메뉴 건너뛰기




Volumn 5, Issue 3, 2013, Pages 301-314

Microvascular complications and diabetic retinopathy: Recent advances and future implications

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CGC 11047; CGC 11093; CGC 11144; CGC 11150; COMBRETASTATIN A4; DEXAMETHASONE; DOBESILATE CALCIUM; E10030; FIBROBLAST GROWTH FACTOR 2; IMATINIB; IMISOPASEM MANGANESE; MIDOSTAURIN; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; N [4 METHYL 3 [4 (3 PYRIDINYL) 2 PYRIMIDINYLAMINO]PHENYL]BENZAMIDE; PEGAPTANIB; PLACEBO; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; POLYAMINE DERIVATIVE; PROTEIN; RANIBIZUMAB; RECOMBINANT PROTEIN; RUBOXISTAURIN; THIOCTIC ACID; THROMBOSPONDIN; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULAR TARGETING AGENT; VASOHIBIN; VOLOCIXIMAB;

EID: 84874701768     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.12.206     Document Type: Review
Times cited : (71)

References (141)
  • 1
    • 67749088340 scopus 로고    scopus 로고
    • Microvascular lesions of diabetic retinopathy: Clues towards understanding pathogenesis?
    • Curtis TM, Gardiner TA, Stitt AW. Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis? Eye (Lond.) 23(7), 1496-1508 (2009).
    • (2009) Eye (Lond.) , vol.23 , Issue.7 , pp. 1496-1508
    • Curtis, T.M.1    Gardiner, T.A.2    Stitt, A.W.3
  • 3
    • 32944465911 scopus 로고    scopus 로고
    • Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema
    • Strom C, Sander B, Klemp K, Aiello LP, Lund-Andersen H, Larsen M. Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema. Invest. Ophthalmol. Vis. Sci. 46(10), 3855-3858 (2005).
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , Issue.10 , pp. 3855-3858
    • Strom, C.1    Sander, B.2    Klemp, K.3    Aiello, L.P.4    Lund-Andersen, H.5    Larsen, M.6
  • 4
    • 80051597186 scopus 로고    scopus 로고
    • Microvascular modifications in diabetic retinopathy
    • Durham JT, Herman IM. Microvascular modifications in diabetic retinopathy. Curr. Diab. Rep. 11(4), 253-264 (2011).
    • (2011) Curr. Diab. Rep. , vol.11 , Issue.4 , pp. 253-264
    • Durham, J.T.1    Herman, I.M.2
  • 5
    • 0037093011 scopus 로고    scopus 로고
    • Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons
    • Wong TY, Klein R, Sharrett AR et al. Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons. JAMA 287(19), 2528-2533 (2002).
    • (2002) JAMA , vol.287 , Issue.19 , pp. 2528-2533
    • Wong, T.Y.1    Klein, R.2    Sharrett, A.R.3
  • 6
    • 0031860340 scopus 로고    scopus 로고
    • Protein kinase C activation and the development of diabetic complications
    • Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes 47(6), 859-866 (1998).
    • (1998) Diabetes , vol.47 , Issue.6 , pp. 859-866
    • Koya, D.1    King, G.L.2
  • 7
    • 77749304040 scopus 로고    scopus 로고
    • Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy
    • Kim JH, Jun HO, Yu YS, Kim KW. Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy. Am. J. Pathol. 176(3), 1517-1524 (2010).
    • (2010) Am. J. Pathol. , vol.176 , Issue.3 , pp. 1517-1524
    • Kim, J.H.1    Jun, H.O.2    Yu, Y.S.3    Kim, K.W.4
  • 8
    • 33947717467 scopus 로고    scopus 로고
    • Diabetes downregulates large-conductance Ca2+-activated potassium beta 1 channel subunit in retinal arteriolar smooth muscle
    • Mcgahon MK, Dash DP, Arora A et al. Diabetes downregulates large-conductance Ca2+-activated potassium beta 1 channel subunit in retinal arteriolar smooth muscle. Circ. Res. 100(5), 703-711 (2007).
    • (2007) Circ. Res. , vol.100 , Issue.5 , pp. 703-711
    • McGahon, M.K.1    Dash, D.P.2    Arora, A.3
  • 9
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
    • Benjamin LE, Hemo I, Keshet E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 125(9), 1591-1598 (1998).
    • (1998) Development , vol.125 , Issue.9 , pp. 1591-1598
    • Benjamin, L.E.1    Hemo, I.2    Keshet, E.3
  • 10
    • 0023585264 scopus 로고
    • Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells
    • Orlidge A, D'amore PA. Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells. J. Cell Biol. 105(3), 1455-1462 (1987).
    • (1987) J. Cell Biol. , vol.105 , Issue.3 , pp. 1455-1462
    • Orlidge, A.1    D'Amore, P.A.2
  • 11
    • 70449108112 scopus 로고    scopus 로고
    • Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
    • Geraldes P, Hiraoka-Yamamoto J, Matsumoto M et al. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat. Med. 15(11), 1298-1306 (2009).
    • (2009) Nat. Med. , vol.15 , Issue.11 , pp. 1298-1306
    • Geraldes, P.1    Hiraoka-Yamamoto, J.2    Matsumoto, M.3
  • 12
    • 7044228789 scopus 로고    scopus 로고
    • A central role for inflammation in the pathogenesis of diabetic retinopathy
    • Joussen AM, Poulaki V, Le ML et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 18(12), 1450-1452 (2004).
    • (2004) FASEB J. , vol.18 , Issue.12 , pp. 1450-1452
    • Joussen, A.M.1    Poulaki Le, V.M.L.2
  • 13
    • 0036174019 scopus 로고    scopus 로고
    • Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo
    • Joussen AM, Poulaki V, Qin W et al. Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am. J. Pathol. 160(2), 501-509 (2002).
    • (2002) Am. J. Pathol. , vol.160 , Issue.2 , pp. 501-509
    • Joussen, A.M.1    Poulaki, V.2    Qin, W.3
  • 15
    • 0030019991 scopus 로고    scopus 로고
    • Fibronectin overexpression in retinal microvessels of patients with diabetes
    • Roy S, Cagliero E, Lorenzi M. Fibronectin overexpression in retinal microvessels of patients with diabetes. Invest. Ophthalmol. Vis. Sci. 37(2), 258-266 (1996).
    • (1996) Invest. Ophthalmol. Vis. Sci. , vol.37 , Issue.2 , pp. 258-266
    • Roy, S.1    Cagliero, E.2    Lorenzi, M.3
  • 16
    • 0025055497 scopus 로고
    • Increases in collagen type IV and laminin in galactose-induced retinal capillary basement membrane thickening - Prevention by an aldose reductase inhibitor
    • Das A, Frank RN, Zhang NL, Samadani E. Increases in collagen type IV and laminin in galactose-induced retinal capillary basement membrane thickening - prevention by an aldose reductase inhibitor. Exp. Eye Res. 50(3), 269-280 (1990).
    • (1990) Exp. Eye Res. , vol.50 , Issue.3 , pp. 269-280
    • Das, A.1    Frank, R.N.2    Zhang, N.L.3    Samadani, E.4
  • 17
    • 81255151066 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in retinal diseases
    • Barot M, Gokulgandhi MR, Mitra AK. Mitochondrial dysfunction in retinal diseases. Curr. Eye Res. 36(12), 1069-1077 (2011).
    • (2011) Curr. Eye Res. , vol.36 , Issue.12 , pp. 1069-1077
    • Barot, M.1    Gokulgandhi, M.R.2    Mitra, A.K.3
  • 18
    • 35548939420 scopus 로고    scopus 로고
    • The future implications and indications of anti-vascular endothelial growth factor therapy in ophthalmic practice
    • Hussain N, Ghanekar Y, Kaur I. The future implications and indications of anti-vascular endothelial growth factor therapy in ophthalmic practice. Indian J. Ophthalmol. 55(6), 445-450 (2007).
