Exercise preserves endothelium-dependent relaxation in coronary arteries of hypercholesterolemic male pigs

Journal of Applied Physiology

Volumn 96, Issue 3, 2004, Pages 1114-1126

  Thompson, Mark A ^b   Henderson, Kyle K ^b   Woodman, Christopher R ^b   Turk, James R ^b   Rush, James W E ^b   Price, Elmer ^b   Laughlin, M Harold ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b NONE

Author keywords

Endothelial nitric oxide synthase; Endothelium independent relaxation; Nitric oxide; Prostacyclin; Vascular smooth muscle

Indexed keywords

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CORONARY ARTERY DILATATION; ENZYME INHIBITION; EXERCISE; HYPERCHOLESTEROLEMIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LIPID DIET; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITTING; THROMBOCYTE AGGREGATION; TISSUE LEVEL; TRAINING;

ANIMALS; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HYPERCHOLESTEROLEMIA; MALE; PHYSICAL CONDITIONING, ANIMAL; SEROTONIN; SWINE; VASODILATION;

EID: 1342325475     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00768.2003     Document Type: Article

References (40)

1. Best PJ, Lerman LO, Romero JC, Richardson D, Holmes DR Jr, and Lerman A. Coronary endothelial function is preserved with chronic endothelin receptor antagonism in experimental hypercholesterolemia in vitro. Arterioscler Thromb Vasc Biol 19: 2769-2775, 1999.
2. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, and Panza JA. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation 88: 2541-2547, 1993.
3. Cohen RA, Zitnay KM, Haudenschild C, and Cunningham LD. Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries. Circ Res 63: 903-910, 1988.
4. Delp MD, McAllister RM, and Laughlin MH. Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta. J Appl Physiol 75: 1354-1363, 1993.
5. Dixon JL, Stoops JD, Parker JL, Laughlin MH, Weisman GA, and Sturek M. Dyslipidemia and vascular dysfunction in diabetic pigs fed an atherogenic diet. Arterioscler Thromb Vasc Biol 19: 2981-2992, 1999.
6. Dzau VJ. Pathobiology of atherosclerosis and plaque complications. Am Heart J 128: 1300-1304, 1994.
7. Feron O, Dessy C, Moniotte S, Desager JP, and Balligand JL. Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase. J Clin Invest 103: 897-905, 1999.
8. Govers R and Rabelink TJ. Cellular regulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol 280: F193-F206, 2001.
9. Govers R, van der Sluijs P, van Donselaar E, Slot JW, and Rabelink TJ. Endothelial nitric oxide synthase and its negative regulator caveolin-1 localize to distinct perinuclear organelles. J Histochem Cytochem 50: 779-788, 2002.
10. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, Schoene N, and Schuler G. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 342: 454-460, 2000.
11. Heistad DD, Armstrong ML, Marcus ML, Piegors DJ, and Mark AL. Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atheroclerotic monkeys. Circ Res 54: 711-718, 1984.
12. Johnson LR, Rush JW, Turk JR, Price EM, and Laughlin MH. Short-term exercise training increases ACh-induced relaxation and eNOS protein in porcine pulmonary arteries. J Appl Physiol 90: 1102-1110, 2001.
13. Komori K, Shimokawa H, and Vanhoutte PM. Hypercholesterolemia impairs endothelium-dependent relaxations to aggregating platelets in porcine iliac arteries. J Vasc Surg 10: 318-325, 1989.
14. Laughlin MH, Overholser KA, and Bhatte MJ. Exercise training increases coronary transport reserve in miniature swine. J Appl Physiol 67: 1140-1149, 1989.
15. Laughlin MH, Pollock JS, Amann JF, Hollis ML, Woodman CR, and Price EM. Training induces nonuniform increases in eNOS content along the coronary arterial tree. J Appl Physiol 90: 501-510, 2001.
16. Laughlin MH, Welshons WV, Sturek M, Rush JW, Turk JR, Taylor JA, Judy BM, Henderson KK, and Ganjam VK. Gender, exercise training, and eNOS expression in porcine skeletal muscle arteries. J Appl Physiol 95: 250-264, 2003.
