메뉴 건너뛰기




Volumn 5, Issue 1, 2009, Pages 33-38

Pegaptanib sodium for the treatment of proliferative diabetic retinopathy and diabetic macular edema

Author keywords

Diabetes mellitus; Diabetic macular edema; Pegaptanib sodium (Macugen); Proliferative diabetic retinopathy

Indexed keywords

ANGIOGENESIS INHIBITOR; PEGAPTANIB; VASCULOTROPIN; APTAMER; VASCULOTROPIN A;

EID: 65549120576     PISSN: 15733998     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339909787314158     Document Type: Review
Times cited : (11)

References (54)
  • 2
    • 11144356305 scopus 로고    scopus 로고
    • The prevalence of diabetic retinopathy among adults in the United States
    • For the eye diseases prevalence research group
    • Kempen JH, O'Colmain BJ, Leske MC, et al. For the eye diseases prevalence research group. The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol 2004; 122: 552-63.
    • (2004) Arch Ophthalmol , vol.122 , pp. 552-563
    • Kempen, J.H.1    O'Colmain, B.J.2    Leske, M.C.3
  • 3
    • 0041358796 scopus 로고    scopus 로고
    • Diabetic retinopathy and diabetic macular edema: Pathophysiology, screening, and novel therapies
    • Ciulla TA, Amador AG, Zinman B. Diabetic retinopathy and diabetic macular edema: pathophysiology, screening, and novel therapies. Diabetes Care 2003; 26: 2653-64.
    • (2003) Diabetes Care , vol.26 , pp. 2653-2664
    • Ciulla, T.A.1    Amador, A.G.2    Zinman, B.3
  • 4
    • 21444439235 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and diabetic retinopathy: Role of oxidative stress
    • Caldwell RB, Bartoli M, Behzadian MA, et al. Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress. Curr Drug Targets 2005; 6: 511-24.
    • (2005) Curr Drug Targets , vol.6 , pp. 511-524
    • Caldwell, R.B.1    Bartoli, M.2    Behzadian, M.A.3
  • 5
    • 21744446220 scopus 로고    scopus 로고
    • Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration
    • Ng EW, Adamis AP. Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration. Can J Ophthalmol 2005; 40: 352-68.
    • (2005) Can J Ophthalmol , vol.40 , pp. 352-368
    • Ng, E.W.1    Adamis, A.P.2
  • 6
    • 33750809382 scopus 로고
    • Retinal vascular patterns. IV. Diabetic retinopathy
    • Cogan D, Toussaint, D, Kuwabara T. Retinal vascular patterns. IV. Diabetic retinopathy. Arch Ophthalmol 1961; 66: 366-78.
    • (1961) Arch Ophthalmol , vol.66 , pp. 366-378
    • Cogan, D.1    Toussaint, D.2    Kuwabara, T.3
  • 7
    • 0017039089 scopus 로고
    • Clinicopathologic correlations in diabetic retinopathy. I. Histology and fluorescein angiography of microaneyrysms
    • DeVenecia G, Davis M, Engerman R. Clinicopathologic correlations in diabetic retinopathy. I. Histology and fluorescein angiography of microaneyrysms. Arch Ophthalmol 1976; 94: 1766-73.
    • (1976) Arch Ophthalmol , vol.94 , pp. 1766-1773
    • DeVenecia, G.1    Davis, M.2    Engerman, R.3
  • 8
    • 0021720327 scopus 로고
    • Intraretinal neovascularization in diabetic retinopathy
    • Muraoka K, Shimizu K. Intraretinal neovascularization in diabetic retinopathy. Ophthalmology 1984; 91: 1440-6.
    • (1984) Ophthalmology , vol.91 , pp. 1440-1446
    • Muraoka, K.1    Shimizu, K.2
  • 9
    • 0020416832 scopus 로고
    • Clinical and experimental studies on retinal neovascularization. XXXIX Edward Jackson Memorial Lecture
    • Patz A. Clinical and experimental studies on retinal neovascularization. XXXIX Edward Jackson Memorial Lecture. Am J Ophthalmol 1982; 94: 715-43.
    • (1982) Am J Ophthalmol , vol.94 , pp. 715-743
    • Patz, A.1
  • 10
    • 0346777254 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives
    • Caldwell RB, Bartoli M, Behzadian MA, et al. Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Diabetes Metab Res Rev 2003; 19: 442-55.