    • (2007) Indian J. Ophthalmol. , vol.55 , Issue.6 , pp. 445-450
    • Hussain, N.1    Ghanekar, Y.2    Kaur, I.3
  • 19
    • 23944480405 scopus 로고    scopus 로고
    • Angiogenic pathways in diabetic retinopathy
    • Aiello LP. Angiogenic pathways in diabetic retinopathy. N. Engl. J. Med. 353(8), 839-841 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , Issue.8 , pp. 839-841
    • Aiello, L.P.1
  • 20
    • 23944523376 scopus 로고    scopus 로고
    • Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy
    • Watanabe D, Suzuma K, Matsui S et al. Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy. N. Engl. J. Med. 353(8), 782-792 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , Issue.8 , pp. 782-792
    • Watanabe, D.1    Suzuma, K.2    Matsui, S.3
  • 21
    • 15044347979 scopus 로고    scopus 로고
    • Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy
    • Watanabe D, Suzuma K, Suzuma I et al. Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy. Am. J. Ophthalmol. 139(3), 476-481 (2005).
    • (2005) Am. J. Ophthalmol. , vol.139 , Issue.3 , pp. 476-481
    • Watanabe, D.1    Suzuma, K.2    Suzuma, I.3
  • 22
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, Avery RL, Arrigg PG et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331(22), 1480-1487 (1994).
    • (1994) N. Engl. J. Med. , vol.331 , Issue.22 , pp. 1480-1487
    • Aiello, L.P.1    Avery, R.L.2    Arrigg, P.G.3
  • 23
    • 80051954929 scopus 로고    scopus 로고
    • Increased levels of vascular endothelial growth factor in aqueous humor of patients with diabetic retinopathy: Is it the whole truth?
    • Santhan Gopal KS. Increased levels of vascular endothelial growth factor in aqueous humor of patients with diabetic retinopathy: is it the whole truth? Indian J. Ophthalmol. 59(5), 405-406 (2011).
    • (2011) Indian J. Ophthalmol. , vol.59 , Issue.5 , pp. 405-406
    • Santhan Gopal, K.S.1
  • 24
    • 65549159481 scopus 로고    scopus 로고
    • Anti-angiogenic drugs as an adjunctive therapy in the surgical treatment of diabetic retinopathy
    • Figueroa MS, Contreras I, Noval S. Anti-angiogenic drugs as an adjunctive therapy in the surgical treatment of diabetic retinopathy. Curr. Diabetes Rev. 5(1), 52-56 (2009).
    • (2009) Curr. Diabetes Rev. , vol.5 , Issue.1 , pp. 52-56
    • Figueroa, M.S.1    Contreras, I.2    Noval, S.3
  • 25
    • 38449100932 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor therapy for ocular neovascular disease
    • Andreoli CM, Miller JW. Anti-vascular endothelial growth factor therapy for ocular neovascular disease. Curr. Opin. Ophthalmol. 18(6), 502-508 (2007).
    • (2007) Curr. Opin. Ophthalmol. , vol.18 , Issue.6 , pp. 502-508
    • Andreoli, C.M.1    Miller, J.W.2
  • 26
    • 84860186303 scopus 로고    scopus 로고
    • Neovascular age-related macular degeneration
    • Veritti D, Sarao V, Lanzetta P. Neovascular age-related macular degeneration. Ophthalmologica 227(Suppl. 1), 11-20 (2012).
    • (2012) Ophthalmologica , vol.227 , Issue.SUPPL. 1 , pp. 11-20
    • Veritti, D.1    Sarao, V.2    Lanzetta, P.3
  • 27
    • 76449106209 scopus 로고    scopus 로고
    • Intravitreal bevacizumab treatment of macular edema in central retinal vein occlusion: One-year results
    • Beutel J, Ziemssen F, Luke M, Partsch M, Bartz-Schmidt KU, Gelisken F. Intravitreal bevacizumab treatment of macular edema in central retinal vein occlusion: one-year results. Int. Ophthalmol. 30(1), 15-22 (2010).
    • (2010) Int. Ophthalmol. , vol.30 , Issue.1 , pp. 15-22
    • Beutel, J.1    Ziemssen, F.2    Luke, M.3    Partsch, M.4    Bartz-Schmidt, K.U.5    Gelisken, F.6
  • 29
    • 84863308447 scopus 로고    scopus 로고
    • Intravitreal bevacizumab for pseudophakic cystoid macular edema
    • Carifi G. Intravitreal bevacizumab for pseudophakic cystoid macular edema. Eur. J. Ophthalmol. 22(3), 513 (2012).
    • (2012) Eur. J. Ophthalmol. , vol.22 , Issue.3 , pp. 513
    • Carifi, G.1
  • 30
    • 33748982649 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) in the treatment of proliferative diabetic retinopathy
    • Avery RL, Pearlman J, Pieramici DJ et al. Intravitreal bevacizumab (Avastin) in the treatment of proliferative diabetic retinopathy. Ophthalmology 113(10), 1695 (2006).
    • (2006) Ophthalmology , vol.113 , Issue.10 , pp. 1695
    • Avery, R.L.1    Pearlman, J.2    Pieramici, D.J.3
  • 31
    • 34748876124 scopus 로고    scopus 로고
    • A Phase II randomized clinical trial of intravitreal bevacizumab for diabetic macular edema
    • Scott IU, Edwards AR, Beck RW et al. A Phase II randomized clinical trial of intravitreal bevacizumab for diabetic macular edema. Ophthalmology 114(10), 1860-1867 (2007).
    • (2007) Ophthalmology , vol.114 , Issue.10 , pp. 1860-1867
    • Scott, I.U.1    Edwards, A.R.2    Beck, R.W.3
  • 32
    • 25844513658 scopus 로고    scopus 로고
    • A Phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema
    • Cunningham ET Jr, Adamis AP, Altaweel M et al. A Phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology 112(10), 1747-1757 (2005).
    • (2005) Ophthalmology , vol.112 , Issue.10 , pp. 1747-1757
    • Cunningham Jr., E.T.1    Adamis, A.P.2    Altaweel, M.3
  • 33
    • 33845658622 scopus 로고    scopus 로고
    • Anti-VEGF aptamer (pegaptanib) therapy for ocular vascular diseases
    • Ng EW, Adamis AP. Anti-VEGF aptamer (pegaptanib) therapy for ocular vascular diseases. Ann. NY Acad. Sci. 1082, 151-171 (2006).
    • (2006) Ann. NY Acad. Sci. , vol.1082 , pp. 151-171
    • Ng, E.W.1    Adamis, A.P.2
  • 34
    • 65549120576 scopus 로고    scopus 로고
    • Pegaptanib sodium for the treatment of proliferative diabetic retinopathy and diabetic macular edema
    • Giuliari GP, Guel DA, Gonzalez VH. Pegaptanib sodium for the treatment of proliferative diabetic retinopathy and diabetic macular edema. Curr. Diabetes Rev. 5(1), 33-38 (2009).
    • (2009) Curr. Diabetes Rev. , vol.5 , Issue.1 , pp. 33-38
    • Giuliari, G.P.1    Guel, D.A.2    Gonzalez, V.H.3
  • 35
    • 79955558683 scopus 로고    scopus 로고
    • Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients
    • Boyer DS, Faber D, Gupta S et al. Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients. Retina 31(5), 915-923 (2011).
    • (2011) Retina , vol.31 , Issue.5 , pp. 915-923
    • Boyer, D.S.1    Faber, D.2    Gupta, S.3
  • 36
    • 77749330682 scopus 로고    scopus 로고
    • Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema
    • Haller JA, Kuppermann BD, Blumenkranz MS et al. Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema. Arch. Ophthalmol. 128(3), 289-296 (2010).
    • (2010) Arch. Ophthalmol. , vol.128 , Issue.3 , pp. 289-296
    • Haller, J.A.1    Kuppermann, B.D.2    Blumenkranz, M.S.3
  • 37
    • 42449092862 scopus 로고    scopus 로고
    • Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas
    • Zhang X, Bao S, Lai D, Rapkins RW, Gillies MC. Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas. Diabetes 57(4), 1026-1033 (2008).