17. 2, and ADP. Circulation 79: 698-705, 1989.
18. Luscher TF, Tanner FC, Tschudi MR, and Noll G. Endothelial dysfunction in coronary artery disease. Annu Rev Med 44: 395-418, 1993.
19. McAllister RM, and Laughlin MH. Short-term exercise training alters responses of porcine femoral and brachial arteries. J Appl Physiol 82: 1438-1444, 1997.
20. McLenachan JM, Williams JK, Fish RD, Ganz P, and Selwyn AP. Loss of flow-mediated endothelium-dependent dilation occurs early in the development of atherosclerosis. Circulation 84: 1273-1278, 1991.
21. Meredith IT, Yeung AC, Weidinger FF, Anderson TJ, Uehata A, Ryan TJJ, Selwyn AP, and Ganz P. Role of impaired endothelium-dependent vasodilation in ischemic manifestations of coronary artery diseases. Circulation 87: 56-66, 1993.
22. Muller JM, Myers PR, and Laughlin MH. Vasodilator responses of coronary resistance arteries of exercise-trained pigs. Circulation 89: 2308-2314, 1994.
23. Muller JM, Myers PR, and Laughlin MH. Vasodilator responses of coronary resistance arteries of exercise-trained pigs. Circulation 89: 2308-2314, 1994.
24. Nava E, Noll G, and Luscher TF. Nitric oxide in cardiovascular diseases. Ann Med 27: 343-351, 1995.
25. Oltman CL, Parker JL, Adams HR, and Laughlin MH. Effects of exercise training on vasomotor reactivity of porcine coronary arteries. Am J Physiol Heart Circ Physiol 263: H372-H382, 1992.
26. Oltman CL, Parker JL, and Laughlin MH. Endothelium-dependent vasodilation of proximal coronary arteries from exercise-trained pigs. J Appl Physiol 79: 33-40, 1995.
27. Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, and Galis ZS. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 98: 2572-2579, 1996.
28. Rush JWE, Laughlin MH, Woodman CR, and Price EM. SOD-1 expression in pig coronary arterioles is increased by exercise training. Am J Physiol Heart Circ Physiol 279: H1890-H1897, 2000.
29. Rush JWE, Turk JR, and Laughlin MH. Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium. Am J Physiol Heart Circ Physiol 284: H1378-H1387, 2003.
30. Shimokawa H and Vanhoutte PM. Hypercholesterolemia causes generalized impairment of endothelium-dependent relaxation to aggregating platelets in porcine arteries. J Am Coll Cardiol 13: 1402-1408, 1989.
31. Shimokawa H and Vanhoutte PM. Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis. Circ Res 64: 900-914, 1989.
32. Thomas TR, Pellechia J, Rector RS, Sun GY, Sturek MS, and Laughlin MH. Exercise training does not reduce hyperlipidemia in pigs fed a high-fat diet. Metabolism 51: 1587-1595, 2002.
33. Underwood FB, Laughlin MH, and Sturek M. Altered control of calcium in coronary smooth muscle cells by exercise training. Med Sci Sports Exerc 26: 1230-1238, 1994.
34. Ungvari Z, Csiszar A, Edwards JG, Kaminski PM, Wolin MS, Kaley G, and Koller A. Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase. Arterioscler Thromb Vasc Biol 23: 418-424, 2003.
35. Vita JA and Keaney JF Jr. Endothelial function: a barometer for cardiovascular risk? Circulation 106: 640-642, 2002.
36. 2+ signaling. Am J Physiol Heart Circ Physiol 283: H2397-H2410, 2002.
37. Wang J, Wolin MS, and Hintze TH. Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs. Circ Res 73: 829-838, 1993.
38. Woodman CR, Muller JM, Laughlin MH, and Price EM. Induction of nitric oxide synthase mRNA in coronary resistance arteries isolated from exercise-trained pigs. Am J Physiol Heart Circ Physiol 273: H2575-H2579, 1997.
39. Woodman CR, Turk JR, Rush JWE, and Laughlin MH. Exercise attenuates the effects of hypercholesterolemia on endothelium-dependent relaxation in coronary arteries from adult female pigs. J Appl Physiol 96: 1105-1113, 2004.
40. Woodman CR, Turk JR, Williams DP, and Laughlin MH. Exercise training preserves endothelium-dependent relaxation in brachial arteries from hyperlipidemic pigs. J Appl Physiol 94: 2017-2026, 2003.