    • (2003) Diabetes Metab Res Rev , vol.19 , pp. 442-455
    • Caldwell, R.B.1    Bartoli, M.2    Behzadian, M.A.3
  • 11
    • 0031660311 scopus 로고    scopus 로고
    • In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats
    • Miyamoto K, Hiroshiba N, Tsujikawa A, et al. In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats. Invest Ophthalmol Vis Sci 1998; 39: 2190-4.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 2190-2194
    • Miyamoto, K.1    Hiroshiba, N.2    Tsujikawa, A.3
  • 12
    • 9444269815 scopus 로고    scopus 로고
    • Pharmacotherapy for diabetic retinopathy
    • Comer GM, Ciulla TA. Pharmacotherapy for diabetic retinopathy. Curr Opin Ophthalmol 2004; 15: 508-18.
    • (2004) Curr Opin Ophthalmol , vol.15 , pp. 508-518
    • Comer, G.M.1    Ciulla, T.A.2
  • 13
    • 0031836159 scopus 로고    scopus 로고
    • VEGF induces hyperpermeability by a direct action on endothelial cells
    • Hippenstiel S, Krüll M, Ikemann A, et al. VEGF induces hyperpermeability by a direct action on endothelial cells. Am J Physiol 1998; 274: L678-84.
    • (1998) Am J Physiol , vol.274
    • Hippenstiel, S.1    Krüll, M.2    Ikemann, A.3
  • 14
    • 0036943831 scopus 로고    scopus 로고
    • Diabetic retinopathy: More than meets the eye
    • Gardner TW, Antonetti DA, Barber AJ, et al. Diabetic retinopathy: more than meets the eye. Surv Ophthalmol 2002; 47(Suppl 2): S253-62.
    • (2002) Surv Ophthalmol , vol.47 , Issue.SUPPL. 2
    • Gardner, T.W.1    Antonetti, D.A.2    Barber, A.J.3
  • 15
    • 33746760142 scopus 로고    scopus 로고
    • Clinical validation of a link between TNF-alpha and the glycosylation enzyme core 2 GlcNAc-T and the relationship of this link to diabetic retinopathy
    • Ben-Mahmud BM, Chan WH, Abdulahad RM, et al. Clinical validation of a link between TNF-alpha and the glycosylation enzyme core 2 GlcNAc-T and the relationship of this link to diabetic retinopathy. Diabetologia 2006; 49: 2185-91.
    • (2006) Diabetologia , vol.49 , pp. 2185-2191
    • Ben-Mahmud, B.M.1    Chan, W.H.2    Abdulahad, R.M.3
  • 16
    • 0037184495 scopus 로고    scopus 로고
    • Molecular understanding of hyperglycemia's adverse effects for diabetic complications
    • Sheetz MJ, King GL. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA 2002; 288: 2579-88.
    • (2002) JAMA , vol.288 , pp. 2579-2588
    • Sheetz, M.J.1    King, G.L.2
  • 17
    • 22144442836 scopus 로고    scopus 로고
    • Intravitreal injection of specific receptor tyrosine kinase inhibitor PTK787/ZK222 584 improves ischemia-induced retinopathy in mice
    • Maier P, Unsoeld AS, Junker B, et al. Intravitreal injection of specific receptor tyrosine kinase inhibitor PTK787/ZK222 584 improves ischemia-induced retinopathy in mice. Graefe's Arch Clin Exp Ophthalmol 2005; 243: 593-600.
    • (2005) Graefe's Arch Clin Exp Ophthalmol , vol.243 , pp. 593-600
    • Maier, P.1    Unsoeld, A.S.2    Junker, B.3
  • 18
    • 10144222652 scopus 로고    scopus 로고
    • Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo
    • Kuroki M, Voest EE, Amano S, et al. Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo. J Clin Invest 1996; 98: 1667-75.
    • (1996) J Clin Invest , vol.98 , pp. 1667-1675
    • Kuroki, M.1    Voest, E.E.2    Amano, S.3
  • 19
    • 0032520871 scopus 로고    scopus 로고
    • Advanced glycation end products increase retinal vascular endothelial growth factor expression
    • Lu M, Kuroki M, Amano S, et al. Advanced glycation end products increase retinal vascular endothelial growth factor expression. J Clin Invest 1998; 101: 1219-24.
    • (1998) J Clin Invest , vol.101 , pp. 1219-1224
    • Lu, M.1    Kuroki, M.2    Amano, S.3
  • 20
    • 18244372934 scopus 로고    scopus 로고
    • Vitreous levels of vascular endothelial growth factor and intercellular adhesion molecule 1 are related to diabetic macular edema
    • Funatsu H, Yamashita H, Sakata K, et al. Vitreous levels of vascular endothelial growth factor and intercellular adhesion molecule 1 are related to diabetic macular edema. Ophthalmology 2005; 112: 806-16.