    • (2008) Diabetes , vol.57 , Issue.4 , pp. 1026-1033
    • Zhang, X.1    Bao, S.2    Lai, D.3    Rapkins, R.W.4    Gillies, M.C.5
  • 38
    • 0842267262 scopus 로고    scopus 로고
    • Intravitreal triamcinolone acetonide for diabetic diffuse macular edema: Preliminary results of a prospective controlled trial
    • discussion 224-225
    • Massin P, Audren F, Haouchine B et al. Intravitreal triamcinolone acetonide for diabetic diffuse macular edema: preliminary results of a prospective controlled trial. Ophthalmology 111(2), 218-224; discussion 224-225 (2004).
    • (2004) Ophthalmology , vol.111 , Issue.2 , pp. 218-224
    • Massin, P.1    Audren, F.2    Haouchine, B.3
  • 39
    • 62449171859 scopus 로고    scopus 로고
    • Three-year follow-up of a randomized trial comparing focal/grid photocoagulation and intravitreal triamcinolone for diabetic macular edema
    • Beck RW, Edwards AR, Aiello LP et al. Three-year follow-up of a randomized trial comparing focal/grid photocoagulation and intravitreal triamcinolone for diabetic macular edema. Arch. Ophthalmol. 127(3), 245-251 (2009).
    • (2009) Arch. Ophthalmol. , vol.127 , Issue.3 , pp. 245-251
    • Beck, R.W.1    Edwards, A.R.2    Aiello, L.P.3
  • 40
    • 50249149459 scopus 로고    scopus 로고
    • A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema
    • Diabetic Retinopathy Clinical Research Network
    • Diabetic Retinopathy Clinical Research Network. A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema. Ophthalmology 115(9), 1447-1449 (2008).
    • (2008) Ophthalmology , vol.115 , Issue.9 , pp. 1447-1449
  • 41
    • 0041358796 scopus 로고    scopus 로고
    • Diabetic retinopathy and diabetic macular edema: Pathophysiology, screening, and novel therapies
    • Ciulla TA, Amador AG, Zinman B. Diabetic retinopathy and diabetic macular edema: pathophysiology, screening, and novel therapies. Diabetes Care 26(9), 2653-2664 (2003).
    • (2003) Diabetes Care , vol.26 , Issue.9 , pp. 2653-2664
    • Ciulla, T.A.1    Amador, A.G.2    Zinman, B.3
  • 42
    • 13344293711 scopus 로고    scopus 로고
    • Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor
    • Ishii H, Jirousek MR, Koya D et al. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 272(5262), 728-731 (1996).
    • (1996) Science , vol.272 , Issue.5262 , pp. 728-731
    • Ishii, H.1    Jirousek, M.R.2    Koya, D.3
  • 43
    • 33644842187 scopus 로고    scopus 로고
    • Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients
    • Aiello LP, Clermont A, Arora V, Davis MD, Sheetz MJ, Bursell SE. Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients. Invest. Ophthalmol. Vis. Sci. 47(1), 86-92 (2006).
    • (2006) Invest. Ophthalmol. Vis. Sci. , vol.47 , Issue.1 , pp. 86-92
    • Aiello, L.P.1    Clermont, A.2    Arora, V.3    Davis, M.D.4    Sheetz, M.J.5    Bursell, S.E.6
  • 44
    • 9444269815 scopus 로고    scopus 로고
    • Pharmacotherapy for diabetic retinopathy
    • Comer GM, Ciulla TA. Pharmacotherapy for diabetic retinopathy. Curr. Opin. Ophthalmol. 15(6), 508-518 (2004).
    • (2004) Curr. Opin. Ophthalmol. , vol.15 , Issue.6 , pp. 508-518
    • Comer, G.M.1    Ciulla, T.A.2
  • 45
    • 79958295090 scopus 로고    scopus 로고
    • Effect of ruboxistaurin (RBX) on visual acuity decline over a 6 year period with cessation and reinstitution of therapy: Results of an open-label extension of the Protein Kinase C Diabetic Retinopathy Study 2 (PKC-DRS2)
    • Sheetz MJ, Aiello LP, Shahri N, Davis MD, Kles KA, Danis RP. Effect of ruboxistaurin (RBX) On visual acuity decline over a 6 year period with cessation and reinstitution of therapy: results of an open-label extension of the Protein Kinase C Diabetic Retinopathy Study 2 (PKC-DRS2). Retina 31(6), 1053-1059 (2011).
    • (2011) Retina , vol.31 , Issue.6 , pp. 1053-1059
    • Sheetz, M.J.1    Aiello, L.P.2    Shahri, N.3    Davis, M.D.4    Kles, K.A.5    Danis, R.P.6
  • 46
    • 80055100383 scopus 로고    scopus 로고
    • Oral protein kinase C beta inhibition using ruboxistaurin: Efficacy, safety, and causes of vision loss among 813 patients (1392 eyes) with diabetic retinopathy in the protein kinase C beta inhibitor-diabetic retinopathy study and the protein kinase c beta inhibitor-diabetic retinopathy study 2
    • Aiello LP, Vignati L, Sheetz MJ et al. Oral protein kinase C beta inhibition using ruboxistaurin: efficacy, safety, and causes of vision loss among 813 patients (1392 eyes) with diabetic retinopathy in the protein kinase C beta inhibitor-diabetic retinopathy study and the protein kinase c beta inhibitor-diabetic retinopathy study 2. Retina 31(10), 2084-2094 (2011).
    • (2011) Retina , vol.31 , Issue.10 , pp. 2084-2094
    • Aiello, L.P.1    Vignati, L.2    Sheetz, M.J.3
  • 47
    • 1542742166 scopus 로고    scopus 로고
    • Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412
    • Campochiaro PA. Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412. Invest. Ophthalmol. Vis. Sci. 45(3), 922-931 (2004).
    • (2004) Invest. Ophthalmol. Vis. Sci. , vol.45 , Issue.3 , pp. 922-931
    • Campochiaro, P.A.1
  • 48
    • 29244438157 scopus 로고    scopus 로고
    • Progressive changes in diabetics and their management
    • Aylward GW. Progressive changes in diabetics and their management. Eye (Lond.) 19(10), 1115-1118 (2005).
    • (2005) Eye (Lond.) , vol.19 , Issue.10 , pp. 1115-1118
    • Aylward, G.W.1
  • 49
    • 1942502810 scopus 로고    scopus 로고
    • Regulation of tight junctions and loss of barrier function in pathophysiology
    • Harhaj NS, Antonetti DA. Regulation of tight junctions and loss of barrier function in pathophysiology. Int. J. Biochem. Cell Biol. 36(7), 1206-1237 (2004).
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , Issue.7 , pp. 1206-1237
    • Harhaj, N.S.1    Antonetti, D.A.2
  • 50
    • 0022256975 scopus 로고
    • Early retinal microangiopathy: Prevention with aldose reductase inhibitors
    • Robison WG Jr, Kador PF, Kinoshita JH. Early retinal microangiopathy: prevention with aldose reductase inhibitors. Diabet. Med. 2(3), 196-199 (1985).
    • (1985) Diabet. Med. , vol.2 , Issue.3 , pp. 196-199
    • Robison Jr., W.G.1    Kador, P.F.2    Kinoshita, J.H.3
  • 51
    • 34247394257 scopus 로고    scopus 로고
    • Oxidative stress and diabetic retinopathy
    • Kowluru RA, Chan PS. Oxidative stress and diabetic retinopathy. Exp. Diabetes Res. 2007, 43603 (2007).
    • (2007) Exp. Diabetes Res. , vol.2007 , pp. 43603
    • Kowluru, R.A.1    Chan, P.S.2
  • 52
    • 0034773628 scopus 로고    scopus 로고
    • Molecular aspects of lipoic acid in the prevention of diabetes complications
    • Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 17(10), 888-895 (2001).
