Calcium dobesilate: Pharmacology and future approaches

General Pharmacology

Volumn 31, Issue 3, 1998, Pages 357-360

  Tejerina, T ^a   Ruiz, E ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Calcium dobesilate; Cat; Diabetic vascular reactivity; Rabbit; Rat; Venous insufficiency

Indexed keywords

DOBESILATE CALCIUM; NITRIC OXIDE;

BLOOD VESSEL PERMEABILITY; BLOOD VESSEL REACTIVITY; BLOOD VISCOSITY; CAT; CHRONIC VEIN INSUFFICIENCY; DIABETIC RETINOPATHY; DRUG ACTIVITY; DRUG MECHANISM; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; REVIEW; THROMBOCYTE AGGREGATION;

ANIMALS; BLOOD VISCOSITY; CALCIUM DOBESILATE; CAPILLARY PERMEABILITY; HUMANS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; VASODILATION;

EID: 0032168570     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(98)00040-8     Document Type: Review

References (39)

1. Barnes A., Locke P., Scudden P., Dormandy R., Dormandy J., Slack S. Is hyperviscosity a treatable component of diabetic microcirculatory disease? Lancet. 11:1997;789-791.
2. Barras J., Graf C. Hyperviscosity in diabetic retinopathy treated with Doxium (calcium dobesilate). Vasa. 9:1980;161-164.
3. Benakis A., Glasson B., Bouvier C.A., Ritschard J., Krahenbuhl B., Jung A., Hachen H. Metabolisme et pharmacocinétique du dobesilate de calcium chez l'homme. Therapie. 29:1974;211-219.
4. Beyer J., Meissner J., Cordes V. Calcium dobesilate reduces microvascular permeability to plasma proteins in diabetes mellitus. Med. Wxchr. 105:1980;1604-1610.
5. Binkhorst P.G., van Bijsterveld M.D. Calcium dobesilate versus placebo in the treatment of diabetic retinopathy. a double blind cross-over study Curr. Ther. Res. 20:1976;283-288.
6. Bussolino F., Biffignandi P., Arese P. Platelet-activating factor. a powerful lipid autacoid possibly involved in microangiopathy Acta Haematol. 75:1986;129-140.
7. Dintenfass L., Davies E. Blood viscosity factors and capillary abnormalities in diabetes mellitus. Adv. Microcirc. 7:1977;96-109.
8. Elliot T., Cockcroft J., Groop P., Earle K., Morocutti A., Viberti G., Ritter J. Vascular responses in the forearm of microalbuminuric type I (insulin-dependent) diabetic patients. evidence of altered nitric oxide biosynthesis Diabetologia. 35(Suppl. 1):1992;A19.
9. Garay R., Brunet J., Hannaert P. In vitro antioxidant properties of calcium dobesilate. Focus Diabetic Retinopathy. 2:1995;64.
10. Hachen H., Lorenz P. Double-blind clinical and plethysmographic study of calcium dobesilate in patients with peripheral microvascular disorders. Angiology. 33:1982;480-488.
11. Harris K., MacLeod K. Influence of the endothelium on contractile responses of arteries from diabetic rats. Eur. J. Pharmac. 153:1988;55-64.
12. Heidrich H., Gerke E., Nekarda H. Thrombozytenag gregationshammung unter calcium dobesilate. Arzneim.-Forsch. 3:1983;580-584.
13. Hoare E., Barnes A., Dormandy J. Abnormal blood viscosity in diabetes mellitus and retinopathy. Biorheology. 13:1976;21-25.
14. Hudomel J., Nemeth B., Palfalvy M., Farkas A. Effect of calcium dobesilate (Doxium) on blood hyperviscosity in cases of diabetic retinopathy. Ophthalmic Res. 9:1977;25-30.
15. Kappert A. The effect of drugs on modified capillary function. Z. Ther. 2:1974;71-76.
16. Kolb-Bachofen V., Suschek C. Investigation on the biological action of calcium dobesilate. evidence for increased endothelial NO release Focus Diabetic Retinopathy. 2:1995;65.
17. Koltringer P., Eber O., Rothlauer W., Klima G., Lind P., Langsteger W., Wakoning P. Calcium dobesilate and its effects on hemorheology and microcirculation. Int. J. Clin. Pharmac. Ther. Toxicol. 26:1988;500-502.