    • (2005) Ophthalmology , vol.112 , pp. 806-816
    • Funatsu, H.1    Yamashita, H.2    Sakata, K.3
  • 21
    • 0033400347 scopus 로고    scopus 로고
    • The pathogenesis of edema in diabetic maculopathy
    • Antcliff RJ, Marshall J. The pathogenesis of edema in diabetic maculopathy. Semin Ophthalmol 1999; 14: 223-32.
    • (1999) Semin Ophthalmol , vol.14 , pp. 223-232
    • Antcliff, R.J.1    Marshall, J.2
  • 22
    • 0029803087 scopus 로고    scopus 로고
    • Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate
    • Tolentino MJ, Miller JW, Gragoudas ES, et al. Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. Ophthalmology 1996; 103: 1820-8.
    • (1996) Ophthalmology , vol.103 , pp. 1820-1828
    • Tolentino, M.J.1    Miller, J.W.2    Gragoudas, E.S.3
  • 23
    • 0036179104 scopus 로고    scopus 로고
    • Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate
    • Tolentino MJ, McLeod DS, Taomoto M, et al. Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate. Am J Ophthalmol 2002; 133: 373-85.
    • (2002) Am J Ophthalmol , vol.133 , pp. 373-385
    • Tolentino, M.J.1    McLeod, D.S.2    Taomoto, M.3
  • 24
    • 10044242430 scopus 로고    scopus 로고
    • Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone
    • Brooks HL Jr, Caballero S Jr, Newell CK, et al. Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone. Arch Ophthalmol 2004; 122: 1801-7.
    • (2004) Arch Ophthalmol , vol.122 , pp. 1801-1807
    • Brooks Jr, H.L.1    Caballero Jr, S.2    Newell, C.K.3
  • 25
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994; 331: 1480-7.
    • (1994) N Engl J Med , vol.331 , pp. 1480-1487
    • Aiello, L.P.1    Avery, R.L.2    Arrigg, P.G.3
  • 26
    • 0028123090 scopus 로고
    • Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
    • Adamis AP, Miller JW, Bernal MT, et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 1994; 118: 445-50.
    • (1994) Am J Ophthalmol , vol.118 , pp. 445-450
    • Adamis, A.P.1    Miller, J.W.2    Bernal, M.T.3
  • 28
    • 0034790850 scopus 로고    scopus 로고
    • Relationship between vascular endothelial growth factor and interleukin-6 in diabetic retinopathy
    • Funatsu H, Yamashita H, Shimizu E, et al. Relationship between vascular endothelial growth factor and interleukin-6 in diabetic retinopathy. Retina 2001; 21: 469-77.
    • (2001) Retina , vol.21 , pp. 469-477
    • Funatsu, H.1    Yamashita, H.2    Shimizu, E.3
  • 29
    • 33645095226 scopus 로고    scopus 로고
    • Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
    • Ng EW, Shima DT, Calias P, et al. Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov 2006; 5: 123-32.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 123-132
    • Ng, E.W.1    Shima, D.T.2    Calias, P.3
  • 30
    • 11144239923 scopus 로고    scopus 로고
    • Pegaptanib for neovascular age-related macular degeneration
    • for the VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group
    • Gragoudas ES, Adamis AP, Cunningham ET Jr, Feinsod M, Guyer DR, for the VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group. Pegaptanib for neovascular age-related macular degeneration. N Engl J Med 2004; 351: 2805-16.
    • (2004) N Engl J Med , vol.351 , pp. 2805-2816
    • Gragoudas, E.S.1    Adamis, A.P.2    Cunningham Jr, E.T.3    Feinsod, M.4    Guyer, D.R.5
  • 31
    • 65649138591 scopus 로고    scopus 로고
    • Chakravarthy U, Adamis AP, Cunningham ET Jr, et al, for the VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group. Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration. Ophthalmology 2006; 113: 1508.e1-25.
    • Chakravarthy U, Adamis AP, Cunningham ET Jr, et al, for the VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group. Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration. Ophthalmology 2006; 113: 1508.e1-25.
  • 32
    • 33646948521 scopus 로고    scopus 로고
    • D'Amico DJ, Masonson HN, Patel M, et al, for the VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group. Pegaptanib sodium for neovascular age-related macular degeneration: two-year safety results of the two prospective, multicenter, controlled clinical trials. Ophthalmology 2006; 113: 992-1001.
    • D'Amico DJ, Masonson HN, Patel M, et al, for the VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group. Pegaptanib sodium for neovascular age-related macular degeneration: two-year safety results of the two prospective, multicenter, controlled clinical trials. Ophthalmology 2006; 113: 992-1001.