    • (2001) Nutrition , vol.17 , Issue.10 , pp. 888-895
    • Packer, L.1    Kraemer, K.2    Rimbach, G.3
  • 53
    • 28844466951 scopus 로고    scopus 로고
    • Diabetic retinopathy: Mitochondrial dysfunction and retinal capillary cell death
    • Kowluru RA. Diabetic retinopathy: mitochondrial dysfunction and retinal capillary cell death. Antioxid. Redox Signal 7(11-12), 1581-1587 (2005).
    • (2005) Antioxid. Redox Signal , vol.7 , Issue.11-12 , pp. 1581-1587
    • Kowluru, R.A.1
  • 54
    • 33646413409 scopus 로고    scopus 로고
    • Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy
    • Lin J, Bierhaus A, Bugert P et al. Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy. Diabetologia 49(5), 1089-1096 (2006).
    • (2006) Diabetologia , vol.49 , Issue.5 , pp. 1089-1096
    • Lin, J.1    Bierhaus, A.2    Bugert, P.3
  • 55
    • 9444224415 scopus 로고    scopus 로고
    • Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats
    • Kowluru RA, Odenbach S. Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Diabetes 53(12), 3233-3238 (2004).
    • (2004) Diabetes , vol.53 , Issue.12 , pp. 3233-3238
    • Kowluru, R.A.1    Odenbach, S.2
  • 56
    • 0037438946 scopus 로고    scopus 로고
    • Early oxidative stress in the diabetic kidney: Effect of dl-alpha-lipoic acid
    • Obrosova IG, Fathallah L, Liu E, Nourooz-Zadeh J. Early oxidative stress in the diabetic kidney: effect of dl-alpha-lipoic acid. Free Radic. Biol. Med. 34(2), 186-195 (2003).
    • (2003) Free Radic. Biol. Med. , vol.34 , Issue.2 , pp. 186-195
    • Obrosova, I.G.1    Fathallah, L.2    Liu, E.3    Nourooz-Zadeh, J.4
  • 57
    • 0033397275 scopus 로고    scopus 로고
    • Calcium dobesilate: Pharmacological profile related to its use in diabetic retinopathy
    • Berthet P, Farine JC, Barras JP. Calcium dobesilate: pharmacological profile related to its use in diabetic retinopathy. Int. J. Clin. Pract. 53(8), 631-636 (1999).
    • (1999) Int. J. Clin. Pract. , vol.53 , Issue.8 , pp. 631-636
    • Berthet, P.1    Farine, J.C.2    Barras, J.P.3
  • 58
    • 0032168570 scopus 로고    scopus 로고
    • Calcium dobesilate: Pharmacology and future approaches
    • Tejerina T, Ruiz E. Calcium dobesilate: pharmacology and future approaches. Gen. Pharmacol. 31(3), 357-360 (1998).
    • (1998) Gen. Pharmacol. , vol.31 , Issue.3 , pp. 357-360
    • Tejerina, T.1    Ruiz, E.2
  • 59
    • 33751545952 scopus 로고    scopus 로고
    • Effect of calcium dobesilate on progression of early diabetic retinopathy: A randomised double-blind study
    • Ribeiro ML, Seres AI, Carneiro AM et al. Effect of calcium dobesilate on progression of early diabetic retinopathy: a randomised double-blind study. Graefes Arch. Clin. Exp. Ophthalmol. 244(12), 1591-1600 (2006).
    • (2006) Graefes Arch. Clin. Exp. Ophthalmol. , vol.244 , Issue.12 , pp. 1591-1600
    • Ribeiro, M.L.1    Seres, A.I.2    Carneiro, A.M.3
  • 60
    • 0042343848 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization
    • Nambu H, Nambu R, Melia M, Campochiaro PA. Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 44(8), 3650-3655 (2003).
    • (2003) Invest. Ophthalmol. Vis. Sci. , vol.44 , Issue.8 , pp. 3650-3655
    • Nambu, H.1    Nambu, R.2    Melia, M.3    Campochiaro, P.A.4
  • 61
    • 0035064594 scopus 로고    scopus 로고
    • Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo
    • Galbraith SM, Chaplin DJ, Lee F et al. Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo. Anticancer Res. 21(1A), 93-102 (2001).
    • (2001) Anticancer Res , vol.21 , Issue.1 A , pp. 93-102
    • Galbraith, S.M.1    Chaplin, D.J.2    Lee, F.3
  • 62
    • 0030951899 scopus 로고    scopus 로고
    • Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
    • Dark GG, Hill SA, Prise VE, Tozer GM, Pettit GR, Chaplin DJ. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Cancer Res. 57(10), 1829-1834 (1997).
    • (1997) Cancer Res , vol.57 , Issue.10 , pp. 1829-1834
    • Dark, G.G.1    Hill, S.A.2    Prise, V.E.3    Tozer, G.M.4    Pettit, G.R.5    Chaplin, D.J.6
  • 63
    • 68749089715 scopus 로고    scopus 로고
    • Anti-angiogenic and vascular disrupting effects of C9, a new microtubule-depolymerizing agent
    • Ren X, Dai M, Lin LP, Li PK, Ding J. Anti-angiogenic and vascular disrupting effects of C9, a new microtubule-depolymerizing agent. Br. J. Pharmacol. 156(8), 1228-1238 (2009).
    • (2009) Br. J. Pharmacol. , vol.156 , Issue.8 , pp. 1228-1238
    • Ren, X.1    Dai, M.2    Lin, L.P.3    Li, P.K.4    Ding, J.5
  • 64
    • 79956005855 scopus 로고    scopus 로고
    • Selective blockade of cytoskeletal actin remodeling reduces experimental choroidal neovascularization
    • Caballero S, Yang R, Grant MB, Chaqour B. Selective blockade of cytoskeletal actin remodeling reduces experimental choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 52(5), 2490-2496 (2011).
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , Issue.5 , pp. 2490-2496
    • Caballero, S.1    Yang, R.2    Grant, M.B.3    Chaqour, B.4
  • 65
    • 64249090496 scopus 로고    scopus 로고
    • Inhibition of angiogenesis in vitro: A central role for beta-actin dependent cytoskeletal remodeling
    • Durham JT, Herman IM. Inhibition of angiogenesis in vitro: a central role for beta-actin dependent cytoskeletal remodeling. Microvasc. Res. 77(3), 281-288 (2009).
    • (2009) Microvasc. Res. , vol.77 , Issue.3 , pp. 281-288
    • Durham, J.T.1    Herman, I.M.2
  • 66
    • 33745249512 scopus 로고    scopus 로고
    • Microtubule-targeting agents in angiogenesis: Where do we stand?
    • Pasquier E, Honore S, Braguer D. Microtubule-targeting agents in angiogenesis: where do we stand? Drug Resist. Updat. 9(1-2), 74-86 (2006).
    • (2006) Drug Resist. Updat. , vol.9 , Issue.1-2 , pp. 74-86
    • Pasquier, E.1    Honore, S.2    Braguer, D.3
  • 67
    • 80052188022 scopus 로고    scopus 로고
    • Cardiovascular toxicity profiles of vascular-disrupting agents
    • Subbiah IM, Lenihan DJ, Tsimberidou AM. Cardiovascular toxicity profiles of vascular-disrupting agents. Oncologist 16(8), 1120-1130 (2011).
    • (2011) Oncologist , vol.16 , Issue.8 , pp. 1120-1130
    • Subbiah, I.M.1    Lenihan, D.J.2    Tsimberidou, A.M.3
  • 68
    • 0021957738 scopus 로고
    • Platelet-derived growth factor is chemotactic for human retinal pigment epithelial cells
    • Campochiaro PA, Glaser BM. Platelet-derived growth factor is chemotactic for human retinal pigment epithelial cells. Arch. Ophthalmol. 103(4), 576-579 (1985).