18. Leite E., Mota M., Faria de Adreu J., Cunha-Vaz J. Effect of calcium dobesilate on the blood-retinal barrier in the early diabetic retinopathy. Int. Ophthalmol. 14:1990;81-88.
19. Little H. The role of abnormal hemorheolodynamics in the pathogenesis of diabetic retinopathy. Trans. Am. Ophthalmol. Soc. 74:1976;573-636.
20. MacLeod K., McNeill M. The influence of chronic experimental diabetes on contractile responses of rat isolated blood vessels. Can. J. Physiol. Pharmac. 63:1985;52-55.
21. Marmo E. Calcium dobesilate in medical treatment. experimental and clinical aspects Eur. Rev. Med. Pharmac. Sci. 9:1971;1-6.
22. McMillan D. Deterioration of the microcirculation in diabetes. Diabetes. 24:1975;944-957.
23. McMillan D. Plasma protein changes, blood viscosity and diabetic microangiopathy. Diabetes. 25(Suppl. 2):1976;25-33.
24. McVeigh G., Brennan G., Johnston G., McDermott G., McGrath B., Henry L., Andrews J., Hayes J. Impaired endothelium-dependent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 35:1992;771-776.
25. Michal M., Gotti C. Effect of calcium dobesilate on platelet function. Thromb. Res. 51:1988;593-605.
26. Oyama Y., Kawasaki H., Hattori Y., Kanno M. Attenuation of endothelium-dependent relaxation in aorta from diabetic rats. Eur. J. Pharmac. 131:1986;75-82.
27. Pieper G.M., Gross G.J. Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta. Am. J. Physiol. 255:1988;H825-H833.
28. Royle J. A double-blind trial of calcium dobesilate in chronic venous insufficiency. Angiology. 39:1988;853-857.
29. Ruiz E., Lorente R., Tejerina T. Calcium dobesilate increases the synthesis of endothelium-dependent relaxing factors in isolated rabbit aorta. Br. J. Pharmac. 121:1997;711-715.
30. Salama B., Brodsky I., Rubinstein M., Viggiano C., Salama E. Treatment of blood hyperviscosity with calcium dobesilate in patients with diabetic retinopathy. Ophthalmic Res. 17:1985;131-138.
31. Skovborg F., Nielsen A., Schlichztkrull J., Ditzel J. Blood viscosity in diabetic patient. Lancet. 1:1966;129-131.
32. Tesfamariam B., Cohen R. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am. J. Physiol. 263:1992;H321-H326.
33. Thomas J., Dorme N., Sergent M., Raynaud G., Bouvet P. Action du dobésilate du calcium sur la resistance et la permeabilité capillaries et sur le temps de saignement et la adhesivité plaquetaire modifiés par le dextran. Ann. Pharmac. Franc. 30:1972;415-420.
34. Vinnazer H., Hachen H.J. Influence of calcium dobesilate (Doxium) on blood viscosity and coagulation parameters in diabetic retinopathy. Vasa. 16:1987;190-192.
35. Vojnikovic B. Hyperviscoisty in whole blood, plasma and aqueous humor decreased by Doxium (calcium dobesilate) in diabetics with retinopathy and glaucoma. a double-blind controlled study Ophthalmic Res. 16:1984;150-162.
36. Vojnikovic B. Doxium (calcium dobesilate) reduces blood hyperviscosity and lowers elevated intraocular pressure in patients with diabetic retinopathy and glaucoma. Ophthalmic Res. 23:1991;12-20.
37. Wakabayashi I., Hatake K., Kimura N., Kakishita E., Nagai K. Modulation of the vascular tonus by the endothelium in experimental diabetes. Life Sci. 40:1987;603-610.
38. Weidman P., Piccoli C., Keuschm M., Mutagic M., Grimm M., Meier A., Zeigler W. Sodium-volume factor, cardiovascular reactivity and hypotensive mechanism of diuretic therapy in mild hypertension associated with diabetes. Am. J. Med. 67:1979;779-783.
39. Widmer L., Biland L., Barras P. Doxium 500 in chronic venous insufficiency. a double-blind placebo-controlled multicentre study Int. Angiol. 9:1990;105-110.