Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo

American Journal of Pathology

Volumn 160, Issue 2, 2002, Pages 501-509

  Joussen, Antonia M ^a,b,e   Poulaki, Vassiliki ^a,b   Qin, Wenying ^a,b   Kirchhof, Bernd ^e   Mitsiades, Nicholas ^c   Wiegand, Stanley J ^d   Rudge, John ^d   Yancopoulos, George D ^d   Adamis, Anthony P ^a,b  

^a MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d REGENERON PHARMACEUTICALS INC   (United States)

^e UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD11 ANTIGEN; CD18 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; VASCULOTROPIN;

ANIMAL TISSUE; ARTICLE; BLOOD RETINA BARRIER; BLOOD VESSEL PERMEABILITY; DIABETES MELLITUS; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; LEUKOCYTE ADHERENCE; LEUKOSTASIS; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; RETINA DISEASE; SUBRETINAL NEOVASCULARIZATION; VASCULAR ENDOTHELIUM;

EID: 0036174019     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64869-9     Document Type: Article

References (29)

1. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition
2. Leukocyte-mediated endothelial cell injury and death in the diabetic retina
3. Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes
4. Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy
5. Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid
6. Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate Ophthalmology
7. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice
8. VEGF increases retinal vascular ICAM-1 expression in vivo
9. Vascular endothelial growth factor-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1)
10. The relation between expression of vascular endothelial growth factor and breakdown of the blood retinal barrier in diabetic rat retinas
11. Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy
12. Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/nitric oxide pathway and modulates migration of brain microvascular endothelial cells
13. Nitric oxide synthase activity and expression in experimental diabetic neuropathy
14. Vascular endothelial growth factor is induced by longterm high glucose concentration and up-regulated by acute glucose deprivation in cultured bovine retinal pigmented epithelial cells
15. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium
16. Experimental subretinal neovascularization is inhibited by adenovirus-mediated soluble VEGF/flt-1 receptor gene transfection: A role of VEGF and possible treatment for SRN in age-related macular degeneration
17. Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis
18. Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy
19. Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid
20. Neutrophil-induced transmigration of tumour cells treated with tumour-conditioned medium is facilitated by granulocyte-macrophage colony-stimulating factor
21. Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
22. Intracellular pool of vascular endothelial growth factor in human neutrophils
23. Human mesangial cells and peripheral blood mononuclear cells produce vascular permeability factor
24. Expression of vascular endothelial growth factor by human eosinophils: Upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5
25. Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: A potential role for T cells in angiogenesis
26. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
27. Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: Correlation with blood-retinal barrier permeability
28. NO reduces PMN adhesion to human vascular endothelial cells due to downregulationof ICAM-1 mRNA and surface expression
29. Hemodynamic alterations in hepatic I/R, ICAM-1 mRNA, Wong PY NO modulates P-selectin