    • (1985) Arch. Ophthalmol. , vol.103 , Issue.4 , pp. 576-579
    • Campochiaro, P.A.1    Glaser, B.M.2
  • 69
    • 0034491076 scopus 로고    scopus 로고
    • Photoreceptor-specific expression of platelet-derived growth factor-B results in traction retinal detachment
    • Seo MS, Okamoto N, Vinores MA et al. Photoreceptor-specific expression of platelet-derived growth factor-B results in traction retinal detachment. Am. J. Pathol. 157(3), 995-1005 (2000).
    • (2000) Am. J. Pathol. , vol.157 , Issue.3 , pp. 995-1005
    • Seo, M.S.1    Okamoto, N.2    Vinores, M.A.3
  • 70
    • 33947308655 scopus 로고    scopus 로고
    • Combination therapy for the treatment of ocular neovascularization
    • Bradley J, Ju M, Robinson GS. Combination therapy for the treatment of ocular neovascularization. Angiogenesis 10(2), 141-148 (2007).
    • (2007) Angiogenesis , vol.10 , Issue.2 , pp. 141-148
    • Bradley, J.1    Ju, M.2    Robinson, G.S.3
  • 71
    • 33744728068 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization
    • Jo N, Mailhos C, Ju M et al. Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. Am. J. Pathol. 168(6), 2036-2053 (2006).
    • (2006) Am. J. Pathol. , vol.168 , Issue.6 , pp. 2036-2053
    • Jo, N.1    Mailhos, C.2    Ju, M.3
  • 72
    • 0033882794 scopus 로고    scopus 로고
    • Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization
    • Ozaki H, Seo MS, Ozaki K et al. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am. J. Pathol. 156(2), 697-707 (2000).
    • (2000) Am. J. Pathol. , vol.156 , Issue.2 , pp. 697-707
    • Ozaki, H.1    Seo, M.S.2    Ozaki, K.3
  • 74
    • 0000379427 scopus 로고    scopus 로고
    • Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor
    • Seo MS, Kwak N, Ozaki H et al. Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor. Am. J. Pathol. 154(6), 1743-1753 (1999).
    • (1999) Am. J. Pathol. , vol.154 , Issue.6 , pp. 1743-1753
    • Seo, M.S.1    Kwak, N.2    Ozaki, H.3
  • 75
    • 80051756405 scopus 로고    scopus 로고
    • Ophthalmic lesions in neonatal foals evaluated for nonophthalmic disease at referral hospitals
    • Labelle AL, Hamor RE, Townsend WM et al. Ophthalmic lesions in neonatal foals evaluated for nonophthalmic disease at referral hospitals. J. Am. Vet. Med. Assoc. 239(4), 486-492 (2011).
    • (2011) J. Am. Vet. Med. Assoc. , vol.239 , Issue.4 , pp. 486-492
    • Labelle, A.L.1    Hamor, R.E.2    Townsend, W.M.3
  • 76
    • 77953530014 scopus 로고    scopus 로고
    • The ophthotech anti-PDGF in AMD study group. Combined inhibition of platelet derived (PDGF) and vascular endothelial (VEGF) growth factors for the treatment of neovascular age-related macular degeneration (NV-AMD) - Results of a Phase i study
    • e-Abstract 1260
    • Boyer DS. The ophthotech anti-PDGF in AMD study group. Combined inhibition of platelet derived (PDGF) and vascular endothelial (VEGF) growth factors for the treatment of neovascular age-related macular degeneration (NV-AMD) - results of a Phase I study. Invest. Ophthalmol. Vis. Sci. 50, e-Abstract 1260 (2009).
    • (2009) Invest. Ophthalmol. Vis. Sci. , vol.50
    • Boyer, D.S.1
  • 77
    • 0032758384 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor
    • Smith LE, Shen W, Perruzzi C et al. Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Nat. Med. 5(12), 1390-1395 (1999).
    • (1999) Nat. Med. , vol.5 , Issue.12 , pp. 1390-1395
    • Smith, L.E.1    Shen, W.2    Perruzzi, C.3
  • 78
    • 0030863133 scopus 로고    scopus 로고
    • Essential role of growth hormone in ischemia-induced retinal neovascularization
    • Smith LE, Kopchick JJ, Chen W et al. Essential role of growth hormone in ischemia-induced retinal neovascularization. Science 276(5319), 1706-1709 (1997).
    • (1997) Science , vol.276 , Issue.5319 , pp. 1706-1709
    • Smith, L.E.1    Kopchick, J.J.2    Chen, W.3
  • 79
    • 11144354304 scopus 로고    scopus 로고
    • Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease
    • Ruberte J, Ayuso E, Navarro M et al. Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease. J. Clin. Invest. 113(8), 1149-1157 (2004).
    • (2004) J. Clin. Invest. , vol.113 , Issue.8 , pp. 1149-1157
    • Ruberte, J.1    Ayuso, E.2    Navarro, M.3
  • 80
    • 2342526664 scopus 로고    scopus 로고
    • Angiopoietin-2 enhances retinal vessel sensitivity to vascular endothelial growth factor
    • Oshima Y, Deering T, Oshima S et al. Angiopoietin-2 enhances retinal vessel sensitivity to vascular endothelial growth factor. J. Cell Physiol. 199(3), 412-417 (2004).
    • (2004) J. Cell Physiol. , vol.199 , Issue.3 , pp. 412-417
    • Oshima, Y.1    Deering, T.2    Oshima, S.3
  • 81
    • 79960559106 scopus 로고    scopus 로고
    • GSK-3beta/CREB axis mediates IGF-1-induced ECM/adhesion molecule expression, cell cycle progression and monolayer permeability in retinal capillary endothelial cells: Implications for diabetic retinopathy
    • Devi TS, Singh LP, Hosoya K, Terasaki T. GSK-3beta/CREB axis mediates IGF-1-induced ECM/adhesion molecule expression, cell cycle progression and monolayer permeability in retinal capillary endothelial cells: Implications for diabetic retinopathy. Biochim. Biophys. Acta 1812(9), 1080-1088 (2011).
    • (2011) Biochim. Biophys. Acta , vol.1812 , Issue.9 , pp. 1080-1088
    • Devi, T.S.1    Singh, L.P.2    Hosoya, K.3    Terasaki, T.4
  • 83
    • 0021359304 scopus 로고
    • Heparin affinity: Purification of a tumor-derived capillary endothelial cell growth factor
    • Shing Y, Folkman J, Sullivan R, Butterfield C, Murray J, Klagsbrun M. Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science 223(4642), 1296-1299 (1984).
    • (1984) Science , vol.223 , Issue.4642 , pp. 1296-1299
    • Shing, Y.1    Folkman, J.2    Sullivan, R.3    Butterfield, C.4    Murray, J.5    Klagsbrun, M.6
  • 84
    • 0024077722 scopus 로고
    • Autocrine activities of basic fibroblast growth factor: Regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis
    • Sato Y, Rifkin DB. Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. J. Cell Biol. 107(3), 1199-1205 (1988).
    • (1988) J. Cell Biol. , vol.107 , Issue.3 , pp. 1199-1205
    • Sato, Y.1    Rifkin, D.B.2
  • 86
    • 0342312351 scopus 로고
    • Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration
    • Moscatelli D, Presta M, Rifkin DB. Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration. Proc. Natl Acad. Sci. USA 83(7), 2091-2095 (1986).
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , Issue.7 , pp. 2091-2095
    • Moscatelli, D.1    Presta, M.2    Rifkin, D.B.3
  • 87
    • 0034849484 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 decreases hyperoxia-induced photoreceptor cell death in mice
    • Yamada H, Yamada E, Ando A et al. Fibroblast growth factor-2 decreases hyperoxia-induced photoreceptor cell death in mice. Am. J. Pathol. 159(3), 1113-1120 (2001).
