cell line derived neurotrophic factor receptor 1; Mitogen activated protein kinase; Phosphatidylinositol 3 kinase; Survival

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR ALPHA1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; MALE; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL DIFFERENTIATION; CELL SURVIVAL; CHROMONES; DROSOPHILA PROTEINS; ENZYME INHIBITORS; FLAVONOIDS; GENE EXPRESSION REGULATION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; MAP KINASE SIGNALING SYSTEM; MORPHOLINES; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; PC12 CELLS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; TRANSFECTION;

EID: 0035837429     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00093-8     Document Type: Article

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