  • 33
    • 0043125643 scopus 로고    scopus 로고
    • VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization
    • Ishida S, Usui T, Yamashiro K, et al. VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med 2003; 198: 483-9.
    • (2003) J Exp Med , vol.198 , pp. 483-489
    • Ishida, S.1    Usui, T.2    Yamashiro, K.3
  • 34
    • 25844513658 scopus 로고    scopus 로고
    • A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema
    • Cunningham ET Jr, Adamis AP, Altaweel M, et al. A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology 2005; 112: 1747-57.
    • (2005) Ophthalmology , vol.112 , pp. 1747-1757
    • Cunningham Jr, E.T.1    Adamis, A.P.2    Altaweel, M.3
  • 35
    • 29644444716 scopus 로고    scopus 로고
    • Changes in retinal neovascularization after pegaptanib (Macugen) therapy in diabetic individuals
    • Adamis AP, Altaweel M, Bressler NM, et al. Changes in retinal neovascularization after pegaptanib (Macugen) therapy in diabetic individuals. Ophthalmology 2006; 113: 23-8.
    • (2006) Ophthalmology , vol.113 , pp. 23-28
    • Adamis, A.P.1    Altaweel, M.2    Bressler, N.M.3
  • 36
    • 0037407757 scopus 로고    scopus 로고
    • VEGF164 is proinflammatory in the diabetic retina
    • Ishida S, Usui T, Yamashiro K, et al. VEGF164 is proinflammatory in the diabetic retina. Invest Ophthalmol Vis Sci 2003; 44: 2155-62.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 2155-2162
    • Ishida, S.1    Usui, T.2    Yamashiro, K.3
  • 37
    • 65649124340 scopus 로고    scopus 로고
    • Su Y-TJ, Gonzalez VH, Vann VR, et al. Pegaptanib Sodium (Macugen®) as an Adjunct in the Management of Refractory Proliferative Diabetic Retinopathy and Clinically Significant Macular Edema. Presented at the 2007 annual meeting of the Association for Research in Vision and Ophthalmology, May 07, Fort Lauderdale, Florida. Paper Session 225.
    • Su Y-TJ, Gonzalez VH, Vann VR, et al. Pegaptanib Sodium (Macugen®) as an Adjunct in the Management of Refractory Proliferative Diabetic Retinopathy and Clinically Significant Macular Edema. Presented at the 2007 annual meeting of the Association for Research in Vision and Ophthalmology, May 07, Fort Lauderdale, Florida. Paper Session 225.
  • 38
    • 65649150170 scopus 로고    scopus 로고
    • Gonzalez VH, Vann VR, Banda RM. Use of Pegaptanib Sodium (Macugen®) for the Regression of Proliferative Diabetic Retinopathy. Presented at the 2006 annual meeting of the Association for Research in Vision and Ophthalmology, May 02, Fort Lauderdale, Florida. Paper Session 312.
    • Gonzalez VH, Vann VR, Banda RM. Use of Pegaptanib Sodium (Macugen®) for the Regression of Proliferative Diabetic Retinopathy. Presented at the 2006 annual meeting of the Association for Research in Vision and Ophthalmology, May 02, Fort Lauderdale, Florida. Paper Session 312.
  • 39
    • 0742303239 scopus 로고
    • ETDRS report no. 2: Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema
    • Early Treatment Diabetic Retinopathy Study Research Group
    • Early Treatment Diabetic Retinopathy Study Research Group. ETDRS report no. 2: treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema. Ophthalmology 1987; 94: 761-74.
    • (1987) Ophthalmology , vol.94 , pp. 761-774
  • 40
    • 0002708592 scopus 로고
    • Techniques for scatter and local photocoagulation treatment of diabetic retinopathy: ETDRS report no. 3
    • Early Treatment Diabetic Retinopathy Study Research Group
    • Early Treatment Diabetic Retinopathy Study Research Group. Techniques for scatter and local photocoagulation treatment of diabetic retinopathy: ETDRS report no. 3. Int Ophthalmol Clin 1987; 274: 254-64.
    • (1987) Int Ophthalmol Clin , vol.274 , pp. 254-264
  • 41
    • 0019473351 scopus 로고
    • Photocoagulation treatment of proliferative diabetic retinopathy: Clinical applications of Diabetic Retinopathy Study. DRS
    • The Diabetic Retinopathy Study Research Group
    • The Diabetic Retinopathy Study Research Group. Photocoagulation treatment of proliferative diabetic retinopathy: clinical applications of Diabetic Retinopathy Study. DRS Report number 8. Ophthalmology 1981; 88: 583-600.