    • (2001) Am. J. Pathol. , vol.159 , Issue.3 , pp. 1113-1120
    • Yamada, H.1    Yamada, E.2    Ando, A.3
  • 88
    • 0031659904 scopus 로고    scopus 로고
    • Basic fibroblast growth factor is neither necessary nor sufficient for the development of retinal neovascularization
    • Ozaki H, Okamoto N, Ortega S et al. Basic fibroblast growth factor is neither necessary nor sufficient for the development of retinal neovascularization. Am. J. Pathol. 153(3), 757-765 (1998).
    • (1998) Am. J. Pathol. , vol.153 , Issue.3 , pp. 757-765
    • Ozaki, H.1    Okamoto, N.2    Ortega, S.3
  • 89
    • 0033838367 scopus 로고    scopus 로고
    • Cell injury unmasks a latent proangiogenic phenotype in mice with increased expression of FGF2 in the retina
    • Yamada H, Yamada E, Kwak N et al. Cell injury unmasks a latent proangiogenic phenotype in mice with increased expression of FGF2 in the retina. J. Cell. Physiol. 185(1), 135-142 (2000).
    • (2000) J. Cell. Physiol. , vol.185 , Issue.1 , pp. 135-142
    • Yamada, H.1    Yamada, E.2    Kwak, N.3
  • 90
    • 0030463146 scopus 로고    scopus 로고
    • Integrin-dependent induction of early growth response genes in capillary endothelial cells
    • Dike LE, Ingber DE. Integrin-dependent induction of early growth response genes in capillary endothelial cells. J. Cell Sci. 109 (Pt 12), 2855-2863 (1996).
    • (1996) J. Cell Sci. , vol.109 , Issue.PART 12 , pp. 2855-2863
    • Dike, L.E.1    Ingber, D.E.2
  • 91
    • 33745137492 scopus 로고    scopus 로고
    • Suppression and regression of choroidal neovascularization by systemic administration of an alpha5beta1 integrin antagonist
    • Umeda N, Kachi S, Akiyama H et al. Suppression and regression of choroidal neovascularization by systemic administration of an alpha5beta1 integrin antagonist. Mol. Pharmacol. 69(6), 1820-1828 (2006).
    • (2006) Mol. Pharmacol. , vol.69 , Issue.6 , pp. 1820-1828
    • Umeda, N.1    Kachi, S.2    Akiyama, H.3
  • 92
    • 0042328366 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 is deposited in the extracellular matrix by endothelial cells and is a ligand for the alpha 5 beta 1 integrin
    • Orecchia A, Lacal PM, Schietroma C, Morea V, Zambruno G, Failla CM. Vascular endothelial growth factor receptor-1 is deposited in the extracellular matrix by endothelial cells and is a ligand for the alpha 5 beta 1 integrin. J. Cell Sci. 116(Pt 17), 3479-3489 (2003).
    • (2003) J. Cell Sci. , vol.116 , Issue.PART 17 , pp. 3479-3489
    • Orecchia, A.1    Lacal, P.M.2    Schietroma, C.3    Morea, V.4    Zambruno, G.5    Failla, C.M.6
  • 93
    • 0029859140 scopus 로고    scopus 로고
    • Antagonists of integrin alpha v beta 3 inhibit retinal neovascularization in a murine model
    • Luna J, Tobe T, Mousa SA, Reilly TM, Campochiaro PA. Antagonists of integrin alpha v beta 3 inhibit retinal neovascularization in a murine model. Lab. Invest. 75(4), 563-573 (1996).
    • (1996) Lab. Invest. , vol.75 , Issue.4 , pp. 563-573
    • Luna, J.1    Tobe, T.2    Mousa, S.A.3    Reilly, T.M.4    Campochiaro, P.A.5
  • 94
    • 70350731216 scopus 로고    scopus 로고
    • Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization
    • Zahn G, Vossmeyer D, Stragies R et al. Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization. Arch. Ophthalmol. 127(10), 1329-1335 (2009).
    • (2009) Arch. Ophthalmol. , vol.127 , Issue.10 , pp. 1329-1335
    • Zahn, G.1    Vossmeyer, D.2    Stragies, R.3
  • 95
    • 82555189403 scopus 로고    scopus 로고
    • Beta1-integrin: A potential therapeutic target in the battle against cancer recurrence
    • Barkan D, Chambers AF. beta1-integrin: a potential therapeutic target in the battle against cancer recurrence. Clin. Cancer Res. 17(23), 7219-7223 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.23 , pp. 7219-7223
    • Barkan, D.1    Chambers, A.F.2
  • 96
    • 0027751890 scopus 로고
    • The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
    • Park JE, Keller GA, Ferrara N. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell 4(12), 1317-1326 (1993).
    • (1993) Mol. Biol. Cell , vol.4 , Issue.12 , pp. 1317-1326
    • Park, J.E.1    Keller, G.A.2    Ferrara, N.3
  • 97
    • 0025013701 scopus 로고
    • Extracellular matrix-resident growth factors and enzymes: Possible involvement in tumor metastasis and angiogenesis
    • Vlodavsky I, Korner G, Ishai-Michaeli R, Bashkin P, Bar-Shavit R, Fuks Z. Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. Cancer Metastasis Rev. 9(3), 203-226 (1990).
    • (1990) Cancer Metastasis Rev , vol.9 , Issue.3 , pp. 203-226
    • Vlodavsky, I.1    Korner, G.2    Ishai-Michaeli, R.3    Bashkin, P.4    Bar-Shavit, R.5    Fuks, Z.6
  • 98
    • 0005911475 scopus 로고
    • Endothelial cell-derived basic fibroblast growth factor: Synthesis and deposition into subendothelial extracellular matrix
    • Vlodavsky I, Folkman J, Sullivan R et al. Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix. Proc. Natl Acad. Sci. USA 84(8), 2292-2296 (1987).
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , Issue.8 , pp. 2292-2296
    • Vlodavsky, I.1    Folkman, J.2    Sullivan, R.3
  • 99
    • 0033599308 scopus 로고    scopus 로고
    • Antiangiogenic activity of restin, NC10 domain of human collagen XV. comparison to endostatin
    • Ramchandran R, Dhanabal M, Volk R et al. Antiangiogenic activity of restin, NC10 domain of human collagen XV. comparison to endostatin. Biochem. Biophys. Res. Commun. 255(3), 735-739 (1999).
    • (1999) Biochem. Biophys. Res. Commun. , vol.255 , Issue.3 , pp. 735-739
    • Ramchandran, R.1    Dhanabal, M.2    Volk, R.3
  • 100
    • 0031454617 scopus 로고    scopus 로고
    • O'reilly MS, Boehm T, Shing Y, et al
    • O'reilly MS, Boehm T, Shing Y et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88(2), 277-285 (1997).
    • (1997) Cell , vol.88 , Issue.2 , pp. 277-285
  • 101
    • 0033979905 scopus 로고    scopus 로고
    • Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth
    • Kamphaus GD, Colorado PC, Panka DJ et al. Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth. J. Biol. Chem. 275(2), 1209-1215 (2000).
    • (2000) J. Biol. Chem. , vol.275 , Issue.2 , pp. 1209-1215
    • Kamphaus, G.D.1    Colorado, P.C.2    Panka, D.J.3
  • 102
    • 0034194237 scopus 로고    scopus 로고
    • Anti-angiogenic cues from vascular basement membrane collagen
    • Colorado PC, Torre A, Kamphaus G et al. Anti-angiogenic cues from vascular basement membrane collagen. Cancer Res. 60(9), 2520-2526 (2000).
    • (2000) Cancer Res , vol.60 , Issue.9 , pp. 2520-2526
    • Colorado, P.C.1    Torre, A.2    Kamphaus, G.3
  • 103
    • 0036798747 scopus 로고    scopus 로고
    • Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents
    • Auricchio A, Behling KC, Maguire AM et al. Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents. Mol. Ther. 6(4), 490-494 (2002).
