Nandrolone attenuates aortic adaptation to exercise in rats

Cardiovascular Research

Volumn 97, Issue 4, 2013, Pages 686-695

  Sun, Mengwei ^a   Shen, Weili ^b   Zhong, Meifang ^b   Wu, Pingping ^b   Chen, Hong ^b   Lu, Aiyun ^a  

^a SHANGHAI UNIVERSITY OF SPORT   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Aerobic training; Mitochondrial dynamic remodeling; Nandrolone; Oxidative stress; Vessel adaptation

Indexed keywords

AUTOPHAGY PROTEIN 5; AUTOPHAGY RELATED PROTEIN 7; BECLIN 1; CATALASE; DYNAMIN I; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEME OXYGENASE 1; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL ENZYME; MITOFUSIN 2; NANDROLONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); THIOBARBITURIC ACID; UNCLASSIFIED DRUG;

AEROBIC EXERCISE; ANIMAL EXPERIMENT; ARTICLE; CARBONYLATION; COPY NUMBER VARIATION; DNA ISOLATION; GENE DOSAGE; MALE; MITOCHONDRIAL DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; WESTERN BLOTTING;

ACETYLCHOLINE; ADAPTATION, PHYSIOLOGICAL; ANABOLIC AGENTS; ANIMALS; AORTA; AUTOPHAGY; HEME OXYGENASE (DECYCLIZING); MALE; MITOCHONDRIA; NANDROLONE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE III; NITROPRUSSIDE; OXIDATIVE STRESS; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84874686751     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs423     Document Type: Article

References (45)