    • (1981) Ophthalmology , vol.88 , pp. 583-600
  • 43
    • 0025975080 scopus 로고
    • Contrast sensitivity changes in background diabetic retinopathy
    • Khosla PK, Talwar D, Tewari HK. Contrast sensitivity changes in background diabetic retinopathy. Can J Ophthalmol 1991; 26: 7-11.
    • (1991) Can J Ophthalmol , vol.26 , pp. 7-11
    • Khosla, P.K.1    Talwar, D.2    Tewari, H.K.3
  • 44
    • 0023761057 scopus 로고    scopus 로고
    • Kleiner RC, Elman MJ, Murphy RP, Ferris FL 3rd. Transient severe visual loss after panretinal photocoagulation. Am J Ophthalmol 1988; 106: 298-306.
    • Kleiner RC, Elman MJ, Murphy RP, Ferris FL 3rd. Transient severe visual loss after panretinal photocoagulation. Am J Ophthalmol 1988; 106: 298-306.
  • 45
    • 0018850905 scopus 로고
    • Macular edema after scatter laser photocoagulation for proliferative diabetic retinopathy
    • Meyers SM. Macular edema after scatter laser photocoagulation for proliferative diabetic retinopathy. Am J Ophthalmol 1980; 90: 210-16.
    • (1980) Am J Ophthalmol , vol.90 , pp. 210-216
    • Meyers, S.M.1
  • 46
    • 0026651108 scopus 로고
    • Subretinal fibrosis after laser photocoagulation for diabetic macular edema
    • Guyer DR, D'Amico DJ, Smith CW. Subretinal fibrosis after laser photocoagulation for diabetic macular edema. Am J Ophthalmol 1992; 113: 652-6.
    • (1992) Am J Ophthalmol , vol.113 , pp. 652-656
    • Guyer, D.R.1    D'Amico, D.J.2    Smith, C.W.3
  • 47
    • 0026648408 scopus 로고
    • Submacular fibrosis after photocoagulation for diabetic macular edema
    • Han DP, Mieler WF, Burton TC. Submacular fibrosis after photocoagulation for diabetic macular edema. Am J Ophthalmol 1992; 113: 513-21.
    • (1992) Am J Ophthalmol , vol.113 , pp. 513-521
    • Han, D.P.1    Mieler, W.F.2    Burton, T.C.3
  • 48
    • 0025275540 scopus 로고
    • Choroidal neovascularization after laser photocoagulation for diabetic macular edema
    • Lewis H, Schachat AP, Haimann MH, et al. Choroidal neovascularization after laser photocoagulation for diabetic macular edema. Ophthalmology 1990; 97: 503-10.
    • (1990) Ophthalmology , vol.97 , pp. 503-510
    • Lewis, H.1    Schachat, A.P.2    Haimann, M.H.3
  • 49
    • 4444337333 scopus 로고    scopus 로고
    • The impact of diabetic retinopathy: Perspectives from the patient focus groups
    • Coyne KS, Margolis MK, Kennedy-Martin T, et al. The impact of diabetic retinopathy: perspectives from the patient focus groups. Fam Pract 2004; 21: 447-53.
    • (2004) Fam Pract , vol.21 , pp. 447-453
    • Coyne, K.S.1    Margolis, M.K.2    Kennedy-Martin, T.3
  • 50
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306-9.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3
  • 51
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989; 16: 851-8.
    • (1989) Biochem Biophys Res Commun , vol.16 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 52
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to PDGF
    • Keck PJ, Hauser SD, Krivi G, et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989; 246: 1309-12.
    • (1989) Science , vol.246 , pp. 1309-1312
    • Keck, P.J.1    Hauser, S.D.2    Krivi, G.3
  • 53
    • 0029171581 scopus 로고
    • Hypoxic induction of endothelial cell growth factors in retinal cells: Identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen
    • Shima DT, Adamis AP, Ferrara N, et al. Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. Mol Med 1995; 1: 182-93.
    • (1995) Mol Med , vol.1 , pp. 182-193
    • Shima, D.T.1    Adamis, A.P.2    Ferrara, N.3
  • 54
    • 0028826101 scopus 로고
    • Hypoxic regulation of vascular endothelial growth factor in retinal cells
    • Aiello LP, Northrup JM, Keyt BA, et al. Hypoxic regulation of vascular endothelial growth factor in retinal cells. Arch Ophthalmol 1995; 113: 1538-44.
    • (1995) Arch Ophthalmol , vol.113 , pp. 1538-1544
    • Aiello, L.P.1    Northrup, J.M.2    Keyt, B.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.