    • (2002) Mol. Ther. , vol.6 , Issue.4 , pp. 490-494
    • Auricchio, A.1    Behling, K.C.2    Maguire, A.M.3
  • 104
    • 0036297886 scopus 로고    scopus 로고
    • Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor
    • Mori K, Gehlbach P, Ando A, Mcvey D, Wei L, Campochiaro PA. Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor. Invest. Ophthalmol. Vis. Sci. 43(7), 2428-2434 (2002).
    • (2002) Invest. Ophthalmol. Vis. Sci. , vol.43 , Issue.7 , pp. 2428-2434
    • Mori, K.1    Gehlbach, P.2    Ando, A.3    McVey, D.4    Wei, L.5    Campochiaro, P.A.6
  • 105
    • 0036271989 scopus 로고    scopus 로고
    • AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization
    • Mori K, Gehlbach P, Yamamoto S et al. AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 43(6), 1994-2000 (2002).
    • (2002) Invest. Ophthalmol. Vis. Sci. , vol.43 , Issue.6 , pp. 1994-2000
    • Mori, K.1    Gehlbach, P.2    Yamamoto, S.3
  • 106
    • 0034945843 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization
    • Mori K, Duh E, Gehlbach P et al. Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization. J. Cell. Physiol. 188(2), 253-263 (2001).
    • (2001) J. Cell. Physiol. , vol.188 , Issue.2 , pp. 253-263
    • Mori, K.1    Duh, E.2    Gehlbach, P.3
  • 107
    • 0034857729 scopus 로고    scopus 로고
    • Suppression of choroidal neovascularization by adeno-associated virus vector expressing angiostatin
    • Lai CC, Wu WC, Chen SL et al. Suppression of choroidal neovascularization by adeno-associated virus vector expressing angiostatin. Invest. Ophthalmol. Vis. Sci. 42(10), 2401-2407 (2001).
    • (2001) Invest. Ophthalmol. Vis. Sci. , vol.42 , Issue.10 , pp. 2401-2407
    • Lai, C.C.1    Wu, W.C.2    Chen, S.L.3
  • 108
    • 9644262535 scopus 로고    scopus 로고
    • Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis
    • Watanabe K, Hasegawa Y, Yamashita H et al. Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis. J. Clin. Invest. 114(7), 898-907 (2004).
    • (2004) J. Clin. Invest. , vol.114 , Issue.7 , pp. 898-907
    • Watanabe, K.1    Hasegawa, Y.2    Yamashita, H.3
  • 109
    • 84863065957 scopus 로고    scopus 로고
    • Heat treatment of retinal pigment epithelium induces production of elastic lamina components and antiangiogenic activity
    • Sekiyama E, Saint-Geniez M, Yoneda K et al. Heat treatment of retinal pigment epithelium induces production of elastic lamina components and antiangiogenic activity. FASEB J. 26(2), 567-575 (2012).
    • (2012) FASEB J , vol.26 , Issue.2 , pp. 567-575
    • Sekiyama, E.1    Saint-Geniez, M.2    Yoneda, K.3
  • 110
    • 29744436459 scopus 로고    scopus 로고
    • Impaired expression of thrombospondin-1 in eyes with age related macular degeneration
    • Uno K, Bhutto IA, Mcleod DS, Merges C, Lutty GA. Impaired expression of thrombospondin-1 in eyes with age related macular degeneration. Br. J. Ophthalmol. 90(1), 48-54 (2006).
    • (2006) Br. J. Ophthalmol. , vol.90 , Issue.1 , pp. 48-54
    • Uno, K.1    Bhutto, I.A.2    McLeod, D.S.3    Merges, C.4    Lutty, G.A.5
  • 111
    • 32944481724 scopus 로고    scopus 로고
    • Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: Results of a Phase i clinical trial
    • Campochiaro PA, Nguyen QD, Shah SM et al. Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a Phase I clinical trial. Hum. Gene Ther. 17(2), 167-176 (2006).
    • (2006) Hum. Gene Ther. , vol.17 , Issue.2 , pp. 167-176
    • Campochiaro, P.A.1    Nguyen, Q.D.2    Shah, S.M.3
  • 112
    • 33646235632 scopus 로고    scopus 로고
    • Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization
    • Shen J, Yang X, Xiao WH, Hackett SF, Sato Y, Campochiaro PA. Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization. FASEB J. 20(6), 723-725 (2006).
    • (2006) FASEB J , vol.20 , Issue.6 , pp. 723-725
    • Shen, J.1    Yang, X.2    Xiao, W.H.3    Hackett, S.F.4    Sato, Y.5    Campochiaro, P.A.6
  • 113
    • 67649969173 scopus 로고    scopus 로고
    • Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis
    • Hosaka T, Kimura H, Heishi T et al. Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis. Am. J. Pathol. 175(1), 430-439 (2009).
    • (2009) Am. J. Pathol. , vol.175 , Issue.1 , pp. 430-439
    • Hosaka, T.1    Kimura, H.2    Heishi, T.3
  • 114
    • 65549132326 scopus 로고    scopus 로고
    • Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis
    • Kimura H, Miyashita H, Suzuki Y et al. Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis. Blood 113(19), 4810-4818 (2009).
    • (2009) Blood , vol.113 , Issue.19 , pp. 4810-4818
    • Kimura, H.1    Miyashita, H.2    Suzuki, Y.3
  • 115
    • 33646835553 scopus 로고    scopus 로고
    • Vasohibin prevents arterial neointimal formation through angiogenesis inhibition
    • Yamashita H, Abe M, Watanabe K et al. Vasohibin prevents arterial neointimal formation through angiogenesis inhibition. Biochem. Biophys. Res. Commun 345(3), 919-925 (2006).
    • (2006) Biochem. Biophys. Res. Commun , vol.345 , Issue.3 , pp. 919-925
    • Yamashita, H.1    Abe, M.2    Watanabe, K.3
  • 116
    • 0037248088 scopus 로고    scopus 로고
    • Periocular gene transfer of sFlt-1 suppresses ocular neovascularization and vascular endothelial growth factor-induced breakdown of the blood-retinal barrier
    • Gehlbach P, Demetriades AM, Yamamoto S et al. Periocular gene transfer of sFlt-1 suppresses ocular neovascularization and vascular endothelial growth factor-induced breakdown of the blood-retinal barrier. Hum. Gene Ther. 14(2), 129-141 (2003).
    • (2003) Hum. Gene Ther. , vol.14 , Issue.2 , pp. 129-141
    • Gehlbach, P.1    Demetriades, A.M.2    Yamamoto, S.3
  • 117
    • 0034919401 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization
    • Lai CM, Brankov M, Zaknich T et al. Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization. Hum. Gene Ther. 12(10), 1299-1310 (2001).
    • (2001) Hum. Gene Ther. , vol.12 , Issue.10 , pp. 1299-1310
    • Lai, C.M.1    Brankov, M.2    Zaknich, T.3
  • 118
    • 0034125023 scopus 로고    scopus 로고
    • Experimental subretinal neovascularization is inhibited by adenovirus-mediated soluble VEGF/flt-1 receptor gene transfection: A role of VEGF and possible treatment for SRN in age-related macular degeneration
    • Honda M, Sakamoto T, Ishibashi T, Inomata H, Ueno H. Experimental subretinal neovascularization is inhibited by adenovirus-mediated soluble VEGF/flt-1 receptor gene transfection: a role of VEGF and possible treatment for SRN in age-related macular degeneration. Gene Ther. 7(11), 978-985 (2000).
    • (2000) Gene Ther , vol.7 , Issue.11 , pp. 978-985
    • Honda, M.1    Sakamoto, T.2    Ishibashi, T.3    Inomata, H.4    Ueno, H.5
  • 119
    • 0034913943 scopus 로고    scopus 로고
    • Systemically expressed soluble Tie2 inhibits intraocular neovascularization
    • Hangai M, Moon YS, Kitaya N et al. Systemically expressed soluble Tie2 inhibits intraocular neovascularization. Hum. Gene Ther. 12(10), 1311-1321 (2001).