1. Perry PJ, Lund BC, Deninger MJ, Kutscher EC, Schneider J. Anabolic steroid use in weightlifters and bodybuilders: an internet survey of drug utilization. Clin J Sport Med 2005;15:326-330.
2. Angell P, Chester N, Green D, Somauroo J, Whyte G, George K. Anabolic steroids and cardiovascular risk. Sports Med 2012;42:119-134.
3. Montisci M, El Mazloum R, Cecchetto G, Terranova C, Ferrara SD, Thiene G, et al. Anabolic androgenic steroids abuse and cardiac death in athletes: morphological and toxicological findings in four fatal cases. Forensic Sci Int 2012;217:e13-18.
4. McCrohon JA, Jessup W, Handelsman DJ, Celermajer DS. Androgen exposure increases human monocyte adhesion to vascular endothelium and endothelial cell expression of vascular cell adhesion molecule-1. Circulation 1999;99:2317-2322.
5. McCrohon JA, Death AK, Nakhla S, Jessup W, Handelsman DJ, Stanley KK, et al. Androgen receptor expression is greater in macrophages from male than from female donors. A sex difference with implications for atherogenesis. Circulation 2000;101:224-226.
6. Ungvari Z, Sonntag WE, Csiszar A. Mitochondria and aging in the vascular system. J Mol Med (Berl) 2010;88:1021-1027.
7. Chen H, Chan DC. Mitochondrial dynamics in mammals. Curr Top Dev Biol 2004;59: 119-144.
8. Sesaki H, Jensen RE. Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J Cell Biol 1999;147:699-706.
9. Manczak M, Calkins MJ, Reddy PH. Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. Hum Mol Genet 2010;20: 2495-2509.
10. Bo H, Zhang Y, Ji LL. Redefining the role of mitochondria in exercise: a dynamic remodeling. Ann N Y Acad Sci 2010;1201:121-128.
11. Feng Z, Bai L, Yan J, Li Y, Shen W,Wang Y, et al. Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: regulatory effects of hydroxytyrosol. Free Radic Biol Med 2011;50:1437-1446.
12. Holloszy JO, Coyle EF. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 1984;56:831-838.
13. Dela F, Mikines KJ, von Linstow M, Secher NH, Galbo H. Effect of training on insulinmediated glucose uptake in human muscle. Am J Physiol 1992;263:E1134-1143.
14. Cartoni R, Leger B, Hock MB, Praz M, Crettenand A, Pich S, et al. Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J Physiol 2005;567:349-358.
15. Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE, et al. Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation 2011;124:444-453.
16. Dikalova AE, Bikineyeva AT, Budzyn K, Nazarewicz RR, McCann L, Lewis W, et al. Therapeutic targeting of mitochondrial superoxide in hypertension. Circ Res 2010; 107:106-116.
17. Sun MW, Zhong MF, Gu J, Qian FL, Gu JZ, Chen H. Effects of different levels of exercise volume on endothelium-dependent vasodilation: roles of nitric oxide synthase and heme oxygenase. Hypertens Res 2008;31:805-816.
18. Sun MW, Qian FL, Wang J, Tao T, Guo J, Wang L, et al. Low-intensity voluntary running lowers blood pressure with simultaneous improvement in endotheliumdependent vasodilatation and insulin sensitivity in aged spontaneously hypertensive rats. Hypertens Res 2008;31:543-552.
19. Saborido A, Vila J, Molano F, Megias A. Effect of anabolic steroids on mitochondria and sarcotubular system of skeletal muscle. J Appl Physiol 1991;70:1038-1043.
20. Molano F, Saborido A, Delgado J, Moran M, Megias A. Rat liver lysosomal and mitochondrial activities are modified by anabolic-androgenic steroids. Med Sci Sports Exerc 1999;31:243-250.
21. Patane G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM. Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition. Diabetes 2002;51:2749-2756.
22. McCredie RJ, McCrohon JA, Turner L, Griffiths KA, Handelsman DJ, Celermajer DS. Vascular reactivity is impaired in genetic females taking high-dose androgens. J Am Coll Cardiol 1998;32:1331-1335.
23. Herman SM, Robinson JT, McCredie RJ, Adams MR, Boyer MJ, Celermajer DS. Androgen deprivation is associated with enhanced endothelium-dependent dilatation in adult men. Arterioscler Thromb Vasc Biol 1997;17:2004-2009.
24. Sader MA, Griffiths KA, McCredie RJ, Handelsman DJ, Celermajer DS. Androgenic anabolic steroids and arterial structure and function in male bodybuilders. J Am Coll Cardiol 2001;37:224-230.
25. Bedford TG, Tipton CM, Wilson NC, Oppliger RA, Gisolfi CV. Maximum oxygen consumption of rats and its changes with various experimental procedures. J Appl Physiol 1979;47:1278-1283.
26. Woodman CR, Turk JR, Williams DP, Laughlin MH. Exercise training preserves endothelium-dependent relaxation in brachial arteries from hyperlipidemic pigs. J Appl Physiol 2003;94:2017-2026.
27. Padilla J, Simmons GH, Bender SB, Arce-Esquivel AA, Whyte JJ, Laughlin MH. Vascular effects of exercise: endothelial adaptations beyond active muscle beds. Physiology (Bethesda) 2011;26:132-145.
28. Johnson LR, Rush JW, Turk JR, Price EM, Laughlin MH. Short-term exercise training increases ACh-induced relaxation and eNOS protein in porcine pulmonary arteries. J Appl Physiol 2001;90:1102-1110.
29. Johnson LR, Parker JL, Laughlin MH. Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs. J Appl Physiol 2000;88:443-451.
30. Thompson MA, Henderson KK, Woodman CR, Turk JR, Rush JW, Price E, et al. Exercise preserves endothelium-dependent relaxation in coronary arteries of hypercholesterolemic male pigs. J Appl Physiol 2004;96:1114-1126.
31. Zhong MF, Shen WL, Wang J, Yang J, Yuan WJ, He J, et al. Paradoxical effects of streptozotocin-induced diabetes on endothelial dysfunction in stroke-prone spontaneously hypertensive rats. J Physiol 2011;589:5153-5165.
32. Steed MM, Tyagi N, Sen U, Schuschke DA, Joshua IG, Tyagi SC. Functional consequences of the collagen/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS2/2, and iNOS2/2 mice. Am J Physiol Lung Cell Mol Physiol 2010;299:L301-311.
33. Cunha TS, Moura MJ, Bernardes CF, Tanno AP, Marcondes FK. Vascular sensitivity to phenylephrine in rats submitted to anaerobic training and nandrolone treatment. Hypertension 2005;46:1010-1015.
34. Hayakawa T, Noda M, Yasuda K, Yorifuji H, Taniguchi S, Miwa I, et al. Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic beta-cell line betaHC9. J Biol Chem 1998;273:20300-20307.
35. Shen W, Liu K, Tian C, Yang L, Li X, Ren J, et al. R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. Diabetologia 2008;51:165-174.
36. Liu J, Yeo HC, Overvik-Douki E, Hagen T, Doniger SJ, Chyu DWet al. Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants. J Appl Physiol 2000;89:21-28.
37. Sun M, Qian F, Shen W, Tian C, Hao J, Sun L, et al. Mitochondrial nutrients stimulate performance and mitochondrial biogenesis in exhaustively exercised rats. Scand J Med Sci Sports 2012;22:764-775.
38. Liu J, Atamna H, Kuratsune H, Ames BN. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann N Y Acad Sci 2002;959: 133-166.
39. Liu J, ShenW, Zhao B,Wang Y,Wertz K,Weber P, et al. Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: hope from natural mitochondrial nutrients. Adv Drug Deliv Rev 2009;61:1343-1352.
40. Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. Embo J 2008;27:433-446.
41. Yan J, Feng Z, Liu J, Shen W, Wang Y, Wertz K, et al. Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: ameliorating effects of (-)-epigallocatechin-3-gallate. J Nutr Biochem 2011;23:716-724.
42. Ashrafi G, Schwarz TL. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 2013;20:31-42.
43. Grumati P, Coletto L, Schiavinato A, Castagnaro S, Bertaggia E, Sandri M, et al. Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles. Autophagy 2011;7:1415-1423.
44. Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell 2005;120: 483-495.
45. Tonkonogi M, Walsh B, Svensson M, Sahlin K. Mitochondrial function and antioxidative defence in human muscle: effects of endurance training and oxidative stress. J Physiol 2000;528 (Pt 2):379-388.