    • (2001) Hum. Gene Ther. , vol.12 , Issue.10 , pp. 1311-1321
    • Hangai, M.1    Moon, Y.S.2    Kitaya, N.3
  • 120
    • 0034529765 scopus 로고    scopus 로고
    • Inhibition of experimental choroidal neovascularization by overexpression of tissue inhibitor of metalloproteinases-3 in retinal pigment epithelium cells
    • Takahashi T, Nakamura T, Hayashi A et al. Inhibition of experimental choroidal neovascularization by overexpression of tissue inhibitor of metalloproteinases-3 in retinal pigment epithelium cells. Am. J. Ophthalmol. 130(6), 774-781 (2000).
    • (2000) Am. J. Ophthalmol. , vol.130 , Issue.6 , pp. 774-781
    • Takahashi, T.1    Nakamura, T.2    Hayashi, A.3
  • 121
    • 0038661164 scopus 로고    scopus 로고
    • Intraocular expression of endostatin reduces VEGF-induced retinal vascular permeability, neovascularization, and retinal detachment
    • Takahashi K, Saishin Y, Silva RL et al. Intraocular expression of endostatin reduces VEGF-induced retinal vascular permeability, neovascularization, and retinal detachment. FASEB J. 17(8), 896-898 (2003).
    • (2003) FASEB J , vol.17 , Issue.8 , pp. 896-898
    • Takahashi, K.1    Saishin, Y.2    Silva, R.L.3
  • 122
    • 0035404544 scopus 로고    scopus 로고
    • Inhibition of choroidal neovascularization by intravenous injection of adenoviral vectors expressing secretable endostatin
    • Mori K, Ando A, Gehlbach P et al. Inhibition of choroidal neovascularization by intravenous injection of adenoviral vectors expressing secretable endostatin. Am. J. Pathol. 159(1), 313-320 (2001).
    • (2001) Am. J. Pathol. , vol.159 , Issue.1 , pp. 313-320
    • Mori, K.1    Ando, A.2    Gehlbach, P.3
  • 123
    • 34648825492 scopus 로고    scopus 로고
    • Oxidative damage in the retinal mitochondria of diabetic mice: Possible protection by superoxide dismutase
    • Kanwar M, Chan PS, Kern TS, Kowluru RA. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest. Ophthalmol. Vis. Sci. 48(8), 3805-3811 (2007).
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , Issue.8 , pp. 3805-3811
    • Kanwar, M.1    Chan, P.S.2    Kern, T.S.3    Kowluru, R.A.4
  • 124
    • 0142221070 scopus 로고    scopus 로고
    • Diabetes-induced mitochondrial dysfunction in the retina
    • Kowluru RA, Abbas SN. Diabetes-induced mitochondrial dysfunction in the retina. Invest. Ophthalmol. Vis. Sci. 44(12), 5327-5334 (2003).
    • (2003) Invest. Ophthalmol. Vis. Sci. , vol.44 , Issue.12 , pp. 5327-5334
    • Kowluru, R.A.1    Abbas, S.N.2
  • 125
    • 77249096912 scopus 로고    scopus 로고
    • Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase
    • Madsen-Bouterse SA, Zhong Q, Mohammad G, Ho YS, Kowluru RA. Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase. Free Radic. Res. 44(3), 313-321 (2010).
    • (2010) Free Radic. Res. , vol.44 , Issue.3 , pp. 313-321
    • Madsen-Bouterse, S.A.1    Zhong, Q.2    Mohammad, G.3    Ho, Y.S.4    Kowluru, R.A.5
  • 126
    • 77956238386 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction
    • Mohammad G, Kowluru RA. Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction. Lab. Invest. 90(9), 1365-1372 (2010).
    • (2010) Lab. Invest. , vol.90 , Issue.9 , pp. 1365-1372
    • Mohammad, G.1    Kowluru, R.A.2
  • 127
    • 0036468992 scopus 로고    scopus 로고
    • Effects of the superoxide dismutase-mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats
    • Nassar T, Kadery B, Lotan C, Da'as N, Kleinman Y, Haj-Yehia A. Effects of the superoxide dismutase-mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 436(1-2), 111-118 (2002).
    • (2002) Eur. J. Pharmacol. , vol.436 , Issue.1-2 , pp. 111-118
    • Nassar, T.1    Kadery, B.2    Lotan, C.3    Da'As, N.4    Kleinman, Y.5    Haj-Yehia, A.6
  • 128
    • 0034846860 scopus 로고    scopus 로고
    • Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve
    • Coppey LJ, Gellett JS, Davidson EP et al. Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve. Br. J. Pharmacol. 134(1), 21-29 (2001).
    • (2001) Br. J. Pharmacol. , vol.134 , Issue.1 , pp. 21-29
    • Coppey, L.J.1    Gellett, J.S.2    Davidson, E.P.3
  • 129
    • 84855411960 scopus 로고    scopus 로고
    • Beyond AREDS. is there a place for antioxidant therapy in the prevention/treatment of eye disease?
    • Kowluru RA, Zhong Q. Beyond AREDS. is there a place for antioxidant therapy in the prevention/treatment of eye disease? Invest. Ophthalmol. Vis. Sci. 52(12), 8665-8671 (2011).
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , Issue.12 , pp. 8665-8671
    • Kowluru, R.A.1    Zhong, Q.2
  • 130
    • 6344293916 scopus 로고    scopus 로고
    • Peroxynitrite decomposition catalyst, FP15, and poly(ADP-ribose) polymerase inhibitor, PJ34, inhibit leukocyte entrapment in the retinal microcirculation of diabetic rats
    • Sugawara R, Hikichi T, Kitaya N et al. Peroxynitrite decomposition catalyst, FP15, and poly(ADP-ribose) polymerase inhibitor, PJ34, inhibit leukocyte entrapment in the retinal microcirculation of diabetic rats. Curr. Eye Res. 29(1), 11-16 (2004).
    • (2004) Curr. Eye Res. , vol.29 , Issue.1 , pp. 11-16
    • Sugawara, R.1    Hikichi, T.2    Kitaya, N.3
  • 131
    • 0035434119 scopus 로고    scopus 로고
    • Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy
    • Kowluru RA, Tang J, Kern TS. Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy. Diabetes 50(8), 1938-1942 (2001).
    • (2001) Diabetes , vol.50 , Issue.8 , pp. 1938-1942
    • Kowluru, R.A.1    Tang, J.2    Kern, T.S.3
  • 132
    • 7044229731 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB
    • Zheng L, Szabo C, Kern TS. Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB. Diabetes 53(11), 2960-2967 (2004).
    • (2004) Diabetes , vol.53 , Issue.11 , pp. 2960-2967
    • Zheng, L.1    Szabo, C.2    Kern, T.S.3
  • 133
    • 27244437637 scopus 로고    scopus 로고
    • Suppression and regression of choroidal neovascularization by polyamine analogues
    • Lima E Silva R, Saishin Y, Akiyama H et al. Suppression and regression of choroidal neovascularization by polyamine analogues. Invest. Ophthalmol. Vis. Sci. 46(9), 3323-3330 (2005).
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , Issue.9 , pp. 3323-3330
    • Lima Silva, E.R.1    Saishin, Y.2    Akiyama, H.3
  • 134
    • 33748705734 scopus 로고    scopus 로고
    • Trans-scleral delivery of polyamine analogs for ocular neovascularization
    • Lima E Silva R, Kachi S, Akiyama H et al. Trans-scleral delivery of polyamine analogs for ocular neovascularization. Exp. Eye Res. 83(5), 1260-1267 (2006).
    • (2006) Exp. Eye Res. , vol.83 , Issue.5 , pp. 1260-1267
    • Lima Silva, E.R.1    Kachi, S.2    Akiyama, H.3
  • 136
    • 84874753744 scopus 로고    scopus 로고
    • Hoffmann-La Roche Ltd.
    • Hoffmann-La Roche Ltd. www.roche.com/Investors/Ir-Update/ Inv-Update-2011-2006-29.Htm


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.